LV12018B - PREPARATION PROCESS OF 2-METHYL-THENO-BENZODIAZEPINE AND ITS CRYSTALLINE FORMS - Google Patents

PREPARATION PROCESS OF 2-METHYL-THENO-BENZODIAZEPINE AND ITS CRYSTALLINE FORMS Download PDF

Info

Publication number
LV12018B
LV12018B LVP-97-163A LV970163A LV12018B LV 12018 B LV12018 B LV 12018B LV 970163 A LV970163 A LV 970163A LV 12018 B LV12018 B LV 12018B
Authority
LV
Latvia
Prior art keywords
olanzapine
less
methyl
active ingredient
quot
Prior art date
Application number
LVP-97-163A
Other languages
English (en)
Latvian (lv)
Other versions
LV12018A (lv
Inventor
Charles Arthur Bunnell
Barry Arnold Hendriksen
Samuel Dean Larsen
Original Assignee
Eli Lilly And Company
Lilly Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23621056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV12018(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company, Lilly Industries Limited filed Critical Eli Lilly And Company
Publication of LV12018A publication Critical patent/LV12018A/xx
Publication of LV12018B publication Critical patent/LV12018B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
LVP-97-163A 1995-03-24 1997-09-08 PREPARATION PROCESS OF 2-METHYL-THENO-BENZODIAZEPINE AND ITS CRYSTALLINE FORMS LV12018B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40956695A 1995-03-24 1995-03-24
PCT/US1996/003917 WO1996030375A1 (fr) 1995-03-24 1996-03-22 Formes cristalline de 2-methyl-thieno-benzodiazepine et procede correspondant

Publications (2)

Publication Number Publication Date
LV12018A LV12018A (lv) 1998-04-20
LV12018B true LV12018B (en) 1998-09-20

Family

ID=23621056

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-97-163A LV12018B (en) 1995-03-24 1997-09-08 PREPARATION PROCESS OF 2-METHYL-THENO-BENZODIAZEPINE AND ITS CRYSTALLINE FORMS

Country Status (48)

Country Link
US (1) US5736541A (fr)
EP (3) EP1445259B1 (fr)
JP (1) JPH11502535A (fr)
KR (1) KR100399688B1 (fr)
CN (1) CN1065536C (fr)
AP (1) AP828A (fr)
AR (2) AR010448A1 (fr)
AT (4) ATE204280T1 (fr)
AU (1) AU706471B2 (fr)
BG (1) BG62619B1 (fr)
BR (1) BR9607790A (fr)
CA (1) CA2214005C (fr)
CH (1) CH690579A5 (fr)
CO (1) CO4650278A1 (fr)
CZ (1) CZ292688B6 (fr)
DE (4) DE69630324T2 (fr)
DK (4) DK1445259T3 (fr)
EA (1) EA000149B1 (fr)
EE (1) EE03489B1 (fr)
EG (1) EG23659A (fr)
ES (3) ES2159346T3 (fr)
FI (1) FI973750A0 (fr)
GB (1) GB2313835B (fr)
HU (1) HU224989B1 (fr)
IL (1) IL117610A (fr)
IS (1) IS1896B (fr)
LT (1) LT4349B (fr)
LU (1) LU90096B1 (fr)
LV (1) LV12018B (fr)
MY (1) MY114701A (fr)
NO (1) NO314663B1 (fr)
NZ (1) NZ306110A (fr)
OA (1) OA10510A (fr)
PA (1) PA8353701A1 (fr)
PE (1) PE44897A1 (fr)
PL (1) PL183723B1 (fr)
PT (3) PT733635E (fr)
RO (1) RO118872B1 (fr)
SE (1) SE9703205D0 (fr)
SI (4) SI0733635T1 (fr)
SK (1) SK284143B6 (fr)
SV (1) SV1996000031A (fr)
TR (1) TR199701017T1 (fr)
TW (2) TW513432B (fr)
UA (1) UA44765C2 (fr)
WO (1) WO1996030375A1 (fr)
YU (1) YU49478B (fr)
ZA (2) ZA962344B (fr)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
AU7013196A (en) * 1995-09-29 1997-04-17 Eli Lilly And Company Method for treating a tic disorder
UA57727C2 (uk) * 1996-03-11 2003-07-15 Елі Ліллі Енд Компані Спосіб лікування надмірної агресивності
CZ290198A3 (cs) * 1996-03-11 1999-09-15 Eli Lilly And Company Farmaceutický prostředek pro ošetřování nespavosti
CZ298398A3 (cs) * 1996-03-25 1999-06-16 Eli Lilly And Company Farmaceutický přípravek
WO1997035585A1 (fr) * 1996-03-25 1997-10-02 Eli Lilly And Company Methode d'anesthesie
PL329217A1 (en) * 1996-03-25 1999-03-15 Lilly Co Eli Pain relieving method
WO1997035586A1 (fr) * 1996-03-25 1997-10-02 Eli Lilly And Company Methode de traitement de la douleur
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
CZ299247B6 (cs) * 1996-09-23 2008-05-28 Eli Lilly And Company Olanzapin dihydrát D
ZA982917B (en) * 1997-04-15 1999-10-06 Lilly Co Eli Method for treating cerebral focal stroke.
US20030022889A1 (en) * 1997-04-15 2003-01-30 Bymaster Franklin P. Method for providing neuro-protective effects
DK1155696T3 (da) * 1997-04-15 2004-07-12 Lilly Co Eli Anvendelse af olanzapin til fremstillingen af et medikament til neurobeskyttelse
AU6955998A (en) * 1997-04-15 1998-11-11 Eli Lilly And Company Method for providing neuro-protective effects
USRE43932E1 (en) 1997-07-18 2013-01-15 Novartis Ag Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use
US6617321B2 (en) 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
PL196821B1 (pl) * 1998-09-30 2008-02-29 Lilly Co Eli Sól olanzapiny i jej zastosowanie
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
US6348458B1 (en) 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
US7022698B2 (en) 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
CA2395774C (fr) * 1999-12-28 2009-09-15 Cipla Limited Nouvelles formes polymorphes d'olanzapine
SK2502003A3 (en) * 2000-08-31 2004-03-02 Reddys Lab Ltd Dr Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
WO2002019998A2 (fr) * 2000-09-08 2002-03-14 Eli Lilly And Company Traitement des prises de poids associees a l'utilisation d'antipsychotiques atypiques
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
AU2002340328A1 (en) * 2001-10-29 2003-05-12 Janet I. Cord Olanzapine dihydrate-ii a process for its preparation and use thereof
CA2471341C (fr) * 2001-12-24 2012-01-24 Sun Pharmaceutical Industries Limited Forme cristalline de 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno [2,3-b][1,5]benzodiazepine
WO2004089313A2 (fr) * 2003-04-01 2004-10-21 Transform Pharmaceuticals, Inc. Nouvelles formes de l'olanzapine et methodes de traitement associees
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
WO2004000284A1 (fr) * 2002-06-21 2003-12-31 Transform Pharmaceuticals, Inc. Compositions pharmaceutiques a dissolution amelioree
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
CA2477923C (fr) * 2002-03-01 2021-02-23 University Of South Florida Phases solides multicomposants contentant au moins un principe pharmaceutiquement actif
PL196814B1 (pl) * 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
US7297789B2 (en) 2002-05-31 2007-11-20 Sandoz, Inc. Process of preparation of olanzapine form I
SI21270A (sl) * 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US20060135547A1 (en) * 2003-03-12 2006-06-22 Toth Zoltan G Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
WO2004080461A2 (fr) * 2003-03-12 2004-09-23 TEVA Gyógyszergyár Részvénytársaság Compositions pharmaceutiques stables de desloratadine
GB0314149D0 (en) * 2003-06-18 2003-07-23 Generics Uk Ltd Novel amorphous forms
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
US20070148218A1 (en) * 2003-11-18 2007-06-28 Gordon Ryan D Olanzapine containing transdermal drug delivery compositions
DE602004014264D1 (de) * 2003-12-22 2008-07-17 Teva Pharma Verfahren zur herstellung von olanzapin
US20050272720A1 (en) * 2004-01-27 2005-12-08 Rolf Keltjens Process for making olanzapine Form I
ATE504588T1 (de) 2004-01-27 2011-04-15 Synthon Bv Stabile salze von olanzapin
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
WO2006027800A1 (fr) * 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited Nouveau procede pour la preparation de forme i polymorphe d'olanzapine de purete pharmaceutique
AU2005307797B2 (en) * 2004-11-16 2011-06-02 Alkermes Pharma Ireland Limited Injectable nanoparticulate olanzapine formulations
PL1838716T3 (pl) 2005-01-05 2011-09-30 Lilly Co Eli Dihydrat embonianu olanzapiny
CZ297214B6 (cs) * 2005-02-02 2006-10-11 Zentiva, A. S. Lécivý prípravek obsahující jako úcinnou slozku olanzapin a zpusob jeho výroby
BRPI0608484E2 (pt) * 2005-03-21 2014-10-29 Reddys Lab Ltd Dr Processo de preparação da forma i cristalina de olanzapina
US20070021605A1 (en) * 2005-07-20 2007-01-25 Rolf Keltjens Process and composition for making olanzapine form i
WO2007020080A1 (fr) * 2005-08-17 2007-02-22 Synthon B.V. Procede de fabrication d’olanzapine de forme i
GB0522474D0 (en) * 2005-11-03 2005-12-14 Actavis Group A pharmaceutical formulation
HUP0501046A2 (en) * 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
US8721202B2 (en) 2005-12-08 2014-05-13 Ncr Corporation Two-sided thermal print switch
US8222184B2 (en) 2006-03-07 2012-07-17 Ncr Corporation UV and thermal guard
US8367580B2 (en) 2006-03-07 2013-02-05 Ncr Corporation Dual-sided thermal security features
ES2279715B1 (es) 2005-12-26 2008-06-01 Laboratorios Lesvi, S.L. Formulacion oral de olanzapina.
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
WO2007134845A2 (fr) * 2006-05-18 2007-11-29 Synthon B.V. Composition pharmaceutique d'olanzapine
CL2007002807A1 (es) * 2006-09-29 2008-04-11 Synthon Bv Composicion farmaceutica en estado solido que comprende olanzapina o una sal farmaceuticamente aceptable de la misma y lactosa anhidra; tableta farmaceutica oral; procedimiento de preparacion de dicha tableta, util en el tratamiento de la esquizofren
US8039461B1 (en) 2006-11-10 2011-10-18 Pisgah Laboratories, Inc. Physical states of a pharmaceutical drug substance
US7718649B1 (en) 2006-11-10 2010-05-18 Pisgah Labs, Inc. Physical states of a pharmaceutical drug substance
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2591644A1 (fr) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Nouvelles methodes de synthese de la forme-i de l'olanzapine
US9056488B2 (en) 2007-07-12 2015-06-16 Ncr Corporation Two-side thermal printer
US8883863B1 (en) 2008-04-03 2014-11-11 Pisgah Laboratories, Inc. Safety of psuedoephedrine drug products
CN101735239B (zh) * 2008-11-06 2011-08-31 齐鲁制药有限公司 一种无水奥氮平晶型ii的制备方法
EP2292624A1 (fr) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Processus de purification d'olanzapine
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
CN102093386B (zh) * 2011-01-05 2016-06-01 浙江华海药业股份有限公司 一种制备奥兰扎平晶型ⅱ的方法
WO2012153347A2 (fr) 2011-05-04 2012-11-15 Zentiva K.S. Composition pharmaceutique d'olanzapine de forme 1 à administration par voie orale
US9494608B2 (en) 2012-08-21 2016-11-15 Janssen Pharmaceutica Nv Antibodies to olanzapine and use thereof
JP6389177B2 (ja) 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ．ベー． オランザピンハプテンに対する抗体及びその使用
CN104736565B (zh) 2012-08-21 2019-03-12 詹森药业有限公司 利培酮半抗原的抗体及其用途
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
CN103848847B (zh) * 2012-12-04 2018-02-06 广东东阳光药业有限公司 一种改进制备奥氮平及其晶型ii的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法
CN103145731B (zh) * 2013-02-26 2014-02-19 江苏豪森药业股份有限公司 奥氮平晶型及其制备方法和用途
KR20240130825A (ko) 2022-01-20 2024-08-29 테바 파마슈티컬스 인터내셔널 게엠베하 올란자핀, 이의 조성물 및 이의 사용 방법
DK4554562T3 (da) 2023-01-10 2025-12-01 Medincell Sa Olanzapinsammensætninger og fremgangsmåder til anvendelse deraf

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
CA1097233A (fr) 1977-07-20 1981-03-10 George K. E. Gregory Emballages
US4237279A (en) * 1979-07-27 1980-12-02 Eli Lilly And Company Crystalline 3-hydroxycephalosporin solvates
IE53696B1 (en) 1981-12-02 1989-01-18 Wyeth John & Brother Ltd Solid shaped articles
US5079018A (en) 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5039540A (en) 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
DK0582368T3 (da) * 1992-05-29 2001-02-05 Lilly Co Eli Thienobenzodiazepinderivater til behandling af forstyrrelser i centralnervesystemet
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5457101A (en) * 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine

Also Published As

Publication number Publication date
HUP9802824A2 (hu) 1999-06-28
HUP9802824A3 (en) 2000-01-28
MX9707183A (es) 1997-11-29
US5736541A (en) 1998-04-07
IS1896B (is) 2003-10-20
DK1095941T3 (da) 2004-02-16
EP0733635B1 (fr) 2001-08-16
GB2313835B (en) 1998-09-16
DE19681286T1 (de) 1998-04-02
CN1179160A (zh) 1998-04-15
PT1095941E (pt) 2004-02-27
EE9700232A (et) 1998-04-15
JPH11502535A (ja) 1999-03-02
HK1013988A1 (en) 1999-09-17
DE69630324D1 (de) 2003-11-13
EG23659A (en) 2007-03-26
SV1996000031A (es) 1998-03-27
ATE251627T1 (de) 2003-10-15
FI973750L (fi) 1997-09-22
EP1095941A1 (fr) 2001-05-02
GB9719819D0 (en) 1997-11-19
PA8353701A1 (es) 1998-09-18
PT1445259E (pt) 2006-10-31
TW442488B (en) 2001-06-23
AP9701065A0 (en) 1997-10-31
AR010448A1 (es) 2000-06-28
SK284143B6 (sk) 2004-10-05
CN1065536C (zh) 2001-05-09
NO314663B1 (no) 2003-04-28
AU706471B2 (en) 1999-06-17
CA2214005A1 (fr) 1996-10-03
AT406771B (de) 2000-08-25
CZ292688B6 (cs) 2003-11-12
DE69630324T2 (de) 2004-07-29
AR002719A1 (es) 1998-04-29
DK1445259T3 (da) 2006-10-16
FI973750A7 (fi) 1997-09-22
CO4650278A1 (es) 1998-09-03
DE69636313T2 (de) 2007-05-31
SK121897A3 (en) 1998-03-04
EP1445259A1 (fr) 2004-08-11
ES2159346T3 (es) 2001-10-01
SE9703205L (sv) 1997-09-05
DE69636313D1 (de) 2006-08-10
ZA962342B (en) 1997-09-22
HU224989B1 (en) 2006-05-29
FI973750A0 (fi) 1997-09-22
EP1095941B1 (fr) 2003-10-08
PL322501A1 (en) 1998-02-02
EA000149B1 (ru) 1998-10-29
NO974365L (no) 1997-09-22
EP0733635A1 (fr) 1996-09-25
MY114701A (en) 2002-12-31
KR100399688B1 (ko) 2004-02-18
SI0733635T1 (en) 2002-06-30
DK0733635T3 (da) 2001-10-08
ES2208220T3 (es) 2004-06-16
EE03489B1 (et) 2001-08-15
UA44765C2 (uk) 2002-03-15
AU5427996A (en) 1996-10-16
ZA962344B (en) 1997-09-22
TW513432B (en) 2002-12-11
PT733635E (pt) 2001-12-28
CA2214005C (fr) 2001-07-03
AP828A (en) 2000-04-28
SI9620040B (sl) 2002-02-28
BG62619B1 (bg) 2000-03-31
DE69614426T2 (de) 2002-05-23
ATE331719T1 (de) 2006-07-15
DK108997A (da) 1997-11-12
CZ300097A3 (en) 1997-12-17
RO118872B1 (ro) 2003-12-30
ES2266719T3 (es) 2007-03-01
BG101900A (en) 1999-03-31
NO974365D0 (no) 1997-09-22
WO1996030375A1 (fr) 1996-10-03
ATA902196A (de) 2000-01-15
TR199701017T1 (xx) 1998-01-21
YU17796A (sh) 1999-03-04
SI1445259T1 (sl) 2006-10-31
CH690579A5 (de) 2000-10-31
IL117610A (en) 2001-08-26
LV12018A (lv) 1998-04-20
EA199700262A1 (ru) 1998-02-26
NZ306110A (en) 1998-09-24
IL117610A0 (en) 1996-07-23
DE69614426D1 (de) 2001-09-20
EP1445259B1 (fr) 2006-06-28
IS4564A (is) 1997-09-22
OA10510A (en) 2002-04-24
SI9620040A (sl) 1998-06-30
LU90096B1 (fr) 1997-07-22
LT4349B (lt) 1998-05-25
SI1095941T1 (en) 2003-12-31
BR9607790A (pt) 1998-07-07
GB2313835A (en) 1997-12-10
ATE204280T1 (de) 2001-09-15
PL183723B1 (pl) 2002-07-31
KR19980703188A (ko) 1998-10-15
PE44897A1 (es) 1997-10-22
LT97148A (lt) 1998-01-26
YU49478B (sh) 2006-05-25
SE9703205D0 (sv) 1997-09-05

Similar Documents

Publication Publication Date Title
CA2214005C (fr) Formes cristalline de 2-methyl-thieno-benzodiazepine et procede correspondant
AU720366B2 (en) Olanzapine dihydrate D
WO1996038151A1 (fr) Procede de traitement du dysfonctionnement cognitif
HK1013988B (en) Crystal forms of a thieno(2,3-b)(1,5) benzodiazepine derivative and process for their preparation
MXPA97007183A (en) A process and glass forms of 2-methyl-tieno-benzodiazep
US20020177590A1 (en) Method for treating cognitive dysfunction
HK1009809B (en) Olanzapine dihydrate d