ZA962344B - Process and crystal forms of 2-methyl-thieno-benzodiazepine. - Google Patents

Process and crystal forms of 2-methyl-thieno-benzodiazepine.

Info

Publication number
ZA962344B
ZA962344B ZA9602344A ZA962344A ZA962344B ZA 962344 B ZA962344 B ZA 962344B ZA 9602344 A ZA9602344 A ZA 9602344A ZA 962344 A ZA962344 A ZA 962344A ZA 962344 B ZA962344 B ZA 962344B
Authority
ZA
South Africa
Prior art keywords
benzodiazepine
thieno
methyl
crystal forms
crystal
Prior art date
Application number
ZA9602344A
Other languages
English (en)
Inventor
Charles Arthur Bunnell
Barry Arnold Hendriksen
Samuel Dean Larsen
Original Assignee
Lilly Co Eli
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23621056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA962344(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli, Lilly Industries Ltd filed Critical Lilly Co Eli
Publication of ZA962344B publication Critical patent/ZA962344B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
ZA9602344A 1995-03-24 1996-03-22 Process and crystal forms of 2-methyl-thieno-benzodiazepine. ZA962344B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40956695A 1995-03-24 1995-03-24

Publications (1)

Publication Number Publication Date
ZA962344B true ZA962344B (en) 1997-09-22

Family

ID=23621056

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA9602342A ZA962342B (en) 1995-03-24 1996-03-22 Process for preparing olanzapine.
ZA9602344A ZA962344B (en) 1995-03-24 1996-03-22 Process and crystal forms of 2-methyl-thieno-benzodiazepine.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA9602342A ZA962342B (en) 1995-03-24 1996-03-22 Process for preparing olanzapine.

Country Status (48)

Country Link
US (1) US5736541A (fr)
EP (3) EP0733635B1 (fr)
JP (1) JPH11502535A (fr)
KR (1) KR100399688B1 (fr)
CN (1) CN1065536C (fr)
AP (1) AP828A (fr)
AR (2) AR002719A1 (fr)
AT (4) AT406771B (fr)
AU (1) AU706471B2 (fr)
BG (1) BG62619B1 (fr)
BR (1) BR9607790A (fr)
CA (1) CA2214005C (fr)
CH (1) CH690579A5 (fr)
CO (1) CO4650278A1 (fr)
CZ (1) CZ292688B6 (fr)
DE (4) DE69636313T2 (fr)
DK (4) DK0733635T3 (fr)
EA (1) EA000149B1 (fr)
EE (1) EE03489B1 (fr)
EG (1) EG23659A (fr)
ES (3) ES2266719T3 (fr)
FI (1) FI973750A7 (fr)
GB (1) GB2313835B (fr)
HU (1) HU224989B1 (fr)
IL (1) IL117610A (fr)
IS (1) IS1896B (fr)
LT (1) LT4349B (fr)
LU (1) LU90096B1 (fr)
LV (1) LV12018B (fr)
MY (1) MY114701A (fr)
NO (1) NO314663B1 (fr)
NZ (1) NZ306110A (fr)
OA (1) OA10510A (fr)
PA (1) PA8353701A1 (fr)
PE (1) PE44897A1 (fr)
PL (1) PL183723B1 (fr)
PT (3) PT1445259E (fr)
RO (1) RO118872B1 (fr)
SE (1) SE9703205D0 (fr)
SI (4) SI1095941T1 (fr)
SK (1) SK284143B6 (fr)
SV (1) SV1996000031A (fr)
TR (1) TR199701017T1 (fr)
TW (2) TW513432B (fr)
UA (1) UA44765C2 (fr)
WO (1) WO1996030375A1 (fr)
YU (1) YU49478B (fr)
ZA (2) ZA962342B (fr)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US6274636B1 (en) * 1995-09-29 2001-08-14 Eli Lilly And Company Method for treating a tic disorder
CN1212627A (zh) * 1996-03-11 1999-03-31 伊莱利利公司 失眠症的治疗方法
UA57727C2 (uk) * 1996-03-11 2003-07-15 Елі Ліллі Енд Компані Спосіб лікування надмірної агресивності
EP0932407A4 (fr) * 1996-03-25 2002-04-24 Lilly Co Eli Technique de traitement de la douleur due a la migraine
EP0904083A4 (fr) * 1996-03-25 2002-05-22 Lilly Co Eli Methode d'anesthesie
IL126064A0 (en) * 1996-03-25 1999-05-09 Lilly Co Eli Method for treating pain
CN1494907A (zh) * 1996-03-25 2004-05-12 治疗疼痛的药物组合物
TR199900639T2 (xx) * 1996-09-23 1999-06-21 Eli Lilly And Company Olanzapin dihidrat D.
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
WO1998046596A1 (fr) * 1997-04-15 1998-10-22 Eli Lilly And Company Methode destinee a produire des effets neuro-protecteurs
DK1155696T3 (da) * 1997-04-15 2004-07-12 Lilly Co Eli Anvendelse af olanzapin til fremstillingen af et medikament til neurobeskyttelse
ZA982917B (en) * 1997-04-15 1999-10-06 Lilly Co Eli Method for treating cerebral focal stroke.
US20030022889A1 (en) * 1997-04-15 2003-01-30 Bymaster Franklin P. Method for providing neuro-protective effects
USRE43932E1 (en) 1997-07-18 2013-01-15 Novartis Ag Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use
US6617321B2 (en) 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
DE69917663T2 (de) * 1998-09-30 2005-05-25 Eli Lilly And Co., Indianapolis 2-methyl-thieno-benzodiazepin-formulierung
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
US7022698B2 (en) 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
US6348458B1 (en) 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
WO2001047933A1 (fr) * 1999-12-28 2001-07-05 Cipla Limited Nouvelles formes polymorphes d'olanzapine
EP1313742A1 (fr) * 2000-08-31 2003-05-28 Dr. Reddy's Laboratories Ltd. Procede de preparation d'hydrates d'olanzapine et de conversion de ceux-ci en formes cristallines d'olanzapine
AU2001282913A1 (en) * 2000-09-08 2002-03-22 Eli Lilly And Company A method of treating weight gain associated with atypical antipsychotic use
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
CA2464306A1 (fr) * 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation
JP4530664B2 (ja) * 2001-12-24 2010-08-25 サン・ファーマシューティカル・インダストリーズ・リミテッド ２−メチル−４−（４−メチル−１−ピペラジニル）−１０Ｈ−チエノ［２，３−ｂ］［１，５］ベンゾジアゼピンの結晶形Ｉ、この結晶形Ｉの製造方法、及び医薬組成物
WO2003074474A2 (fr) * 2002-03-01 2003-09-12 University Of South Florida Phases solides multicomposants contentant au moins un principe pharmaceutiquement actif
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US20050025791A1 (en) * 2002-06-21 2005-02-03 Julius Remenar Pharmaceutical compositions with improved dissolution
WO2004089313A2 (fr) * 2003-04-01 2004-10-21 Transform Pharmaceuticals, Inc. Nouvelles formes de l'olanzapine et methodes de traitement associees
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
PL196814B1 (pl) * 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
SI1513846T1 (sl) * 2002-05-31 2011-11-30 Sandoz Ag Postopek za pripravo olanzapina form I
SI21270A (sl) * 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US20060135547A1 (en) * 2003-03-12 2006-06-22 Toth Zoltan G Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
US20040242619A1 (en) * 2003-03-12 2004-12-02 Toth Zoltan G. Processes for preparation of polymorphic forms of desloratadine
GB0314149D0 (en) * 2003-06-18 2003-07-23 Generics Uk Ltd Novel amorphous forms
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
EP1684734A2 (fr) * 2003-11-18 2006-08-02 3M Innovative Properties Company Compositions d'administration medicamenteuse transdermique renfermant de l'olanzapine
CN1906201A (zh) * 2003-12-22 2007-01-31 特瓦制药工业有限公司 合成奥氮平的方法
US20050272720A1 (en) * 2004-01-27 2005-12-08 Rolf Keltjens Process for making olanzapine Form I
ATE504588T1 (de) 2004-01-27 2011-04-15 Synthon Bv Stabile salze von olanzapin
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
WO2006027800A1 (fr) * 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited Nouveau procede pour la preparation de forme i polymorphe d'olanzapine de purete pharmaceutique
AU2005307797B2 (en) * 2004-11-16 2011-06-02 Alkermes Pharma Ireland Limited Injectable nanoparticulate olanzapine formulations
EP1838716B1 (fr) 2005-01-05 2011-06-01 Eli Lilly And Company Dihydrate d'olanzapine pamoate
CZ297214B6 (cs) * 2005-02-02 2006-10-11 Zentiva, A. S. Lécivý prípravek obsahující jako úcinnou slozku olanzapin a zpusob jeho výroby
US20100174066A1 (en) * 2005-03-21 2010-07-08 Venkataraman Sundaram Process for preparing crystalline form i of olanzapine
US20070021605A1 (en) * 2005-07-20 2007-01-25 Rolf Keltjens Process and composition for making olanzapine form i
WO2007020080A1 (fr) * 2005-08-17 2007-02-22 Synthon B.V. Procede de fabrication d’olanzapine de forme i
GB0522474D0 (en) * 2005-11-03 2005-12-14 Actavis Group A pharmaceutical formulation
HUP0501046A2 (en) * 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
US8222184B2 (en) 2006-03-07 2012-07-17 Ncr Corporation UV and thermal guard
US8367580B2 (en) 2006-03-07 2013-02-05 Ncr Corporation Dual-sided thermal security features
US8721202B2 (en) 2005-12-08 2014-05-13 Ncr Corporation Two-sided thermal print switch
ES2279715B1 (es) 2005-12-26 2008-06-01 Laboratorios Lesvi, S.L. Formulacion oral de olanzapina.
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
WO2007134845A2 (fr) * 2006-05-18 2007-11-29 Synthon B.V. Composition pharmaceutique d'olanzapine
US20080138409A1 (en) * 2006-09-29 2008-06-12 Osinga Niels J Olanzapine pharmaceutical composition
US7718649B1 (en) 2006-11-10 2010-05-18 Pisgah Labs, Inc. Physical states of a pharmaceutical drug substance
US8039461B1 (en) 2006-11-10 2011-10-18 Pisgah Laboratories, Inc. Physical states of a pharmaceutical drug substance
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2591644A1 (fr) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Nouvelles methodes de synthese de la forme-i de l'olanzapine
US9056488B2 (en) 2007-07-12 2015-06-16 Ncr Corporation Two-side thermal printer
US8883863B1 (en) 2008-04-03 2014-11-11 Pisgah Laboratories, Inc. Safety of psuedoephedrine drug products
CN101735239B (zh) * 2008-11-06 2011-08-31 齐鲁制药有限公司 一种无水奥氮平晶型ii的制备方法
EP2292624A1 (fr) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Processus de purification d'olanzapine
PL3446565T3 (pl) 2010-08-23 2024-04-02 Alkermes Pharma Ireland Limited Sposoby leczenia przyrostu masy ciała wywołanego lekami przeciwpsychotycznymi
CN102093386B (zh) * 2011-01-05 2016-06-01 浙江华海药业股份有限公司 一种制备奥兰扎平晶型ⅱ的方法
WO2012153347A2 (fr) 2011-05-04 2012-11-15 Zentiva K.S. Composition pharmaceutique d'olanzapine de forme 1 à administration par voie orale
US20140057303A1 (en) 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Antibodies to Olanzapine Haptens and Use Thereof
WO2014031645A1 (fr) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Anticorps dirigés contre des haptènes de rispéridone et leur utilisation
JP6216926B2 (ja) 2012-08-21 2017-10-25 ヤンセン ファーマシューティカ エヌ．ベー． オランザピンに対する抗体及びその使用
WO2014078568A1 (fr) 2012-11-14 2014-05-22 The Johns Hopkins University Méthodes et compositions pour le traitement de la schizophrénie
CN103848847B (zh) * 2012-12-04 2018-02-06 广东东阳光药业有限公司 一种改进制备奥氮平及其晶型ii的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法
CN103145731B (zh) * 2013-02-26 2014-02-19 江苏豪森药业股份有限公司 奥氮平晶型及其制备方法和用途
JP2025503013A (ja) 2022-01-20 2025-01-30 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー オランザピン、その組成物及びその使用方法
PE20252752A1 (es) 2023-01-10 2025-12-05 Medincell Sa Composiciones de olanzapina y metodos de uso

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
CA1097233A (fr) 1977-07-20 1981-03-10 George K. E. Gregory Emballages
US4237279A (en) * 1979-07-27 1980-12-02 Eli Lilly And Company Crystalline 3-hydroxycephalosporin solvates
IE53696B1 (en) 1981-12-02 1989-01-18 Wyeth John & Brother Ltd Solid shaped articles
US5079018A (en) 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5039540A (en) 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
AU668159B2 (en) * 1992-05-29 1996-04-26 Lilly Industries Limited Pharmaceutical compounds
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5457101A (en) * 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine

Also Published As

Publication number Publication date
SK121897A3 (en) 1998-03-04
CN1179160A (zh) 1998-04-15
LV12018B (en) 1998-09-20
FI973750L (fi) 1997-09-22
NO974365D0 (no) 1997-09-22
WO1996030375A1 (fr) 1996-10-03
KR19980703188A (ko) 1998-10-15
ATA902196A (de) 2000-01-15
IS4564A (is) 1997-09-22
SE9703205L (sv) 1997-09-05
DE19681286T1 (de) 1998-04-02
EP1445259A1 (fr) 2004-08-11
ES2266719T3 (es) 2007-03-01
AU5427996A (en) 1996-10-16
LV12018A (lv) 1998-04-20
SI9620040B (sl) 2002-02-28
CZ292688B6 (cs) 2003-11-12
TW442488B (en) 2001-06-23
IL117610A (en) 2001-08-26
CN1065536C (zh) 2001-05-09
SI9620040A (sl) 1998-06-30
PT733635E (pt) 2001-12-28
EG23659A (en) 2007-03-26
PA8353701A1 (es) 1998-09-18
PT1445259E (pt) 2006-10-31
DK1095941T3 (da) 2004-02-16
LT4349B (lt) 1998-05-25
YU49478B (sh) 2006-05-25
UA44765C2 (uk) 2002-03-15
HUP9802824A3 (en) 2000-01-28
AP9701065A0 (en) 1997-10-31
AR010448A1 (es) 2000-06-28
IL117610A0 (en) 1996-07-23
LU90096B1 (fr) 1997-07-22
TW513432B (en) 2002-12-11
EA000149B1 (ru) 1998-10-29
ATE251627T1 (de) 2003-10-15
HU224989B1 (en) 2006-05-29
EE9700232A (et) 1998-04-15
KR100399688B1 (ko) 2004-02-18
EP0733635B1 (fr) 2001-08-16
CA2214005A1 (fr) 1996-10-03
US5736541A (en) 1998-04-07
TR199701017T1 (xx) 1998-01-21
JPH11502535A (ja) 1999-03-02
HUP9802824A2 (hu) 1999-06-28
AT406771B (de) 2000-08-25
NZ306110A (en) 1998-09-24
ES2159346T3 (es) 2001-10-01
SK284143B6 (sk) 2004-10-05
NO314663B1 (no) 2003-04-28
PL183723B1 (pl) 2002-07-31
ZA962342B (en) 1997-09-22
EE03489B1 (et) 2001-08-15
EP1095941B1 (fr) 2003-10-08
PE44897A1 (es) 1997-10-22
ATE331719T1 (de) 2006-07-15
MX9707183A (es) 1997-11-29
AU706471B2 (en) 1999-06-17
IS1896B (is) 2003-10-20
SI1445259T1 (sl) 2006-10-31
DE69614426T2 (de) 2002-05-23
DK108997A (da) 1997-11-12
ES2208220T3 (es) 2004-06-16
OA10510A (en) 2002-04-24
CH690579A5 (de) 2000-10-31
ATE204280T1 (de) 2001-09-15
EP0733635A1 (fr) 1996-09-25
GB9719819D0 (en) 1997-11-19
MY114701A (en) 2002-12-31
SI0733635T1 (en) 2002-06-30
AP828A (en) 2000-04-28
AR002719A1 (es) 1998-04-29
BR9607790A (pt) 1998-07-07
SE9703205D0 (sv) 1997-09-05
SV1996000031A (es) 1998-03-27
DE69636313T2 (de) 2007-05-31
DK0733635T3 (da) 2001-10-08
FI973750A0 (fi) 1997-09-22
EP1095941A1 (fr) 2001-05-02
DE69614426D1 (de) 2001-09-20
SI1095941T1 (en) 2003-12-31
PL322501A1 (en) 1998-02-02
RO118872B1 (ro) 2003-12-30
HK1013988A1 (en) 1999-09-17
BG101900A (en) 1999-03-31
DK1445259T3 (da) 2006-10-16
NO974365L (no) 1997-09-22
DE69636313D1 (de) 2006-08-10
GB2313835A (en) 1997-12-10
GB2313835B (en) 1998-09-16
FI973750A7 (fi) 1997-09-22
DE69630324D1 (de) 2003-11-13
CO4650278A1 (es) 1998-09-03
PT1095941E (pt) 2004-02-27
EA199700262A1 (ru) 1998-02-26
BG62619B1 (bg) 2000-03-31
DE69630324T2 (de) 2004-07-29
LT97148A (lt) 1998-01-26
CZ300097A3 (en) 1997-12-17
YU17796A (sh) 1999-03-04
EP1445259B1 (fr) 2006-06-28
CA2214005C (fr) 2001-07-03

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