EE04567B1 - Kristalliline monohdraat, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks - Google Patents

Kristalliline monohdraat, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks

Info

Publication number
EE04567B1
EE04567B1 EEP200300171A EEP200300171A EE04567B1 EE 04567 B1 EE04567 B1 EE 04567B1 EE P200300171 A EEP200300171 A EE P200300171A EE P200300171 A EEP200300171 A EE P200300171A EE 04567 B1 EE04567 B1 EE 04567B1
Authority
EE
Estonia
Prior art keywords
monoh
drape
medicament
crystalline
manufacture
Prior art date
Application number
EEP200300171A
Other languages
English (en)
Estonian (et)
Inventor
Banholzer Rolf
Sieger Peter
Kulinna Christian
Trunk Michael
Ludwig August Graulich Manfred
Specht Peter
Meissner Helmut
Mathes Andreas
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04567(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of EE200300171A publication Critical patent/EE200300171A/xx
Publication of EE04567B1 publication Critical patent/EE04567B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP200300171A 2000-10-12 2001-09-28 Kristalliline monohdraat, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks EE04567B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12
PCT/EP2001/011225 WO2002030928A1 (fr) 2000-10-12 2001-09-28 Monohydrate cristallin, procede permettant sa preparation et son utilisation pour la preparation d'un produit pharmaceutique

Publications (2)

Publication Number Publication Date
EE200300171A EE200300171A (et) 2003-06-16
EE04567B1 true EE04567B1 (et) 2005-12-15

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300171A EE04567B1 (et) 2000-10-12 2001-09-28 Kristalliline monohdraat, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks

Country Status (46)

Country Link
EP (2) EP1326862B1 (fr)
JP (1) JP3764422B2 (fr)
KR (1) KR100823860B1 (fr)
CN (2) CN1221549C (fr)
AP (1) AP1572A (fr)
AR (2) AR034389A1 (fr)
AT (1) ATE276253T1 (fr)
AU (2) AU1499602A (fr)
BG (1) BG66161B1 (fr)
BR (1) BR0114584A (fr)
CA (1) CA2425539C (fr)
CR (1) CR6938A (fr)
CZ (1) CZ301841B6 (fr)
DE (1) DE50103666D1 (fr)
DK (1) DK1326862T3 (fr)
DZ (1) DZ3478A1 (fr)
EA (1) EA004381B1 (fr)
EC (1) ECSP034540A (fr)
EE (1) EE04567B1 (fr)
EG (1) EG24142A (fr)
ES (1) ES2228965T3 (fr)
GE (1) GEP20063905B (fr)
HR (1) HRP20030276B1 (fr)
HU (1) HU226830B1 (fr)
IL (2) IL155335A0 (fr)
IS (1) IS2339B (fr)
MA (1) MA25842A1 (fr)
ME (2) ME00243B (fr)
MX (1) MXPA03003221A (fr)
MY (1) MY126931A (fr)
NO (1) NO328465B1 (fr)
NZ (1) NZ525733A (fr)
OA (1) OA12403A (fr)
PE (1) PE20020422A1 (fr)
PL (1) PL207870B1 (fr)
PT (1) PT1326862E (fr)
RS (1) RS50218B (fr)
SA (1) SA01220412B1 (fr)
SI (1) SI1326862T1 (fr)
SK (1) SK287009B6 (fr)
TR (1) TR200402579T4 (fr)
TW (1) TW589313B (fr)
UA (1) UA74215C2 (fr)
UY (2) UY26962A1 (fr)
WO (1) WO2002030928A1 (fr)
ZA (1) ZA200302500B (fr)

Families Citing this family (74)

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US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
JP5165244B2 (ja) 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
DK2083007T3 (da) * 2003-11-03 2013-07-29 Boehringer Ingelheim Int Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
ME00349B (fr) * 2003-11-03 2011-05-10 Boehringer Ingelheim Int Nouvel anhydrate cristallin a effet anticholinergique
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
DK2422786T3 (da) 2004-04-22 2014-11-17 Boehringer Ingelheim Int Nye lægemiddelkombinationer til behandling af luftvejssygdomme
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ES2322148T3 (es) 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
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DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
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CA2600636A1 (fr) * 2005-03-09 2006-09-14 Boehringer Ingelheim International Gmbh Nouvelles compositions pharmaceutiques a base d'anticholinergiques et d'inhibiteurs de pde 5
JP5053997B2 (ja) 2005-04-28 2012-10-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性疾患の治療用の新規化合物
JP2008540367A (ja) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
WO2006117299A2 (fr) 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Formes cristallines de bromure de tiotropium
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DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
EP1915158A1 (fr) * 2005-08-06 2008-04-30 Boehringer Ingelheim International GmbH Utilisation de sels de tiotropium pour traiter l asthme grave persistant
BRPI0614410A2 (pt) 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
US20070086957A1 (en) * 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
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EP1925295A1 (fr) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Formule de poudre stable contenant un nouveau anticholinergique
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MX2010004026A (es) 2007-10-19 2010-04-30 Boehringer Ingelheim Int Piperidino-dihidrotienopirimidinas sustituidas.
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EP2513086B1 (fr) 2009-12-17 2015-04-29 Boehringer Ingelheim International GmbH Nouveaux antagonistes pour CCR2 et utilisations associées
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EP2731941B1 (fr) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Antagonistes ccr2, nouveaux et sélectifs
KR101986484B1 (ko) 2011-07-26 2019-06-10 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴놀린 및 이의 약제로서의 용도
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
PT2914593T (pt) 2012-11-05 2017-04-03 Zentiva Ks Estabilização de solvatos de tiotrópio
EP2913332A1 (fr) * 2014-02-27 2015-09-02 Euticals S.P.A. Forme cristalline de bromure de tiotropium et de lactose
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RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (fr) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Forme cristalline d'anhydrate de bromure de tiotropium
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Also Published As

Publication number Publication date
NO20031694L (no) 2003-04-11
IS2339B (is) 2008-02-15
RS50218B (sr) 2009-07-15
CA2425539A1 (fr) 2003-04-11
KR20030042008A (ko) 2003-05-27
TW589313B (en) 2004-06-01
EG24142A (en) 2008-08-06
EP1326862B1 (fr) 2004-09-15
KR100823860B1 (ko) 2008-04-21
JP2004526668A (ja) 2004-09-02
YU27303A (sh) 2006-05-25
AU2002214996B2 (en) 2007-03-15
HUP0301022A3 (en) 2005-12-28
AU1499602A (en) 2002-04-22
PL366041A1 (en) 2005-01-24
NZ525733A (en) 2005-01-28
MA25842A1 (fr) 2003-07-01
ATE276253T1 (de) 2004-10-15
NO328465B1 (no) 2010-02-22
IS6772A (is) 2003-04-09
AR068527A2 (es) 2009-11-18
UY34901A (es) 2015-02-27
NO20031694D0 (no) 2003-04-11
CZ301841B6 (cs) 2010-07-07
CN1733761A (zh) 2006-02-15
BR0114584A (pt) 2003-08-26
IL155335A0 (en) 2003-11-23
HUP0301022A2 (hu) 2003-10-28
CN100519558C (zh) 2009-07-29
DK1326862T3 (da) 2004-11-22
BG107687A (bg) 2003-09-30
AP2003002775A0 (en) 2003-03-31
MXPA03003221A (es) 2004-12-03
TR200402579T4 (tr) 2004-12-21
ES2228965T3 (es) 2005-04-16
SA01220412B1 (ar) 2006-11-05
MY126931A (en) 2006-10-31
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
GEP20063905B (en) 2006-08-25
SK287009B6 (sk) 2009-09-07
BG66161B1 (bg) 2011-09-30
EP1326862A1 (fr) 2003-07-16
WO2002030928A1 (fr) 2002-04-18
ZA200302500B (en) 2004-04-22
HU226830B1 (en) 2009-11-30
EP1468998A1 (fr) 2004-10-20
AP1572A (en) 2006-02-13
EA200300457A1 (ru) 2003-10-30
HK1060567A1 (en) 2004-08-13
CA2425539C (fr) 2007-04-03
UA74215C2 (uk) 2005-11-15
JP3764422B2 (ja) 2006-04-05
HRP20030276B1 (en) 2006-02-28
DZ3478A1 (fr) 2002-04-18
PE20020422A1 (es) 2002-06-28
HRP20030276A2 (en) 2005-02-28
PT1326862E (pt) 2004-11-30
MEP40008A (en) 2011-02-10
HK1086557A1 (zh) 2006-09-22
OA12403A (en) 2006-04-18
EA004381B1 (ru) 2004-04-29
ECSP034540A (es) 2003-07-25
DE50103666D1 (de) 2004-10-21
SK4362003A3 (en) 2003-08-05
CN1469877A (zh) 2004-01-21
IL155335A (en) 2009-02-11
AR034389A1 (es) 2004-02-25
CR6938A (es) 2004-10-28
SI1326862T1 (sl) 2005-02-28
ME00243B (me) 2011-05-10
PL207870B1 (pl) 2011-02-28
UY26962A1 (es) 2002-06-20

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