MA32360B1 - Thérapie pour cancer hépatique - Google Patents

Thérapie pour cancer hépatique

Info

Publication number
MA32360B1
MA32360B1 MA33323A MA33323A MA32360B1 MA 32360 B1 MA32360 B1 MA 32360B1 MA 33323 A MA33323 A MA 33323A MA 33323 A MA33323 A MA 33323A MA 32360 B1 MA32360 B1 MA 32360B1
Authority
MA
Morocco
Prior art keywords
chemotherapeutic agent
glypican
antibody
medicinal composition
hepatic cancer
Prior art date
Application number
MA33323A
Other languages
Arabic (ar)
English (en)
Inventor
Yasuko Kinoshita
Masamichi Sugimoto
Takahiro Ishiguro
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41135076&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32360(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/JP2008/002690 external-priority patent/WO2009041062A1/fr
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MA32360B1 publication Critical patent/MA32360B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne une nouvelle composition médicinale destinée à traiter ou à prévenir le carcinome hépatocellulaire, ainsi qu'un procédé thérapeutique. Ladite composition médicinale destinée à traiter ou à prévenir le cancer hépatique comprend un agent chimiothérapeutique associé à un anticorps glypicane 3. L'invention concerne en outre une composition médicinale à utiliser en association avec un agent chimiothérapeutique dans le traitement ou la prévention du cancer hépatique, qui comprend un anticorps glypicane 3 en tant qu'ingrédient actif. L'invention concerne également une composition médicinale à utiliser en association avec un anticorps glypicane 3 dans le traitement ou la prévention du cancer hépatique, qui comprend un agent chimiothérapeutique en tant qu'ingrédient actif. L'utilisation combinée d'un agent chimiothérapeutique et d'un anticorps glypicane 3 permet d'obtenir un meilleur effet thérapeutique que l'utilisation de l'agent chimiothérapeutique seul. En outre, il est possible de réduire les effets secondaires dans le traitement du cancer hépatique grâce à l'utilisation dudit agent chimiothérapeutique.
MA33323A 2008-04-04 2010-11-03 Thérapie pour cancer hépatique MA32360B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008098309 2008-04-04
PCT/JP2008/002690 WO2009041062A1 (fr) 2007-09-28 2008-09-26 Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée
PCT/JP2009/001249 WO2009122667A1 (fr) 2008-04-04 2009-03-19 Thérapie pour cancer hépatique

Publications (1)

Publication Number Publication Date
MA32360B1 true MA32360B1 (fr) 2011-06-01

Family

ID=41135076

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33323A MA32360B1 (fr) 2008-04-04 2010-11-03 Thérapie pour cancer hépatique

Country Status (23)

Country Link
US (1) US20110104157A1 (fr)
EP (1) EP2275135A4 (fr)
JP (2) JP5306327B2 (fr)
KR (1) KR101612139B1 (fr)
CN (1) CN102046200B (fr)
AR (1) AR071003A1 (fr)
AU (1) AU2009233301B2 (fr)
BR (1) BRPI0911147A2 (fr)
CA (1) CA2720359A1 (fr)
CL (1) CL2009000647A1 (fr)
CO (1) CO6300964A2 (fr)
CR (1) CR11769A (fr)
EC (1) ECSP10010589A (fr)
IL (1) IL208451A0 (fr)
MA (1) MA32360B1 (fr)
MX (1) MX2010010954A (fr)
NZ (1) NZ588913A (fr)
PE (1) PE20091655A1 (fr)
RU (1) RU2523897C2 (fr)
SG (1) SG189754A1 (fr)
TW (1) TWI468175B (fr)
UA (1) UA103614C2 (fr)
WO (1) WO2009122667A1 (fr)

Families Citing this family (20)

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SI1674111T1 (sl) * 2004-07-09 2011-02-28 Chugai Pharmaceutical Co Ltd Protitelo proti glipikanu 3
AU2005297772B2 (en) * 2004-10-26 2011-06-23 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody having modified sugar chain
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US8497355B2 (en) * 2007-09-28 2013-07-30 Chugai Seiyaku Kabushiki Kaisha Anti-glypican-3 antibody having improved kinetics in plasma
SG11201407972RA (en) * 2012-06-01 2015-01-29 Us Health High-affinity monoclonal antibodies to glypican-3 and use thereof
TWI693073B (zh) * 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
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WO2019059411A1 (fr) 2017-09-20 2019-03-28 Chugai Seiyaku Kabushiki Kaisha Posologie pour polythérapie utilisant des antagonistes de liaison d'axe pd-1 et un agent de ciblage gpc3
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CN117062834A (zh) * 2021-02-10 2023-11-14 先声再明医药有限公司 Gpc3人源化抗体及其应用

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Also Published As

Publication number Publication date
SG189754A1 (en) 2013-05-31
JP5306327B2 (ja) 2013-10-02
CN102046200A (zh) 2011-05-04
RU2523897C2 (ru) 2014-07-27
CL2009000647A1 (es) 2010-06-04
UA103614C2 (uk) 2013-11-11
IL208451A0 (en) 2010-12-30
AR071003A1 (es) 2010-05-19
AU2009233301B2 (en) 2014-01-23
BRPI0911147A2 (pt) 2019-09-24
RU2010145177A (ru) 2012-05-20
CN102046200B (zh) 2015-03-25
CA2720359A1 (fr) 2009-10-08
JP2011068682A (ja) 2011-04-07
TWI468175B (zh) 2015-01-11
MX2010010954A (es) 2011-03-24
CR11769A (es) 2011-03-30
JPWO2009122667A1 (ja) 2011-07-28
WO2009122667A1 (fr) 2009-10-08
EP2275135A1 (fr) 2011-01-19
KR20100132060A (ko) 2010-12-16
ECSP10010589A (es) 2010-12-30
JP5506654B2 (ja) 2014-05-28
KR101612139B1 (ko) 2016-04-12
TW200950804A (en) 2009-12-16
HK1151734A1 (en) 2012-02-10
PE20091655A1 (es) 2009-11-04
CO6300964A2 (es) 2011-07-21
US20110104157A1 (en) 2011-05-05
EP2275135A4 (fr) 2013-03-06
AU2009233301A1 (en) 2009-10-08
NZ588913A (en) 2012-10-26

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