IL87290A - Epipodophyllotoxin glucoside 4)-phosphate derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Epipodophyllotoxin glucoside 4)-phosphate derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number: IL87290A
Authority: IL; Israel
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; phosphate derivatives; epipodophyllotoxin glucoside
Prior art date: 1987-08-04

Application number

IL87290A

Other languages

English (en)

Other versions

IL87290A0 (en

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-04

Filing date

1988-08-01

Publication date

1993-01-31

1988-08-01 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1989-01-31 Publication of IL87290A0 publication Critical patent/IL87290A0/xx

1993-01-31 Publication of IL87290A publication Critical patent/IL87290A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Mechanical Coupling Of Light Guides (AREA)
Cable Accessories (AREA)

IL87290A 1987-08-04 1988-08-01 Epipodophyllotoxin glucoside 4)-phosphate derivatives, their preparation and pharmaceutical compositions containing them IL87290A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8149387A	1987-08-04	1987-08-04
US07/199,731 US4904768A (en)	1987-08-04	1988-05-27	Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number	Publication Date
IL87290A0 IL87290A0 (en)	1989-01-31
IL87290A true IL87290A (en)	1993-01-31

Family

ID=26765636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87290A IL87290A (en)	1987-08-04	1988-08-01	Epipodophyllotoxin glucoside 4)-phosphate derivatives, their preparation and pharmaceutical compositions containing them

Country Status (34)

Country	Link
US (3)	US4904768A (fr)
JP (1)	JPH0699465B2 (fr)
KR (1)	KR900006230B1 (fr)
CN (1)	CN1027169C (fr)
AT (1)	AT398974B (fr)
BE (1)	BE1002982A4 (fr)
CA (1)	CA1310637C (fr)
CH (1)	CH676716A5 (fr)
CY (1)	CY1625A (fr)
CZ (1)	CZ286893B6 (fr)
DD (2)	DD299067A5 (fr)
DE (1)	DE3826562A1 (fr)
DK (2)	DK169344B1 (fr)
ES (1)	ES2010775A6 (fr)
FI (1)	FI87790C (fr)
FR (1)	FR2622193B1 (fr)
GB (1)	GB2207674B (fr)
GR (1)	GR1000490B (fr)
HK (1)	HK6392A (fr)
HU (3)	HU208147B (fr)
IE (1)	IE61040B1 (fr)
IL (1)	IL87290A (fr)
IT (1)	IT1226825B (fr)
LU (2)	LU87290A1 (fr)
MX (1)	MX173843B (fr)
MY (1)	MY104321A (fr)
NL (2)	NL192683C (fr)
NO (4)	NO170284C (fr)
NZ (1)	NZ225615A (fr)
PT (1)	PT88186B (fr)
SE (1)	SE502214C2 (fr)
SG (1)	SG101291G (fr)
SK (1)	SK279325B6 (fr)
YU (3)	YU143688A (fr)

Families Citing this family (64)

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US5191071A (en) *	1987-08-21	1993-03-02	Novo Nordisk A/S	Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) *	1989-05-19	1990-10-23	Bristol-Myers Company	Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
US5066645A (en) *	1989-09-01	1991-11-19	Bristol-Myers Company	Epipodophyllotoxin altroside derivatives
US6610299B1 (en)	1989-10-19	2003-08-26	Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en)	1990-10-18	2002-11-05	Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en)	1989-10-20	2007-07-10	Sanofi-Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en)	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) *	1989-11-20	1991-07-23	Bristol-Myers Squibb Company	Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) *	1990-04-30	1992-01-14	Bristol-Myers Squibb Co.	4'-demethylepipodophyllotoxin glycosides
US4997931A (en) *	1990-06-11	1991-03-05	Bristol-Myers Squibb Company	Epipodophyllotoxin glycosides
TW260671B (fr) *	1991-04-29	1995-10-21	Bristol Myers Squibb Co
IT1250692B (it) *	1991-07-23	1995-04-21		Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) *	1991-10-08	1997-07-15	Bristol-Myers Squibb	Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (fr) *	1991-12-23	1996-07-16	Uday Shankar Gogate	Hexahydrate stable d'etoposide-4'-phosphate, sel disodique
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) *	1992-04-24	2000-07-10	日本化薬株式会社	エトポシド燐酸エステルの製造法
US5459248A (en) *	1993-11-04	1995-10-17	Bristol-Myers Squibb Company	Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) *	1994-10-21	1997-01-10	Pf Medicament	Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) *	1995-06-07	1999-08-24	Thomas Jefferson University	Anti-fungal agents and methods of identifying and using the same
KR20060025233A (ko)	1996-04-01	2006-03-20	에픽스 메디칼, 인코포레이티드	생체활성화 진단용 영상 콘트라스트 제제
US6207673B1 (en)	1997-03-12	2001-03-27	The University Of North Carolina At Chapel Hill	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (fr) *	1997-12-23	1999-07-01	Korea Research Institute Of Chemical Technology	DERIVES D'ACETAL DE 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE
EP2266607A3 (fr)	1999-10-01	2011-04-20	Immunogen, Inc.	Des immunoconjugués pour le traitement des cancers.
US6624317B1 (en)	2000-09-25	2003-09-23	The University Of North Carolina At Chapel Hill	Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en)	2001-05-01	2003-01-14	Telik, Inc.	Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
JP2005511550A (ja) *	2001-10-26	2005-04-28	サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィク	エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物
ES2524325T3 (es)	2002-07-15	2014-12-05	Board Of Regents, The University Of Texas System	Anticuerpos seleccionados que se unen a aminofosfolípidos y su uso en el tratamiento del cáncer
ES2368941T3 (es) *	2003-01-06	2011-11-23	Angiochem Inc.	Angiopep-1, compuestos relacionados y utilizaciones correspondientes.
CN100334090C (zh) *	2005-02-02	2007-08-29	南京医科大学	吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) *	2005-02-18	2009-01-15	Richard Beliveau	Delivery of antibodies to the central nervous system
BRPI0520032A2 (pt) *	2005-02-18	2009-04-14	Angiochem Inc	moléculas para transportar um composto através da barreira hematoencefálica
SI2233156T1 (sl) *	2005-07-15	2013-09-30	Angiochem Inc.	Uporaba polipeptidov aprotinina kot nosilce v farmacevtskih konjugatih
CN100410266C (zh) *	2006-01-11	2008-08-13	重庆华邦制药股份有限公司	鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en)	2006-01-20	2012-06-17	نوفارتيس ايه جي	Pi-3 inhibitors and methods of use
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TW200808739A (en) *	2006-04-06	2008-02-16	Novartis Vaccines & Diagnostic	Quinazolines for PDK1 inhibition
GB0625283D0 (en) *	2006-12-19	2007-01-24	Cyclacel Ltd	Combination
US9365634B2 (en) *	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) *	2007-09-13	2012-09-11	Bristol-Myers Squibb Company	Cytotoxic xanthone compounds
EP2614837A1 (fr)	2007-11-09	2013-07-17	Affitech Research AS	Compositions d'anticorps anti-VEGF et procédés
CA2710122A1 (fr)	2007-12-20	2009-07-02	Novartis Ag	Derives de thiazole utilises comme inhibiteur de la pi 3 kinase
MX355683B (es) *	2008-04-18	2018-04-26	Angiochem Inc	Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso.
CN102245636A (zh)	2008-10-15	2011-11-16	安吉奥开米公司	用于药物递送的依托泊苷和多柔比星结合物
MX2011004017A (es)	2008-10-15	2011-06-24	Angiochem Inc	Conjugados de agonistas glp-1 y usos de los mismos.
BRPI0922689A2 (pt) *	2008-12-05	2018-11-06	Angiochem Inc.	conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
BRPI0922611A2 (pt)	2008-12-17	2018-11-06	Angiochem Inc	inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos
RU2011146654A (ru)	2009-04-20	2013-05-27	Ангиокем Инк.	Способы лечения рака яичников с применением конъюгированного средства
US8293753B2 (en)	2009-07-02	2012-10-23	Novartis Ag	Substituted 2-carboxamide cycloamino ureas
JP5932642B2 (ja)	2009-07-02	2016-06-08	アンジオケムインコーポレーテッド	多量体ペプチドコンジュゲートおよびその使用
RU2012139182A (ru)	2010-02-22	2014-03-27	Ф. Хоффманн-Ля Рош Аг	ПИРИДО[3,2-d]ПИРИМИДИНЫ - ИНГИБИТОРЫ PI3К ДЕЛЬТА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US9586954B2 (en)	2010-06-22	2017-03-07	Demerx, Inc.	N-substituted noribogaine prodrugs
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FR1171314A (fr) *	1955-05-13	1959-01-23	Sandoz Ag	Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (fr) *	1965-09-21	1967-03-22
CH464957A (de) *	1965-12-14	1968-11-15	Sandoz Ag	Verfahren zur Herstellung eines neuen Glucosids
CH481913A (de) *	1966-12-13	1969-11-30	Sandoz Ag	Verfahren zur Herstellung neuer Glucoside
CH514578A (de) *	1968-02-27	1971-10-31	Sandoz Ag	Verfahren zur Herstellung von Glucosiden
CH543502A (de) *	1970-11-20	1973-10-31	Sandoz Ag	Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) *	1971-06-05	1975-05-29	Villax I	Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) *	1973-06-07	1977-07-15	Sandoz Ag	Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) *	1977-07-11	1979-02-09	Rhone Poulenc Ind	Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE3374317D1 (en) *	1982-11-26	1987-12-10	Nippon Kayaku Kk	Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) *	1984-02-03	1986-01-28	Tony Durst	2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) *	1984-03-31	1985-10-21	Green Cross Corp:The	水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
US4739046A (en) *	1985-08-19	1988-04-19	Luzio Nicholas R Di	Soluble phosphorylated glucan
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) *	1987-01-08	1990-04-10	Bristol-Myers Company	Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) *	1987-02-06	1988-08-10	Nippon Kayaku Co Ltd	４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) *	1987-07-01	1989-10-17	Bristol-Meyers Company	3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

1988
- 1988-05-27 US US07/199,731 patent/US4904768A/en not_active Ceased
- 1988-07-21 MY MYPI88000819A patent/MY104321A/en unknown
- 1988-07-22 LU LU87290A patent/LU87290A1/fr active Protection Beyond IP Right Term
- 1988-07-25 YU YU01436/88A patent/YU143688A/xx unknown
- 1988-07-26 NO NO883299A patent/NO170284C/no not_active IP Right Cessation
- 1988-07-28 IT IT8821535A patent/IT1226825B/it active
- 1988-07-29 NZ NZ225615A patent/NZ225615A/en unknown
- 1988-07-29 FR FR8810258A patent/FR2622193B1/fr not_active Expired - Lifetime
- 1988-08-01 FI FI883596A patent/FI87790C/fi not_active IP Right Cessation
- 1988-08-01 IL IL87290A patent/IL87290A/xx not_active IP Right Cessation
- 1988-08-02 CZ CS19885412A patent/CZ286893B6/cs not_active IP Right Cessation
- 1988-08-02 SK SK5412-88A patent/SK279325B6/sk unknown
- 1988-08-03 AT AT0195588A patent/AT398974B/de active
- 1988-08-03 NL NL8801934A patent/NL192683C/nl not_active IP Right Cessation
- 1988-08-03 ES ES8802434A patent/ES2010775A6/es not_active Expired
- 1988-08-03 HU HU905862A patent/HU208147B/hu unknown
- 1988-08-03 JP JP63194307A patent/JPH0699465B2/ja not_active Expired - Lifetime
- 1988-08-03 DK DK434088A patent/DK169344B1/da not_active IP Right Cessation
- 1988-08-03 PT PT88186A patent/PT88186B/pt not_active IP Right Cessation
- 1988-08-03 IE IE237888A patent/IE61040B1/en not_active IP Right Cessation
- 1988-08-03 DD DD88326917A patent/DD299067A5/de unknown
- 1988-08-03 SE SE8802815A patent/SE502214C2/sv not_active IP Right Cessation
- 1988-08-03 KR KR1019880009910A patent/KR900006230B1/ko not_active Expired
- 1988-08-03 BE BE8800898A patent/BE1002982A4/fr not_active IP Right Cessation
- 1988-08-03 DD DD88318652A patent/DD274423A5/de unknown
- 1988-08-03 GB GB8818462A patent/GB2207674B/en not_active Expired - Lifetime
- 1988-08-03 HU HU884081A patent/HU202547B/hu unknown
- 1988-08-04 CH CH2962/88A patent/CH676716A5/de not_active IP Right Cessation
- 1988-08-04 GR GR880100512A patent/GR1000490B/el not_active IP Right Cessation
- 1988-08-04 DE DE3826562A patent/DE3826562A1/de active Granted
- 1988-08-04 CA CA000573861A patent/CA1310637C/fr not_active Expired - Lifetime
1989
- 1989-12-14 US US07/450,718 patent/US5041424A/en not_active Expired - Lifetime
1990
- 1990-01-19 YU YU00104/90A patent/YU10490A/xx unknown
- 1990-01-19 YU YU00103/90A patent/YU10390A/xx unknown
1991
- 1991-10-30 CN CN91108384A patent/CN1027169C/zh not_active Expired - Lifetime
- 1991-11-29 SG SG1012/91A patent/SG101291G/en unknown
1992
- 1992-01-16 HK HK63/92A patent/HK6392A/xx not_active IP Right Cessation
- 1992-01-22 NO NO920277A patent/NO920277D0/no unknown
- 1992-01-31 DK DK011992A patent/DK11992A/da not_active Application Discontinuation
- 1992-02-20 NO NO920665A patent/NO172440C/no not_active IP Right Cessation
- 1992-06-12 MX MX9202851A patent/MX173843B/es unknown
- 1992-07-10 CY CY1625A patent/CY1625A/en unknown
1994
- 1994-04-19 US US08/229,659 patent/USRE35524E/en not_active Expired - Lifetime
1995
- 1995-06-22 HU HU95P/P00387P patent/HU211960A9/hu unknown
1997
- 1997-09-24 LU LU90138C patent/LU90138I2/fr unknown
- 1997-12-05 NL NL970042C patent/NL970042I1/nl unknown
1998
- 1998-01-14 NO NO1998002C patent/NO1998002I1/no unknown

Also Published As

Publication number	Publication date
CN1027169C (zh)	1994-12-28
CY1625A (en)	1992-07-10
GB8818462D0 (en)	1988-09-07
DK11992D0 (da)	1992-01-31
SE8802815L (sv)	1989-02-05
DE3826562A1 (de)	1989-02-16
GR880100512A (en)	1989-05-25
PT88186A (pt)	1989-06-30
NL8801934A (nl)	1989-03-01
FR2622193B1 (fr)	1993-12-17
FR2622193A1 (fr)	1989-04-28
CA1310637C (fr)	1992-11-24
DK169344B1 (da)	1994-10-10
NO920277L (no)	1989-02-24
NO920665L (no)	1989-02-24
AU2030688A (en)	1989-06-08
USRE35524E (en)	1997-06-03
DE3826562C2 (fr)	1993-04-08
FI883596A0 (fi)	1988-08-01
US4904768A (en)	1990-02-27
YU10490A (en)	1990-06-30
CZ286893B6 (cs)	2000-07-12
LU90138I2 (fr)	1997-11-26
NL192683C (nl)	1997-12-02
GB2207674B (en)	1991-09-11
HU905862D0 (en)	1991-03-28
DK434088A (da)	1989-02-05
CN1061225A (zh)	1992-05-20
FI87790C (fi)	1993-02-25
US5041424A (en)	1991-08-20
SE502214C2 (sv)	1995-09-18
IE61040B1 (en)	1994-09-07
DD274423A5 (de)	1989-12-20
DK11992A (da)	1992-01-31
CH676716A5 (fr)	1991-02-28
GB2207674A (en)	1989-02-08
HUT47303A (en)	1989-02-28
CZ541288A3 (cs)	1999-12-15
SG101291G (en)	1992-01-17
MY104321A (en)	1994-03-31
SK541288A3 (en)	1998-10-07
HU202547B (en)	1991-03-28
GR1000490B (el)	1992-07-30
FI883596A7 (fi)	1989-02-05
MX9202851A (es)	1992-06-30
AU610619B2 (en)	1991-05-23
HU211960A9 (en)	1996-01-29
NO170284B (no)	1992-06-22
NL970042I1 (nl)	1998-03-02
PT88186B (pt)	1995-07-03
NL192683B (fr)	1997-08-01
NZ225615A (en)	1991-06-25
NO170284C (no)	1992-09-30
HK6392A (en)	1992-01-17
NO883299L (no)	1989-02-24
JPH0699465B2 (ja)	1994-12-07
NO920277D0 (no)	1992-01-22
IT1226825B (it)	1991-02-19
HU208147B (en)	1993-08-30
ES2010775A6 (es)	1989-12-01
NO1998002I1 (no)	1998-01-14
DD299067A5 (de)	1992-03-26
MX173843B (es)	1994-03-30
YU143688A (en)	1990-04-30
BE1002982A4 (fr)	1991-10-15
IE882378L (en)	1989-02-04
JPH01100188A (ja)	1989-04-18
KR890003790A (ko)	1989-04-18
NO172440B (no)	1993-04-13
NO172440C (no)	1993-07-21
DK434088D0 (da)	1988-08-03
IL87290A0 (en)	1989-01-31
SE8802815D0 (sv)	1988-08-03
FI87790B (fi)	1992-11-13
NO883299D0 (no)	1988-07-26
ATA195588A (de)	1994-07-15
KR900006230B1 (ko)	1990-08-27
LU87290A1 (fr)	1990-02-07
NL970042I2 (fr)	2005-06-01
IT8821535A0 (it)	1988-07-28
YU10390A (en)	1990-06-30
SK279325B6 (sk)	1998-10-07
NO920665D0 (no)	1992-02-20
AT398974B (de)	1995-02-27

Legal Events

Date	Code	Title
1998-12-27	KB	Patent renewed
2002-09-12	KB	Patent renewed
2003-09-17	PEL	Intention of commissioner to extend period of protection
2005-11-20	EXTC	Patent extension cancelled
2006-09-05	KB	Patent renewed
2009-02-11	EXP	Patent expired
2010-04-14	EXP	Patent expired

Publication	Publication Date	Title
IL87290A (en)	1993-01-31	Epipodophyllotoxin glucoside 4)-phosphate derivatives, their preparation and pharmaceutical compositions containing them
IL88184A0 (en)	1989-06-30	Tetrahydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IL88363A0 (en)	1989-06-30	Fluorocytidine derivatives,their production and pharmaceutical compositions containing them
IL82671A0 (en)	1987-11-30	1,5-diaryl-3-substituted-pyrazoles,their preparation and pharmaceutical compositions containing them
IL91129A0 (en)	1990-03-19	Aminomethyloxooxazolidinyl arylbenzene derivatives,their preparation and pharmaceutical compositions containing them
IL90245A0 (en)	1989-12-15	Ethenediamine derivatives,their preparation and pharmaceutical compositions containing them
IL86798A0 (en)	1988-11-30	2,2-dimethylchroman-3-ol derivatives,their preparation and pharmaceutical compositions containing them
IL83432A (en)	1992-06-21	N-phenylcarboxamide derivatives,their preparation and pharmaceutical compositions containing them
IL84832A (en)	1993-01-14	6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5- tetrahydropyridazin-3- ones, their preparation and pharmaceutical compositions containing them
IL87949A0 (en)	1989-03-31	Dideoxycytidine derivatives,their preparation and pharmaceutical compositions containing them
IL87644A0 (en)	1989-02-28	Oxadiazolyl-azabicycloheptanes,their preparation and pharmaceutical compositions containing them
IL84128A0 (en)	1988-03-31	3-propenylcephem derivatives,their preparation and pharmaceutical compositions containing them
IL88002A0 (en)	1989-06-30	2,2-dimethylchromene derivatives,their preparation and pharmaceutical compositions containing them
IL88138A0 (en)	1989-06-30	Purine derivatives,their preparation and pharmaceutical compositions containing them
NZ220604A (en)	1989-10-27	Anthracycline glycoside derivatives, their preparation and pharmaceutical compositions containing them
IL91245A0 (en)	1990-03-19	Benzopyranol derivatives,their preparation and pharmaceutical compositions containing them
IL92634A0 (en)	1990-08-31	Adenosine derivatives,their preparation and pharmaceutical compositions containing them
IL86888A0 (en)	1988-11-30	3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives and pharmaceutical compositions containing them
IL83753A (en)	1991-07-18	Sulphonamidoethyl derivatives,their preparation and pharmaceutical compositions containing them
IL88827A (en)	1993-01-14	5,5-dimethyl-3-styryl -2-cyclohexene-1-one oxime derivatives, their preparation and pharmaceutical compositions containing them
IL90002A0 (en)	1989-12-15	Phosphonoalkylpurine derivatives,their preparation and pharmaceutical compositions containing them
IL87016A0 (en)	1988-12-30	Phenylpiperidine derivatives,their preparation and pharmaceutical compositions containing them
IL90231A0 (en)	1989-12-15	1,1-dioxo-cephem-4-carbothiolic acid derivatives,their preparation and pharmaceutical compositions containing them
IL87586A (en)	1993-07-08	3(-demethoxypipo- dophyllotoxin glucoside derivatives and pharmaceutical compositions containing them
IL86926A0 (en)	1988-11-30	1h-pyrazole-1-alkanamides,their preparation and pharmaceutical compositions containing them