JPH0413698B2 - - Google Patents
Info
- Publication number
- JPH0413698B2 JPH0413698B2 JP8255184A JP8255184A JPH0413698B2 JP H0413698 B2 JPH0413698 B2 JP H0413698B2 JP 8255184 A JP8255184 A JP 8255184A JP 8255184 A JP8255184 A JP 8255184A JP H0413698 B2 JPH0413698 B2 JP H0413698B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- coupler
- acrylate
- methacrylate
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 silver halide Chemical class 0.000 claims description 70
- 229920000642 polymer Polymers 0.000 claims description 41
- 239000000178 monomer Substances 0.000 claims description 22
- 125000002947 alkylene group Chemical group 0.000 claims description 20
- 229910052709 silver Inorganic materials 0.000 claims description 19
- 239000004332 silver Substances 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 125000000732 arylene group Chemical group 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 238000005859 coupling reaction Methods 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 2
- 239000004816 latex Substances 0.000 description 22
- 229920000126 latex Polymers 0.000 description 22
- 125000001424 substituent group Chemical group 0.000 description 22
- 238000000034 method Methods 0.000 description 20
- 239000000243 solution Substances 0.000 description 17
- 108010010803 Gelatin Proteins 0.000 description 12
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 12
- 229920000159 gelatin Polymers 0.000 description 12
- 239000008273 gelatin Substances 0.000 description 12
- 235000019322 gelatine Nutrition 0.000 description 12
- 235000011852 gelatine desserts Nutrition 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 12
- 229910052801 chlorine Inorganic materials 0.000 description 11
- 125000001309 chloro group Chemical group Cl* 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 11
- 239000000975 dye Substances 0.000 description 11
- 239000007864 aqueous solution Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 9
- 125000005843 halogen group Chemical group 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 239000003960 organic solvent Substances 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000000084 colloidal system Substances 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 5
- 238000010556 emulsion polymerization method Methods 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 229910052731 fluorine Inorganic materials 0.000 description 5
- 125000001153 fluoro group Chemical group F* 0.000 description 5
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 5
- 239000003505 polymerization initiator Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 4
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 4
- 239000011976 maleic acid Substances 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 4
- 125000000565 sulfonamide group Chemical group 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical group CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 3
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 3
- 150000003926 acrylamides Chemical class 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 125000004442 acylamino group Chemical group 0.000 description 3
- 125000004423 acyloxy group Chemical group 0.000 description 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000000921 elemental analysis Methods 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical group CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 230000000379 polymerizing effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- UZKWTJUDCOPSNM-UHFFFAOYSA-N 1-ethenoxybutane Chemical compound CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 2
- AXFVIWBTKYFOCY-UHFFFAOYSA-N 1-n,1-n,3-n,3-n-tetramethylbutane-1,3-diamine Chemical compound CN(C)C(C)CCN(C)C AXFVIWBTKYFOCY-UHFFFAOYSA-N 0.000 description 2
- SDJHPPZKZZWAKF-UHFFFAOYSA-N 2,3-dimethylbuta-1,3-diene Chemical compound CC(=C)C(C)=C SDJHPPZKZZWAKF-UHFFFAOYSA-N 0.000 description 2
- RUYYZQCJUGZUCW-UHFFFAOYSA-N 2-(prop-2-enoylamino)ethyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCCNC(=O)C=C RUYYZQCJUGZUCW-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 description 2
- KFNGWPXYNSJXOP-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propane-1-sulfonic acid Chemical compound CC(=C)C(=O)OCCCS(O)(=O)=O KFNGWPXYNSJXOP-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Natural products CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Natural products OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 2
- AOJOEFVRHOZDFN-UHFFFAOYSA-N benzyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC1=CC=CC=C1 AOJOEFVRHOZDFN-UHFFFAOYSA-N 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical class C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 2
- 125000004956 cyclohexylene group Chemical group 0.000 description 2
- 150000002012 dioxanes Chemical class 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000007720 emulsion polymerization reaction Methods 0.000 description 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 150000002688 maleic acid derivatives Chemical class 0.000 description 2
- 238000001819 mass spectrum Methods 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- 125000004957 naphthylene group Chemical group 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical class C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 description 2
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 2
- GYDSPAVLTMAXHT-UHFFFAOYSA-N pentyl 2-methylprop-2-enoate Chemical compound CCCCCOC(=O)C(C)=C GYDSPAVLTMAXHT-UHFFFAOYSA-N 0.000 description 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pentâ4âenâ2âone Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- SMUQFGGVLNAIOZ-UHFFFAOYSA-N quinaldine Chemical compound C1=CC=CC2=NC(C)=CC=C21 SMUQFGGVLNAIOZ-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 150000003440 styrenes Chemical class 0.000 description 2
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 150000003852 triazoles Chemical class 0.000 description 2
- 239000001043 yellow dye Substances 0.000 description 2
- HNISBYCBIMPXKH-UHFFFAOYSA-N (1,1-dichloro-2-ethoxyethyl) prop-2-enoate Chemical compound CCOCC(Cl)(Cl)OC(=O)C=C HNISBYCBIMPXKH-UHFFFAOYSA-N 0.000 description 1
- GBVJQAULALBKDU-UHFFFAOYSA-N (1-bromo-2-methoxyethyl) prop-2-enoate Chemical compound COCC(Br)OC(=O)C=C GBVJQAULALBKDU-UHFFFAOYSA-N 0.000 description 1
- NGDOLKDENPCYIS-UHFFFAOYSA-N (2-chlorocyclohexyl) prop-2-enoate Chemical compound ClC1CCCCC1OC(=O)C=C NGDOLKDENPCYIS-UHFFFAOYSA-N 0.000 description 1
- MRIKSZXJKCQQFT-UHFFFAOYSA-N (3-hydroxy-2,2-dimethylpropyl) prop-2-enoate Chemical compound OCC(C)(C)COC(=O)C=C MRIKSZXJKCQQFT-UHFFFAOYSA-N 0.000 description 1
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 description 1
- CDDDRVNOHLVEED-UHFFFAOYSA-N 1-cyclohexyl-3-[1-[[1-(cyclohexylcarbamoylamino)cyclohexyl]diazenyl]cyclohexyl]urea Chemical compound C1CCCCC1(N=NC1(CCCCC1)NC(=O)NC1CCCCC1)NC(=O)NC1CCCCC1 CDDDRVNOHLVEED-UHFFFAOYSA-N 0.000 description 1
- LGJCFVYMIJLQJO-UHFFFAOYSA-N 1-dodecylperoxydodecane Chemical compound CCCCCCCCCCCCOOCCCCCCCCCCCC LGJCFVYMIJLQJO-UHFFFAOYSA-N 0.000 description 1
- GXZPMXGRNUXGHN-UHFFFAOYSA-N 1-ethenoxy-2-methoxyethane Chemical compound COCCOC=C GXZPMXGRNUXGHN-UHFFFAOYSA-N 0.000 description 1
- YAOJJEJGPZRYJF-UHFFFAOYSA-N 1-ethenoxyhexane Chemical compound CCCCCCOC=C YAOJJEJGPZRYJF-UHFFFAOYSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- GIVBQSUFWURSOS-UHFFFAOYSA-N 1-ethenyltriazole Chemical compound C=CN1C=CN=N1 GIVBQSUFWURSOS-UHFFFAOYSA-N 0.000 description 1
- CBQFBEBEBCHTBK-UHFFFAOYSA-N 1-phenylprop-2-ene-1-sulfonic acid Chemical compound OS(=O)(=O)C(C=C)C1=CC=CC=C1 CBQFBEBEBCHTBK-UHFFFAOYSA-N 0.000 description 1
- HECLRDQVFMWTQS-RGOKHQFPSA-N 1755-01-7 Chemical compound C1[C@H]2[C@@H]3CC=C[C@@H]3[C@@H]1C=C2 HECLRDQVFMWTQS-RGOKHQFPSA-N 0.000 description 1
- CISIJYCKDJSTMX-UHFFFAOYSA-N 2,2-dichloroethenylbenzene Chemical compound ClC(Cl)=CC1=CC=CC=C1 CISIJYCKDJSTMX-UHFFFAOYSA-N 0.000 description 1
- BUZAXYQQRMDUTM-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-yl prop-2-enoate Chemical compound CC(C)(C)CC(C)(C)OC(=O)C=C BUZAXYQQRMDUTM-UHFFFAOYSA-N 0.000 description 1
- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 description 1
- QGTBRAFPWNISIJ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound CCCCOCCOCCOC(=O)C(C)=C QGTBRAFPWNISIJ-UHFFFAOYSA-N 0.000 description 1
- KEVOENGLLAAIKA-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethyl prop-2-enoate Chemical compound CCCCOCCOCCOC(=O)C=C KEVOENGLLAAIKA-UHFFFAOYSA-N 0.000 description 1
- WFTWWOCWRSUGAW-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound CCOCCOCCOC(=O)C(C)=C WFTWWOCWRSUGAW-UHFFFAOYSA-N 0.000 description 1
- ZKLMKZINKNMVKA-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(O)COC(C)CO ZKLMKZINKNMVKA-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- DAVVKEZTUOGEAK-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound COCCOCCOC(=O)C(C)=C DAVVKEZTUOGEAK-UHFFFAOYSA-N 0.000 description 1
- HZMXJTJBSWOCQB-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethyl prop-2-enoate Chemical compound COCCOCCOC(=O)C=C HZMXJTJBSWOCQB-UHFFFAOYSA-N 0.000 description 1
- PRAMZQXXPOLCIY-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethanesulfonic acid Chemical compound CC(=C)C(=O)OCCS(O)(=O)=O PRAMZQXXPOLCIY-UHFFFAOYSA-N 0.000 description 1
- IBDVWXAVKPRHCU-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCCOC(=O)C(C)=C IBDVWXAVKPRHCU-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- UTZYQZQFXMSRAQ-UHFFFAOYSA-N 2-(3-phenylpropoxy)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCCC1=CC=CC=C1 UTZYQZQFXMSRAQ-UHFFFAOYSA-N 0.000 description 1
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 description 1
- WTBIHKZYDZQMQA-UHFFFAOYSA-N 2-(n-ethylanilino)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCN(CC)C1=CC=CC=C1 WTBIHKZYDZQMQA-UHFFFAOYSA-N 0.000 description 1
- MVYVKSBVZFBBPL-UHFFFAOYSA-N 2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(C)NC(=O)C=C MVYVKSBVZFBBPL-UHFFFAOYSA-N 0.000 description 1
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 1
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
- RCSBILYQLVXLJG-UHFFFAOYSA-N 2-Propenyl hexanoate Chemical compound CCCCCC(=O)OCC=C RCSBILYQLVXLJG-UHFFFAOYSA-N 0.000 description 1
- PFHOSZAOXCYAGJ-UHFFFAOYSA-N 2-[(2-cyano-4-methoxy-4-methylpentan-2-yl)diazenyl]-4-methoxy-2,4-dimethylpentanenitrile Chemical compound COC(C)(C)CC(C)(C#N)N=NC(C)(C#N)CC(C)(C)OC PFHOSZAOXCYAGJ-UHFFFAOYSA-N 0.000 description 1
- WYGWHHGCAGTUCH-UHFFFAOYSA-N 2-[(2-cyano-4-methylpentan-2-yl)diazenyl]-2,4-dimethylpentanenitrile Chemical compound CC(C)CC(C)(C#N)N=NC(C)(C#N)CC(C)C WYGWHHGCAGTUCH-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- MZGMQAMKOBOIDR-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCO MZGMQAMKOBOIDR-UHFFFAOYSA-N 0.000 description 1
- REIAETDXSWRCRG-UHFFFAOYSA-N 2-[2-(prop-2-enoylamino)ethoxy]ethyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCCOCCNC(=O)C=C REIAETDXSWRCRG-UHFFFAOYSA-N 0.000 description 1
- ZTJNPDLOIVDEEL-UHFFFAOYSA-N 2-acetyloxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOC(C)=O ZTJNPDLOIVDEEL-UHFFFAOYSA-N 0.000 description 1
- UFIOPCXETLAGLR-UHFFFAOYSA-N 2-acetyloxyethyl prop-2-enoate Chemical compound CC(=O)OCCOC(=O)C=C UFIOPCXETLAGLR-UHFFFAOYSA-N 0.000 description 1
- ICGLGDINCXDWJB-UHFFFAOYSA-N 2-benzylprop-2-enamide Chemical compound NC(=O)C(=C)CC1=CC=CC=C1 ICGLGDINCXDWJB-UHFFFAOYSA-N 0.000 description 1
- CDZAAIHWZYWBSS-UHFFFAOYSA-N 2-bromoethyl prop-2-enoate Chemical compound BrCCOC(=O)C=C CDZAAIHWZYWBSS-UHFFFAOYSA-N 0.000 description 1
- DJKKWVGWYCKUFC-UHFFFAOYSA-N 2-butoxyethyl 2-methylprop-2-enoate Chemical compound CCCCOCCOC(=O)C(C)=C DJKKWVGWYCKUFC-UHFFFAOYSA-N 0.000 description 1
- SBYMUDUGTIKLCR-UHFFFAOYSA-N 2-chloroethenylbenzene Chemical compound ClC=CC1=CC=CC=C1 SBYMUDUGTIKLCR-UHFFFAOYSA-N 0.000 description 1
- WHBAYNMEIXUTJV-UHFFFAOYSA-N 2-chloroethyl prop-2-enoate Chemical compound ClCCOC(=O)C=C WHBAYNMEIXUTJV-UHFFFAOYSA-N 0.000 description 1
- AEPWOCLBLLCOGZ-UHFFFAOYSA-N 2-cyanoethyl prop-2-enoate Chemical compound C=CC(=O)OCCC#N AEPWOCLBLLCOGZ-UHFFFAOYSA-N 0.000 description 1
- XUOKWZRAWBZOQM-UHFFFAOYSA-N 2-cyclohexylprop-2-enamide Chemical compound NC(=O)C(=C)C1CCCCC1 XUOKWZRAWBZOQM-UHFFFAOYSA-N 0.000 description 1
- JWCDUUFOAZFFMX-UHFFFAOYSA-N 2-ethenoxy-n,n-dimethylethanamine Chemical compound CN(C)CCOC=C JWCDUUFOAZFFMX-UHFFFAOYSA-N 0.000 description 1
- FWWXYLGCHHIKNY-UHFFFAOYSA-N 2-ethoxyethyl prop-2-enoate Chemical compound CCOCCOC(=O)C=C FWWXYLGCHHIKNY-UHFFFAOYSA-N 0.000 description 1
- WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 description 1
- CTHJQRHPNQEPAB-UHFFFAOYSA-N 2-methoxyethenylbenzene Chemical compound COC=CC1=CC=CC=C1 CTHJQRHPNQEPAB-UHFFFAOYSA-N 0.000 description 1
- YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
- HFCUBKYHMMPGBY-UHFFFAOYSA-N 2-methoxyethyl prop-2-enoate Chemical compound COCCOC(=O)C=C HFCUBKYHMMPGBY-UHFFFAOYSA-N 0.000 description 1
- FSAHAOQXCSZZHG-UHFFFAOYSA-N 2-methyl-2-(2-methylprop-2-enoylamino)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(C)(CC)NC(=O)C(C)=C FSAHAOQXCSZZHG-UHFFFAOYSA-N 0.000 description 1
- VSSGDAWBDKMCMI-UHFFFAOYSA-N 2-methyl-2-(2-methylprop-2-enoylamino)propane-1-sulfonic acid Chemical compound CC(=C)C(=O)NC(C)(C)CS(O)(=O)=O VSSGDAWBDKMCMI-UHFFFAOYSA-N 0.000 description 1
- LPNSCOVIJFIXTJ-UHFFFAOYSA-N 2-methylidenebutanamide Chemical compound CCC(=C)C(N)=O LPNSCOVIJFIXTJ-UHFFFAOYSA-N 0.000 description 1
- GASMGDMKGYYAHY-UHFFFAOYSA-N 2-methylidenehexanamide Chemical compound CCCCC(=C)C(N)=O GASMGDMKGYYAHY-UHFFFAOYSA-N 0.000 description 1
- YICILWNDMQTUIY-UHFFFAOYSA-N 2-methylidenepentanamide Chemical compound CCCC(=C)C(N)=O YICILWNDMQTUIY-UHFFFAOYSA-N 0.000 description 1
- BTOVVHWKPVSLBI-UHFFFAOYSA-N 2-methylprop-1-enylbenzene Chemical compound CC(C)=CC1=CC=CC=C1 BTOVVHWKPVSLBI-UHFFFAOYSA-N 0.000 description 1
- ODPPVFMETNCIRW-UHFFFAOYSA-N 2-methylprop-2-enoyloxymethanesulfonic acid Chemical compound CC(=C)C(=O)OCS(O)(=O)=O ODPPVFMETNCIRW-UHFFFAOYSA-N 0.000 description 1
- RUMACXVDVNRZJZ-UHFFFAOYSA-N 2-methylpropyl 2-methylprop-2-enoate Chemical compound CC(C)COC(=O)C(C)=C RUMACXVDVNRZJZ-UHFFFAOYSA-N 0.000 description 1
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- FMFHUEMLVAIBFI-UHFFFAOYSA-N 2-phenylethenyl acetate Chemical compound CC(=O)OC=CC1=CC=CC=C1 FMFHUEMLVAIBFI-UHFFFAOYSA-N 0.000 description 1
- IMOLAGKJZFODRK-UHFFFAOYSA-N 2-phenylprop-2-enamide Chemical compound NC(=O)C(=C)C1=CC=CC=C1 IMOLAGKJZFODRK-UHFFFAOYSA-N 0.000 description 1
- SEILKFZTLVMHRR-UHFFFAOYSA-N 2-phosphonooxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOP(O)(O)=O SEILKFZTLVMHRR-UHFFFAOYSA-N 0.000 description 1
- UDXXYUDJOHIIDZ-UHFFFAOYSA-N 2-phosphonooxyethyl prop-2-enoate Chemical compound OP(O)(=O)OCCOC(=O)C=C UDXXYUDJOHIIDZ-UHFFFAOYSA-N 0.000 description 1
- GQTFHSAAODFMHB-UHFFFAOYSA-N 2-prop-2-enoyloxyethanesulfonic acid Chemical compound OS(=O)(=O)CCOC(=O)C=C GQTFHSAAODFMHB-UHFFFAOYSA-N 0.000 description 1
- JPXZAISSLVEZTK-UHFFFAOYSA-N 2-propan-2-yloxyethyl 2-methylprop-2-enoate Chemical compound CC(C)OCCOC(=O)C(C)=C JPXZAISSLVEZTK-UHFFFAOYSA-N 0.000 description 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 1
- JBTDFRNUVWFUGL-UHFFFAOYSA-N 3-aminopropyl carbamimidothioate;dihydrobromide Chemical compound Br.Br.NCCCSC(N)=N JBTDFRNUVWFUGL-UHFFFAOYSA-N 0.000 description 1
- IWTYTFSSTWXZFU-UHFFFAOYSA-N 3-chloroprop-1-enylbenzene Chemical compound ClCC=CC1=CC=CC=C1 IWTYTFSSTWXZFU-UHFFFAOYSA-N 0.000 description 1
- XHULUQRDNLRXPF-UHFFFAOYSA-N 3-ethenyl-1,3-oxazolidin-2-id-4-one Chemical compound C(=C)N1[CH-]OCC1=O XHULUQRDNLRXPF-UHFFFAOYSA-N 0.000 description 1
- UVRCNEIYXSRHNT-UHFFFAOYSA-N 3-ethylpent-2-enamide Chemical compound CCC(CC)=CC(N)=O UVRCNEIYXSRHNT-UHFFFAOYSA-N 0.000 description 1
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 1
- NWKKCUWIMOZYOO-UHFFFAOYSA-N 3-methoxybutyl 2-methylprop-2-enoate Chemical compound COC(C)CCOC(=O)C(C)=C NWKKCUWIMOZYOO-UHFFFAOYSA-N 0.000 description 1
- NPYMXLXNEYZTMQ-UHFFFAOYSA-N 3-methoxybutyl prop-2-enoate Chemical compound COC(C)CCOC(=O)C=C NPYMXLXNEYZTMQ-UHFFFAOYSA-N 0.000 description 1
- CEBRPXLXYCFYGU-UHFFFAOYSA-N 3-methylbut-1-enylbenzene Chemical compound CC(C)C=CC1=CC=CC=C1 CEBRPXLXYCFYGU-UHFFFAOYSA-N 0.000 description 1
- ZTHJQCDAHYOPIK-UHFFFAOYSA-N 3-methylbut-2-en-2-ylbenzene Chemical compound CC(C)=C(C)C1=CC=CC=C1 ZTHJQCDAHYOPIK-UHFFFAOYSA-N 0.000 description 1
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 1
- NYUTUWAFOUJLKI-UHFFFAOYSA-N 3-prop-2-enoyloxypropane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCOC(=O)C=C NYUTUWAFOUJLKI-UHFFFAOYSA-N 0.000 description 1
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 1
- JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- VVAAYFMMXYRORI-UHFFFAOYSA-N 4-butoxy-2-methylidene-4-oxobutanoic acid Chemical compound CCCCOC(=O)CC(=C)C(O)=O VVAAYFMMXYRORI-UHFFFAOYSA-N 0.000 description 1
- MSZCRKZKNKSJNU-UHFFFAOYSA-N 4-chlorobutyl prop-2-enoate Chemical compound ClCCCCOC(=O)C=C MSZCRKZKNKSJNU-UHFFFAOYSA-N 0.000 description 1
- LZHLUTZGFZAYCH-UHFFFAOYSA-N 4-cyano-2-methylidenebutanamide Chemical compound NC(=O)C(=C)CCC#N LZHLUTZGFZAYCH-UHFFFAOYSA-N 0.000 description 1
- RTTAGBVNSDJDTE-UHFFFAOYSA-N 4-ethoxy-2-methylidene-4-oxobutanoic acid Chemical compound CCOC(=O)CC(=C)C(O)=O RTTAGBVNSDJDTE-UHFFFAOYSA-N 0.000 description 1
- YKXAYLPDMSGWEV-UHFFFAOYSA-N 4-hydroxybutyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCO YKXAYLPDMSGWEV-UHFFFAOYSA-N 0.000 description 1
- OIYTYGOUZOARSH-UHFFFAOYSA-N 4-methoxy-2-methylidene-4-oxobutanoic acid Chemical compound COC(=O)CC(=C)C(O)=O OIYTYGOUZOARSH-UHFFFAOYSA-N 0.000 description 1
- PIRPEUWCTMKABH-UHFFFAOYSA-N 4-methoxy-2-methylidenebutanamide Chemical compound COCCC(=C)C(N)=O PIRPEUWCTMKABH-UHFFFAOYSA-N 0.000 description 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
- DYNVQFRFBXYXJQ-UHFFFAOYSA-N 5-amino-2-(2,3-dichlorophenyl)-4h-pyrazol-3-one Chemical compound O=C1CC(N)=NN1C1=CC=CC(Cl)=C1Cl DYNVQFRFBXYXJQ-UHFFFAOYSA-N 0.000 description 1
- INRQKLGGIVSJRR-UHFFFAOYSA-N 5-hydroxypentyl prop-2-enoate Chemical compound OCCCCCOC(=O)C=C INRQKLGGIVSJRR-UHFFFAOYSA-N 0.000 description 1
- RYHAZBFRQQCSOJ-UHFFFAOYSA-N 5-methoxypent-1-en-3-one Chemical compound COCCC(=O)C=C RYHAZBFRQQCSOJ-UHFFFAOYSA-N 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- NUXLDNTZFXDNBA-UHFFFAOYSA-N 6-bromo-2-methyl-4h-1,4-benzoxazin-3-one Chemical compound C1=C(Br)C=C2NC(=O)C(C)OC2=C1 NUXLDNTZFXDNBA-UHFFFAOYSA-N 0.000 description 1
- OMIHGPLIXGGMJB-UHFFFAOYSA-N 7-oxabicyclo[4.1.0]hepta-1,3,5-triene Chemical group C1=CC=C2OC2=C1 OMIHGPLIXGGMJB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- LYJHVEDILOKZCG-UHFFFAOYSA-N Allyl benzoate Chemical compound C=CCOC(=O)C1=CC=CC=C1 LYJHVEDILOKZCG-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 description 1
- IEPRKVQEAMIZSS-WAYWQWQTSA-N Diethyl maleate Chemical compound CCOC(=O)\C=C/C(=O)OCC IEPRKVQEAMIZSS-WAYWQWQTSA-N 0.000 description 1
- XLYMOEINVGRTEX-ARJAWSKDSA-N Ethyl hydrogen fumarate Chemical compound CCOC(=O)\C=C/C(O)=O XLYMOEINVGRTEX-ARJAWSKDSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- MZNHUHNWGVUEAT-XBXARRHUSA-N Hexyl crotonate Chemical compound CCCCCCOC(=O)\C=C\C MZNHUHNWGVUEAT-XBXARRHUSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- CNCOEDDPFOAUMB-UHFFFAOYSA-N N-Methylolacrylamide Chemical compound OCNC(=O)C=C CNCOEDDPFOAUMB-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Chemical group 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- LCXXNKZQVOXMEH-UHFFFAOYSA-N Tetrahydrofurfuryl methacrylate Chemical compound CC(=C)C(=O)OCC1CCCO1 LCXXNKZQVOXMEH-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- LKOIPYBSUJWJSM-UHFFFAOYSA-N [2-(dimethylamino)-2-phenoxyethyl] 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(N(C)C)OC1=CC=CC=C1 LKOIPYBSUJWJSM-UHFFFAOYSA-N 0.000 description 1
- DQVUUGHMHQPVSI-UHFFFAOYSA-N [chloro(phenyl)methyl] 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(Cl)C1=CC=CC=C1 DQVUUGHMHQPVSI-UHFFFAOYSA-N 0.000 description 1
- CXSXCWXUCMJUGI-UHFFFAOYSA-N [methoxy(phenyl)methyl] prop-2-enoate Chemical compound C=CC(=O)OC(OC)C1=CC=CC=C1 CXSXCWXUCMJUGI-UHFFFAOYSA-N 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000005129 aryl carbonyl group Chemical group 0.000 description 1
- 125000005162 aryl oxy carbonyl amino group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- ZJRCIQAMTAINCB-UHFFFAOYSA-N benzoylacetonitrile Chemical compound N#CCC(=O)C1=CC=CC=C1 ZJRCIQAMTAINCB-UHFFFAOYSA-N 0.000 description 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 description 1
- GCTPMLUUWLLESL-UHFFFAOYSA-N benzyl prop-2-enoate Chemical compound C=CC(=O)OCC1=CC=CC=C1 GCTPMLUUWLLESL-UHFFFAOYSA-N 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- MPMBRWOOISTHJV-UHFFFAOYSA-N but-1-enylbenzene Chemical compound CCC=CC1=CC=CC=C1 MPMBRWOOISTHJV-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- BHDFTVNXJDZMQK-UHFFFAOYSA-N chloromethane;2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound ClC.CN(C)CCOC(=O)C(C)=C BHDFTVNXJDZMQK-UHFFFAOYSA-N 0.000 description 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
- HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 description 1
- 229940018557 citraconic acid Drugs 0.000 description 1
- FCSHDIVRCWTZOX-DVTGEIKXSA-N clobetasol Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O FCSHDIVRCWTZOX-DVTGEIKXSA-N 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 125000006165 cyclic alkyl group Chemical group 0.000 description 1
- OIWOHHBRDFKZNC-UHFFFAOYSA-N cyclohexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1CCCCC1 OIWOHHBRDFKZNC-UHFFFAOYSA-N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- KBLWLMPSVYBVDK-UHFFFAOYSA-N cyclohexyl prop-2-enoate Chemical compound C=CC(=O)OC1CCCCC1 KBLWLMPSVYBVDK-UHFFFAOYSA-N 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 description 1
- JBSLOWBPDRZSMB-BQYQJAHWSA-N dibutyl (e)-but-2-enedioate Chemical compound CCCCOC(=O)\C=C\C(=O)OCCCC JBSLOWBPDRZSMB-BQYQJAHWSA-N 0.000 description 1
- JBSLOWBPDRZSMB-FPLPWBNLSA-N dibutyl (z)-but-2-enedioate Chemical compound CCCCOC(=O)\C=C/C(=O)OCCCC JBSLOWBPDRZSMB-FPLPWBNLSA-N 0.000 description 1
- OGVXYCDTRMDYOG-UHFFFAOYSA-N dibutyl 2-methylidenebutanedioate Chemical compound CCCCOC(=O)CC(=C)C(=O)OCCCC OGVXYCDTRMDYOG-UHFFFAOYSA-N 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- ZEFVHSWKYCYFFL-UHFFFAOYSA-N diethyl 2-methylidenebutanedioate Chemical compound CCOC(=O)CC(=C)C(=O)OCC ZEFVHSWKYCYFFL-UHFFFAOYSA-N 0.000 description 1
- XSBSXJAYEPDGSF-UHFFFAOYSA-N diethyl 3,5-dimethyl-1h-pyrrole-2,4-dicarboxylate Chemical compound CCOC(=O)C=1NC(C)=C(C(=O)OCC)C=1C XSBSXJAYEPDGSF-UHFFFAOYSA-N 0.000 description 1
- IEPRKVQEAMIZSS-AATRIKPKSA-N diethyl fumarate Chemical compound CCOC(=O)\C=C\C(=O)OCC IEPRKVQEAMIZSS-AATRIKPKSA-N 0.000 description 1
- ZWWQRMFIZFPUAA-UHFFFAOYSA-N dimethyl 2-methylidenebutanedioate Chemical compound COC(=O)CC(=C)C(=O)OC ZWWQRMFIZFPUAA-UHFFFAOYSA-N 0.000 description 1
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 description 1
- 229960004419 dimethyl fumarate Drugs 0.000 description 1
- LDCRTTXIJACKKU-ARJAWSKDSA-N dimethyl maleate Chemical compound COC(=O)\C=C/C(=O)OC LDCRTTXIJACKKU-ARJAWSKDSA-N 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- XJELOQYISYPGDX-UHFFFAOYSA-N ethenyl 2-chloroacetate Chemical compound ClCC(=O)OC=C XJELOQYISYPGDX-UHFFFAOYSA-N 0.000 description 1
- CMXXMZYAYIHTBU-UHFFFAOYSA-N ethenyl 2-hydroxybenzoate Chemical compound OC1=CC=CC=C1C(=O)OC=C CMXXMZYAYIHTBU-UHFFFAOYSA-N 0.000 description 1
- AFIQVBFAKUPHOA-UHFFFAOYSA-N ethenyl 2-methoxyacetate Chemical compound COCC(=O)OC=C AFIQVBFAKUPHOA-UHFFFAOYSA-N 0.000 description 1
- WNMORWGTPVWAIB-UHFFFAOYSA-N ethenyl 2-methylpropanoate Chemical compound CC(C)C(=O)OC=C WNMORWGTPVWAIB-UHFFFAOYSA-N 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- LZWYWAIOTBEZFN-UHFFFAOYSA-N ethenyl hexanoate Chemical compound CCCCCC(=O)OC=C LZWYWAIOTBEZFN-UHFFFAOYSA-N 0.000 description 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- XWNVSPGTJSGNPU-UHFFFAOYSA-N ethyl 4-chloro-1h-indole-2-carboxylate Chemical compound C1=CC=C2NC(C(=O)OCC)=CC2=C1Cl XWNVSPGTJSGNPU-UHFFFAOYSA-N 0.000 description 1
- FKIRSCKRJJUCNI-UHFFFAOYSA-N ethyl 7-bromo-1h-indole-2-carboxylate Chemical compound C1=CC(Br)=C2NC(C(=O)OCC)=CC2=C1 FKIRSCKRJJUCNI-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 description 1
- XLYMOEINVGRTEX-UHFFFAOYSA-N fumaric acid monoethyl ester Natural products CCOC(=O)C=CC(O)=O XLYMOEINVGRTEX-UHFFFAOYSA-N 0.000 description 1
- NKHAVTQWNUWKEO-UHFFFAOYSA-N fumaric acid monomethyl ester Natural products COC(=O)C=CC(O)=O NKHAVTQWNUWKEO-UHFFFAOYSA-N 0.000 description 1
- DWXAVNJYFLGAEF-UHFFFAOYSA-N furan-2-ylmethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC1=CC=CO1 DWXAVNJYFLGAEF-UHFFFAOYSA-N 0.000 description 1
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 description 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- LNCPIMCVTKXXOY-UHFFFAOYSA-N hexyl 2-methylprop-2-enoate Chemical compound CCCCCCOC(=O)C(C)=C LNCPIMCVTKXXOY-UHFFFAOYSA-N 0.000 description 1
- LNMQRPPRQDGUDR-UHFFFAOYSA-N hexyl prop-2-enoate Chemical compound CCCCCCOC(=O)C=C LNMQRPPRQDGUDR-UHFFFAOYSA-N 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- PTFYQSWHBLOXRZ-UHFFFAOYSA-N imidazo[4,5-e]indazole Chemical compound C1=CC2=NC=NC2=C2C=NN=C21 PTFYQSWHBLOXRZ-UHFFFAOYSA-N 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- LOCAIGRSOJUCTB-UHFFFAOYSA-N indazol-3-one Chemical compound C1=CC=C2C(=O)N=NC2=C1 LOCAIGRSOJUCTB-UHFFFAOYSA-N 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000006626 methoxycarbonylamino group Chemical group 0.000 description 1
- ZQMHJBXHRFJKOT-UHFFFAOYSA-N methyl 2-[(1-methoxy-2-methyl-1-oxopropan-2-yl)diazenyl]-2-methylpropanoate Chemical compound COC(=O)C(C)(C)N=NC(C)(C)C(=O)OC ZQMHJBXHRFJKOT-UHFFFAOYSA-N 0.000 description 1
- MPHUYCIKFIKENX-UHFFFAOYSA-N methyl 2-ethenylbenzoate Chemical compound COC(=O)C1=CC=CC=C1C=C MPHUYCIKFIKENX-UHFFFAOYSA-N 0.000 description 1
- NKHAVTQWNUWKEO-IHWYPQMZSA-N methyl hydrogen fumarate Chemical compound COC(=O)\C=C/C(O)=O NKHAVTQWNUWKEO-IHWYPQMZSA-N 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- REOJLIXKJWXUGB-UHFFFAOYSA-N mofebutazone Chemical group O=C1C(CCCC)C(=O)NN1C1=CC=CC=C1 REOJLIXKJWXUGB-UHFFFAOYSA-N 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
- YKYONYBAUNKHLG-UHFFFAOYSA-N n-Propyl acetate Natural products CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 description 1
- QYZFTMMPKCOTAN-UHFFFAOYSA-N n-[2-(2-hydroxyethylamino)ethyl]-2-[[1-[2-(2-hydroxyethylamino)ethylamino]-2-methyl-1-oxopropan-2-yl]diazenyl]-2-methylpropanamide Chemical compound OCCNCCNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCCNCCO QYZFTMMPKCOTAN-UHFFFAOYSA-N 0.000 description 1
- YRVUCYWJQFRCOB-UHFFFAOYSA-N n-butylprop-2-enamide Chemical compound CCCCNC(=O)C=C YRVUCYWJQFRCOB-UHFFFAOYSA-N 0.000 description 1
- RCLLINSDAJVOHP-UHFFFAOYSA-N n-ethyl-n',n'-dimethylprop-2-enehydrazide Chemical compound CCN(N(C)C)C(=O)C=C RCLLINSDAJVOHP-UHFFFAOYSA-N 0.000 description 1
- XFHJDMUEHUHAJW-UHFFFAOYSA-N n-tert-butylprop-2-enamide Chemical compound CC(C)(C)NC(=O)C=C XFHJDMUEHUHAJW-UHFFFAOYSA-N 0.000 description 1
- HVYCQBKSRWZZGX-UHFFFAOYSA-N naphthalen-1-yl 2-methylprop-2-enoate Chemical compound C1=CC=C2C(OC(=O)C(=C)C)=CC=CC2=C1 HVYCQBKSRWZZGX-UHFFFAOYSA-N 0.000 description 1
- 150000004780 naphthols Chemical class 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 description 1
- 229940065472 octyl acrylate Drugs 0.000 description 1
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- HVAMZGADVCBITI-UHFFFAOYSA-M pent-4-enoate Chemical compound [O-]C(=O)CCC=C HVAMZGADVCBITI-UHFFFAOYSA-M 0.000 description 1
- ULDDEWDFUNBUCM-UHFFFAOYSA-N pentyl prop-2-enoate Chemical compound CCCCCOC(=O)C=C ULDDEWDFUNBUCM-UHFFFAOYSA-N 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 description 1
- QIWKUEJZZCOPFV-UHFFFAOYSA-N phenyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1=CC=CC=C1 QIWKUEJZZCOPFV-UHFFFAOYSA-N 0.000 description 1
- WRAQQYDMVSCOTE-UHFFFAOYSA-N phenyl prop-2-enoate Chemical compound C=CC(=O)OC1=CC=CC=C1 WRAQQYDMVSCOTE-UHFFFAOYSA-N 0.000 description 1
- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- IBGXDQCATAOYOE-UHFFFAOYSA-N prop-2-enoyloxymethanesulfonic acid Chemical compound OS(=O)(=O)COC(=O)C=C IBGXDQCATAOYOE-UHFFFAOYSA-N 0.000 description 1
- FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 description 1
- ZQMAPKVSTSACQB-UHFFFAOYSA-N prop-2-enyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC=C ZQMAPKVSTSACQB-UHFFFAOYSA-N 0.000 description 1
- BOQSSGDQNWEFSX-UHFFFAOYSA-N propan-2-yl 2-methylprop-2-enoate Chemical compound CC(C)OC(=O)C(C)=C BOQSSGDQNWEFSX-UHFFFAOYSA-N 0.000 description 1
- LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 description 1
- BWJUFXUULUEGMA-UHFFFAOYSA-N propan-2-yl propan-2-yloxycarbonyloxy carbonate Chemical compound CC(C)OC(=O)OOC(=O)OC(C)C BWJUFXUULUEGMA-UHFFFAOYSA-N 0.000 description 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 description 1
- 229940090181 propyl acetate Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- CJGJYOBXQLCLRG-UHFFFAOYSA-M sodium;2-hydroxy-3-prop-2-enoxypropane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(O)COCC=C CJGJYOBXQLCLRG-UHFFFAOYSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical group O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- MUTNCGKQJGXKEM-UHFFFAOYSA-N tamibarotene Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1NC(=O)C1=CC=C(C(O)=O)C=C1 MUTNCGKQJGXKEM-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- KOZCZZVUFDCZGG-UHFFFAOYSA-N vinyl benzoate Chemical compound C=COC(=O)C1=CC=CC=C1 KOZCZZVUFDCZGG-UHFFFAOYSA-N 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C7/00—Multicolour photographic processes or agents therefor; Regeneration of such processing agents; Photosensitive materials for multicolour processes
- G03C7/30—Colour processes using colour-coupling substances; Materials therefor; Preparing or processing such materials
- G03C7/32—Colour coupling substances
- G03C7/327—Macromolecular coupling substances
- G03C7/3275—Polymers obtained by reactions involving only carbon-to-carbon unsaturated bonds, e.g. vinyl polymers
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
Description
ãçºæã®è©³çŽ°ãªèª¬æã
çºæã®èæ¯
æè¡åé
æ¬çºæã¯è³éŠæ第ïŒçŽã¢ãã³ç³»çºè²çŸåäž»è¬ã®
é žåäœãšã«ãããªã³ã°ããŠè²çŽ ã圢æãããæ°èŠ
ãªããŒã³ã¿è²çŽ 圢ææ§ããªããŒã«ãã©ãŒãå«æã
ãããã²ã³åéåçæå ææãç¹ã«ããã²ã³åé
ã«ã©ãŒåçæå ææã«é¢ãããã®ã§ããã æžè²æ³ã«åºã¥ãã«ã©ãŒåçç»åã®åœ¢æã«ãããŠ
ã¯ãäžè¬ã«ãããã²ã³åéã«ã©ãŒåçæå ææã
åæ§é²å ããåŸãã·ã¢ã³ã«ãã©ãŒãããŒã³ã¿ã«ã
ã©ãŒããã³ã€ãšããŒã«ãã©ãŒã®ååšäžã«è³éŠæ第
ïŒçŽã¢ãã³ç³»çºè²çŸåäž»è¬ãçšããŠçºè²çŸååŠç
ããããšã«ãã€ãŠè¡ãªãããããã®éãé²å ãã
ãããã²ã³åéã«ã©ãŒåçæå ææã®ããã²ã³å
éç²åã¯ãçºè²çŸåäž»è¬ã«ãã€ãŠéã«éå ããã
åæã«çæããçºè²çŸåäž»è¬ã®é žåäœã¯ã«ãã©ãŒ
ãšã«ãããªã³ã°åå¿ããŠãã·ã¢ã³è²çŽ ãããŒã³ã¿
è²çŽ ããã³ã€ãšããŒè²çŽ ãããªãã«ã©ãŒåçç»å
ã圢æããã ãããã®ã«ãã©ãŒã¯ãå åŒçºè²æ³ã§ã¯ãããã²
ã³åéä¹³å€äžã«ããŸãå€åŒçºè²æ³ã§ã¯ãçºè²çŸå
液äžã«å«æããããŠãããçŸåšã¯ãçºè²çŸåãäž
床ã§ããç°¡åãªå åŒã«ã©ãŒæ¹åŒãå€ãçšããããŠ
ããã ã€ãšããŒè²çŽ ç»åã圢æããããããã«ã¯ãäŸ
ãã°ãã¢ã·ã«ã¢ã»ãã¢ããªããåã¯ãã³ãŸã€ã«ã¡
ã¿ã³ç³»ã«ãã©ãŒã䜿ãããããŒã³ã¿è²çŽ ç»åã圢
æããããã«ã¯ãäž»ãšããŠããã©ãŸãã³ããã©ãŸ
ããã³ãã€ãããŸãŒã«ãã·ã¢ãã¢ã»ãããšãã³ãŸ
ãã¯ã€ã³ããŸãã³ç³»ã«ãã©ãŒã䜿ãããã·ã¢ã³è²
çŽ ç»åã圢æããããã«ã¯ãäž»ãšããŠãããšããŒ
ã«ç³»ã«ãã©ãŒãäŸãã°ããšããŒã«é¡ãããããŒã«
é¡ã䜿ãããã ã«ãã©ãŒã¯ãçºè²çŸåã«ããåã«è²çŽ ç»åã圢
æããã ãã§ãªããäŸãã°ãçºè²çŸåæ§ãè¯ãã
ãšãããã²ã³åéä¹³å€ãžã®åæ£æ§ããã³å®å®æ§ã
è¯ãããšããŸãã圢æãããè²çŽ ç»åãå ãç±ã
湿æ°çã«å¯ŸããŠé·æã«ãããé«åºŠã®å®å®æ§ãæã
ãŠããããšãããã«ãå åžåæ³¢é·åãæãŸããç¯
å²ã«ããããšçã®èŠä»¶ã«åèŽããŠããªããã°ãªã
ãªãã ãšããã§ãå€å±€æ§æãããªãããã²ã³åéã«ã©
ãŒåçæå ææã§ã¯ãåè²çŽ ã®æ··è²ãå°ãªããã
è²åçŸæ§ãããããããã«ããããã®ã«ãã©ãŒã
åé¢ããå±€ã«åºå®ããããšãå¿ èŠã§ããã ãã®ã«ãã©ãŒã®æ¡æ£é²æ¢ã®æ¹æ³ãšããŠã¯åçš®ã®
æ¹æ³ãç¥ãããŠããã ãã®ïŒã€ã®æ¹æ³ã¯ã«ãã©ãŒã®ååäžã«ãæ¡æ£ã
é²ãããã«é·éã®èèªæåºïŒæ¡æ£é²æ¢åºïŒãå°å ¥
ãããã®ã§ããããã®æ¹æ³ã«ããã«ãã©ãŒã¯ãŒã©
ãã³æ°Žæº¶æ¶²ãšæ··åããªãããã¢ã«ã«ãªã«å¯æº¶åã
ããŠãŒã©ãã³æ°Žæº¶æ¶²ã«æ·»å ãããããããã¯æ²¹æº¶
æ§ã®ãã©ã¹ãåºïŒæ¡æ£é²æ¢åºïŒãæã€ãã«ãã©ãŒ
ãçé¢æŽ»æ§å€ã®å©ãããããé«æ²žç¹ã®ææ©æº¶å€ãš
å ±ã«ãŒã©ãã³æ°Žæº¶æ¶²äžã«ã³ãã€ãç²åãšããŠåæ£
ããããšãå¿ èŠã§ããããã®ãããªã«ãã©ãŒã¯ã
ã«ãã©ãŒäžã®èŠªæ°Žæ§åºããŒã©ãã³ãšçžäºäœçšãèµ·
ãããç¹ã«å¡åžå·¥çšäžãå¢ç²çŸåãåŒãèµ·ããã®
ã§é«éåäžå¡åžã®é害ã«ãªã€ããããŸãã¯ä¹³å€äž
ã§çµæ¶ã®æåºãåŒãèµ·ããããããããŸããé«æ²ž
ç¹ã®ææ©æº¶å€ãçšããå Žåã«ã¯ãä¹³å€å±€ãè»åã
ããããå€éã®ãŒã©ãã³ãå¿ èŠãšãããã®çµæä¹³
å€å±€ã®èèåãå°é£ã§ãã€ãã äžæ¹ãã«ãã©ãŒãèæ¡æ£åããå¥ã®æ¹æ³ã¯ãã«
ãã©ãŒååã«éåå¯èœãªäžé£œåçµåãå«ãåºãå°
å ¥ããåéäœã«ãã©ãŒãéåããŠåŸãããããªã
ãŒã«ãã©ãŒãçšããæ¹æ³ã§ããã ããªããŒã«ãã©ãŒã¯ã©ããã¯ã¹ã®åœ¢ã§èŠªæ°Žæ§ã³
ãã€ãçµæç©ã«å ããããã®æ¹æ³ã«ã¯ã次ã®æ¹æ³
ããããïŒã€ã¯ã«ãã©ãŒã¢ãããŒãå¿ èŠã«ããä»
ã®å ±éåæåïŒã³ã¢ãããŒïŒãšå ±ã«ä¹³åéåæ³ã«
ããéåãçŽæ¥ã©ããã¯ã¹ã圢æããããããã²
ã³åéä¹³å€ã«å ããæ¹æ³ã§ãããä»ã®ïŒã€ã¯ãã«
ãã©ãŒã¢ãããŒãå¿ èŠã«ããä»ã®å ±éåæåïŒã³
ã¢ãããŒïŒãšå ±ã«æº¶æ¶²éåã«ããéåãåŸããã
ããªããŒã«ãã©ãŒã溶åªã«æº¶è§£ããã®ã¡ããããŒ
ã©ãã³æ°Žæº¶æ¶²äžã«åæ£ãã©ããã¯ã¹ãšããæ¹æ³ã§
ãããåè ã®ä¹³åéåæ³ã«ã€ããŠã¯ç±³åœç¹èš±
3370952å·ãããã³å4080211å·ã«ããããèšèŒã
ããŠãããåŸè ã®æ¹æ³ã«ã€ããŠã¯ãäŸãã°ç±³åœç¹
èš±3451820å·ã«èšèŒãããŠããããã®ãããªããª
ããŒã«ãã©ãŒãã©ããã¯ã¹ã®åœ¢ã§èŠªæ°Žæ§ã³ãã€ã
çµæç©ã«å ããæ¹æ³ã¯ä»ã®æ¹æ³ã«æ¯ã¹ãŠæ¬¡ã®ãã
ãªå€ãã®å©ç¹ãæããã ãŸãã(1)ã©ããã¯ã¹ãšãããããªããŒã«ãã©ãŒ
ã¯é«æ¿åºŠã®ã«ãã©ãŒåäœãå«ãããšãã§ããã®ã§
容æã«é«æ¿åºŠã®ã«ãã©ãŒãä¹³å€ã«å«æãããããš
ãã§ããã(2)ããããã«ãã©ãŒãåæ£ããããã
ã®é«æ²žç¹ã®ææ©æº¶å€ãå«ãŸããªããšãããããè
èåãå¯èœã§ããã(3)ç»åã®é®®éæ§ãåäžããã
ããšãã§ããã(4)ãŒã©ãã³æ°Žæº¶æ¶²ã®å¢ç²çŸè±¡ãå°
ãªãããé«éåäžå¡åžãå¯èœãšãªãã(5)ããªããŒ
ã«ãã©ãŒã¯ã©ããã¯ã¹åãããŠãããã圢æãã
ãèã®åŒ·åºŠãå£åãããããšããªãã(6)ããã«ã
ãªããŒã«ãã©ãŒã¯ãé«ååäžã«ã«ãã©ãŒåäœãçµ
ã¿èŸŒãŸããŠããããåžæã®å±€äžã«çãŸãä»å±€ã«ç§»
è¡ããããšããªãããè²çŽ ã®æ··è²ã®å¿é ããªãã
ãããä¹³å€èã®äžã§ã®ã«ãã©ãŒã®æåºãå°ãªãã è±åœç¹èš±1247688å·ãç±³åœç¹èš±3451820å·ã«ã¯ã
ïŒåœéããŒã³ã¿ããªããŒã«ãã©ãŒã®ã©ããã¯ã¹ã
ããã²ã³åéä¹³å€ã«å ããäŸãèšèŒãããŠããã
ãŸã西ç¬ç¹èš±2725591å·åã³ç±³åœç¹èš±3926436å·ã«
ã¯ã³ã³ããŒãã³ã°ã«ãã©ãŒãšã®å ±éåäœã®ã©ãã
ã¯ã¹ã®äŸãèšèŒãããŠããããŸããç±³åœç¹èš±
3767412å·ã«ã¯ã·ã¢ã³ã«ãã©ãŒã®ã©ããã¯ã¹ãèš
èŒãããŠããã ããããªããããããã®ããªããŒã«ãã©ãŒã®ã©
ããã¯ã¹ã¯äžèšã®ãããªããããå€ãã®å©ç¹ãæ
ããŠãããã次ã®ãããªæ¹è¯ãã¹ãåé¡ç¹ãæã
ãŠããããããã®æ¹è¯ãæãŸããŠããã (1) ã«ãããªã³ã°ã®åå¿é床ãé ãããååãªè²
çŽ æ¿åºŠãåŸãããªãã (2) çºè²çŸåã«ããäžå¿ èŠãªã«ããªãçããã
ãã (3) ã«ãã©ãŒã¢ãããŒã®æº¶è§£æ§ãäœãã極ããŠé
åæ§ãäœãã (4) 圢æãããè²çŽ ç»åã®æ¹¿ç±å ç¢æ§ãå£ãã çºæã®ç®ç åŸã€ãŠãæ¬çºæã®ç¬¬ïŒã®ç®çã¯ããã®ãããªåŸ
æ¥ã®æ¬ ç¹ãé€ããããã€çºè²æ§ã«åªããå®äŸ¡ã«è£œ
é å¯èœãªããŒã³ã¿ããªããŒã«ãã©ãŒãå«æããã
ãã²ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãå¡åžå±€ãèèåããã
é®®é床ã®åäžããè²çŽ ç»åãåŸãããšãã§ããã
ãã²ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãè匷床ã®å€§ããããã²
ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãçºè²çŸååŠçåŸã®ã«ã©
ãŒåçã«ãããŠãå ãç±ã湿ç±ã«å¯ŸããŠå ç¢ãªè²
çŽ ç»åã圢æããããã²ã³åéåçæå ææãæ
äŸããããšã«ããã çºæã®å ·äœçæ§æ æ¬çºæè çã¯ãçš®ã ã®ç 究ãéããçµæãæ¬çº
æã®ãããã®ç®çã¯ãäžèšäžè¬åŒããã§ç€ºãã
ãåéäœããèªå°ãããç¹°ãè¿ãåäœãæããã
ãŒã³ã¿è²çŽ 圢ææ§ããªããŒã«ãã©ãŒãå«æããå
çæ§æå±€ãæããããã²ã³åéåçæå ææã«ã
ãéæãããããšãèŠãåºããã äžè¬åŒãã åŒäžãã¯ãšãã¬ã³æ§äžé£œååºãŸãã¯ãšãã¬ã³
æ§äžé£œååºãæããåºãè¡šããããã¯ããã
ãâNHCONHâãâNHCOOâãŸãã¯â
OCONHâãè¡šãããã¯æ°ŽçŽ ååãŸãã¯çºè²çŸ
åäž»è¬ã®é žåäœãšã®ã«ãããªã³ã°åå¿ã«ããé¢è±
å¯èœãªåºãè¡šãããR1ãR2ã¯ããããã¢ã«ãã¬
ã³åºãã¢ãªãŒã¬ã³åºãã¢ã«ãã¬ã³ãªããµã€ãåºãŸ
ãã¯
é žåäœãšã«ãããªã³ã°ããŠè²çŽ ã圢æãããæ°èŠ
ãªããŒã³ã¿è²çŽ 圢ææ§ããªããŒã«ãã©ãŒãå«æã
ãããã²ã³åéåçæå ææãç¹ã«ããã²ã³åé
ã«ã©ãŒåçæå ææã«é¢ãããã®ã§ããã æžè²æ³ã«åºã¥ãã«ã©ãŒåçç»åã®åœ¢æã«ãããŠ
ã¯ãäžè¬ã«ãããã²ã³åéã«ã©ãŒåçæå ææã
åæ§é²å ããåŸãã·ã¢ã³ã«ãã©ãŒãããŒã³ã¿ã«ã
ã©ãŒããã³ã€ãšããŒã«ãã©ãŒã®ååšäžã«è³éŠæ第
ïŒçŽã¢ãã³ç³»çºè²çŸåäž»è¬ãçšããŠçºè²çŸååŠç
ããããšã«ãã€ãŠè¡ãªãããããã®éãé²å ãã
ãããã²ã³åéã«ã©ãŒåçæå ææã®ããã²ã³å
éç²åã¯ãçºè²çŸåäž»è¬ã«ãã€ãŠéã«éå ããã
åæã«çæããçºè²çŸåäž»è¬ã®é žåäœã¯ã«ãã©ãŒ
ãšã«ãããªã³ã°åå¿ããŠãã·ã¢ã³è²çŽ ãããŒã³ã¿
è²çŽ ããã³ã€ãšããŒè²çŽ ãããªãã«ã©ãŒåçç»å
ã圢æããã ãããã®ã«ãã©ãŒã¯ãå åŒçºè²æ³ã§ã¯ãããã²
ã³åéä¹³å€äžã«ããŸãå€åŒçºè²æ³ã§ã¯ãçºè²çŸå
液äžã«å«æããããŠãããçŸåšã¯ãçºè²çŸåãäž
床ã§ããç°¡åãªå åŒã«ã©ãŒæ¹åŒãå€ãçšããããŠ
ããã ã€ãšããŒè²çŽ ç»åã圢æããããããã«ã¯ãäŸ
ãã°ãã¢ã·ã«ã¢ã»ãã¢ããªããåã¯ãã³ãŸã€ã«ã¡
ã¿ã³ç³»ã«ãã©ãŒã䜿ãããããŒã³ã¿è²çŽ ç»åã圢
æããããã«ã¯ãäž»ãšããŠããã©ãŸãã³ããã©ãŸ
ããã³ãã€ãããŸãŒã«ãã·ã¢ãã¢ã»ãããšãã³ãŸ
ãã¯ã€ã³ããŸãã³ç³»ã«ãã©ãŒã䜿ãããã·ã¢ã³è²
çŽ ç»åã圢æããããã«ã¯ãäž»ãšããŠãããšããŒ
ã«ç³»ã«ãã©ãŒãäŸãã°ããšããŒã«é¡ãããããŒã«
é¡ã䜿ãããã ã«ãã©ãŒã¯ãçºè²çŸåã«ããåã«è²çŽ ç»åã圢
æããã ãã§ãªããäŸãã°ãçºè²çŸåæ§ãè¯ãã
ãšãããã²ã³åéä¹³å€ãžã®åæ£æ§ããã³å®å®æ§ã
è¯ãããšããŸãã圢æãããè²çŽ ç»åãå ãç±ã
湿æ°çã«å¯ŸããŠé·æã«ãããé«åºŠã®å®å®æ§ãæã
ãŠããããšãããã«ãå åžåæ³¢é·åãæãŸããç¯
å²ã«ããããšçã®èŠä»¶ã«åèŽããŠããªããã°ãªã
ãªãã ãšããã§ãå€å±€æ§æãããªãããã²ã³åéã«ã©
ãŒåçæå ææã§ã¯ãåè²çŽ ã®æ··è²ãå°ãªããã
è²åçŸæ§ãããããããã«ããããã®ã«ãã©ãŒã
åé¢ããå±€ã«åºå®ããããšãå¿ èŠã§ããã ãã®ã«ãã©ãŒã®æ¡æ£é²æ¢ã®æ¹æ³ãšããŠã¯åçš®ã®
æ¹æ³ãç¥ãããŠããã ãã®ïŒã€ã®æ¹æ³ã¯ã«ãã©ãŒã®ååäžã«ãæ¡æ£ã
é²ãããã«é·éã®èèªæåºïŒæ¡æ£é²æ¢åºïŒãå°å ¥
ãããã®ã§ããããã®æ¹æ³ã«ããã«ãã©ãŒã¯ãŒã©
ãã³æ°Žæº¶æ¶²ãšæ··åããªãããã¢ã«ã«ãªã«å¯æº¶åã
ããŠãŒã©ãã³æ°Žæº¶æ¶²ã«æ·»å ãããããããã¯æ²¹æº¶
æ§ã®ãã©ã¹ãåºïŒæ¡æ£é²æ¢åºïŒãæã€ãã«ãã©ãŒ
ãçé¢æŽ»æ§å€ã®å©ãããããé«æ²žç¹ã®ææ©æº¶å€ãš
å ±ã«ãŒã©ãã³æ°Žæº¶æ¶²äžã«ã³ãã€ãç²åãšããŠåæ£
ããããšãå¿ èŠã§ããããã®ãããªã«ãã©ãŒã¯ã
ã«ãã©ãŒäžã®èŠªæ°Žæ§åºããŒã©ãã³ãšçžäºäœçšãèµ·
ãããç¹ã«å¡åžå·¥çšäžãå¢ç²çŸåãåŒãèµ·ããã®
ã§é«éåäžå¡åžã®é害ã«ãªã€ããããŸãã¯ä¹³å€äž
ã§çµæ¶ã®æåºãåŒãèµ·ããããããããŸããé«æ²ž
ç¹ã®ææ©æº¶å€ãçšããå Žåã«ã¯ãä¹³å€å±€ãè»åã
ããããå€éã®ãŒã©ãã³ãå¿ èŠãšãããã®çµæä¹³
å€å±€ã®èèåãå°é£ã§ãã€ãã äžæ¹ãã«ãã©ãŒãèæ¡æ£åããå¥ã®æ¹æ³ã¯ãã«
ãã©ãŒååã«éåå¯èœãªäžé£œåçµåãå«ãåºãå°
å ¥ããåéäœã«ãã©ãŒãéåããŠåŸãããããªã
ãŒã«ãã©ãŒãçšããæ¹æ³ã§ããã ããªããŒã«ãã©ãŒã¯ã©ããã¯ã¹ã®åœ¢ã§èŠªæ°Žæ§ã³
ãã€ãçµæç©ã«å ããããã®æ¹æ³ã«ã¯ã次ã®æ¹æ³
ããããïŒã€ã¯ã«ãã©ãŒã¢ãããŒãå¿ èŠã«ããä»
ã®å ±éåæåïŒã³ã¢ãããŒïŒãšå ±ã«ä¹³åéåæ³ã«
ããéåãçŽæ¥ã©ããã¯ã¹ã圢æããããããã²
ã³åéä¹³å€ã«å ããæ¹æ³ã§ãããä»ã®ïŒã€ã¯ãã«
ãã©ãŒã¢ãããŒãå¿ èŠã«ããä»ã®å ±éåæåïŒã³
ã¢ãããŒïŒãšå ±ã«æº¶æ¶²éåã«ããéåãåŸããã
ããªããŒã«ãã©ãŒã溶åªã«æº¶è§£ããã®ã¡ããããŒ
ã©ãã³æ°Žæº¶æ¶²äžã«åæ£ãã©ããã¯ã¹ãšããæ¹æ³ã§
ãããåè ã®ä¹³åéåæ³ã«ã€ããŠã¯ç±³åœç¹èš±
3370952å·ãããã³å4080211å·ã«ããããèšèŒã
ããŠãããåŸè ã®æ¹æ³ã«ã€ããŠã¯ãäŸãã°ç±³åœç¹
èš±3451820å·ã«èšèŒãããŠããããã®ãããªããª
ããŒã«ãã©ãŒãã©ããã¯ã¹ã®åœ¢ã§èŠªæ°Žæ§ã³ãã€ã
çµæç©ã«å ããæ¹æ³ã¯ä»ã®æ¹æ³ã«æ¯ã¹ãŠæ¬¡ã®ãã
ãªå€ãã®å©ç¹ãæããã ãŸãã(1)ã©ããã¯ã¹ãšãããããªããŒã«ãã©ãŒ
ã¯é«æ¿åºŠã®ã«ãã©ãŒåäœãå«ãããšãã§ããã®ã§
容æã«é«æ¿åºŠã®ã«ãã©ãŒãä¹³å€ã«å«æãããããš
ãã§ããã(2)ããããã«ãã©ãŒãåæ£ããããã
ã®é«æ²žç¹ã®ææ©æº¶å€ãå«ãŸããªããšãããããè
èåãå¯èœã§ããã(3)ç»åã®é®®éæ§ãåäžããã
ããšãã§ããã(4)ãŒã©ãã³æ°Žæº¶æ¶²ã®å¢ç²çŸè±¡ãå°
ãªãããé«éåäžå¡åžãå¯èœãšãªãã(5)ããªããŒ
ã«ãã©ãŒã¯ã©ããã¯ã¹åãããŠãããã圢æãã
ãèã®åŒ·åºŠãå£åãããããšããªãã(6)ããã«ã
ãªããŒã«ãã©ãŒã¯ãé«ååäžã«ã«ãã©ãŒåäœãçµ
ã¿èŸŒãŸããŠããããåžæã®å±€äžã«çãŸãä»å±€ã«ç§»
è¡ããããšããªãããè²çŽ ã®æ··è²ã®å¿é ããªãã
ãããä¹³å€èã®äžã§ã®ã«ãã©ãŒã®æåºãå°ãªãã è±åœç¹èš±1247688å·ãç±³åœç¹èš±3451820å·ã«ã¯ã
ïŒåœéããŒã³ã¿ããªããŒã«ãã©ãŒã®ã©ããã¯ã¹ã
ããã²ã³åéä¹³å€ã«å ããäŸãèšèŒãããŠããã
ãŸã西ç¬ç¹èš±2725591å·åã³ç±³åœç¹èš±3926436å·ã«
ã¯ã³ã³ããŒãã³ã°ã«ãã©ãŒãšã®å ±éåäœã®ã©ãã
ã¯ã¹ã®äŸãèšèŒãããŠããããŸããç±³åœç¹èš±
3767412å·ã«ã¯ã·ã¢ã³ã«ãã©ãŒã®ã©ããã¯ã¹ãèš
èŒãããŠããã ããããªããããããã®ããªããŒã«ãã©ãŒã®ã©
ããã¯ã¹ã¯äžèšã®ãããªããããå€ãã®å©ç¹ãæ
ããŠãããã次ã®ãããªæ¹è¯ãã¹ãåé¡ç¹ãæã
ãŠããããããã®æ¹è¯ãæãŸããŠããã (1) ã«ãããªã³ã°ã®åå¿é床ãé ãããååãªè²
çŽ æ¿åºŠãåŸãããªãã (2) çºè²çŸåã«ããäžå¿ èŠãªã«ããªãçããã
ãã (3) ã«ãã©ãŒã¢ãããŒã®æº¶è§£æ§ãäœãã極ããŠé
åæ§ãäœãã (4) 圢æãããè²çŽ ç»åã®æ¹¿ç±å ç¢æ§ãå£ãã çºæã®ç®ç åŸã€ãŠãæ¬çºæã®ç¬¬ïŒã®ç®çã¯ããã®ãããªåŸ
æ¥ã®æ¬ ç¹ãé€ããããã€çºè²æ§ã«åªããå®äŸ¡ã«è£œ
é å¯èœãªããŒã³ã¿ããªããŒã«ãã©ãŒãå«æããã
ãã²ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãå¡åžå±€ãèèåããã
é®®é床ã®åäžããè²çŽ ç»åãåŸãããšãã§ããã
ãã²ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãè匷床ã®å€§ããããã²
ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãçºè²çŸååŠçåŸã®ã«ã©
ãŒåçã«ãããŠãå ãç±ã湿ç±ã«å¯ŸããŠå ç¢ãªè²
çŽ ç»åã圢æããããã²ã³åéåçæå ææãæ
äŸããããšã«ããã çºæã®å ·äœçæ§æ æ¬çºæè çã¯ãçš®ã ã®ç 究ãéããçµæãæ¬çº
æã®ãããã®ç®çã¯ãäžèšäžè¬åŒããã§ç€ºãã
ãåéäœããèªå°ãããç¹°ãè¿ãåäœãæããã
ãŒã³ã¿è²çŽ 圢ææ§ããªããŒã«ãã©ãŒãå«æããå
çæ§æå±€ãæããããã²ã³åéåçæå ææã«ã
ãéæãããããšãèŠãåºããã äžè¬åŒãã åŒäžãã¯ãšãã¬ã³æ§äžé£œååºãŸãã¯ãšãã¬ã³
æ§äžé£œååºãæããåºãè¡šããããã¯ããã
ãâNHCONHâãâNHCOOâãŸãã¯â
OCONHâãè¡šãããã¯æ°ŽçŽ ååãŸãã¯çºè²çŸ
åäž»è¬ã®é žåäœãšã®ã«ãããªã³ã°åå¿ã«ããé¢è±
å¯èœãªåºãè¡šãããR1ãR2ã¯ããããã¢ã«ãã¬
ã³åºãã¢ãªãŒã¬ã³åºãã¢ã«ãã¬ã³ãªããµã€ãåºãŸ
ãã¯
ãåŒãåºïŒR3ããã³R4ã¯ãããã
ç°ç¶ã¢ã«ãã¬ã³åºãŸãã¯ã¢ãªãŒã¬ã³åºãè¡šããã
R5ããã³R6ã¯ããããæ°ŽçŽ ååãã¢ã«ãã«åºãŸ
ãã¯ã¢ãªãŒã«åºãè¡šãããïŒãè¡šãããäžèšã¢ã«
ãã¬ã³æåã¯çŽéã§ãåå²ã§ããããã¯â
CONHâãŸãã¯âNHCONHâãè¡šãããArã¯
ã¢ãªãŒã«åºãŸãã¯è€çŽ ç°åºãè¡šãããïœã¯ïŒã20
ã®æŽæ°ãè¡šããã äžèšäžè¬åŒããã§ç€ºãããã¯ãšãã¬ã³æ§äž
飜ååºãŸãã¯ãšãã¬ã³æ§äžé£œååºãæããåºãè¡š
ãããã奜ãŸããã¯ãäžèšäžè¬åŒããã§ç€ºãã
ãã äžè¬åŒãã åŒäžãR7ã¯æ°ŽçŽ ååãããã²ã³ååïŒå¥œãŸã
ãã¯å¡©çŽ ååïŒãŸãã¯ã¢ã«ãã«åºã奜ãŸããã¯ç
çŽ ååæ°ïŒãïŒã®ã¢ã«ãã«åºïŒäŸãã°ãã¡ãã«
åºããšãã«åºçïŒãè¡šããããã®ã¢ã«ãã«åºã¯çœ®
æåºãæããŠããããR8ã¯ã¢ã«ãã¬ã³åºïŒå¥œãŸ
ããã¯ççŽ ååæ°ïŒã10ã®ã¢ã«ãã¬ã³åºã§ããã
äŸãã°ãšãã¬ã³åºããããã¬ã³åºçïŒãŸãã¯ã¢ãª
ãŒã¬ã³åºïŒããšãã¬ã³åºçïŒã®äºäŸ¡ã®åºãè¡šã
ãã該ã¢ã«ãã¬ã³åºã¯çŽéã§ãåå²éã§ãããã
äŸãã°ãã¡ãã¬ã³åºãã¡ãã«ã¡ãã¬ã³åºããžã¡ã
ã¬ã³åºããã«ã¡ãã¬ã³åºçã§ããããŸãäžèšã¢ã«
ãã¬ã³åºãŸãã¯ããšãã¬ã³åºã¯çœ®æåºãæããŠã
ãããã¯âCOâãâCONHâãâCOOâãŸãã¯
âSO2âãè¡šãããïœãïœã¯ããããïŒãŸãã¯ïŒ
ãè¡šããã åèšR7ã§è¡šããããã¢ã«ãã«åºããã³R8ã§è¡š
ããããã¢ã«ãã¬ã³åºãŸãã¯ã¢ãªãŒã¬ã³åºã®çœ®æ
åºãšããŠã¯ãã¢ã«ãã«åºïŒäŸãã°ãã¡ãã«åºããš
ãã«åºçïŒãã¢ãªãŒã«åºïŒäŸãã°ããšãã«åºçïŒã
ãããåºãæ°Žé žåºãã·ã¢ãåºãã¢ããåºãã¹ã«ã
åºãã¢ã«ã³ãã·åºïŒäŸãã°ãšããã·åºçïŒãã¢ã·
ã«ãªãã·åºïŒäŸãã°ã¢ã»ããã·åºçïŒãã¢ã·ã«ã¢
ããåºïŒäŸãã°ã¢ã»ãã«ã¢ããåºçïŒãã¹ã«ãã³
ã¢ããåºïŒäŸãã°ã¡ã¿ã³ã¹ã«ãã³ã¢ããåºçïŒã
ã¹ã«ãã¢ã¢ã€ã«åºïŒäŸãã°ã¡ãã«ã¹ã«ãã¢ã¢ã€ã«
åºçïŒãããã²ã³ååïŒäŸãã°ããçŽ ååãå¡©çŽ
ååãèçŽ ååçïŒãã«ã«ããã·ã«åºãã«ã«ãã¢
ã€ã«åºïŒäŸãã°ã¡ãã«ã«ã«ãã¢ã€ã«åºçïŒãã¢ã«
ã³ãã·ã«ã«ãã¢ã€ã«åºïŒäŸãã°ã¡ããã·ã«ã«ãã¢
ã€ã«åºçïŒãã¹ã«ããã«åºïŒäŸãã°ã¡ãã«ã¹ã«ã
ãã«åºçïŒããŠã¬ã€ãåºçãæãããããããã
ã®çœ®æåºã¯ïŒå以äžæããŠããŠãå·®æ¯ããªããã
ã®å Žåã¯ãããã®çœ®æåºãåäžã§ãã€ãŠãç°ãªã€
ãŠããŠãããã åèšäžè¬åŒããã«ãããŠã奜ãŸããã¯ïœãïŒ
ãã€ïœïŒïŒã®å Žåã§ã¯ãR7ãæ°ŽçŽ ååã§ããã
R8ãããšãã¬ã³åºãŸãã¯ããšãã«ã¡ãã¬ã³åºã§
ãããïœãïŒã€ãïœïŒïŒã®å Žåã§ã¯ãR7ãæ°ŽçŽ
ååãå¡©çŽ ååãŸãã¯ã¡ãã«åºã§ããããâ
COâãâCONHâãŸãã¯âCOOâã§ãããïœã
ïŒãã€ïœïŒïŒã®å Žåã§ã¯ãR7ãæ°ŽçŽ ååãå¡©çŽ
ååãŸãã¯ã¡ãã«åºã§ãããR8ããšãã¬ã³åºãŸ
ãã¯ãããã¬ã³åºã§ããããâCONHâãâ
SO2âãŸãã¯âCOOâã§ããããšã§ãããïœãšïœ
ãåæã«ïŒãšãªã€ãŠãããã åèšäžè¬åŒããã§ç€ºãããR1ãR2ã¯ããã
ããã¢ã«ãã¬ã³åºïŒäŸãã°ãïœâããã¬ã³åºãïœ
âããã·ã¬ã³åºçïŒãã¢ãªãŒã¬ã³åºïŒäŸãã°ãã
ãšãã¬ã³åºããããã¬ã³åºçïŒãã¢ã«ãã¬ã³ãªã
ãµã€ãåºïŒäŸãã°ããšãã¬ã³ãªããµã€ãåºãããª
ãšãã¬ã³ãªããµã€ãåºãããªãããã¬ã³ãªããµã€
ãåºçïŒãã¢ãªãŒã¬ã³ãªããµã€ãåºïŒäŸãã°ããš
ãã¬ã³ãªããµã€ãåºçïŒãŸãã¯äžèšäžè¬åŒãã
ã§ç€ºãããåºã§ãããã äžè¬åŒãã
R5ããã³R6ã¯ããããæ°ŽçŽ ååãã¢ã«ãã«åºãŸ
ãã¯ã¢ãªãŒã«åºãè¡šãããïŒãè¡šãããäžèšã¢ã«
ãã¬ã³æåã¯çŽéã§ãåå²ã§ããããã¯â
CONHâãŸãã¯âNHCONHâãè¡šãããArã¯
ã¢ãªãŒã«åºãŸãã¯è€çŽ ç°åºãè¡šãããïœã¯ïŒã20
ã®æŽæ°ãè¡šããã äžèšäžè¬åŒããã§ç€ºãããã¯ãšãã¬ã³æ§äž
飜ååºãŸãã¯ãšãã¬ã³æ§äžé£œååºãæããåºãè¡š
ãããã奜ãŸããã¯ãäžèšäžè¬åŒããã§ç€ºãã
ãã äžè¬åŒãã åŒäžãR7ã¯æ°ŽçŽ ååãããã²ã³ååïŒå¥œãŸã
ãã¯å¡©çŽ ååïŒãŸãã¯ã¢ã«ãã«åºã奜ãŸããã¯ç
çŽ ååæ°ïŒãïŒã®ã¢ã«ãã«åºïŒäŸãã°ãã¡ãã«
åºããšãã«åºçïŒãè¡šããããã®ã¢ã«ãã«åºã¯çœ®
æåºãæããŠããããR8ã¯ã¢ã«ãã¬ã³åºïŒå¥œãŸ
ããã¯ççŽ ååæ°ïŒã10ã®ã¢ã«ãã¬ã³åºã§ããã
äŸãã°ãšãã¬ã³åºããããã¬ã³åºçïŒãŸãã¯ã¢ãª
ãŒã¬ã³åºïŒããšãã¬ã³åºçïŒã®äºäŸ¡ã®åºãè¡šã
ãã該ã¢ã«ãã¬ã³åºã¯çŽéã§ãåå²éã§ãããã
äŸãã°ãã¡ãã¬ã³åºãã¡ãã«ã¡ãã¬ã³åºããžã¡ã
ã¬ã³åºããã«ã¡ãã¬ã³åºçã§ããããŸãäžèšã¢ã«
ãã¬ã³åºãŸãã¯ããšãã¬ã³åºã¯çœ®æåºãæããŠã
ãããã¯âCOâãâCONHâãâCOOâãŸãã¯
âSO2âãè¡šãããïœãïœã¯ããããïŒãŸãã¯ïŒ
ãè¡šããã åèšR7ã§è¡šããããã¢ã«ãã«åºããã³R8ã§è¡š
ããããã¢ã«ãã¬ã³åºãŸãã¯ã¢ãªãŒã¬ã³åºã®çœ®æ
åºãšããŠã¯ãã¢ã«ãã«åºïŒäŸãã°ãã¡ãã«åºããš
ãã«åºçïŒãã¢ãªãŒã«åºïŒäŸãã°ããšãã«åºçïŒã
ãããåºãæ°Žé žåºãã·ã¢ãåºãã¢ããåºãã¹ã«ã
åºãã¢ã«ã³ãã·åºïŒäŸãã°ãšããã·åºçïŒãã¢ã·
ã«ãªãã·åºïŒäŸãã°ã¢ã»ããã·åºçïŒãã¢ã·ã«ã¢
ããåºïŒäŸãã°ã¢ã»ãã«ã¢ããåºçïŒãã¹ã«ãã³
ã¢ããåºïŒäŸãã°ã¡ã¿ã³ã¹ã«ãã³ã¢ããåºçïŒã
ã¹ã«ãã¢ã¢ã€ã«åºïŒäŸãã°ã¡ãã«ã¹ã«ãã¢ã¢ã€ã«
åºçïŒãããã²ã³ååïŒäŸãã°ããçŽ ååãå¡©çŽ
ååãèçŽ ååçïŒãã«ã«ããã·ã«åºãã«ã«ãã¢
ã€ã«åºïŒäŸãã°ã¡ãã«ã«ã«ãã¢ã€ã«åºçïŒãã¢ã«
ã³ãã·ã«ã«ãã¢ã€ã«åºïŒäŸãã°ã¡ããã·ã«ã«ãã¢
ã€ã«åºçïŒãã¹ã«ããã«åºïŒäŸãã°ã¡ãã«ã¹ã«ã
ãã«åºçïŒããŠã¬ã€ãåºçãæãããããããã
ã®çœ®æåºã¯ïŒå以äžæããŠããŠãå·®æ¯ããªããã
ã®å Žåã¯ãããã®çœ®æåºãåäžã§ãã€ãŠãç°ãªã€
ãŠããŠãããã åèšäžè¬åŒããã«ãããŠã奜ãŸããã¯ïœãïŒ
ãã€ïœïŒïŒã®å Žåã§ã¯ãR7ãæ°ŽçŽ ååã§ããã
R8ãããšãã¬ã³åºãŸãã¯ããšãã«ã¡ãã¬ã³åºã§
ãããïœãïŒã€ãïœïŒïŒã®å Žåã§ã¯ãR7ãæ°ŽçŽ
ååãå¡©çŽ ååãŸãã¯ã¡ãã«åºã§ããããâ
COâãâCONHâãŸãã¯âCOOâã§ãããïœã
ïŒãã€ïœïŒïŒã®å Žåã§ã¯ãR7ãæ°ŽçŽ ååãå¡©çŽ
ååãŸãã¯ã¡ãã«åºã§ãããR8ããšãã¬ã³åºãŸ
ãã¯ãããã¬ã³åºã§ããããâCONHâãâ
SO2âãŸãã¯âCOOâã§ããããšã§ãããïœãšïœ
ãåæã«ïŒãšãªã€ãŠãããã åèšäžè¬åŒããã§ç€ºãããR1ãR2ã¯ããã
ããã¢ã«ãã¬ã³åºïŒäŸãã°ãïœâããã¬ã³åºãïœ
âããã·ã¬ã³åºçïŒãã¢ãªãŒã¬ã³åºïŒäŸãã°ãã
ãšãã¬ã³åºããããã¬ã³åºçïŒãã¢ã«ãã¬ã³ãªã
ãµã€ãåºïŒäŸãã°ããšãã¬ã³ãªããµã€ãåºãããª
ãšãã¬ã³ãªããµã€ãåºãããªãããã¬ã³ãªããµã€
ãåºçïŒãã¢ãªãŒã¬ã³ãªããµã€ãåºïŒäŸãã°ããš
ãã¬ã³ãªããµã€ãåºçïŒãŸãã¯äžèšäžè¬åŒãã
ã§ç€ºãããåºã§ãããã äžè¬åŒãã
ãåŒã
åŒäžãR3ãR4ã¯ãããããç°ç¶ã¢ã«ãã¬ã³åº
ïŒäŸãã°ãã·ã¯ãããã·ã¬ã³åºããã·ã¯ãããã
ã¬ã³åºçïŒãã¢ãªãŒã¬ã³åºïŒäŸãã°ãããšãã¬ã³
åºããããã¬ã³åºçïŒãè¡šãããåäžã§ãã€ãŠã
ç°ãªã€ãŠããããR5ãR6ã¯ãããããæ°ŽçŽ ååã
ã¢ã«ãã«åºïŒäŸãã°ãã¡ãã«åºããšãã«åºããã³
ãžã«åºçïŒãŸãã¯ã¢ãªãŒã«åºïŒäŸãã°ãããšãã«
åºããããã«åºçïŒãè¡šãããåäžã§ãã€ãŠãç°
ãªã€ãŠããããäžèšR3ãR4ãR5ããã³R6ã¯ãã
ãã眮æåºãæããŠãããã äžèšR1ãR2ã§è¡šããããã¢ã«ãã¬ã³åºã¯ãçŽ
éã§ãåå²ã§ãããã奜ãŸããã¯ççŽ ååæ°ïŒã
30ã®ã¢ã«ãã¬ã³åºã§ãããäŸãã°ãã¡ãã¬ã³åºã
ã¡ãã«ã¡ãã¬ã³åºããããµã¡ãã¬ã³åºããã«ã¡ã
ã¬ã³åºãã·ã¯ãããã·ã¬ã³åºããã·ã¯ããããã¬
ã³åºçã§ãããããã«å¥œãŸããã¯ïœâããã¬ã³
åºãïœâããã·ã¬ã³åºã§ããããããã¯çœ®æåºã
æããŠãããã äžèšR1ãR2ã§è¡šããããã¢ãªãŒã¬ã³åºã¯ã奜
ãŸããã¯ããšãã¬ã³åºã§ããã眮æåºãæããŠã
ããã åèšR1ãR2ã§è¡šããããã¢ã«ãã¬ã³åºãã¢ãª
ãŒã¬ã³åºãã¢ã«ãã¬ã³ãªããµã€ãåºããã³åèšäž
è¬åŒããã§è¡šããããåºã®R3ãR4ãR5ããã³
R6ã®çœ®æåºãšããŠã¯ãã¢ã«ãã«åºïŒäŸãã°ãã¡
ãã«åºããšãã«åºçïŒãã¢ãªãŒã«åºïŒäŸãã°ãã
ãšãã«åºçïŒããããåºãæ°Žé žåºãã·ã¢ãåºãã¢
ããåºãã¹ã«ãåºãã¢ã«ã³ãã·åºïŒäŸãã°ãšãã
ã·åºçïŒãã¢ã·ã«ãªãã·åºïŒäŸãã°ã¢ã»ããã·åº
çïŒãã¢ã·ã«ã¢ããåºïŒäŸãã°ã¢ã»ãã«ã¢ããåº
çïŒãã¹ã«ãã³ã¢ããåºïŒäŸãã°ã¡ã¿ã³ã¹ã«ãã³
ã¢ããåºçïŒãã¹ã«ãã¢ã¢ã€ã«åºïŒäŸãã°ã¡ãã«
ã¹ã«ãã¢ã¢ã€ã«åºçïŒãããã²ã³ååïŒäŸãã°ã
ããçŽ ååãå¡©çŽ ååãèçŽ ååçïŒãã«ã«ãã
ã·ã«åºãã«ã«ãã¢ã€ã«åºïŒäŸãã°ã¡ãã«ã«ã«ãã¢
ã€ã«åºçïŒãã¢ã«ã³ãã·ã«ã«ãã¢ã€ã«åºïŒäŸãã°
ã¡ããã·ã«ã«ãã¢ã€ã«åºçïŒãã¹ã«ããã«åºïŒäŸ
ãã°ã¡ãã«ã¹ã«ããã«åºçïŒããŠã¬ã€ãåºçãã
ããããããããã®çœ®æåºã¯ïŒå以äžæããŠããŠ
ãå·®æ¯ããªãããã®å Žåã¯ãããã®çœ®æåºãåäž
ã§ãã€ãŠãç°ãªã€ãŠããŠãããã åèšäžè¬åŒããã«ãããŠïŒ«ã¯âNHCONH
âãâNHCOOâãŸãã¯âOCONHâãè¡šãããã
ïœãïŒä»¥äžã®å Žåã¯äºãã«ç°ãªãåºãè¡šãããŠã
ãããïœãïŒã®ãšããã¯å¥œãŸããã¯â
NHCONHâãŸãã¯âOCONHâã§ãããããã«
奜ãŸããã¯âNHCONHâã§ããã åèšäžè¬åŒããã«ãããŠArãè¡šããã¢ãªãŒ
ã«åºãšããŠã¯çœ®æåºãæããããšãã«åºãŸãã¯çœ®
æåºãæããªãããšãã«åºãããããããšãã«åº
ã眮æåºãæããå Žåã«ã¯ã奜ãŸããã¯äžèšäžè¬
åŒããã§è¡šããããšãã§ããã äžè¬åŒãã åŒäžãã¯ããã²ã³ååïŒäŸãã°ãå¡©çŽ ååã
èçŽ ååïŒãŸãã¯ççŽ ååæ°ïŒãïŒã®ã¢ã«ãã«åº
ãè¡šãããã¢ã«ãã«åºãšããŠã¯ãäŸãã°ã¡ãã«
åºããšãã«åºããããã«åºãããã«åºçãããã
眮æåºãæããŠããŠãããã眮æåºãšããŠã¯ãå¡©
çŽ ååãããçŽ ååçã®ããã²ã³ååãã¢ã«ãã«
ã¹ã«ããã«åºããã³ã¢ãªãŒã«ã¹ã«ããã«åºçãã
ãã眮æåºãšããŠå¥œãŸããã¯ããã²ã³ååã§ã
ããã®ããã«å¥œãŸããã¯å¡©çŽ ååãŸãã¯ããçŽ
ååã§ããããŸããã¯é»ååžåŒæ§ã®çœ®æåºãè¡š
ããããé»ååžåŒæ§ã®çœ®æåºãšã¯Hammettãã«
ãã€ãŠå®çŸ©ãããÎŽå€ãããã¯Swainããã³
Luptonãã«ãã€ãŠå°ãããå€ãïŒããã倧ãª
ã眮æåºãšããŠå®çŸ©ããããå ·äœçãªé»ååžåŒæ§
ã®çœ®æåºãšããŠã¯ãäŸãã°ããã²ã³ååãããã²
ã³åã¢ã«ãã«åºãã«ã«ããã·ã«åºãã¹ã«ãåºãã
ããåºãã·ã¢ãåºãã¢ã«ãã«ã¹ã«ããã«åºãã¢ã«
ãã«ã¹ã«ãã¢ã¢ã€ã«åºãã¢ã»ãã«åºãã¢ã«ã³ãã·
åºãã«ã«ããã«åºçãæããããããããã«J.
Med Chem.Vol.16ïŒ1207é ïŒ1973ïŒãJ.Med
Chem.Vol.20ã304é ïŒ1977ïŒã«èšèŒãããŠãã
åºçãå«ããããšãã§ãããããã§ïŒ¹ãšããŠå¥œãŸ
ããã¯å¡©çŽ ååãããçŽ ååçã®ããã²ã³ååãŸ
ãã¯ãžã¡ãã«ã¹ã«ãã¢ã¢ã€ã«åºçã®ã¢ã«ãã«ã¹ã«
ãã¢ã¢ã€ã«åºã§ãããããã«å¥œãŸããã¯å¡©çŽ åå
ã§ããã ïœã¯ïŒãïŒã®æŽæ°ãè¡šãããïœãïŒä»¥äžã®ãš
ããïŒã€ä»¥äžããã¯åäžã§ãç°ãªã€ãŠããŠãã
ãã ãŸããArãè¡šããè€çŽ ç°åºãšããŠã¯ã眮æåº
ãæããŠãããïŒå¡ãŸãã¯ïŒå¡ã®è€çŽ ç°åºãçž®å
è€çŽ ç°åºçãããã該è€çŽ ç°ã圢æããååã®ã
ã¡å°ãªããšãïŒã€ã¯é žçŽ ååãçªçŽ ååãŸãã¯ã€
ãªãŠååããéžã°ãããã®ã§ãè€çŽ ç°åºã®äŸãšã
ãŠã¯ãããªã¢ãŸãŒã«ããã¢ãŸãŒã«ããã³ãºãã¢ãŸ
ãŒã«ããã©ã³ãã€ãããŸãŒã«ããªããµãŸãŒã«ãã
ã³ãºãªããµãŸãŒã«ãããªããžã³ãããã«ãžã³ãã
ãªãžã³çãæããããšãã§ããããããŠãããè€
çŽ ç°åºã®çœ®æåºãšããŠã¯ãäŸãã°ççŽ ååæ°ïŒã
10ã®çŽéãªããã¯åå²ç¶ã®ã¢ã«ãã«åºïŒäŸãã°ã
ã¡ãã«åºãïœâããã«åºãïœâãªã¯ãã«åºïŒãç°
ç¶ã¢ã«ãã«åºïŒäŸãã°ãã·ã¯ããã³ãã«åºãã·ã¯
ãããã·ã«åºïŒãã¢ã©ã«ãã«åºïŒäŸãã°ããã³ãž
ã«åºïŒãã¢ãªãŒã«åºïŒäŸãã°ãããšãã«åºãããª
ã«åºïŒãã¢ã«ã³ãã·åºïŒäŸãã°ãã¡ããã·åºããš
ããã·åºïŒãã¢ã«ã³ãã·ã«ã«ããã«åºïŒäŸãã°ã
ã¡ããã·ã«ã«ããã«åºïŒãã¢ãªãŒã«ãªãã·åºïŒäŸ
ãã°ãããšããã·åºïŒãã¢ãªãŒã«ãªãã·ã«ã«ãã
ã«åïŒäŸãã°ãããšããã·ã«ã«ããã«åºïŒãã¢ã©
ã«ãã«ãªãã·ã«ã«ããã«åºïŒäŸãã°ããã³ãžã«ãª
ãã·ã«ã«ããã«åºïŒãã¢ã«ãã«ããªåºïŒäŸãã°ã
ã¡ãã«ããªåºããšãã«ããªåºïŒãã«ã«ããã·ã«åºã
ã¢ã·ã«ã¢ããåºïŒäŸãã°ãã¢ã»ãã«ã¢ããåºãã
ã³ãŸã€ã«ã¢ããåºïŒããžã¢ã·ã«ã¢ããåºïŒäŸãã°ã
ãžã¢ã»ãã«ã¢ããåºããžãã³ãŸã€ã«ã¢ããåºïŒã
âã¢ã«ãã«ã¢ã·ã«ã¢ããåºïŒäŸãã°ãâã¡ã
ã«ã¢ã»ãã«ã¢ããåºïŒãâã¢ãªãŒã«ã¢ã·ã«ã¢ã
ãåºïŒäŸãã°ãâããšãã«ã¢ã»ãã«ã¢ããåºïŒã
ãŠã¬ã€ãåºïŒäŸãã°ããŠã¬ã€ããã¡ãã«ãŠã¬ã€ã
åºïŒãããªãŠã¬ã€ãåºïŒäŸãã°ãããªãŠã¬ã€ãã
ã¡ãã«ããªãŠã¬ã€ãåºïŒãã¢ã«ãã«ãªãã·ã«ã«ã
ãã«ã¢ããåºïŒäŸãã°ãã¡ããã·ã«ã«ããã«ã¢ã
ãåºïŒãã¢ãªãŒã«ãªãã·ã«ã«ããã«ã¢ããåºïŒäŸ
ãã°ãããšããã·ã«ã«ããã«ã¢ããåºïŒãã¢ãã
åºãã¢ããªãåºãã¢ã«ãã«ã¢ããåºïŒäŸãã°ãã¡
ãã«ã¢ããåºïŒãã·ã¯ãã¢ããåºïŒäŸãã°ãã·ã¯
ãããã·ã«ã¢ããåºïŒãã¢ã«ãã«ã«ã«ããã«åº
ïŒäŸãã°ãã¢ã»ãã«åºïŒãã¢ãªãŒã«ã«ã«ããã«åº
ïŒäŸãã°ããã³ãŸã€ã«åºïŒãã¹ã«ãã³ã¢ããåºïŒäŸ
ãã°ãã¡ãã«ã¹ã«ãã³ã¢ããåºãã¹ã«ãã³ã¢ãã
åºïŒãã«ã«ãã¢ã€ã«åºïŒäŸãã°ãã«ã«ãã¢ã€ã«åºã
ã¡ãã«ã«ã«ãã¢ã€ã«åºïŒãã¹ã«ãã¢ã¢ã€ã«åºïŒäŸ
ãã°ãã¹ã«ãã¢ã¢ã€ã«åºãã¡ãã«ã¹ã«ãã¢ã¢ã€ã«
åºïŒãã·ã¢ãåºãã¢ã·ã«ãªãã·åºïŒäŸãã°ãã¢ã»
ãã«ãªãã·åºããã³ãŸã€ã«ãªãã·åºïŒãã¹ã«ãã
ã«åºãã¹ã«ããã«ãªãã·åºãã¢ã«ãã«ã¹ã«ããã«
åºïŒäŸãã°ãã¡ãã«ã¹ã«ããã«åºïŒãã¢ãªãŒã«ã¹
ã«ããã«åºïŒäŸãã°ãããšãã«ã¹ã«ããã«åºïŒã
ã¹ã«ãåºããããåºãããããã·åºãããã²ã³å
åïŒäŸãã°ãå¡©çŽ ååïŒãŸãã¯è€çŽ ç°åºïŒäŸã
ã°ããã¢ãŸãŒã«åºããªããµãŸãŒã«åºïŒçãæãã
ããšãã§ããã åèšäžè¬åŒããã«ãããŠïŒºã§è¡šããããçºè²
çŸåäž»è¬ã®é žåäœãšã«ãããªã³ã°åå¿ããéã«é¢
è±ãåŸãåºã¯ã詳ããã¯äžèšäžè¬åŒãVaãã
ãVbããŸãã¯ãVcãã§è¡šããããã äžè¬åŒãVaã ââR9 äžè¬åŒãVbã ââR10 äžè¬åŒãVcã åŒäžãR9ãR10ã¯ã¢ã«ãã«åºãã¢ãªãŒã«åºãã¢
ã·ã«åºçãè¡šãããR11ã¯ïŒå¡ãŸãã¯ïŒå¡ã®è€çŽ
ç°ïŒäŸãã°ã€ãããŸãŒã«ç°ããã©ãŸãŒã«ç°ããã
ãªãžã³ç°ãã¢ã«ããªã³ç°ãã¹ã¯ã·ã³ã€ããç°ãã
ãªã¢ãŸãŒã«ç°çïŒã圢æããã®ã«å¿ èŠãªééå±å
å矀ãè¡šããã 次ã«äžè¬åŒãVaãããVbãåã³ãVcãã§è¡šã
ãããã®ãã¡ã奜ãŸããå ·äœäŸãäžèšã«ç€ºãã
æ¬çºæã¯ããã«éå®ãããªãã (1) äžè¬åŒãVaãã®ââR1ã«è©²åœããå ·äœäŸ ââC12H25ã
ïŒäŸãã°ãã·ã¯ãããã·ã¬ã³åºããã·ã¯ãããã
ã¬ã³åºçïŒãã¢ãªãŒã¬ã³åºïŒäŸãã°ãããšãã¬ã³
åºããããã¬ã³åºçïŒãè¡šãããåäžã§ãã€ãŠã
ç°ãªã€ãŠããããR5ãR6ã¯ãããããæ°ŽçŽ ååã
ã¢ã«ãã«åºïŒäŸãã°ãã¡ãã«åºããšãã«åºããã³
ãžã«åºçïŒãŸãã¯ã¢ãªãŒã«åºïŒäŸãã°ãããšãã«
åºããããã«åºçïŒãè¡šãããåäžã§ãã€ãŠãç°
ãªã€ãŠããããäžèšR3ãR4ãR5ããã³R6ã¯ãã
ãã眮æåºãæããŠãããã äžèšR1ãR2ã§è¡šããããã¢ã«ãã¬ã³åºã¯ãçŽ
éã§ãåå²ã§ãããã奜ãŸããã¯ççŽ ååæ°ïŒã
30ã®ã¢ã«ãã¬ã³åºã§ãããäŸãã°ãã¡ãã¬ã³åºã
ã¡ãã«ã¡ãã¬ã³åºããããµã¡ãã¬ã³åºããã«ã¡ã
ã¬ã³åºãã·ã¯ãããã·ã¬ã³åºããã·ã¯ããããã¬
ã³åºçã§ãããããã«å¥œãŸããã¯ïœâããã¬ã³
åºãïœâããã·ã¬ã³åºã§ããããããã¯çœ®æåºã
æããŠãããã äžèšR1ãR2ã§è¡šããããã¢ãªãŒã¬ã³åºã¯ã奜
ãŸããã¯ããšãã¬ã³åºã§ããã眮æåºãæããŠã
ããã åèšR1ãR2ã§è¡šããããã¢ã«ãã¬ã³åºãã¢ãª
ãŒã¬ã³åºãã¢ã«ãã¬ã³ãªããµã€ãåºããã³åèšäž
è¬åŒããã§è¡šããããåºã®R3ãR4ãR5ããã³
R6ã®çœ®æåºãšããŠã¯ãã¢ã«ãã«åºïŒäŸãã°ãã¡
ãã«åºããšãã«åºçïŒãã¢ãªãŒã«åºïŒäŸãã°ãã
ãšãã«åºçïŒããããåºãæ°Žé žåºãã·ã¢ãåºãã¢
ããåºãã¹ã«ãåºãã¢ã«ã³ãã·åºïŒäŸãã°ãšãã
ã·åºçïŒãã¢ã·ã«ãªãã·åºïŒäŸãã°ã¢ã»ããã·åº
çïŒãã¢ã·ã«ã¢ããåºïŒäŸãã°ã¢ã»ãã«ã¢ããåº
çïŒãã¹ã«ãã³ã¢ããåºïŒäŸãã°ã¡ã¿ã³ã¹ã«ãã³
ã¢ããåºçïŒãã¹ã«ãã¢ã¢ã€ã«åºïŒäŸãã°ã¡ãã«
ã¹ã«ãã¢ã¢ã€ã«åºçïŒãããã²ã³ååïŒäŸãã°ã
ããçŽ ååãå¡©çŽ ååãèçŽ ååçïŒãã«ã«ãã
ã·ã«åºãã«ã«ãã¢ã€ã«åºïŒäŸãã°ã¡ãã«ã«ã«ãã¢
ã€ã«åºçïŒãã¢ã«ã³ãã·ã«ã«ãã¢ã€ã«åºïŒäŸãã°
ã¡ããã·ã«ã«ãã¢ã€ã«åºçïŒãã¹ã«ããã«åºïŒäŸ
ãã°ã¡ãã«ã¹ã«ããã«åºçïŒããŠã¬ã€ãåºçãã
ããããããããã®çœ®æåºã¯ïŒå以äžæããŠããŠ
ãå·®æ¯ããªãããã®å Žåã¯ãããã®çœ®æåºãåäž
ã§ãã€ãŠãç°ãªã€ãŠããŠãããã åèšäžè¬åŒããã«ãããŠïŒ«ã¯âNHCONH
âãâNHCOOâãŸãã¯âOCONHâãè¡šãããã
ïœãïŒä»¥äžã®å Žåã¯äºãã«ç°ãªãåºãè¡šãããŠã
ãããïœãïŒã®ãšããã¯å¥œãŸããã¯â
NHCONHâãŸãã¯âOCONHâã§ãããããã«
奜ãŸããã¯âNHCONHâã§ããã åèšäžè¬åŒããã«ãããŠArãè¡šããã¢ãªãŒ
ã«åºãšããŠã¯çœ®æåºãæããããšãã«åºãŸãã¯çœ®
æåºãæããªãããšãã«åºãããããããšãã«åº
ã眮æåºãæããå Žåã«ã¯ã奜ãŸããã¯äžèšäžè¬
åŒããã§è¡šããããšãã§ããã äžè¬åŒãã åŒäžãã¯ããã²ã³ååïŒäŸãã°ãå¡©çŽ ååã
èçŽ ååïŒãŸãã¯ççŽ ååæ°ïŒãïŒã®ã¢ã«ãã«åº
ãè¡šãããã¢ã«ãã«åºãšããŠã¯ãäŸãã°ã¡ãã«
åºããšãã«åºããããã«åºãããã«åºçãããã
眮æåºãæããŠããŠãããã眮æåºãšããŠã¯ãå¡©
çŽ ååãããçŽ ååçã®ããã²ã³ååãã¢ã«ãã«
ã¹ã«ããã«åºããã³ã¢ãªãŒã«ã¹ã«ããã«åºçãã
ãã眮æåºãšããŠå¥œãŸããã¯ããã²ã³ååã§ã
ããã®ããã«å¥œãŸããã¯å¡©çŽ ååãŸãã¯ããçŽ
ååã§ããããŸããã¯é»ååžåŒæ§ã®çœ®æåºãè¡š
ããããé»ååžåŒæ§ã®çœ®æåºãšã¯Hammettãã«
ãã€ãŠå®çŸ©ãããÎŽå€ãããã¯Swainããã³
Luptonãã«ãã€ãŠå°ãããå€ãïŒããã倧ãª
ã眮æåºãšããŠå®çŸ©ããããå ·äœçãªé»ååžåŒæ§
ã®çœ®æåºãšããŠã¯ãäŸãã°ããã²ã³ååãããã²
ã³åã¢ã«ãã«åºãã«ã«ããã·ã«åºãã¹ã«ãåºãã
ããåºãã·ã¢ãåºãã¢ã«ãã«ã¹ã«ããã«åºãã¢ã«
ãã«ã¹ã«ãã¢ã¢ã€ã«åºãã¢ã»ãã«åºãã¢ã«ã³ãã·
åºãã«ã«ããã«åºçãæããããããããã«J.
Med Chem.Vol.16ïŒ1207é ïŒ1973ïŒãJ.Med
Chem.Vol.20ã304é ïŒ1977ïŒã«èšèŒãããŠãã
åºçãå«ããããšãã§ãããããã§ïŒ¹ãšããŠå¥œãŸ
ããã¯å¡©çŽ ååãããçŽ ååçã®ããã²ã³ååãŸ
ãã¯ãžã¡ãã«ã¹ã«ãã¢ã¢ã€ã«åºçã®ã¢ã«ãã«ã¹ã«
ãã¢ã¢ã€ã«åºã§ãããããã«å¥œãŸããã¯å¡©çŽ åå
ã§ããã ïœã¯ïŒãïŒã®æŽæ°ãè¡šãããïœãïŒä»¥äžã®ãš
ããïŒã€ä»¥äžããã¯åäžã§ãç°ãªã€ãŠããŠãã
ãã ãŸããArãè¡šããè€çŽ ç°åºãšããŠã¯ã眮æåº
ãæããŠãããïŒå¡ãŸãã¯ïŒå¡ã®è€çŽ ç°åºãçž®å
è€çŽ ç°åºçãããã該è€çŽ ç°ã圢æããååã®ã
ã¡å°ãªããšãïŒã€ã¯é žçŽ ååãçªçŽ ååãŸãã¯ã€
ãªãŠååããéžã°ãããã®ã§ãè€çŽ ç°åºã®äŸãšã
ãŠã¯ãããªã¢ãŸãŒã«ããã¢ãŸãŒã«ããã³ãºãã¢ãŸ
ãŒã«ããã©ã³ãã€ãããŸãŒã«ããªããµãŸãŒã«ãã
ã³ãºãªããµãŸãŒã«ãããªããžã³ãããã«ãžã³ãã
ãªãžã³çãæããããšãã§ããããããŠãããè€
çŽ ç°åºã®çœ®æåºãšããŠã¯ãäŸãã°ççŽ ååæ°ïŒã
10ã®çŽéãªããã¯åå²ç¶ã®ã¢ã«ãã«åºïŒäŸãã°ã
ã¡ãã«åºãïœâããã«åºãïœâãªã¯ãã«åºïŒãç°
ç¶ã¢ã«ãã«åºïŒäŸãã°ãã·ã¯ããã³ãã«åºãã·ã¯
ãããã·ã«åºïŒãã¢ã©ã«ãã«åºïŒäŸãã°ããã³ãž
ã«åºïŒãã¢ãªãŒã«åºïŒäŸãã°ãããšãã«åºãããª
ã«åºïŒãã¢ã«ã³ãã·åºïŒäŸãã°ãã¡ããã·åºããš
ããã·åºïŒãã¢ã«ã³ãã·ã«ã«ããã«åºïŒäŸãã°ã
ã¡ããã·ã«ã«ããã«åºïŒãã¢ãªãŒã«ãªãã·åºïŒäŸ
ãã°ãããšããã·åºïŒãã¢ãªãŒã«ãªãã·ã«ã«ãã
ã«åïŒäŸãã°ãããšããã·ã«ã«ããã«åºïŒãã¢ã©
ã«ãã«ãªãã·ã«ã«ããã«åºïŒäŸãã°ããã³ãžã«ãª
ãã·ã«ã«ããã«åºïŒãã¢ã«ãã«ããªåºïŒäŸãã°ã
ã¡ãã«ããªåºããšãã«ããªåºïŒãã«ã«ããã·ã«åºã
ã¢ã·ã«ã¢ããåºïŒäŸãã°ãã¢ã»ãã«ã¢ããåºãã
ã³ãŸã€ã«ã¢ããåºïŒããžã¢ã·ã«ã¢ããåºïŒäŸãã°ã
ãžã¢ã»ãã«ã¢ããåºããžãã³ãŸã€ã«ã¢ããåºïŒã
âã¢ã«ãã«ã¢ã·ã«ã¢ããåºïŒäŸãã°ãâã¡ã
ã«ã¢ã»ãã«ã¢ããåºïŒãâã¢ãªãŒã«ã¢ã·ã«ã¢ã
ãåºïŒäŸãã°ãâããšãã«ã¢ã»ãã«ã¢ããåºïŒã
ãŠã¬ã€ãåºïŒäŸãã°ããŠã¬ã€ããã¡ãã«ãŠã¬ã€ã
åºïŒãããªãŠã¬ã€ãåºïŒäŸãã°ãããªãŠã¬ã€ãã
ã¡ãã«ããªãŠã¬ã€ãåºïŒãã¢ã«ãã«ãªãã·ã«ã«ã
ãã«ã¢ããåºïŒäŸãã°ãã¡ããã·ã«ã«ããã«ã¢ã
ãåºïŒãã¢ãªãŒã«ãªãã·ã«ã«ããã«ã¢ããåºïŒäŸ
ãã°ãããšããã·ã«ã«ããã«ã¢ããåºïŒãã¢ãã
åºãã¢ããªãåºãã¢ã«ãã«ã¢ããåºïŒäŸãã°ãã¡
ãã«ã¢ããåºïŒãã·ã¯ãã¢ããåºïŒäŸãã°ãã·ã¯
ãããã·ã«ã¢ããåºïŒãã¢ã«ãã«ã«ã«ããã«åº
ïŒäŸãã°ãã¢ã»ãã«åºïŒãã¢ãªãŒã«ã«ã«ããã«åº
ïŒäŸãã°ããã³ãŸã€ã«åºïŒãã¹ã«ãã³ã¢ããåºïŒäŸ
ãã°ãã¡ãã«ã¹ã«ãã³ã¢ããåºãã¹ã«ãã³ã¢ãã
åºïŒãã«ã«ãã¢ã€ã«åºïŒäŸãã°ãã«ã«ãã¢ã€ã«åºã
ã¡ãã«ã«ã«ãã¢ã€ã«åºïŒãã¹ã«ãã¢ã¢ã€ã«åºïŒäŸ
ãã°ãã¹ã«ãã¢ã¢ã€ã«åºãã¡ãã«ã¹ã«ãã¢ã¢ã€ã«
åºïŒãã·ã¢ãåºãã¢ã·ã«ãªãã·åºïŒäŸãã°ãã¢ã»
ãã«ãªãã·åºããã³ãŸã€ã«ãªãã·åºïŒãã¹ã«ãã
ã«åºãã¹ã«ããã«ãªãã·åºãã¢ã«ãã«ã¹ã«ããã«
åºïŒäŸãã°ãã¡ãã«ã¹ã«ããã«åºïŒãã¢ãªãŒã«ã¹
ã«ããã«åºïŒäŸãã°ãããšãã«ã¹ã«ããã«åºïŒã
ã¹ã«ãåºããããåºãããããã·åºãããã²ã³å
åïŒäŸãã°ãå¡©çŽ ååïŒãŸãã¯è€çŽ ç°åºïŒäŸã
ã°ããã¢ãŸãŒã«åºããªããµãŸãŒã«åºïŒçãæãã
ããšãã§ããã åèšäžè¬åŒããã«ãããŠïŒºã§è¡šããããçºè²
çŸåäž»è¬ã®é žåäœãšã«ãããªã³ã°åå¿ããéã«é¢
è±ãåŸãåºã¯ã詳ããã¯äžèšäžè¬åŒãVaãã
ãVbããŸãã¯ãVcãã§è¡šããããã äžè¬åŒãVaã ââR9 äžè¬åŒãVbã ââR10 äžè¬åŒãVcã åŒäžãR9ãR10ã¯ã¢ã«ãã«åºãã¢ãªãŒã«åºãã¢
ã·ã«åºçãè¡šãããR11ã¯ïŒå¡ãŸãã¯ïŒå¡ã®è€çŽ
ç°ïŒäŸãã°ã€ãããŸãŒã«ç°ããã©ãŸãŒã«ç°ããã
ãªãžã³ç°ãã¢ã«ããªã³ç°ãã¹ã¯ã·ã³ã€ããç°ãã
ãªã¢ãŸãŒã«ç°çïŒã圢æããã®ã«å¿ èŠãªééå±å
å矀ãè¡šããã 次ã«äžè¬åŒãVaãããVbãåã³ãVcãã§è¡šã
ãããã®ãã¡ã奜ãŸããå ·äœäŸãäžèšã«ç€ºãã
æ¬çºæã¯ããã«éå®ãããªãã (1) äžè¬åŒãVaãã®ââR1ã«è©²åœããå ·äœäŸ ââC12H25ã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
(2) äžè¬åŒãVbãã®ââR2ã«è©²åœããå
·äœäŸ
ãåŒã
âSC12H2ã
ãåŒãâSC13H27ãâSC2H5ãâ
SCH2CH2OHã
ãåŒã
ãåŒã
(3) äžè¬åŒãVcãã®
ãåŒãã«è©²åœã
ãå
·äœäŸ
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
以äžã«æ¬çºæã«ãããŠçšããããåèšäžè¬åŒ
ããã§ç€ºãããã«ãã©ãŒã¢ãããŒã®å ·äœäŸã瀺
ãããæ¬çºæã¯ãããã«éå®ããããã®ã§ã¯ãª
ãã äŸç€ºååç© ä»¥äžã«åèšäžè¬åŒããã§ç€ºããæ¬çºæã®ã«ã
ã©ãŒã¢ãããŒã®ä»£è¡šçãªåæäŸã瀺ãããæ¬çºæ
ã¯ãããã«éå®ãããªãã åæäŸ ïŒ äŸç€ºååç©(2)ã®åæ èžç粟補ããããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒã
13.0ïœïŒ0.10ã¢ã«ïŒãè±æ°Žç²Ÿè£œãããžãªããµã³
200mlã«æº¶è§£ããïŒïŒ4â²âãžããšãã«ã¡ã¿ã³ãžã€
ãœã·ã¢ããŒã25.0ïœïŒ0.10ã¢ã«ïŒãå ãã宀枩ã§
10æéæ¹æãç¶ããïŒâïŒïŒïŒïŒâãžã¯ããããš
ãã«ïŒâïŒâã¢ããâïŒâãã©ãŸãªã³âïŒâãªã³
24.5ïœïŒ0.10ã¢ã«ïŒãšããã©ã¡ãã«ãã¿ã³ãžã¢ã
ã³0.5ïœãè±æ°Žç²Ÿè£œãããžãªããµã³400mlã«æº¶è§£ã
ã溶液äžã«30åã§æ»Žäžããããã«30åæ¹æãç¶ã
ãåŸã«50âã«å ç±ãïŒæéæ¹æããŠå®€æž©ãŸã§å·åŽ
ããã次ã«åå¿æ¶²ããããµã³ïŒã«æ³šã蟌ã¿ãåº
圢ç©ãå£å¥ããåŸã«ã¡ã¿ããŒã«ã§åçµæ¶ããŠäŸç€º
ååç©(2)48.7ïœãåŸããåç78ïŒ ã§ãã€ãããã®
ã«ãã©ãŒã¢ãããŒã®æ§é ã¯ãIRãNMR.FDâ
massã¹ãã¯ãã«ã«ãã確èªããã åæäŸ ïŒ äŸç€ºååç©(8)ã®åæ èžç粟補ããããããã·ãããã«ã¡ã¿ã¯ãªã¬ãŒ
ã7.3ïœïŒ0.05ã¢ã«ïŒãè±æ°Žç²Ÿè£œãããžãªããµã³
120mlã«æº¶è§£ããïŒïŒïŒâãããµã³ãžã€ãœã·ã¢ã
ãŒã8.3ïœïŒ0.05ã¢ã«ïŒãå ãã宀枩ã§10æéæ¹
æãç¶ãã次ãã§ïŒâïŒïŒïŒïŒâãžã¯ããããšã
ã«ïŒâïŒâã¢ããâïŒâãã©ãŸãªã³âïŒâãªã³
12.2ïœïŒ0.05ã¢ã«ïŒãšããã©ã¡ãã«ãã¿ã³ãžã¢ã
ã³0.2ïœãè±æ°Žç²Ÿè£œãããžãªããµã³250mlã«æº¶è§£ã
ã溶液äžã«30åã§æ»Žäžããããã«30åæ¹æãç¶ã
ãåŸã«50âã«å ç±ãïŒæéæ¹æããŠå®€æž©ãŸã§å·åŽ
ããã次ã«åå¿æ¶²ããããµã³ïŒã«æ³šã蟌ã¿ãåº
圢ç©ãå£å¥ããåŸã«ã¡ã¿ããŒã«ã§åçµæ¶ããŠäŸç€º
ååç©(8)20.2ïœãåŸããåç73ïŒ ã§ãã€ãããã®
ã«ãã©ãŒã¢ãããŒã®æ§é ã¯IRãNMRãFDâ
massã¹ãã¯ãã«ãçšããŠç¢ºèªããã 以äžãåæäŸã«ç€ºããåŠããæ¬çºæã®ã«ãã©ãŒ
ã¢ãããŒã¯åŸæ¥çšããããŠããé žã¯ãã©ã€ãã«å¯Ÿ
ãå®äŸ¡ãªã€ãœã·ã¢ããŒããçšããŠè£œé ã§ããã®
ã§ã該ã«ãã©ãŒãçšããŠåŸãããããã²ã³åéå
çæå ææã®äœäŸ¡æ Œåã«å¯äžã§ããã æ¬çºæã«ä¿ãããªããŒã«ãã©ãŒã¯ãåèšäžè¬åŒ
ããã§ç€ºãããã«ãã©ãŒã¢ãããŒããèªå°ãã
ãç¹°ãè¿ãåäœã®ã¿ãããªããããããã¢ããªã
ãŒã§ãã€ãŠãããããŸããä»ã®å ±éåãåŸãã³ã¢
ãããŒã®ïŒçš®ãŸãã¯ïŒçš®ä»¥äžãšã®ããããã³ããª
ããŒã§ãã€ãŠãããã æ¬çºæã«ä¿ãããªããŒã«ãã©ãŒã¯éåäžãã
ã³ïŒãŸãã¯éååå¿çµäºåŸã«çœ®æåå¿ãä»å åå¿
çãè¡ãªãããšãã§ããã å ±éåãããã³ã¢ãããŒã®äŸã«ã¯ãã¢ã¯ãªã«é ž
ãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ãã«ãã¯ããã³é žãš
ã¹ãã«ãããã«ãšã¹ãã«ããã¬ã€ã³é žãžãšã¹ã
ã«ãããã«é žãžãšã¹ãã«ãã€ã¿ã³ã³é žãžãšã¹ã
ã«ããªã¬ãã€ã³é¡ãã¹ãã¬ã³é¡çãæããããã ãããã®ã³ã¢ãããŒã«ã€ããŠæŽã«å ·äœçã«ç€ºã
ãšãã¢ã¯ãªã«é žãšã¹ãã«ãšããŠã¯ãã¡ãã«ã¢ã¯ãª
ã¬ãŒãããšãã«ã¢ã¯ãªã¬ãŒããïœâãããã«ã¢ã¯
ãªã¬ãŒããã€ãœãããã«ã¢ã¯ãªã¬ãŒããïœâãã
ã«ã¢ã¯ãªã¬ãŒããã€ãœããã«ã¢ã¯ãªã¬ãŒããsec
âããã«ã¢ã¯ãªã¬ãŒããtertâããã«ã¢ã¯ãªã¬ãŒ
ããã¢ãã«ã¢ã¯ãªã¬ãŒããããã·ã«ã¢ã¯ãªã¬ãŒ
ããïŒâãšãã«ããã·ã«ã¢ã¯ãªã¬ãŒãããªã¯ãã«
ã¢ã¯ãªã¬ãŒããtertâãªã¯ãã«ã¢ã¯ãªã¬ãŒããïŒ
âã¯ãããšãã«ã¢ã¯ãªã¬ãŒããïŒâããã¢ãšãã«
ã¢ã¯ãªã¬ãŒããïŒâã¯ããããã«ã¢ã¯ãªã¬ãŒãã
ã·ã¢ããšãã«ã¢ã¯ãªã¬ãŒããïŒâã¢ã»ããã·ãšã
ã«ã¢ã¯ãªã¬ãŒãããžã¡ãã«ã¢ãããšãã«ã¢ã¯ãªã¬
ãŒãããã³ãžã«ã¢ã¯ãªã¬ãŒããã¡ããã·ãã³ãžã«
ã¢ã¯ãªã¬ãŒããïŒâã¯ããã·ã¯ãããã·ã«ã¢ã¯ãª
ã¬ãŒããã·ã¯ãããã·ã«ã¢ã¯ãªã¬ãŒãããã«ããª
ã«ã¢ã¯ãªã¬ãŒããããã©ããããã«ããªã«ã¢ã¯ãª
ã¬ãŒããããšãã«ã¢ã¯ãªã¬ãŒããïŒâããããã·
ãã³ãã«ã¢ã¯ãªã¬ãŒããïŒïŒïŒâãžã¡ãã«âïŒâ
ããããã·ãããã«ã¢ã¯ãªã¬ãŒããïŒâã¡ããã·
ãšãã«ã¢ã¯ãªã¬ãŒããïŒâã¡ããã·ããã«ã¢ã¯ãª
ã¬ãŒããïŒâãšããã·ãšãã«ã¢ã¯ãªã¬ãŒããïŒâ
isoâããããã·ã¢ã¯ãªã¬ãŒããïŒâãããã·ãš
ãã«ã¢ã¯ãªã¬ãŒããïŒâïŒïŒâã¡ããã·ãšããã·ïŒ
ãšãã«ã¢ã¯ãªã¬ãŒããïŒâïŒïŒâãããã·ãšãã
ã·ïŒãšãã«ã¢ã¯ãªã¬ãŒããÏâã¡ããã·ããªãšã
ã¬ã³ã°ãªã³ãŒã«ã¢ã¯ãªã¬ãŒãïŒä»å ã¢ã«æ°ïœïŒ
ïŒïŒãïŒâããã¢âïŒâã¡ããã·ãšãã«ã¢ã¯ãªã¬
ãŒããïŒïŒïŒâãžã¯ããâïŒâãšããã·ãšãã«ã¢
ã¯ãªã¬ãŒãçãæããããã ã¡ã¿ã¯ãªã«é žãšã¹ãã«ã®äŸãšããŠã¯ãã¡ãã«ã¡
ã¿ã¯ãªã¬ãŒãããšãã«ã¡ã¿ã¯ãªã¬ãŒããïœâãã
ãã«ã¡ã¿ã¯ãªã¬ãŒããã€ãœãããã«ã¡ã¿ã¯ãªã¬ãŒ
ããïœâããã«ã¡ã¿ã¯ãªã¬ãŒããã€ãœããã«ã¡ã¿
ã¯ãªã¬ãŒããsecâããã«ã¡ã¿ã¯ãªã¬ãŒããtert
âããã«ã¡ã¿ã¯ãªã¬ãŒããã¢ãã«ã¡ã¿ã¯ãªã¬ãŒ
ããããã·ã«ã¡ã¿ã¯ãªã¬ãŒããã·ã¯ãããã·ã«ã¡
ã¿ã¯ãªã¬ãŒãããã³ãžã«ã¡ã¿ã¯ãªã¬ãŒããã¯ãã
ãã³ãžã«ã¡ã¿ã¯ãªã¬ãŒãããªã¯ãã«ã¡ã¿ã¯ãªã¬ãŒ
ããã¹ã«ããããã«ã¡ã¿ã¯ãªã¬ãŒããâãšãã«
ââããšãã«ã¢ãããšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒ
âïŒïŒâããšãã«ãããã«ãªãã·ïŒãšãã«ã¡ã¿ã¯
ãªã¬ãŒãããžã¡ãã«ã¢ããããšããã·ãšãã«ã¡ã¿
ã¯ãªã¬ãŒãããã«ããªã«ã¡ã¿ã¯ãªã¬ãŒããããã©
ããããã«ããªã«ã¡ã¿ã¯ãªã¬ãŒããããšãã«ã¡ã¿
ã¯ãªã¬ãŒããã¯ã¬ãžã«ã¡ã¿ã¯ãªã¬ãŒãããããã«
ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãšãã«ã¡ã¿ã¯ãª
ã¬ãŒããïŒâããããã·ããã«ã¡ã¿ã¯ãªã¬ãŒãã
ããªãšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿ã¯ãªã¬ãŒãããž
ãããã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿ã¯ãªã¬ãŒããïŒâ
ã¡ããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâã¡ããã·ã
ãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâã¢ã»ããã·ãšãã«ã¡ã¿
ã¯ãªã¬ãŒããïŒâã¢ã»ãã¢ã»ããã·ãšãã«ã¡ã¿ã¯
ãªã¬ãŒããïŒâãšããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâisoâããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒ
âãããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâïŒïŒâã¡
ããã·ãšããã·ïŒãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâ
ïŒïŒâãšããã·ãšããã·ïŒãšãã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâïŒïŒâãããã·ãšããã·ïŒãšãã«ã¡ã¿ã¯ãªã¬
ãŒããÏâã¡ããã·ããªãšãã¬ã³ã°ãªã³ãŒã«ã¡ã¿
ã¯ãªã¬ãŒãïŒä»å ã¢ã«æ°ïœïŒïŒïŒãã¢ãªã«ã¡ã¿ã¯
ãªã¬ãŒããã¡ã¿ã¯ãªã«é žãžã¡ãã«ã¢ãããšãã«ã¡
ãã«ã¯ãã©ã€ãå¡©ãªã©ãæããããšãã§ããã ããã«ãšã¹ãã«é¡ã®äŸãšããŠã¯ãããã«ã¢ã»ã
ãŒããããã«ããããªããŒããããã«ããã¬ãŒ
ããããã«ã€ãœããã¬ãŒããããã«ã«ãããšãŒ
ããããã«ã¯ããã¢ã»ããŒããããã«ã¡ããã·ã¢
ã»ããŒããããã«ããšãã«ã¢ã»ããŒããå®æ¯éŠé ž
ããã«ããµãªãã«é žããã«ãªã©ãæããããã ãŸããªã¬ãã€ã³é¡ã®äŸãšããŠã¯ããžã·ã¯ããã³
ã¿ãžãšã³ããšãã¬ã³ããããã¬ã³ãïŒâããã³ã
ïŒâãã³ãã³ãå¡©åããã«ãå¡©åãããªãã³ãã€
ãœãã¬ã³ãã¯ãããã¬ã³ããã¿ãžãšã³ãïŒïŒïŒâ
ãžã¡ãã«ãã¿ãžãšã³çãæããããšãã§ããã ã¹ãã¬ã³é¡ãšããŠã¯ãäŸãã°ãã¹ãã¬ã³ãã¡ã
ã«ã¹ãã¬ã³ããžã¡ãã«ã¹ãã¬ã³ãããªã¡ãã«ã¹ã
ã¬ã³ããšãã«ã¹ãã¬ã³ãã€ãœãããã«ã¹ãã¬ã³ã
ã¯ãã«ã¡ãã«ã¹ãã¬ã³ãã¡ããã·ã¹ãã¬ã³ãã¢ã»
ããã·ã¹ãã¬ã³ãã¯ãã«ã¹ãã¬ã³ããžã¯ãã«ã¹ã
ã¬ã³ãããã ã¹ãã¬ã³ãããã«å®æ¯éŠé žã¡ãã«ãš
ã¹ãã«ãªã©ãæããããã ã¯ããã³é žãšã¹ãã«ã®äŸãšããŠã¯ãã¯ããã³é ž
ããã«ãã¯ããã³é žããã·ã«ãªã©ãæããããã ãŸãã€ã¿ã³ã³é žãžãšã¹ãã«é¡ãšããŠã¯ãäŸã
ã°ãã€ã¿ã³ã³é žãžã¡ãã«ãã€ã¿ã³ã³é žãžãšãã«ã
ã€ã¿ã³ã³é žãžããã«ãªã©ãæããããã ãã¬ã€ã³é žãžãšã¹ãã«é¡ãšããŠã¯ãäŸãã°ãã
ã¬ã€ã³é žãžãšãã«ããã¬ã€ã³é žãžã¡ãã«ããã¬ã€
ã³é žãžããã«ãªã©ãæããããã ããã«é žãžãšã¹ãã«é¡ãšããŠã¯ãäŸãã°ããã
ã«é žãžãšãã«ãããã«é žãžã¡ãã«ãããã«é žãžã
ãã«ãªã©ãæããããã ãã®ä»ã®ã³ã¢ãããŒã®äŸãšããŠã¯ã次ã®ãã®ã
æããããã ã¢ã¯ãªã«ã¢ããé¡ãäŸãã°ã¢ã¯ãªã«ã¢ãããã¡
ãã«ã¢ã¯ãªã«ã¢ããããšãã«ã¢ã¯ãªã«ã¢ãããã
ããã«ã¢ã¯ãªã«ã¢ãããããã«ã¢ã¯ãªã«ã¢ããã
tertâããã«ã¢ã¯ãªã«ã¢ãããã·ã¯ãããã·ã«ã¢
ã¯ãªã«ã¢ããããã³ãžã«ã¢ã¯ãªã«ã¢ãããããã
ãã·ã¡ãã«ã¢ã¯ãªã«ã¢ãããã¡ããã·ãšãã«ã¢ã¯
ãªã«ã¢ããããžã¡ãã«ã¢ãããšãã«ã¢ã¯ãªã«ã¢ã
ããããšãã«ã¢ã¯ãªã«ã¢ããããžã¡ãã«ã¢ã¯ãªã«
ã¢ããããžãšãã«ã¢ã¯ãªã«ã¢ãããβâã·ã¢ããš
ãã«ã¢ã¯ãªã«ã¢ãããâïŒïŒâã¢ã»ãã¢ã»ãã
ã·ãšãã«ïŒã¢ã¯ãªã«ã¢ãããªã©ïŒã¢ãªã«ååç©ã
äŸãã°é ¢é žã¢ãªã«ãã«ããã³é žã¢ãªã«ãã©ãŠãªã³
é žã¢ãªã«ãå®æ¯éŠé žã¢ãªã«ãªã©ïŒããã«ãšãŒãã«
é¡ãäŸãã°ã¡ãã«ããã«ãšãŒãã«ãããã«ããã«
ãšãŒãã«ãããã·ã«ããã«ãšãŒãã«ãã¡ããã·ãš
ãã«ããã«ãšãŒãã«ããžã¡ãã«ã¢ãããšãã«ãã
ã«ãšãŒãã«ãªã©ïŒ ããã«ã±ãã³é¡ãäŸãã°ãã¡ãã«ããã«ã±ã
ã³ãããšãã«ããã«ã±ãã³ãã¡ããã·ãšãã«ãã
ã«ã±ãã³ãªã©ïŒ ããã«ç°ç¯ç°ååç©ãäŸãã°ãããã«ããªãž
ã³ãâããã«ã€ãããŸãŒã«ãâããã«ãªããµ
ãŸãªãã³ãâããã«ããªã¢ãŸãŒã«ãâããã«
ãããªãã³ãªã©ïŒ ã°ãªã·ãžã«ãšã¹ãã«é¡ãäŸãã°ãã°ãªã·ãžã«ã¢
ã¯ãªã¬ãŒããã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒããªã©ïŒ äžé£œåãããªã«é¡ãäŸãã°ãã¢ã¯ãªããããª
ã«ãã¡ã¿ã¯ãªããããªã«ãªã©ïŒ å€å®èœæ§ã¢ãããŒãäŸãã°ããžããã«ãã³ãŒ
ã³ãã¡ãã¬ã³ãã¹ã¢ã¯ãªã«ã¢ããããšãã¬ã³ã°ãª
ã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒããªã©ã æŽã«ãã¢ã¯ãªã«é žãã¡ã¿ã¯ãªã«é žãã€ã¿ã³ã³
é žããã¬ã€ã³é žãã€ã¿ã³ã³é žã¢ãã¢ã«ãã«ãäŸã
ã°ãã€ã¿ã³ã³é žã¢ãã¡ãã«ãã€ã¿ã³ã³é žã¢ããšã
ã«ãã€ã¿ã³ã³é žã¢ãããã«ãªã©ïŒãã¬ã€ã³é žã¢ã
ã¢ã«ãã«ãäŸãã°ããã¬ã€ã³é žã¢ãã¡ãã«ããã¬
ã€ã³é žã¢ããšãã«ããã¬ã€ã³é žã¢ãããã«ãªã©ïŒ
ã·ãã©ã³ã³é žãã¹ãã¬ã³ã¹ã«ãã³é žãããã«ãã³
ãžã«ã¹ã«ãã³é žãããã«ã¹ã«ãã³é žãã¢ã¯ãªãã€
ã«ãªãã·ã¢ã«ãã«ã¹ã«ãã³é žãäŸãã°ãã¢ã¯ãªã
ã€ã«ãªãã·ã¡ãã«ã¹ã«ãã³é žãã¢ã¯ãªãã€ã«ãªã
ã·ãšãã«ã¹ã«ãã³é žãã¢ã¯ãªãã€ã«ãªãã·ããã
ã«ã¹ã«ãã³é žãªã©ïŒã¡ã¿ã¯ãªãã€ã«ãªãã·ã¢ã«ã
ã«ã¹ã«ãã³é žãäŸãã°ã¡ã¿ã¯ãªãã€ã«ãªãã·ã¡ã
ã«ã¹ã«ãã³é žãã¡ã¿ã¯ãªãã€ã«ãªãã·ãšãã«ã¹ã«
ãã³é žãã¡ã¿ã¯ãªãã€ã«ãªãã·ãããã«ã¹ã«ãã³
é žãªã©ïŒã¢ã¯ãªã«ã¢ããã¢ã«ãã«ã¹ã«ãã³é žãäŸ
ãã°ïŒâã¢ã¯ãªã«ã¢ããâïŒâã¡ãã«ãšã¿ã³ã¹ã«
ãã³é žãïŒâã¢ã¯ãªã«ã¢ããâïŒâã¡ãã«ããã
ã³ã¹ã«ãã³é žãïŒâã¢ã¯ãªã«ã¢ããâïŒâã¡ãã«
ãã¿ã³ã¹ã«ãã³é žãªã©ïŒã¡ã¿ã¯ãªã«ã¢ããã¢ã«ã
ã«ã¹ã«ãã³é žãäŸãã°ïŒâã¡ã¿ã¯ãªã«ã¢ããâïŒ
âã¡ãã«ãšã¿ã³ã¹ã«ãã³é žãïŒâã¡ã¿ã¯ãªã«ã¢ã
ãâïŒâã¡ãã«ãããã³ã¹ã«ãã³é žãïŒâã¡ã¿ã¯
ãªã«ã¢ããâïŒâã¡ãã«ãã¿ã³ã¹ã«ãã³é žãªã©ïŒ
ã¢ã¯ãªãã€ã«ãªãã·ã¢ã«ãã«ãã¹ããšãŒããäŸã
ã°ãã¢ã¯ãªãã€ã«ãªãã·ãšãã«ãã¹ããšãŒããïŒ
âã¢ã¯ãªãã€ã«ãªãã·ãããã«âïŒâãã¹ããšãŒ
ããªã©ïŒã¡ã¿ã¯ãªãã€ã«ãªãã·ã¢ã«ãã«ãã¹ããš
ãŒããäŸãã°ã¡ã¿ã¯ãªãã€ã«ãªãã·ãšãã«ãã¹ã
ãšãŒããïŒâã¡ã¿ã¯ãªãã€ã«ãªãã·ãããã«âïŒ
âãã¹ããšãŒããªã©ïŒèŠªæ°ŽåºãïŒã±æããïŒâã¢
ãªããã·âïŒâããããã·ãããã³ã¹ã«ãã³é žã
ããªãŠã ãªã©ãæããããããããã®é žã¯ã¢ã«ã«
ãªéå±ïŒäŸãã°ãNaããªã©ïŒãŸãã¯ã¢ã³ã¢ã
ãŠã ã€ãªã³ã®å¡©ã§ãã€ãŠããããããã«ãã®ä»ã®
ã³ã¢ãããŒãšããŠã¯ãç±³åœç¹èš±ç¬¬3459790å·ãå
第3438708å·ãå第3554987å·ãå第4215195å·ã
å第4247673å·ãç¹éæ57â205735å·å ¬å ±æ现æž
çã«èšèŒãããŠããæ¶æ©æ§ã¢ãããŒãçšããããš
ãã§ããããã®ãããªæ¶æ©æ§ã¢ãããŒã®äŸãšããŠ
ã¯ãå ·äœçã«ã¯ïŒ®âïŒïŒâã¢ã»ãã¢ã»ããã·ãšã
ã«ïŒã¢ã¯ãªã«ã¢ãããâïœïŒâïŒïŒâã¢ã»ãã¢ã»
ããã·ãšããã·ïŒãšãã«ïœã¢ã¯ãªã«ã¢ããçãæ
ããããšãã§ããã ãããã®ã³ã¢ãããŒã®äžã§ãã³ã¢ãããŒã®èŠªæ°Ž
æ§ã芪油æ§ãŸãã¯ã³ã¢ãããŒã®å ±éåæ§ããã³æ§
æããããªããŒã«ãã©ãŒã®çºè²æ§ãçæè²çŽ ã®è²
調ãªã©ããã奜ãŸããçšããããã³ã¢ãããŒã«
ã¯ãã¢ã¯ãªã«é žãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ã
ã«ããã¬ã€ã³é žãšã¹ãã«ãã¢ã¯ãªã«ã¢ãããã¡ã¿
ã¯ãªã«ã¢ããé¡ãå«ãŸããããã«å¥œãŸããã¯ãšã¹
ãã«åºãã¢ããåºã®ççŽ ååæ°ã10以äžã®ã¢ã¯ãª
ã«é žãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ãã«ãã¢ã¯ãªã«
ã¢ãããã¡ã¿ã¯ãªã«ã¢ããã§ãããå ·äœçã«ã¯ã¡
ãã«ã¢ã¯ãªã¬ãŒãããšãã«ã¢ã¯ãªã¬ãŒããïœâã
ããã«ã¢ã¯ãªã¬ãŒããïœâãããã«ã¢ã¯ãªã¬ãŒ
ããïœâããã«ã¢ã¯ãªã¬ãŒããïœâããã«ã¢ã¯ãª
ã¬ãŒããïœâããã«ã¢ã¯ãªã¬ãŒããã¢ãã«ã¡ã¿ã¯
ãªã¬ãŒããïŒâãšãã«ããã·ã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâãã
ããã·ã¡ã¿ã¯ãªã¬ãŒãããã³ãžã«ã¡ã¿ã¯ãªã¬ãŒ
ããã¡ãã«ã¡ã¿ã¯ãªã¬ãŒããã¢ã¯ãªã«ã¢ãããã¡
ã¿ã¯ãªã«ã¢ãããïœâããã«ã¢ã¯ãªã«ã¢ããçã§
ããããããã®ã³ã¢ãããŒã¯ãïŒçš®ä»¥äžã䜵çšã
ãŠãããã æ¬çºæã«ä¿ãããªããŒã«ãã©ãŒã¯ãããããã³
ããªããŒã§ããå Žåã奜ãŸãããããã®å Žåã奜
ãŸããã¯ãäžè¬åŒããã§ç€ºãããåéäœããèª
å°ãããç¹°ãè¿ãåäœãééã§å šäœã®ïŒã100ïŒ
å«ãå Žåã§ãããããã«å¥œãŸããã¯40ã100ïŒ ã§
ããã æ¬çºæã®ããŒã³ã¿ããªããŒã«ãã©ãŒã¯ä¹³åéå
æ³ã§äœã€ãŠãããããããã¯åéäœã«ãã©ãŒã®é
åã§åŸãã芪油æ§ããªããŒã«ãã©ãŒãææ©æº¶åªäž
ã«æº¶ããããã®ããŒã©ãã³æ°Žæº¶æ¶²äžã«ã©ããã¯ã¹
ã®åœ¢ã§åæ£ããŠäœã€ãŠããããä¹³åéåæ³ã«ã€ã
ãŠã¯ç±³åœç¹èš±ç¬¬4080211å·ãå第3370952å·ã«ããŸ
ã芪油æ§ããªããŒã«ãã©ãŒããŒã©ãã³æ°Žæº¶æ¶²äžã«
ã©ããã¯ã¹ã®åœ¢ã§åæ£ããæ¹æ³ã«ã€ããŠã¯ç±³åœç¹
蚱第3451820å·ã«èšèŒãããŠããæ¹æ³ãçšããã
ãšãã§ããã ãããã®æ¹æ³ã¯ãã¢ããªããŒã®åœ¢æããã³ã³ã
ãªããŒã®åœ¢æã«ãå¿çšã§ããåŸè ã®å Žåãã³ã¢ã
ããŒã¯æ¶²äœã³ã¢ãããŒã§ãããšãããä¹³åéåã®
å Žåã«ã¯åžžæ ã§åºå®åéäœã®ããã®æº¶åªãšããŠã
äœçšããã æ¬çºæã®ããŒã³ã¿ããªããŒã«ãã©ãŒã®ä¹³åéå
æ³ããã³æº¶æ¶²éåæ³ã«çšããããéåéå§å€ãšã
ãŠã¯ã氎溶æ§éåéå§å€ãšèŠªæ²¹æ§éåéå§å€ãçš
ããããã氎溶æ§éåéå§å€ãšããŠã¯ãäŸãã°é
ç¡«é žã«ãªãŠã ãéç¡«é žã¢ã³ã¢ããŠã ãéç¡«é žãã
ãªãŠã çã®éç¡«é žå¡©é¡ãïŒïŒ4â²âã¢ãŸãã¹âïŒâ
ã·ã¢ãåèé žãããªãŠã ãïŒïŒ2â²âã¢ãŸãã¹ïŒïŒ
âã¢ããžããããã³ïŒå¡©é žå¡©çã®æ°Žæº¶æ§ã¢ãŸåå
ç©ãéé žåæ°ŽçŽ ãçšããããšãã§ããããŸã溶液
éåæ³ã«çšãããã芪油æ§éåéå§å€ãšããŠã¯ã
äŸãã°ã¢ãŸãã¹ã€ãœããããããªã«ãïŒïŒ2â²âã¢
ãŸãã¹âïŒïŒïŒïŒâãžã¡ãã«ãã¬ããããªã«ïŒã
ïŒïŒ2â²âã¢ãŸãã¹ïŒïŒâã¡ããã·âïŒïŒïŒâãžã¡
ãã«ãã¬ããããªã«ïŒãïŒïŒ1â²âã¢ãŸãã¹ïŒã·ã¯
ããããµãã³âïŒâã«ã«ããããªã«ïŒãïŒïŒ2â²â
ã¢ãŸãã¹ã€ãœã·ã¢ãé ªé žãïŒïŒ2â²âã¢ãŸãã¹ã€ãœ
é ªé žãžã¡ãã«çã®èŠªæ²¹æ§ã¢ãŸååç©ããã³ãŸã€ã«
ããŒãªãã·ããã©ãŠãªã«ããŒãªãã·ãããžã€ãœã
ããã«ããŒãªãã·ãžã«ã«ãããŒãããžâtertâã
ãã«ããŒãªãã·ãçã®èŠªæ²¹æ§ããŒãªãã·ããæã
ãããšãã§ããã ä¹³åéåæ³ã«ãããŠçšããããä¹³åå€ãšããŠ
ã¯ãçé¢æŽ»æ§å€ãé«ååä¿è·ã³ãã€ãããã³å ±é
åä¹³åå€ãæãããããçé¢æŽ»æ§å€ãšããŠã¯ãåœ
該åéã«ãããŠå ¬ç¥ã®ã¢ããªã³æŽ»æ§å€ããããªã³
掻æ§å€ãã«ããªã³æŽ»æ§å€åã³äž¡æ§æŽ»æ§å€ãæãã
ãããã¢ããªã³æŽ»æ§å€ã®äŸãšããŠã¯ãç³ã±ã³é¡ã
ããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãããªãŠã ãã©ãŠãª
ã«ç¡«é žãããªãŠã ããžãªã¯ãã«ã¹ã«ãã³ãã¯é žã
ããªãŠã ããããªã³æŽ»æ§å€ã®ç¡«é žå¡©ãæããã
ãããããªã³æŽ»æ§å€ã®äŸãšããŠã¯ãããªãªãã·ãš
ãã¬ã³ããã«ããšãã«ãšãŒãã«ãããªãªãã·ãšã
ã¬ã³ã¹ãã¢ãªã³é žãšã¹ãã«ãããªãªãã·ãšãã¬ã³
ãœã«ãã¿ã³ã¢ãã©ãŠãªã«é žãšã¹ãã«ãããªãªãã·
ãšãã¬ã³âããªãªãã·ãããã¬ã³ãããã¯å ±éå
äœçãæããããããŸãã«ããªã³æŽ»æ§å€ã®äŸãšã
ãŠã¯ãã¢ã«ãã«ããªãžãŠã å¡©ã第ïŒã¢ãã³é¡çã
æããããããŸãäž¡æ§æŽ»æ§å€ã®äŸãšããŠã¯ããžã¡
ãã«ã¢ã«ãã«ãã¿ã€ã³é¡ãã¢ã«ãã«ã°ãªã·ã³é¡ç
ãæããããããŸãé«ååä¿è·ã³ãã€ããšããŠã¯
ããªããã«ã¢ã«ã³ãŒã«ãããããã·ãšãã«ã»ã«ã
ãŒã¹çãæããããããããã®ä¿è·ã³ãã€ãã¯ã
åç¬ã§ä¹³åå€ãšããŠçšããŠãããããŸãä»ã®çé¢
掻æ§å€ãšçµã¿åããŠçšããŠãããããããã®æŽ»æ§
å€ã®çš®é¡ããã³ãã®äœçšã«ã€ããŠã¯ãBelgische
Chemische Industrieã28ïŒ16â20ïŒ1963ïŒã«èš
èŒãããŠããã 溶液éåæ³çã«ãã€ãŠåæããã芪油æ§ããªã
ãŒã«ãã©ãŒããŒã©ãã³æ°Žæº¶æ¶²äžã«ã©ããã¯ã¹ã®åœ¢
ã§åæ£ããã«ã¯ããŸã芪油æ§ããªããŒã«ãã©ãŒã
ææ©æº¶åªäžã«æº¶ãããã®ã¡ãããããŒã©ãã³æ°Žæº¶
液äžã«åæ£å€ã®å©ãããããŠãè¶ é³æ³¢ãã³ãã€ã
ãã«çã«ããã©ããã¯ã¹ç¶ã«åæ£ããã芪油æ§ã
ãªããŒã«ãã©ãŒããŒã©ãã³æ°Žæº¶æ¶²äžã«ã©ããã¯ã¹
ã®åœ¢ã§åæ£ããæ¹æ³ã«ã€ããŠã¯ç±³åœç¹èš±ç¬¬
3451820å·ã«èšèŒãããŠããã芪油æ§ããªããŒã«
ãã©ãŒã溶解ããææ©æº¶åªãšããŠã¯ããšã¹ãã«
é¡ãäŸãã°é ¢é žã¡ãã«ãé ¢é žãšãã«ãé ¢é žããã
ã«çãã¢ã«ã³ãŒã«é¡ãã±ãã³é¡ãããã²ã³åçå
æ°ŽçŽ ããšãŒãã«é¡çãçšããããšãã§ããããŸã
ãããã®ææ©æº¶åªã¯ãåç¬ã§åã¯ïŒçš®ä»¥äžãçµã¿
åããŠçšããããšãã§ããã 次ã«æ¬çºæã®ããªããŒã«ãã©ãŒã®åæã«ã€ããŠ
以äžã«å ·äœçã«ç€ºããæ¬çºæã¯ããã«éå®ãããª
ãã ããŒã³ã¿ããªããŒã«ãã©ãŒã®è£œé 補é äŸ ïŒ äŸç€ºååç©(2)ãšïœâããã«ã¢ã¯ãªã¬ãŒãã®ããª
ããŒã«ãã©ãŒã®ã©ããã¯ã¹ã®è£œé äŸç€ºååç©(2)ã®ã«ãã©ãŒã¢ãããŒ18ïœãïœâã
ãã«ã¢ã¯ãªã¬ãŒã20ïœããã³ãžãªããµã³250mlã®
æ··åç©ãæ¹æäž80âã«å ç±ããªããããžãªããµã³
10mlã«æº¶è§£ããã¢ãŸãã¹ã€ãœããããããªã«350
mgãå ããåŸçŽïŒæéåå¿ãããã次ã«ããã®å
å¿çæç©ã飜åé£å¡©æ°ŽïŒäžã«æ³šã蟌ã¿ãæåºã
ãåºäœãå¥ããæ°Žã§ååã«æŽæµããããã®åå¿
çæç©ã也ç¥ããããšã«ããããªããŒã«ãã©ãŒ
36.8ïœãåŸãããã®ããªããŒã«ãã©ãŒã¯å çŽ åæ
ããåéäœã«ãã©ãŒå«æçã49.8ïŒ ã§ãã€ãããª
ãããã§ããåéäœã«ãã©ãŒå«æçãšããã®ã¯ã
ããªããŒåºåœ¢åäžã«å«ãŸããåéäœã«ãã©ãŒåäœ
ã®ééïŒ ã§ããã 次ã«äžèš(ã€)ããã³(ã)ã®ïŒçš®é¡ã®æº¶æ¶²ã調æŽã
ãã 溶液(ã€) ãŒã©ãã³ã®ïŒééïŒ æ°Žæº¶æ¶²ïŒPH5.7ã35âïŒ 300ïœã32âã«å ç±ããã©ãŠãªã«ç¡«é žãããªãŠ
ã ã®10ééïŒ æ°Žæº¶æ¶²10mlãå ãããã®ã 溶液(ã) äžèšããªããŒã«ãã©ãŒ20ïœã38âã«ãããŠé ¢é ž
ãšãã«100ïœã«æº¶ããããã®ã 次ã«æº¶æ¶²(ã)ãé«éã§æ¹æäžã®é²ææ··åæ©ã«å ¥
ãããã®äžã«æº¶æ¶²(ã€)ãæ¥ã«å ããã®ã¡ïŒåéæ··å
æ©ãåæ¢ãæžå§ã«ãŠé ¢é žãšãã«ãçå»ããããã®
ããã«ããŠããªããŒã«ãã©ãŒãåžãŒã©ãã³æº¶æ¶²äž
ã«åæ£ãããªããŒã«ãã©ãŒã®ã©ããã¯ã¹ãäœã€
ãã 補é äŸ ïŒ äŸç€ºååç©(8)ãšïœâããã«ã¢ã¯ãªã¬ãŒããšã®ã
ãªããŒã«ãã©ãŒã®ã©ããã¯ã¹ã®è£œé äŸç€ºååç©(8)ã§ç€ºãããã«ãã©ãŒã¢ãããŒ(8)20
ïœãïœâããã«ã¢ã¯ãªã¬ãŒã20ïœããã³ãžãªããµ
ã³150mlã®æ··åç©ãæ¹æäžã«80âã«å ç±ããªãã
ãžãªããµã³10mlã«æº¶è§£ããã¢ãŸãã¹ã€ãœãããã
ããªã«350mgãå ããã®ã¡çŽïŒæéåå¿ããã 次ã«ãã®çæç©ã10ééïŒ ã®å¡©åãããªãŠã ã
å«ãæ°·æ°ŽïŒäžã«æ³šãæåºããåºäœãå¥ããã
ãã«ååæ°Žã§æŽæµããããã®çæç©ã也ç¥ããã
ãšã«ããããªããŒã«ãã©ãŒ38.0ïœãåŸãããã®ã
ãªããŒã«ãã©ãŒã¯å çŽ åæããåéäœã«ãã©ãŒå«
æçã50.8ïŒ ã§ãã€ãã 次ãã§åèšè£œé äŸïŒã®ããªããŒã«ãã©ãŒãšåæ§
ã«åŠçããŠããªããŒã«ãã©ãŒã®ã©ããã¯ã¹ãäœ
ã€ãã 補é äŸ ïŒ äŸç€ºååç©(2)ãšïœâããã«ã¢ã¯ãªã¬ãŒããšã®ã
ãªããŒã«ãã©ãŒã®ã©ããã¯ã¹â²ã®è£œé ãªã¬ã€ã«ã¡ãã«ã¿ãŠã©ã€ãã®ãããªãŠã å¡©ïŒïœ
ã®ïŒæ°Žæº¶æ¶²ãçªçŽ æ°æµãéãã€ã€95âã«å ç±ã
ãããã®æ··åç©ã«éç¡«é žã«ãªãŠã 280mgã®40mlæ°Ž
溶液ãå ããã次ãã§ïœâããã«ã¢ã¯ãªã¬ãŒã20
ïœãšã«ãã©ãŒã¢ãããŒ(2)20ïœããšã¿ããŒã«200ml
ã«å ç±æº¶è§£ãçµæ¶ã®æåºãé²ãã€ã€ïŒæéã§æ»Žäž
ããã滎äžåŸïŒæéåå¿ãéç¡«é žã«ãªãŠã 120mg
ã®40ml氎溶液ãå ããæŽã«ïŒæéåå¿ããã®ã¡ãš
ã¿ããŒã«ãšæªåå¿ã®ïœâããã«ã¢ã¯ãªã¬ãŒããšã
æ°Žã®å ±æ²žç©ãšããŠçå»ããã圢æããã©ããã¯ã¹
ãå·åŽãïŒïŒ çé žãããªãŠã 氎溶液ã§PHã6.0ã«
調æŽããã®ã¡éãããã©ããã¯ã¹ã®åºåœ¢åæ¿åºŠ
ã¯12.3ïŒ ã§ã«ãã©ãŒå«æçã¯48.3ïŒ ã§ãã€ããã
ãã§ã«ãã©ãŒå«æçãšã¯ãã©ããã¯ã¹åºåœ¢åäžã«
å«ãŸããã«ãã©ãŒåäœã®ééïŒ ã§ãããå çŽ åæ
æ³ããåŸãããçªçŽ ååã®å«æçã«ãã€ãŠæ±ã
ãã 補é äŸ ïŒ äŸç€ºååç©(8)ãšïœâããã«ã¢ã¯ãªã¬ãŒããšã®ã
ãªããŒã«ãã©ãŒã®ã©ããã¯ã¹â²ã®è£œé ãªã¬ã€ã«ã¡ãã«ã¿ãŠã©ã€ãã®ãããªãŠã å¡©ïŒïœ
ã®ïŒæ°Žæº¶æ¶²ãçªçŽ æ°æµãéãã€ã€95âã«å ç±ã
ãããã®æ··åç©ã«éç¡«é žã«ãªãŠã 280mgã®40mlã®
氎溶液ãå ããã次ãã§ïœâããã«ã¢ã¯ãªã¬ãŒã
20ïœãšã«ãã©ãŒã¢ãããŒ(8)20ïœããšã¿ããŒã«200
mlã«å ç±æº¶è§£ãçµæ¶ã®æåºãé²ãã€ã€ïŒæéã§æ»Ž
äžããã滎äžåŸïŒæéåå¿ãããã®ã¡ãšã¿ããŒã«
ãšæªåå¿ã®ïœâããã«ã¢ã¯ãªã¬ãŒããæ°Žã®å ±æ²žç©
ãšããŠçå»ããã圢æããã©ããã¯ã¹ãå·åŽãïŒ
ïŒ çé žãããªãŠã 氎溶液ã§PHã6.0ã«èª¿æŽããã®
ã¡éãããã©ããã¯ã¹ã®åºåœ¢åæ¿åºŠã¯14.2ïŒ ã§
åéäœã«ãã©ãŒå«æçã¯48.3ïŒ ã§ãã€ãã 補é äŸïŒãïŒãšåæ§ã®æ¹æ³ã«åŸã€ãŠæ¬çºæã®äž
è¬åŒããã§è¡šããããåéäœã«ãã©ãŒãšã³ã¢ã
ããŒã®çš®é¡ãšéãšãå€ããŠè£œé ããããªããŒã«ã
ã©ãŒã®ã©ããã¯ã¹ãããã第ïŒè¡šã«ç€ºãããŸã補
é äŸïŒãïŒã«åŸã€ãŠåæããããªããŒã«ãã©ãŒã®
ã©ããã¯ã¹â²ãâ²ã第ïŒè¡šã«ç€ºãã
ããã§ç€ºãããã«ãã©ãŒã¢ãããŒã®å ·äœäŸã瀺
ãããæ¬çºæã¯ãããã«éå®ããããã®ã§ã¯ãª
ãã äŸç€ºååç© ä»¥äžã«åèšäžè¬åŒããã§ç€ºããæ¬çºæã®ã«ã
ã©ãŒã¢ãããŒã®ä»£è¡šçãªåæäŸã瀺ãããæ¬çºæ
ã¯ãããã«éå®ãããªãã åæäŸ ïŒ äŸç€ºååç©(2)ã®åæ èžç粟補ããããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒã
13.0ïœïŒ0.10ã¢ã«ïŒãè±æ°Žç²Ÿè£œãããžãªããµã³
200mlã«æº¶è§£ããïŒïŒ4â²âãžããšãã«ã¡ã¿ã³ãžã€
ãœã·ã¢ããŒã25.0ïœïŒ0.10ã¢ã«ïŒãå ãã宀枩ã§
10æéæ¹æãç¶ããïŒâïŒïŒïŒïŒâãžã¯ããããš
ãã«ïŒâïŒâã¢ããâïŒâãã©ãŸãªã³âïŒâãªã³
24.5ïœïŒ0.10ã¢ã«ïŒãšããã©ã¡ãã«ãã¿ã³ãžã¢ã
ã³0.5ïœãè±æ°Žç²Ÿè£œãããžãªããµã³400mlã«æº¶è§£ã
ã溶液äžã«30åã§æ»Žäžããããã«30åæ¹æãç¶ã
ãåŸã«50âã«å ç±ãïŒæéæ¹æããŠå®€æž©ãŸã§å·åŽ
ããã次ã«åå¿æ¶²ããããµã³ïŒã«æ³šã蟌ã¿ãåº
圢ç©ãå£å¥ããåŸã«ã¡ã¿ããŒã«ã§åçµæ¶ããŠäŸç€º
ååç©(2)48.7ïœãåŸããåç78ïŒ ã§ãã€ãããã®
ã«ãã©ãŒã¢ãããŒã®æ§é ã¯ãIRãNMR.FDâ
massã¹ãã¯ãã«ã«ãã確èªããã åæäŸ ïŒ äŸç€ºååç©(8)ã®åæ èžç粟補ããããããã·ãããã«ã¡ã¿ã¯ãªã¬ãŒ
ã7.3ïœïŒ0.05ã¢ã«ïŒãè±æ°Žç²Ÿè£œãããžãªããµã³
120mlã«æº¶è§£ããïŒïŒïŒâãããµã³ãžã€ãœã·ã¢ã
ãŒã8.3ïœïŒ0.05ã¢ã«ïŒãå ãã宀枩ã§10æéæ¹
æãç¶ãã次ãã§ïŒâïŒïŒïŒïŒâãžã¯ããããšã
ã«ïŒâïŒâã¢ããâïŒâãã©ãŸãªã³âïŒâãªã³
12.2ïœïŒ0.05ã¢ã«ïŒãšããã©ã¡ãã«ãã¿ã³ãžã¢ã
ã³0.2ïœãè±æ°Žç²Ÿè£œãããžãªããµã³250mlã«æº¶è§£ã
ã溶液äžã«30åã§æ»Žäžããããã«30åæ¹æãç¶ã
ãåŸã«50âã«å ç±ãïŒæéæ¹æããŠå®€æž©ãŸã§å·åŽ
ããã次ã«åå¿æ¶²ããããµã³ïŒã«æ³šã蟌ã¿ãåº
圢ç©ãå£å¥ããåŸã«ã¡ã¿ããŒã«ã§åçµæ¶ããŠäŸç€º
ååç©(8)20.2ïœãåŸããåç73ïŒ ã§ãã€ãããã®
ã«ãã©ãŒã¢ãããŒã®æ§é ã¯IRãNMRãFDâ
massã¹ãã¯ãã«ãçšããŠç¢ºèªããã 以äžãåæäŸã«ç€ºããåŠããæ¬çºæã®ã«ãã©ãŒ
ã¢ãããŒã¯åŸæ¥çšããããŠããé žã¯ãã©ã€ãã«å¯Ÿ
ãå®äŸ¡ãªã€ãœã·ã¢ããŒããçšããŠè£œé ã§ããã®
ã§ã該ã«ãã©ãŒãçšããŠåŸãããããã²ã³åéå
çæå ææã®äœäŸ¡æ Œåã«å¯äžã§ããã æ¬çºæã«ä¿ãããªããŒã«ãã©ãŒã¯ãåèšäžè¬åŒ
ããã§ç€ºãããã«ãã©ãŒã¢ãããŒããèªå°ãã
ãç¹°ãè¿ãåäœã®ã¿ãããªããããããã¢ããªã
ãŒã§ãã€ãŠãããããŸããä»ã®å ±éåãåŸãã³ã¢
ãããŒã®ïŒçš®ãŸãã¯ïŒçš®ä»¥äžãšã®ããããã³ããª
ããŒã§ãã€ãŠãããã æ¬çºæã«ä¿ãããªããŒã«ãã©ãŒã¯éåäžãã
ã³ïŒãŸãã¯éååå¿çµäºåŸã«çœ®æåå¿ãä»å åå¿
çãè¡ãªãããšãã§ããã å ±éåãããã³ã¢ãããŒã®äŸã«ã¯ãã¢ã¯ãªã«é ž
ãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ãã«ãã¯ããã³é žãš
ã¹ãã«ãããã«ãšã¹ãã«ããã¬ã€ã³é žãžãšã¹ã
ã«ãããã«é žãžãšã¹ãã«ãã€ã¿ã³ã³é žãžãšã¹ã
ã«ããªã¬ãã€ã³é¡ãã¹ãã¬ã³é¡çãæããããã ãããã®ã³ã¢ãããŒã«ã€ããŠæŽã«å ·äœçã«ç€ºã
ãšãã¢ã¯ãªã«é žãšã¹ãã«ãšããŠã¯ãã¡ãã«ã¢ã¯ãª
ã¬ãŒãããšãã«ã¢ã¯ãªã¬ãŒããïœâãããã«ã¢ã¯
ãªã¬ãŒããã€ãœãããã«ã¢ã¯ãªã¬ãŒããïœâãã
ã«ã¢ã¯ãªã¬ãŒããã€ãœããã«ã¢ã¯ãªã¬ãŒããsec
âããã«ã¢ã¯ãªã¬ãŒããtertâããã«ã¢ã¯ãªã¬ãŒ
ããã¢ãã«ã¢ã¯ãªã¬ãŒããããã·ã«ã¢ã¯ãªã¬ãŒ
ããïŒâãšãã«ããã·ã«ã¢ã¯ãªã¬ãŒãããªã¯ãã«
ã¢ã¯ãªã¬ãŒããtertâãªã¯ãã«ã¢ã¯ãªã¬ãŒããïŒ
âã¯ãããšãã«ã¢ã¯ãªã¬ãŒããïŒâããã¢ãšãã«
ã¢ã¯ãªã¬ãŒããïŒâã¯ããããã«ã¢ã¯ãªã¬ãŒãã
ã·ã¢ããšãã«ã¢ã¯ãªã¬ãŒããïŒâã¢ã»ããã·ãšã
ã«ã¢ã¯ãªã¬ãŒãããžã¡ãã«ã¢ãããšãã«ã¢ã¯ãªã¬
ãŒãããã³ãžã«ã¢ã¯ãªã¬ãŒããã¡ããã·ãã³ãžã«
ã¢ã¯ãªã¬ãŒããïŒâã¯ããã·ã¯ãããã·ã«ã¢ã¯ãª
ã¬ãŒããã·ã¯ãããã·ã«ã¢ã¯ãªã¬ãŒãããã«ããª
ã«ã¢ã¯ãªã¬ãŒããããã©ããããã«ããªã«ã¢ã¯ãª
ã¬ãŒããããšãã«ã¢ã¯ãªã¬ãŒããïŒâããããã·
ãã³ãã«ã¢ã¯ãªã¬ãŒããïŒïŒïŒâãžã¡ãã«âïŒâ
ããããã·ãããã«ã¢ã¯ãªã¬ãŒããïŒâã¡ããã·
ãšãã«ã¢ã¯ãªã¬ãŒããïŒâã¡ããã·ããã«ã¢ã¯ãª
ã¬ãŒããïŒâãšããã·ãšãã«ã¢ã¯ãªã¬ãŒããïŒâ
isoâããããã·ã¢ã¯ãªã¬ãŒããïŒâãããã·ãš
ãã«ã¢ã¯ãªã¬ãŒããïŒâïŒïŒâã¡ããã·ãšããã·ïŒ
ãšãã«ã¢ã¯ãªã¬ãŒããïŒâïŒïŒâãããã·ãšãã
ã·ïŒãšãã«ã¢ã¯ãªã¬ãŒããÏâã¡ããã·ããªãšã
ã¬ã³ã°ãªã³ãŒã«ã¢ã¯ãªã¬ãŒãïŒä»å ã¢ã«æ°ïœïŒ
ïŒïŒãïŒâããã¢âïŒâã¡ããã·ãšãã«ã¢ã¯ãªã¬
ãŒããïŒïŒïŒâãžã¯ããâïŒâãšããã·ãšãã«ã¢
ã¯ãªã¬ãŒãçãæããããã ã¡ã¿ã¯ãªã«é žãšã¹ãã«ã®äŸãšããŠã¯ãã¡ãã«ã¡
ã¿ã¯ãªã¬ãŒãããšãã«ã¡ã¿ã¯ãªã¬ãŒããïœâãã
ãã«ã¡ã¿ã¯ãªã¬ãŒããã€ãœãããã«ã¡ã¿ã¯ãªã¬ãŒ
ããïœâããã«ã¡ã¿ã¯ãªã¬ãŒããã€ãœããã«ã¡ã¿
ã¯ãªã¬ãŒããsecâããã«ã¡ã¿ã¯ãªã¬ãŒããtert
âããã«ã¡ã¿ã¯ãªã¬ãŒããã¢ãã«ã¡ã¿ã¯ãªã¬ãŒ
ããããã·ã«ã¡ã¿ã¯ãªã¬ãŒããã·ã¯ãããã·ã«ã¡
ã¿ã¯ãªã¬ãŒãããã³ãžã«ã¡ã¿ã¯ãªã¬ãŒããã¯ãã
ãã³ãžã«ã¡ã¿ã¯ãªã¬ãŒãããªã¯ãã«ã¡ã¿ã¯ãªã¬ãŒ
ããã¹ã«ããããã«ã¡ã¿ã¯ãªã¬ãŒããâãšãã«
ââããšãã«ã¢ãããšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒ
âïŒïŒâããšãã«ãããã«ãªãã·ïŒãšãã«ã¡ã¿ã¯
ãªã¬ãŒãããžã¡ãã«ã¢ããããšããã·ãšãã«ã¡ã¿
ã¯ãªã¬ãŒãããã«ããªã«ã¡ã¿ã¯ãªã¬ãŒããããã©
ããããã«ããªã«ã¡ã¿ã¯ãªã¬ãŒããããšãã«ã¡ã¿
ã¯ãªã¬ãŒããã¯ã¬ãžã«ã¡ã¿ã¯ãªã¬ãŒãããããã«
ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãšãã«ã¡ã¿ã¯ãª
ã¬ãŒããïŒâããããã·ããã«ã¡ã¿ã¯ãªã¬ãŒãã
ããªãšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿ã¯ãªã¬ãŒãããž
ãããã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿ã¯ãªã¬ãŒããïŒâ
ã¡ããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâã¡ããã·ã
ãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâã¢ã»ããã·ãšãã«ã¡ã¿
ã¯ãªã¬ãŒããïŒâã¢ã»ãã¢ã»ããã·ãšãã«ã¡ã¿ã¯
ãªã¬ãŒããïŒâãšããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâisoâããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒ
âãããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâïŒïŒâã¡
ããã·ãšããã·ïŒãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâ
ïŒïŒâãšããã·ãšããã·ïŒãšãã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâïŒïŒâãããã·ãšããã·ïŒãšãã«ã¡ã¿ã¯ãªã¬
ãŒããÏâã¡ããã·ããªãšãã¬ã³ã°ãªã³ãŒã«ã¡ã¿
ã¯ãªã¬ãŒãïŒä»å ã¢ã«æ°ïœïŒïŒïŒãã¢ãªã«ã¡ã¿ã¯
ãªã¬ãŒããã¡ã¿ã¯ãªã«é žãžã¡ãã«ã¢ãããšãã«ã¡
ãã«ã¯ãã©ã€ãå¡©ãªã©ãæããããšãã§ããã ããã«ãšã¹ãã«é¡ã®äŸãšããŠã¯ãããã«ã¢ã»ã
ãŒããããã«ããããªããŒããããã«ããã¬ãŒ
ããããã«ã€ãœããã¬ãŒããããã«ã«ãããšãŒ
ããããã«ã¯ããã¢ã»ããŒããããã«ã¡ããã·ã¢
ã»ããŒããããã«ããšãã«ã¢ã»ããŒããå®æ¯éŠé ž
ããã«ããµãªãã«é žããã«ãªã©ãæããããã ãŸããªã¬ãã€ã³é¡ã®äŸãšããŠã¯ããžã·ã¯ããã³
ã¿ãžãšã³ããšãã¬ã³ããããã¬ã³ãïŒâããã³ã
ïŒâãã³ãã³ãå¡©åããã«ãå¡©åãããªãã³ãã€
ãœãã¬ã³ãã¯ãããã¬ã³ããã¿ãžãšã³ãïŒïŒïŒâ
ãžã¡ãã«ãã¿ãžãšã³çãæããããšãã§ããã ã¹ãã¬ã³é¡ãšããŠã¯ãäŸãã°ãã¹ãã¬ã³ãã¡ã
ã«ã¹ãã¬ã³ããžã¡ãã«ã¹ãã¬ã³ãããªã¡ãã«ã¹ã
ã¬ã³ããšãã«ã¹ãã¬ã³ãã€ãœãããã«ã¹ãã¬ã³ã
ã¯ãã«ã¡ãã«ã¹ãã¬ã³ãã¡ããã·ã¹ãã¬ã³ãã¢ã»
ããã·ã¹ãã¬ã³ãã¯ãã«ã¹ãã¬ã³ããžã¯ãã«ã¹ã
ã¬ã³ãããã ã¹ãã¬ã³ãããã«å®æ¯éŠé žã¡ãã«ãš
ã¹ãã«ãªã©ãæããããã ã¯ããã³é žãšã¹ãã«ã®äŸãšããŠã¯ãã¯ããã³é ž
ããã«ãã¯ããã³é žããã·ã«ãªã©ãæããããã ãŸãã€ã¿ã³ã³é žãžãšã¹ãã«é¡ãšããŠã¯ãäŸã
ã°ãã€ã¿ã³ã³é žãžã¡ãã«ãã€ã¿ã³ã³é žãžãšãã«ã
ã€ã¿ã³ã³é žãžããã«ãªã©ãæããããã ãã¬ã€ã³é žãžãšã¹ãã«é¡ãšããŠã¯ãäŸãã°ãã
ã¬ã€ã³é žãžãšãã«ããã¬ã€ã³é žãžã¡ãã«ããã¬ã€
ã³é žãžããã«ãªã©ãæããããã ããã«é žãžãšã¹ãã«é¡ãšããŠã¯ãäŸãã°ããã
ã«é žãžãšãã«ãããã«é žãžã¡ãã«ãããã«é žãžã
ãã«ãªã©ãæããããã ãã®ä»ã®ã³ã¢ãããŒã®äŸãšããŠã¯ã次ã®ãã®ã
æããããã ã¢ã¯ãªã«ã¢ããé¡ãäŸãã°ã¢ã¯ãªã«ã¢ãããã¡
ãã«ã¢ã¯ãªã«ã¢ããããšãã«ã¢ã¯ãªã«ã¢ãããã
ããã«ã¢ã¯ãªã«ã¢ãããããã«ã¢ã¯ãªã«ã¢ããã
tertâããã«ã¢ã¯ãªã«ã¢ãããã·ã¯ãããã·ã«ã¢
ã¯ãªã«ã¢ããããã³ãžã«ã¢ã¯ãªã«ã¢ãããããã
ãã·ã¡ãã«ã¢ã¯ãªã«ã¢ãããã¡ããã·ãšãã«ã¢ã¯
ãªã«ã¢ããããžã¡ãã«ã¢ãããšãã«ã¢ã¯ãªã«ã¢ã
ããããšãã«ã¢ã¯ãªã«ã¢ããããžã¡ãã«ã¢ã¯ãªã«
ã¢ããããžãšãã«ã¢ã¯ãªã«ã¢ãããβâã·ã¢ããš
ãã«ã¢ã¯ãªã«ã¢ãããâïŒïŒâã¢ã»ãã¢ã»ãã
ã·ãšãã«ïŒã¢ã¯ãªã«ã¢ãããªã©ïŒã¢ãªã«ååç©ã
äŸãã°é ¢é žã¢ãªã«ãã«ããã³é žã¢ãªã«ãã©ãŠãªã³
é žã¢ãªã«ãå®æ¯éŠé žã¢ãªã«ãªã©ïŒããã«ãšãŒãã«
é¡ãäŸãã°ã¡ãã«ããã«ãšãŒãã«ãããã«ããã«
ãšãŒãã«ãããã·ã«ããã«ãšãŒãã«ãã¡ããã·ãš
ãã«ããã«ãšãŒãã«ããžã¡ãã«ã¢ãããšãã«ãã
ã«ãšãŒãã«ãªã©ïŒ ããã«ã±ãã³é¡ãäŸãã°ãã¡ãã«ããã«ã±ã
ã³ãããšãã«ããã«ã±ãã³ãã¡ããã·ãšãã«ãã
ã«ã±ãã³ãªã©ïŒ ããã«ç°ç¯ç°ååç©ãäŸãã°ãããã«ããªãž
ã³ãâããã«ã€ãããŸãŒã«ãâããã«ãªããµ
ãŸãªãã³ãâããã«ããªã¢ãŸãŒã«ãâããã«
ãããªãã³ãªã©ïŒ ã°ãªã·ãžã«ãšã¹ãã«é¡ãäŸãã°ãã°ãªã·ãžã«ã¢
ã¯ãªã¬ãŒããã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒããªã©ïŒ äžé£œåãããªã«é¡ãäŸãã°ãã¢ã¯ãªããããª
ã«ãã¡ã¿ã¯ãªããããªã«ãªã©ïŒ å€å®èœæ§ã¢ãããŒãäŸãã°ããžããã«ãã³ãŒ
ã³ãã¡ãã¬ã³ãã¹ã¢ã¯ãªã«ã¢ããããšãã¬ã³ã°ãª
ã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒããªã©ã æŽã«ãã¢ã¯ãªã«é žãã¡ã¿ã¯ãªã«é žãã€ã¿ã³ã³
é žããã¬ã€ã³é žãã€ã¿ã³ã³é žã¢ãã¢ã«ãã«ãäŸã
ã°ãã€ã¿ã³ã³é žã¢ãã¡ãã«ãã€ã¿ã³ã³é žã¢ããšã
ã«ãã€ã¿ã³ã³é žã¢ãããã«ãªã©ïŒãã¬ã€ã³é žã¢ã
ã¢ã«ãã«ãäŸãã°ããã¬ã€ã³é žã¢ãã¡ãã«ããã¬
ã€ã³é žã¢ããšãã«ããã¬ã€ã³é žã¢ãããã«ãªã©ïŒ
ã·ãã©ã³ã³é žãã¹ãã¬ã³ã¹ã«ãã³é žãããã«ãã³
ãžã«ã¹ã«ãã³é žãããã«ã¹ã«ãã³é žãã¢ã¯ãªãã€
ã«ãªãã·ã¢ã«ãã«ã¹ã«ãã³é žãäŸãã°ãã¢ã¯ãªã
ã€ã«ãªãã·ã¡ãã«ã¹ã«ãã³é žãã¢ã¯ãªãã€ã«ãªã
ã·ãšãã«ã¹ã«ãã³é žãã¢ã¯ãªãã€ã«ãªãã·ããã
ã«ã¹ã«ãã³é žãªã©ïŒã¡ã¿ã¯ãªãã€ã«ãªãã·ã¢ã«ã
ã«ã¹ã«ãã³é žãäŸãã°ã¡ã¿ã¯ãªãã€ã«ãªãã·ã¡ã
ã«ã¹ã«ãã³é žãã¡ã¿ã¯ãªãã€ã«ãªãã·ãšãã«ã¹ã«
ãã³é žãã¡ã¿ã¯ãªãã€ã«ãªãã·ãããã«ã¹ã«ãã³
é žãªã©ïŒã¢ã¯ãªã«ã¢ããã¢ã«ãã«ã¹ã«ãã³é žãäŸ
ãã°ïŒâã¢ã¯ãªã«ã¢ããâïŒâã¡ãã«ãšã¿ã³ã¹ã«
ãã³é žãïŒâã¢ã¯ãªã«ã¢ããâïŒâã¡ãã«ããã
ã³ã¹ã«ãã³é žãïŒâã¢ã¯ãªã«ã¢ããâïŒâã¡ãã«
ãã¿ã³ã¹ã«ãã³é žãªã©ïŒã¡ã¿ã¯ãªã«ã¢ããã¢ã«ã
ã«ã¹ã«ãã³é žãäŸãã°ïŒâã¡ã¿ã¯ãªã«ã¢ããâïŒ
âã¡ãã«ãšã¿ã³ã¹ã«ãã³é žãïŒâã¡ã¿ã¯ãªã«ã¢ã
ãâïŒâã¡ãã«ãããã³ã¹ã«ãã³é žãïŒâã¡ã¿ã¯
ãªã«ã¢ããâïŒâã¡ãã«ãã¿ã³ã¹ã«ãã³é žãªã©ïŒ
ã¢ã¯ãªãã€ã«ãªãã·ã¢ã«ãã«ãã¹ããšãŒããäŸã
ã°ãã¢ã¯ãªãã€ã«ãªãã·ãšãã«ãã¹ããšãŒããïŒ
âã¢ã¯ãªãã€ã«ãªãã·ãããã«âïŒâãã¹ããšãŒ
ããªã©ïŒã¡ã¿ã¯ãªãã€ã«ãªãã·ã¢ã«ãã«ãã¹ããš
ãŒããäŸãã°ã¡ã¿ã¯ãªãã€ã«ãªãã·ãšãã«ãã¹ã
ãšãŒããïŒâã¡ã¿ã¯ãªãã€ã«ãªãã·ãããã«âïŒ
âãã¹ããšãŒããªã©ïŒèŠªæ°ŽåºãïŒã±æããïŒâã¢
ãªããã·âïŒâããããã·ãããã³ã¹ã«ãã³é žã
ããªãŠã ãªã©ãæããããããããã®é žã¯ã¢ã«ã«
ãªéå±ïŒäŸãã°ãNaããªã©ïŒãŸãã¯ã¢ã³ã¢ã
ãŠã ã€ãªã³ã®å¡©ã§ãã€ãŠããããããã«ãã®ä»ã®
ã³ã¢ãããŒãšããŠã¯ãç±³åœç¹èš±ç¬¬3459790å·ãå
第3438708å·ãå第3554987å·ãå第4215195å·ã
å第4247673å·ãç¹éæ57â205735å·å ¬å ±æ现æž
çã«èšèŒãããŠããæ¶æ©æ§ã¢ãããŒãçšããããš
ãã§ããããã®ãããªæ¶æ©æ§ã¢ãããŒã®äŸãšããŠ
ã¯ãå ·äœçã«ã¯ïŒ®âïŒïŒâã¢ã»ãã¢ã»ããã·ãšã
ã«ïŒã¢ã¯ãªã«ã¢ãããâïœïŒâïŒïŒâã¢ã»ãã¢ã»
ããã·ãšããã·ïŒãšãã«ïœã¢ã¯ãªã«ã¢ããçãæ
ããããšãã§ããã ãããã®ã³ã¢ãããŒã®äžã§ãã³ã¢ãããŒã®èŠªæ°Ž
æ§ã芪油æ§ãŸãã¯ã³ã¢ãããŒã®å ±éåæ§ããã³æ§
æããããªããŒã«ãã©ãŒã®çºè²æ§ãçæè²çŽ ã®è²
調ãªã©ããã奜ãŸããçšããããã³ã¢ãããŒã«
ã¯ãã¢ã¯ãªã«é žãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ã
ã«ããã¬ã€ã³é žãšã¹ãã«ãã¢ã¯ãªã«ã¢ãããã¡ã¿
ã¯ãªã«ã¢ããé¡ãå«ãŸããããã«å¥œãŸããã¯ãšã¹
ãã«åºãã¢ããåºã®ççŽ ååæ°ã10以äžã®ã¢ã¯ãª
ã«é žãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ãã«ãã¢ã¯ãªã«
ã¢ãããã¡ã¿ã¯ãªã«ã¢ããã§ãããå ·äœçã«ã¯ã¡
ãã«ã¢ã¯ãªã¬ãŒãããšãã«ã¢ã¯ãªã¬ãŒããïœâã
ããã«ã¢ã¯ãªã¬ãŒããïœâãããã«ã¢ã¯ãªã¬ãŒ
ããïœâããã«ã¢ã¯ãªã¬ãŒããïœâããã«ã¢ã¯ãª
ã¬ãŒããïœâããã«ã¢ã¯ãªã¬ãŒããã¢ãã«ã¡ã¿ã¯
ãªã¬ãŒããïŒâãšãã«ããã·ã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâãã
ããã·ã¡ã¿ã¯ãªã¬ãŒãããã³ãžã«ã¡ã¿ã¯ãªã¬ãŒ
ããã¡ãã«ã¡ã¿ã¯ãªã¬ãŒããã¢ã¯ãªã«ã¢ãããã¡
ã¿ã¯ãªã«ã¢ãããïœâããã«ã¢ã¯ãªã«ã¢ããçã§
ããããããã®ã³ã¢ãããŒã¯ãïŒçš®ä»¥äžã䜵çšã
ãŠãããã æ¬çºæã«ä¿ãããªããŒã«ãã©ãŒã¯ãããããã³
ããªããŒã§ããå Žåã奜ãŸãããããã®å Žåã奜
ãŸããã¯ãäžè¬åŒããã§ç€ºãããåéäœããèª
å°ãããç¹°ãè¿ãåäœãééã§å šäœã®ïŒã100ïŒ
å«ãå Žåã§ãããããã«å¥œãŸããã¯40ã100ïŒ ã§
ããã æ¬çºæã®ããŒã³ã¿ããªããŒã«ãã©ãŒã¯ä¹³åéå
æ³ã§äœã€ãŠãããããããã¯åéäœã«ãã©ãŒã®é
åã§åŸãã芪油æ§ããªããŒã«ãã©ãŒãææ©æº¶åªäž
ã«æº¶ããããã®ããŒã©ãã³æ°Žæº¶æ¶²äžã«ã©ããã¯ã¹
ã®åœ¢ã§åæ£ããŠäœã€ãŠããããä¹³åéåæ³ã«ã€ã
ãŠã¯ç±³åœç¹èš±ç¬¬4080211å·ãå第3370952å·ã«ããŸ
ã芪油æ§ããªããŒã«ãã©ãŒããŒã©ãã³æ°Žæº¶æ¶²äžã«
ã©ããã¯ã¹ã®åœ¢ã§åæ£ããæ¹æ³ã«ã€ããŠã¯ç±³åœç¹
蚱第3451820å·ã«èšèŒãããŠããæ¹æ³ãçšããã
ãšãã§ããã ãããã®æ¹æ³ã¯ãã¢ããªããŒã®åœ¢æããã³ã³ã
ãªããŒã®åœ¢æã«ãå¿çšã§ããåŸè ã®å Žåãã³ã¢ã
ããŒã¯æ¶²äœã³ã¢ãããŒã§ãããšãããä¹³åéåã®
å Žåã«ã¯åžžæ ã§åºå®åéäœã®ããã®æº¶åªãšããŠã
äœçšããã æ¬çºæã®ããŒã³ã¿ããªããŒã«ãã©ãŒã®ä¹³åéå
æ³ããã³æº¶æ¶²éåæ³ã«çšããããéåéå§å€ãšã
ãŠã¯ã氎溶æ§éåéå§å€ãšèŠªæ²¹æ§éåéå§å€ãçš
ããããã氎溶æ§éåéå§å€ãšããŠã¯ãäŸãã°é
ç¡«é žã«ãªãŠã ãéç¡«é žã¢ã³ã¢ããŠã ãéç¡«é žãã
ãªãŠã çã®éç¡«é žå¡©é¡ãïŒïŒ4â²âã¢ãŸãã¹âïŒâ
ã·ã¢ãåèé žãããªãŠã ãïŒïŒ2â²âã¢ãŸãã¹ïŒïŒ
âã¢ããžããããã³ïŒå¡©é žå¡©çã®æ°Žæº¶æ§ã¢ãŸåå
ç©ãéé žåæ°ŽçŽ ãçšããããšãã§ããããŸã溶液
éåæ³ã«çšãããã芪油æ§éåéå§å€ãšããŠã¯ã
äŸãã°ã¢ãŸãã¹ã€ãœããããããªã«ãïŒïŒ2â²âã¢
ãŸãã¹âïŒïŒïŒïŒâãžã¡ãã«ãã¬ããããªã«ïŒã
ïŒïŒ2â²âã¢ãŸãã¹ïŒïŒâã¡ããã·âïŒïŒïŒâãžã¡
ãã«ãã¬ããããªã«ïŒãïŒïŒ1â²âã¢ãŸãã¹ïŒã·ã¯
ããããµãã³âïŒâã«ã«ããããªã«ïŒãïŒïŒ2â²â
ã¢ãŸãã¹ã€ãœã·ã¢ãé ªé žãïŒïŒ2â²âã¢ãŸãã¹ã€ãœ
é ªé žãžã¡ãã«çã®èŠªæ²¹æ§ã¢ãŸååç©ããã³ãŸã€ã«
ããŒãªãã·ããã©ãŠãªã«ããŒãªãã·ãããžã€ãœã
ããã«ããŒãªãã·ãžã«ã«ãããŒãããžâtertâã
ãã«ããŒãªãã·ãçã®èŠªæ²¹æ§ããŒãªãã·ããæã
ãããšãã§ããã ä¹³åéåæ³ã«ãããŠçšããããä¹³åå€ãšããŠ
ã¯ãçé¢æŽ»æ§å€ãé«ååä¿è·ã³ãã€ãããã³å ±é
åä¹³åå€ãæãããããçé¢æŽ»æ§å€ãšããŠã¯ãåœ
該åéã«ãããŠå ¬ç¥ã®ã¢ããªã³æŽ»æ§å€ããããªã³
掻æ§å€ãã«ããªã³æŽ»æ§å€åã³äž¡æ§æŽ»æ§å€ãæãã
ãããã¢ããªã³æŽ»æ§å€ã®äŸãšããŠã¯ãç³ã±ã³é¡ã
ããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãããªãŠã ãã©ãŠãª
ã«ç¡«é žãããªãŠã ããžãªã¯ãã«ã¹ã«ãã³ãã¯é žã
ããªãŠã ããããªã³æŽ»æ§å€ã®ç¡«é žå¡©ãæããã
ãããããªã³æŽ»æ§å€ã®äŸãšããŠã¯ãããªãªãã·ãš
ãã¬ã³ããã«ããšãã«ãšãŒãã«ãããªãªãã·ãšã
ã¬ã³ã¹ãã¢ãªã³é žãšã¹ãã«ãããªãªãã·ãšãã¬ã³
ãœã«ãã¿ã³ã¢ãã©ãŠãªã«é žãšã¹ãã«ãããªãªãã·
ãšãã¬ã³âããªãªãã·ãããã¬ã³ãããã¯å ±éå
äœçãæããããããŸãã«ããªã³æŽ»æ§å€ã®äŸãšã
ãŠã¯ãã¢ã«ãã«ããªãžãŠã å¡©ã第ïŒã¢ãã³é¡çã
æããããããŸãäž¡æ§æŽ»æ§å€ã®äŸãšããŠã¯ããžã¡
ãã«ã¢ã«ãã«ãã¿ã€ã³é¡ãã¢ã«ãã«ã°ãªã·ã³é¡ç
ãæããããããŸãé«ååä¿è·ã³ãã€ããšããŠã¯
ããªããã«ã¢ã«ã³ãŒã«ãããããã·ãšãã«ã»ã«ã
ãŒã¹çãæããããããããã®ä¿è·ã³ãã€ãã¯ã
åç¬ã§ä¹³åå€ãšããŠçšããŠãããããŸãä»ã®çé¢
掻æ§å€ãšçµã¿åããŠçšããŠãããããããã®æŽ»æ§
å€ã®çš®é¡ããã³ãã®äœçšã«ã€ããŠã¯ãBelgische
Chemische Industrieã28ïŒ16â20ïŒ1963ïŒã«èš
èŒãããŠããã 溶液éåæ³çã«ãã€ãŠåæããã芪油æ§ããªã
ãŒã«ãã©ãŒããŒã©ãã³æ°Žæº¶æ¶²äžã«ã©ããã¯ã¹ã®åœ¢
ã§åæ£ããã«ã¯ããŸã芪油æ§ããªããŒã«ãã©ãŒã
ææ©æº¶åªäžã«æº¶ãããã®ã¡ãããããŒã©ãã³æ°Žæº¶
液äžã«åæ£å€ã®å©ãããããŠãè¶ é³æ³¢ãã³ãã€ã
ãã«çã«ããã©ããã¯ã¹ç¶ã«åæ£ããã芪油æ§ã
ãªããŒã«ãã©ãŒããŒã©ãã³æ°Žæº¶æ¶²äžã«ã©ããã¯ã¹
ã®åœ¢ã§åæ£ããæ¹æ³ã«ã€ããŠã¯ç±³åœç¹èš±ç¬¬
3451820å·ã«èšèŒãããŠããã芪油æ§ããªããŒã«
ãã©ãŒã溶解ããææ©æº¶åªãšããŠã¯ããšã¹ãã«
é¡ãäŸãã°é ¢é žã¡ãã«ãé ¢é žãšãã«ãé ¢é žããã
ã«çãã¢ã«ã³ãŒã«é¡ãã±ãã³é¡ãããã²ã³åçå
æ°ŽçŽ ããšãŒãã«é¡çãçšããããšãã§ããããŸã
ãããã®ææ©æº¶åªã¯ãåç¬ã§åã¯ïŒçš®ä»¥äžãçµã¿
åããŠçšããããšãã§ããã 次ã«æ¬çºæã®ããªããŒã«ãã©ãŒã®åæã«ã€ããŠ
以äžã«å ·äœçã«ç€ºããæ¬çºæã¯ããã«éå®ãããª
ãã ããŒã³ã¿ããªããŒã«ãã©ãŒã®è£œé 補é äŸ ïŒ äŸç€ºååç©(2)ãšïœâããã«ã¢ã¯ãªã¬ãŒãã®ããª
ããŒã«ãã©ãŒã®ã©ããã¯ã¹ã®è£œé äŸç€ºååç©(2)ã®ã«ãã©ãŒã¢ãããŒ18ïœãïœâã
ãã«ã¢ã¯ãªã¬ãŒã20ïœããã³ãžãªããµã³250mlã®
æ··åç©ãæ¹æäž80âã«å ç±ããªããããžãªããµã³
10mlã«æº¶è§£ããã¢ãŸãã¹ã€ãœããããããªã«350
mgãå ããåŸçŽïŒæéåå¿ãããã次ã«ããã®å
å¿çæç©ã飜åé£å¡©æ°ŽïŒäžã«æ³šã蟌ã¿ãæåºã
ãåºäœãå¥ããæ°Žã§ååã«æŽæµããããã®åå¿
çæç©ã也ç¥ããããšã«ããããªããŒã«ãã©ãŒ
36.8ïœãåŸãããã®ããªããŒã«ãã©ãŒã¯å çŽ åæ
ããåéäœã«ãã©ãŒå«æçã49.8ïŒ ã§ãã€ãããª
ãããã§ããåéäœã«ãã©ãŒå«æçãšããã®ã¯ã
ããªããŒåºåœ¢åäžã«å«ãŸããåéäœã«ãã©ãŒåäœ
ã®ééïŒ ã§ããã 次ã«äžèš(ã€)ããã³(ã)ã®ïŒçš®é¡ã®æº¶æ¶²ã調æŽã
ãã 溶液(ã€) ãŒã©ãã³ã®ïŒééïŒ æ°Žæº¶æ¶²ïŒPH5.7ã35âïŒ 300ïœã32âã«å ç±ããã©ãŠãªã«ç¡«é žãããªãŠ
ã ã®10ééïŒ æ°Žæº¶æ¶²10mlãå ãããã®ã 溶液(ã) äžèšããªããŒã«ãã©ãŒ20ïœã38âã«ãããŠé ¢é ž
ãšãã«100ïœã«æº¶ããããã®ã 次ã«æº¶æ¶²(ã)ãé«éã§æ¹æäžã®é²ææ··åæ©ã«å ¥
ãããã®äžã«æº¶æ¶²(ã€)ãæ¥ã«å ããã®ã¡ïŒåéæ··å
æ©ãåæ¢ãæžå§ã«ãŠé ¢é žãšãã«ãçå»ããããã®
ããã«ããŠããªããŒã«ãã©ãŒãåžãŒã©ãã³æº¶æ¶²äž
ã«åæ£ãããªããŒã«ãã©ãŒã®ã©ããã¯ã¹ãäœã€
ãã 補é äŸ ïŒ äŸç€ºååç©(8)ãšïœâããã«ã¢ã¯ãªã¬ãŒããšã®ã
ãªããŒã«ãã©ãŒã®ã©ããã¯ã¹ã®è£œé äŸç€ºååç©(8)ã§ç€ºãããã«ãã©ãŒã¢ãããŒ(8)20
ïœãïœâããã«ã¢ã¯ãªã¬ãŒã20ïœããã³ãžãªããµ
ã³150mlã®æ··åç©ãæ¹æäžã«80âã«å ç±ããªãã
ãžãªããµã³10mlã«æº¶è§£ããã¢ãŸãã¹ã€ãœãããã
ããªã«350mgãå ããã®ã¡çŽïŒæéåå¿ããã 次ã«ãã®çæç©ã10ééïŒ ã®å¡©åãããªãŠã ã
å«ãæ°·æ°ŽïŒäžã«æ³šãæåºããåºäœãå¥ããã
ãã«ååæ°Žã§æŽæµããããã®çæç©ã也ç¥ããã
ãšã«ããããªããŒã«ãã©ãŒ38.0ïœãåŸãããã®ã
ãªããŒã«ãã©ãŒã¯å çŽ åæããåéäœã«ãã©ãŒå«
æçã50.8ïŒ ã§ãã€ãã 次ãã§åèšè£œé äŸïŒã®ããªããŒã«ãã©ãŒãšåæ§
ã«åŠçããŠããªããŒã«ãã©ãŒã®ã©ããã¯ã¹ãäœ
ã€ãã 補é äŸ ïŒ äŸç€ºååç©(2)ãšïœâããã«ã¢ã¯ãªã¬ãŒããšã®ã
ãªããŒã«ãã©ãŒã®ã©ããã¯ã¹â²ã®è£œé ãªã¬ã€ã«ã¡ãã«ã¿ãŠã©ã€ãã®ãããªãŠã å¡©ïŒïœ
ã®ïŒæ°Žæº¶æ¶²ãçªçŽ æ°æµãéãã€ã€95âã«å ç±ã
ãããã®æ··åç©ã«éç¡«é žã«ãªãŠã 280mgã®40mlæ°Ž
溶液ãå ããã次ãã§ïœâããã«ã¢ã¯ãªã¬ãŒã20
ïœãšã«ãã©ãŒã¢ãããŒ(2)20ïœããšã¿ããŒã«200ml
ã«å ç±æº¶è§£ãçµæ¶ã®æåºãé²ãã€ã€ïŒæéã§æ»Žäž
ããã滎äžåŸïŒæéåå¿ãéç¡«é žã«ãªãŠã 120mg
ã®40ml氎溶液ãå ããæŽã«ïŒæéåå¿ããã®ã¡ãš
ã¿ããŒã«ãšæªåå¿ã®ïœâããã«ã¢ã¯ãªã¬ãŒããšã
æ°Žã®å ±æ²žç©ãšããŠçå»ããã圢æããã©ããã¯ã¹
ãå·åŽãïŒïŒ çé žãããªãŠã 氎溶液ã§PHã6.0ã«
調æŽããã®ã¡éãããã©ããã¯ã¹ã®åºåœ¢åæ¿åºŠ
ã¯12.3ïŒ ã§ã«ãã©ãŒå«æçã¯48.3ïŒ ã§ãã€ããã
ãã§ã«ãã©ãŒå«æçãšã¯ãã©ããã¯ã¹åºåœ¢åäžã«
å«ãŸããã«ãã©ãŒåäœã®ééïŒ ã§ãããå çŽ åæ
æ³ããåŸãããçªçŽ ååã®å«æçã«ãã€ãŠæ±ã
ãã 補é äŸ ïŒ äŸç€ºååç©(8)ãšïœâããã«ã¢ã¯ãªã¬ãŒããšã®ã
ãªããŒã«ãã©ãŒã®ã©ããã¯ã¹â²ã®è£œé ãªã¬ã€ã«ã¡ãã«ã¿ãŠã©ã€ãã®ãããªãŠã å¡©ïŒïœ
ã®ïŒæ°Žæº¶æ¶²ãçªçŽ æ°æµãéãã€ã€95âã«å ç±ã
ãããã®æ··åç©ã«éç¡«é žã«ãªãŠã 280mgã®40mlã®
氎溶液ãå ããã次ãã§ïœâããã«ã¢ã¯ãªã¬ãŒã
20ïœãšã«ãã©ãŒã¢ãããŒ(8)20ïœããšã¿ããŒã«200
mlã«å ç±æº¶è§£ãçµæ¶ã®æåºãé²ãã€ã€ïŒæéã§æ»Ž
äžããã滎äžåŸïŒæéåå¿ãããã®ã¡ãšã¿ããŒã«
ãšæªåå¿ã®ïœâããã«ã¢ã¯ãªã¬ãŒããæ°Žã®å ±æ²žç©
ãšããŠçå»ããã圢æããã©ããã¯ã¹ãå·åŽãïŒ
ïŒ çé žãããªãŠã 氎溶液ã§PHã6.0ã«èª¿æŽããã®
ã¡éãããã©ããã¯ã¹ã®åºåœ¢åæ¿åºŠã¯14.2ïŒ ã§
åéäœã«ãã©ãŒå«æçã¯48.3ïŒ ã§ãã€ãã 補é äŸïŒãïŒãšåæ§ã®æ¹æ³ã«åŸã€ãŠæ¬çºæã®äž
è¬åŒããã§è¡šããããåéäœã«ãã©ãŒãšã³ã¢ã
ããŒã®çš®é¡ãšéãšãå€ããŠè£œé ããããªããŒã«ã
ã©ãŒã®ã©ããã¯ã¹ãããã第ïŒè¡šã«ç€ºãããŸã補
é äŸïŒãïŒã«åŸã€ãŠåæããããªããŒã«ãã©ãŒã®
ã©ããã¯ã¹â²ãâ²ã第ïŒè¡šã«ç€ºãã
ãè¡šã
ãè¡šã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ äžèšäžè¬åŒïŒ»ïŒœã§ç€ºãããåéäœããèªå°
ãããç¹°ãè¿ãåäœãæããããŒã³ã¿è²çŽ 圢ææ§
ããªããŒã«ãã©ãŒãå«æããåçæ§æå±€ãæãã
ããã²ã³åéåçæå æå ææã äžè¬åŒïŒ»ïŒœ åŒäžãã¯ãšãã¬ã³æ§äžé£œååºãŸãã¯ãšãã¬ã³
æ§äžé£œååºãæããåºãè¡šããããã¯ããã
ãâNHCONHâãâNHCOOâãŸãã¯â
OCONHâãè¡šãããã¯æ°ŽçŽ ååãŸãã¯çºè²çŸ
åäž»è¬ã®é žåäœãšã®ã«ãããªã³ã°åå¿ã«ããé¢è±
å¯èœãªåºãè¡šãããR1ãR2ã¯ããããã¢ã«ãã¬
ã³åºãã¢ãªãŒã¬ã³åºãã¢ã«ãã¬ã³ãªããµã€ãåºãŸ
ã㯠ãåŒãåºïŒR3ããã³R4ã¯ããããç°ç¶ ã¢ã«ãã¬ã³åºãŸãã¯ã¢ãªãŒã¬ã³åºãè¡šãããR5
ããã³R6ã¯ããããæ°ŽçŽ ååãã¢ã«ãã«åºãŸã
ã¯ã¢ãªãŒã«åºãè¡šãããïŒãè¡šãããã¯â
CONHâãŸãã¯âNHCONHâãè¡šãããArã¯
ã¢ãªãŒã«åºãŸãã¯è€çŽ ç°åºãè¡šãããïœã¯ïŒã20
ã®æŽæ°ãè¡šããã ïŒ åèšäžè¬åŒïŒ»ïŒœã§ç€ºãããïœãïŒã10ã®æŽ
æ°ãè¡šããããšãç¹åŸŽãšããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒ
é èšèŒã®ããã²ã³åéåçæå ææã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8255184A JPS60225845A (ja) | 1984-04-24 | 1984-04-24 | ããã²ã³åéåçæå ææ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8255184A JPS60225845A (ja) | 1984-04-24 | 1984-04-24 | ããã²ã³åéåçæå ææ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60225845A JPS60225845A (ja) | 1985-11-11 |
| JPH0413698B2 true JPH0413698B2 (ja) | 1992-03-10 |
Family
ID=13777632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8255184A Granted JPS60225845A (ja) | 1984-04-24 | 1984-04-24 | ããã²ã³åéåçæå ææ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60225845A (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2553034B2 (ja) * | 1985-05-27 | 1996-11-13 | æ¥æ¬ãã€ã³ãæ ªåŒäŒç€Ÿ | æå æ§ã¢ãã㌠|
-
1984
- 1984-04-24 JP JP8255184A patent/JPS60225845A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60225845A (ja) | 1985-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3926436A (en) | Silver halide element containing polymeric colour forming couplers | |
| US4340664A (en) | Copolymer latex and photographic silver halide materials containing such latex | |
| US4388404A (en) | Silver halide color photographic light-sensitive material | |
| US4128427A (en) | Silver halide emulsions containing polymeric color couplers | |
| US4455366A (en) | Silver halide color photographic light-sensitive material | |
| JPH02217842A (ja) | ããã²ã³åéåçæå ææ | |
| DE3300665A1 (de) | Farbphotographisches lichtempfindliches silberhalogenidmaterial und verfahren zur erzeugung eines bildes | |
| GB2132370A (en) | Color photographic material compressing polymeric cyan-forming coupler | |
| JPH0413698B2 (ja) | ||
| JPH0642059B2 (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6135444A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6060646A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| US4578346A (en) | Silver halide color photographic light-sensitive materials | |
| JPS615249A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6322572B2 (ja) | ||
| JPH0574811B2 (ja) | ||
| JPS61204631A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6039646A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPH0369088B2 (ja) | ||
| JPH01142633A (ja) | æ°èŠãªåççšã·ã¢ã³ã«ãã©ãŒ | |
| JPS6041043A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6055341A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6136747A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPS6050534A (ja) | ããã²ã³åéã«ã©âåçæå ææ | |
| JPH0554943B2 (ja) |