MA26997A1 - Derives de 3-(4-amidopyrrole-2-ylmethylidene)-2-indolinone utilisables comme inhibiteurs de proteine-kinases - Google Patents

Derives de 3-(4-amidopyrrole-2-ylmethylidene)-2-indolinone utilisables comme inhibiteurs de proteine-kinases

Info

Publication number
MA26997A1
MA26997A1 MA27282A MA27282A MA26997A1 MA 26997 A1 MA26997 A1 MA 26997A1 MA 27282 A MA27282 A MA 27282A MA 27282 A MA27282 A MA 27282A MA 26997 A1 MA26997 A1 MA 26997A1
Authority
MA
Morocco
Prior art keywords
derivatives
amidopyrrole
ylmethylidene
indolinone
protein
Prior art date
Application number
MA27282A
Other languages
English (en)
Inventor
Huiping Guan
Congxin Liang
Li Sun
Peng Cho Tang
Chung Chen Wei
Michael A Mauragis
Tomas Vojkovsky
Qingwu Jin
Paul Matthew Herrinton
Original Assignee
Sugen Inc
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Upjohn Co filed Critical Sugen Inc
Publication of MA26997A1 publication Critical patent/MA26997A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DEPOSANT Sociétés dites : SUGEN, INC. PHARMACIA & UPJOHN COMPANY REVENDICATION DE PRIORITES US 15 Février 2001 60/268,683 US 15 Août 2001 60/312,361 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés de 3-(4-amidopyrrole-2-ylméthylidène) 2-indolinone utilisables comme inhibiteurs de protéine-kinases La présente invention concerne des dérivés de 2-indolinone à substituant pyrrole et leurs sels pharmaceutiquement acceptables qui modulent l'activité de protéine-kinases et pour lesquels il est donc prévu une utilité dans la prévention et le traitement de troubles cellulaires en rapport avec des protéine-kinases, tels que le cancer.
MA27282A 2001-02-15 2003-08-15 Derives de 3-(4-amidopyrrole-2-ylmethylidene)-2-indolinone utilisables comme inhibiteurs de proteine-kinases MA26997A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26868301P 2001-02-15 2001-02-15
US31236101P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
MA26997A1 true MA26997A1 (fr) 2004-12-20

Family

ID=26953263

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27282A MA26997A1 (fr) 2001-02-15 2003-08-15 Derives de 3-(4-amidopyrrole-2-ylmethylidene)-2-indolinone utilisables comme inhibiteurs de proteine-kinases

Country Status (40)

Country Link
US (4) US6653308B2 (fr)
EP (1) EP1370554B1 (fr)
JP (1) JP3677501B2 (fr)
KR (1) KR100884858B1 (fr)
CN (1) CN100338059C (fr)
AP (1) AP1718A (fr)
AR (1) AR042586A1 (fr)
AT (1) ATE307128T1 (fr)
AU (1) AU2002247133B2 (fr)
BG (1) BG108098A (fr)
BR (1) BR0207494A (fr)
CA (1) CA2438314C (fr)
CR (1) CR7056A (fr)
CZ (1) CZ20032414A3 (fr)
DE (1) DE60206736T2 (fr)
DK (1) DK1370554T3 (fr)
EA (1) EA007186B1 (fr)
EE (1) EE200300385A (fr)
ES (1) ES2251580T3 (fr)
GE (1) GEP20053600B (fr)
HR (1) HRP20030657B1 (fr)
HU (1) HUP0303146A3 (fr)
IL (2) IL157418A0 (fr)
IS (1) IS2411B (fr)
MA (1) MA26997A1 (fr)
MX (1) MXPA03007367A (fr)
MY (1) MY126235A (fr)
NO (1) NO326604B1 (fr)
NZ (1) NZ527572A (fr)
OA (1) OA12834A (fr)
PE (1) PE20021006A1 (fr)
PL (1) PL364176A1 (fr)
RS (1) RS51026B (fr)
SI (1) SI1370554T1 (fr)
SK (1) SK11332003A3 (fr)
TN (1) TNSN03055A1 (fr)
TW (1) TWI324155B (fr)
UA (1) UA75635C2 (fr)
WO (1) WO2002066463A1 (fr)
ZA (2) ZA200306335B (fr)

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