ES2074966B1 - Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona. - Google Patents

Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.

Info

Publication number
ES2074966B1
ES2074966B1 ES09400252A ES9400252A ES2074966B1 ES 2074966 B1 ES2074966 B1 ES 2074966B1 ES 09400252 A ES09400252 A ES 09400252A ES 9400252 A ES9400252 A ES 9400252A ES 2074966 B1 ES2074966 B1 ES 2074966B1
Authority
ES
Spain
Prior art keywords
pirido
pirimidin
ona
methyl
isoxazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09400252A
Other languages
English (en)
Spanish (es)
Other versions
ES2074966A1 (es
Inventor
Barjoan Pere Dalmases
Olondriz Francisco Marquillas
Clotet Joan Huguet
Rovira Anna Bosch
CASTILLO NIETO Juan DEL
Ges Jose Caldero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vita Invest SA
Original Assignee
Vita Invest SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest SA filed Critical Vita Invest SA
Priority to ES09400252A priority Critical patent/ES2074966B1/es
Priority to GR950100035A priority patent/GR1002344B/el
Priority to SK156-95A priority patent/SK281752B6/sk
Priority to CZ1995329A priority patent/CZ286398B6/cs
Priority to IS4259A priority patent/IS1766B/is
Priority to EG11595A priority patent/EG20877A/xx
Priority to NO950501A priority patent/NO306022B1/no
Priority to PT101654A priority patent/PT101654B/pt
Priority to FI950579A priority patent/FI110000B/fi
Priority to HU9500418A priority patent/HU222110B1/hu
Priority to RU95101859/04A priority patent/RU2123004C1/ru
Priority to PL95307200A priority patent/PL181420B1/pl
Priority to AT0024995A priority patent/AT405401B/de
Priority to KR1019950002516A priority patent/KR100221108B1/ko
Publication of ES2074966A1 publication Critical patent/ES2074966A1/es
Application granted granted Critical
Publication of ES2074966B1 publication Critical patent/ES2074966B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES09400252A 1994-02-11 1994-02-11 Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona. Expired - Fee Related ES2074966B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES09400252A ES2074966B1 (es) 1994-02-11 1994-02-11 Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.
GR950100035A GR1002344B (el) 1994-02-11 1995-02-01 Μεθοδος για την ληψη 3-{2-[4-(6-φλουορο-βενζο[d]ισοξαζολο-3-υλο)πιπεριδινη-1-ιλο]-εθυλο}-2-μεθυλο-6,7,8,9-τετραυδρο-4η-πυριδο[1,2-α]πυριμιδινη-4-ονης.
SK156-95A SK281752B6 (sk) 1994-02-11 1995-02-07 Spôsob prípravy 3-{2-[4-(6-fluórbenzo[d]izoxazol-3-yl)piperidin- 1-yl]etyl}-2-metyl-6,7,8,9-tetrahydro-4h- pyridol[1,2-a]pyrimidin-4-ónu a medziprodukty tohto spôsobu
CZ1995329A CZ286398B6 (en) 1994-02-11 1995-02-08 Process for preparing 3-{2-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
IS4259A IS1766B (is) 1994-02-11 1995-02-08 Aðferð við að fá fram 3-{2-[4-(6-flúor-bensó[D]isoxasól-3-ýl)píperidín-1-ýl]-etýl}-2-metýl-6,7,8,9-fjórhýdró-4H-pýridó[1,2-A]pýrimidín-4-on
NO950501A NO306022B1 (no) 1994-02-11 1995-02-09 Fremgangsmåte til å oppnå 3-{2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)piperidin-1-yl]-etyl}-2-metyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-on
PT101654A PT101654B (pt) 1994-02-11 1995-02-09 Processo para a obtencao de 3-<<2-{4-(6-fluoro-benzo-{d}-isoxazol-3-il)piperidin-1-il}-etil>>-2-metil-6,7,8,9-tetra-hidro-4h-pirido-{1,2-a}pirimidin-4-ona
EG11595A EG20877A (en) 1994-02-11 1995-02-09 A method for obtaining 3- (2- 4-6- fluoro - benzo (d) isoxazol -3- yl) piperidine 1-il) -ethyl) -2- methyl - 6,7,8-tetrahydro-4h-pyrido (1,2-a) pyrimidine -4- one
FI950579A FI110000B (fi) 1994-02-11 1995-02-10 Menetelmä 3-{2-[4-(6-fluori-bentso[d]-isoksatsol-3-yyli)piperidin-1-yyli]-etyyli}-2-metyyli-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-onin saamiseksi
HU9500418A HU222110B1 (hu) 1994-02-11 1995-02-10 Eljárás 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on előállítására és az eljárás intermedierjei
RU95101859/04A RU2123004C1 (ru) 1994-02-11 1995-02-10 Способ получения 3-{2-/4-(6-фторбензо [d] изоксазол-3-ил)пиперидин-1-ил /этил}-2-метил-6,7,8,9-тетрагидро-4h-пиридо /1,2-а/ пиримидин-4-она и промежуточные соединения для его получения
PL95307200A PL181420B1 (pl) 1994-02-11 1995-02-10 [d]izoksazol-3-ilo)piperydyn-1-ylo]etylo}-2-metylo -6,7,8,9-tetrahydro-4H-pirydo[1,2-a]pirymidyn-4-onu i nowe zwiazki posrednie PL
AT0024995A AT405401B (de) 1994-02-11 1995-02-10 Verfahren zur herstellung von 3-(2-(4-(6-fluor- benzo(d)isoxazol-3-yl)piperidin-1-yl)-ethyl) - 2-methyl-6,7,8,9-tetrahydro-4h- pyrido(1,2-a)pyrimidin-4-on
KR1019950002516A KR100221108B1 (ko) 1994-02-11 1995-02-11 3-{2-[4-(6-플루오로-벤조[d]이속사졸-3-일)피페리딘-1-일]-에틸}-2-메틸-6,7,8,9-테트라하이드로-4H-피리도[1,2-a]피리미딘-4-온의 제조방법 및 이를 위한 중간체

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09400252A ES2074966B1 (es) 1994-02-11 1994-02-11 Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.

Publications (2)

Publication Number Publication Date
ES2074966A1 ES2074966A1 (es) 1995-09-16
ES2074966B1 true ES2074966B1 (es) 1996-06-16

Family

ID=8285178

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400252A Expired - Fee Related ES2074966B1 (es) 1994-02-11 1994-02-11 Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.

Country Status (14)

Country Link
KR (1) KR100221108B1 (de)
AT (1) AT405401B (de)
CZ (1) CZ286398B6 (de)
EG (1) EG20877A (de)
ES (1) ES2074966B1 (de)
FI (1) FI110000B (de)
GR (1) GR1002344B (de)
HU (1) HU222110B1 (de)
IS (1) IS1766B (de)
NO (1) NO306022B1 (de)
PL (1) PL181420B1 (de)
PT (1) PT101654B (de)
RU (1) RU2123004C1 (de)
SK (1) SK281752B6 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
CZ295402B6 (cs) * 2000-05-05 2005-08-17 Rpg Life Sciences Limited Způsob přípravy antipsychotického 3-[2-[4-(6-fluor-1,2-benzizoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2,-a]pyrimidin-4-onu
MXPA03001337A (es) 2000-08-14 2005-06-30 Teva Pharma Preparacion de risperidona.
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
KR20040034996A (ko) 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
WO2004043923A1 (en) 2002-11-13 2004-05-27 Synthon B.V. Process for making risperidone and intermediates therefor
RU2310653C1 (ru) * 2006-07-17 2007-11-20 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУВПО "КубГТУ") СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2-МЕТИЛ-5-(5-МЕТИЛ-2-ФУРИЛ)-4,10-ДИГИДРО-3H-ПИРИДАЗИНО[1,6-b]ИЗОХИНОЛИН-10-ОНА (ВАРИАНТЫ)
US8314110B2 (en) * 2007-04-19 2012-11-20 Youxin Li Compounds for treating mental disorders, and preparation and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT327199B (de) * 1971-10-14 1976-01-26 Sumitomo Chemical Co Verfahren zur herstellung von neuen nitrochinazolinonen
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents

Also Published As

Publication number Publication date
PL307200A1 (en) 1995-08-21
AT405401B (de) 1999-08-25
EG20877A (en) 2000-05-31
FI950579A0 (fi) 1995-02-10
KR950032196A (ko) 1995-12-20
SK281752B6 (sk) 2001-07-10
HUT70169A (en) 1995-09-28
NO950501D0 (no) 1995-02-09
HU222110B1 (hu) 2003-04-28
SK15695A3 (en) 1995-10-11
PT101654B (pt) 2002-01-30
NO950501L (no) 1995-08-14
ATA24995A (de) 1998-12-15
CZ32995A3 (en) 1995-09-13
KR100221108B1 (ko) 1999-09-15
PT101654A (pt) 1995-09-12
HU9500418D0 (en) 1995-03-28
FI110000B (fi) 2002-11-15
CZ286398B6 (en) 2000-04-12
PL181420B1 (pl) 2001-07-31
GR1002344B (el) 1996-05-24
NO306022B1 (no) 1999-09-06
IS1766B (is) 2001-03-15
ES2074966A1 (es) 1995-09-16
FI950579L (fi) 1995-08-12
IS4259A (is) 1995-08-12
RU2123004C1 (ru) 1998-12-10
RU95101859A (ru) 1997-03-20

Similar Documents

Publication Publication Date Title
BR0014352A (pt) Cetoenóis espirocìclicos substituìdos por trifluormetila
FI932104A0 (fi) Nya 4-arylpiperaziner och 4-arylpiperidiner
NO20015226D0 (no) Tri-aryl syrederivater som PPAR reseptor ligander
NO902954D0 (no) Fremgangsmaate for fremstilling av substituerte kinazolinoner som angitensin ii-antagonister.
ES8600305A1 (es) Procedimiento de preparar compuestos beta-lactamicos
ATE236442T1 (de) Fluoreszierende cyaninfarbstoffe
ES2176329T3 (es) Procedimientos para preparar formas anhidras e hidratadas de derivados antihistaminicos de piperidina, sus polimeros y pseudomorfos.
TR199903175T2 (xx) Yeni 2-(�minometil)amino-fenil, t�revleri, haz�rlanmalar�, ila� olarak kullan�mlar� ve bu t�revleri i�eren farmas�tik terkipler.
FI902555A0 (fi) Diarylstyrylkinolindisyror.
ATE144498T1 (de) Herstellung von substituierten piperidinen
ES2074966A1 (es) Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona.
MX9602979A (es) Compuestos heterociclicos terapeuticos.
DE69818042D1 (de) Flüssige benzisochinoline derivate
ES2104865T3 (es) Nuevos derivados de n-ciclohexilbenzamidas, sus preparaciones y sus aplicaciones terapeuticas.
TR200002380T2 (tr) Yeni triazolo (4,5-d) pirimidin bileşikleri
ES2056146T3 (es) Monopersulfatos de acidos amino-(poli)percarboxilicos.
DE69814735D1 (de) Carbazolcarboxamide als 5-HT1F Agonisten
SV2002000126A (es) Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol ref. a-149206
ATE131809T1 (de) Dreizyklische chinoline als antineoplastische wirkstoffe
ATE263810T1 (de) Hals enthaltende hybridfarbstoffe
ES2104174T3 (es) Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
PT736009E (pt) N-oxidos de 4-arilpiperazinas e 4-arilpiperidinas como farmacos antipsicoticos
AR010615A1 (es) Procedimiento para preparar 3-(4-alcoxifenil)-6-alcoxibenzotiofenos y procesos para obtener compuestos de 2-(4-hidroxifenil)-3-(4-(2-aminoetoxi)benzoil)-6-hidroxibenzotiofeno
SV2002000573A (es) Proceso para preparar 2-(4-piridil) amino-6- dialquiloxifenil-pirido[2,3-d] pirimidin-7-onas
ES8203355A1 (es) Un procedimiento para la preparacion de nuevas oxazolinas

Legal Events

Date Code Title Description
GC2A Exploitation certificate registered application with search report

Effective date: 20030305

FD2A Announcement of lapse in spain

Effective date: 20141120