NO178111C - Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater - Google Patents

Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater

Info

Publication number: NO178111C
Authority: NO; Norway
Prior art keywords: treating; formamide; excess; compounds; making
Prior art date: 1989-12-27

Application number

NO913236A

Other languages

English (en)

Norwegian (no)

Other versions

NO178111B (no

NO913236D0 (no

NO913236L (no

Inventor

Armando Vega Noverola

Jose Manuel Prieto Soto

Jacinto Moragues Mauri

Robert W Gristwood

Original Assignee

Almirall Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-27

Filing date

1991-08-19

Publication date

1996-01-24

1991-08-19 Application filed by Almirall Lab filed Critical Almirall Lab

1991-08-19 Publication of NO913236D0 publication Critical patent/NO913236D0/no

1991-08-19 Publication of NO913236L publication Critical patent/NO913236L/no

1995-10-16 Publication of NO178111B publication Critical patent/NO178111B/no

1996-01-24 Publication of NO178111C publication Critical patent/NO178111C/no

Links

LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract 2
229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title 1
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
239000002585 base Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
-1 methylenedioxy Chemical group 0.000 abstract 2
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
LNDZXOWGUAIUBG-UHFFFAOYSA-N 6-aminouracil Chemical compound NC1=CC(=O)NC(=O)N1 LNDZXOWGUAIUBG-UHFFFAOYSA-N 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000005314 Multi-Infarct Dementia Diseases 0.000 abstract 1
201000004810 Vascular dementia Diseases 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
239000000168 bronchodilator agent Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
CSMWJXBSXGUPGY-UHFFFAOYSA-L sodium dithionate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)S([O-])(=O)=O CSMWJXBSXGUPGY-UHFFFAOYSA-L 0.000 abstract 1
229940075931 sodium dithionate Drugs 0.000 abstract 1
235000010288 sodium nitrite Nutrition 0.000 abstract 1
229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Processing Of Stones Or Stones Resemblance Materials (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Re-Forming, After-Treatment, Cutting And Transporting Of Glass Products (AREA)
Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Peptides Or Proteins (AREA)

NO913236A 1989-12-27 1991-08-19 Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater NO178111C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898929208A GB8929208D0 (en)	1989-12-27	1989-12-27	New xanthine derivatives
PCT/GB1990/002027 WO1991009859A1 (en)	1989-12-27	1990-12-27	New xanthine derivatives

Publications (4)

Publication Number	Publication Date
NO913236D0 NO913236D0 (no)	1991-08-19
NO913236L NO913236L (no)	1991-08-19
NO178111B NO178111B (no)	1995-10-16
NO178111C true NO178111C (no)	1996-01-24

Family

ID=10668520

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO913236A NO178111C (no)	1989-12-27	1991-08-19	Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater

Country Status (30)

Country	Link
US (1)	US5223504A (he)
EP (1)	EP0435811B1 (he)
JP (1)	JPH089617B2 (he)
KR (1)	KR970001528B1 (he)
CN (1)	CN1029967C (he)
AT (1)	ATE93860T1 (he)
AU (1)	AU635104B2 (he)
BR (1)	BR9007258A (he)
CA (1)	CA2045478C (he)
CZ (1)	CZ278328B6 (he)
DE (1)	DE69003087T2 (he)
DK (1)	DK0435811T3 (he)
EG (1)	EG19436A (he)
ES (1)	ES2058864T3 (he)
FI (1)	FI96207C (he)
GB (1)	GB8929208D0 (he)
HU (2)	HU208825B (he)
IE (1)	IE64065B1 (he)
IL (1)	IL96708A (he)
MX (1)	MX23884A (he)
MY (1)	MY105303A (he)
NO (1)	NO178111C (he)
NZ (1)	NZ236517A (he)
PL (1)	PL166152B1 (he)
PT (1)	PT96332B (he)
RU (1)	RU2073679C1 (he)
SK (1)	SK278365B6 (he)
UA (1)	UA32512C2 (he)
WO (1)	WO1991009859A1 (he)
ZA (1)	ZA9010240B (he)

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MX9203323A (es) *	1991-07-11	1994-07-29	Hoechst Ag	El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales.
US5521315A (en) *	1993-01-12	1996-05-28	Cell Therapeutics, Inc.	Olefin substituted long chain compounds
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US5922751A (en)	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en)	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5661153A (en) *	1994-07-19	1997-08-26	Japan Energy Corporation	1-arylpyrimidine derivatives and pharmaceutical use thereof
EP0799040B1 (en) *	1994-12-13	2003-08-20	Euroceltique S.A.	Trisubstituted thioxanthines
JPH10508032A (ja)	1994-12-13	1998-08-04	ユーロ−セルティーク，エス．エイ．	アリールチオキサンチン類
US6025361A (en) *	1994-12-13	2000-02-15	Euro-Celtique, S.A.	Trisubstituted thioxanthines
WO1996036638A1 (en) *	1995-05-19	1996-11-21	Chiroscience Limited	Xanthines and their therapeutic use
US6166041A (en)	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en)	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en)	1996-06-06	1999-01-26	Euro-Celtique, S.A.	Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5874437A (en) *	1996-11-01	1999-02-23	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) *	1996-11-01	2001-06-19	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
CA2270118A1 (en) *	1996-11-01	1998-05-14	Nitromed Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) *	1996-11-01	2001-12-18	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US5958926A (en)	1996-11-01	1999-09-28	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
GB9623859D0 (en) *	1996-11-15	1997-01-08	Chiroscience Ltd	Novel compounds
US6472425B1 (en)	1997-10-31	2002-10-29	Nitromed, Inc.	Methods for treating female sexual dysfunctions
IL132407A0 (en) *	1998-10-21	2001-03-19	Pfizer Prod Inc	Method for treating congestive heart failure
ES2228512T3 (es)	1999-05-04	2005-04-16	Altana Pharma Ag	Combinacion sinergica que comprende roflumilast y un inhibidor de pde-3.
PL200923B1 (pl)	1999-08-21	2009-02-27	Nycomed Gmbh	Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
GB0005199D0 (en) *	2000-03-04	2000-04-26	Imp College Innovations Ltd	Modulation of histone deacetylase
CA2402384A1 (en) *	2000-03-16	2001-09-20	Inflazyme Pharmaceuticals Ltd.	Benzylated pde4 inhibitors
KR20040007583A (ko) *	2001-05-23	2004-01-24	다나베 세이야꾸 가부시키가이샤	연골 질환의 재생치료용 조성물
WO2002094321A1 (en) *	2001-05-23	2002-11-28	Tanabe Seiyaku Co., Ltd.	Compositions for promoting healing of bone fracture
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
JP2006522151A (ja)	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
RU2395511C2 (ru) *	2004-02-14	2010-07-27	Смитклайн Бичам Корпорейшн	Новые соединения
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es)	2011-03-01	2018-06-27	Synergy Pharmaceuticals Inc Star	Proceso de preparacion de agonistas c de guanilato ciclasa.
EP2958577A2 (en)	2013-02-25	2015-12-30	Synergy Pharmaceuticals Inc.	Guanylate cyclase receptor agonists for use in colonic cleansing
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
CA2920856C (en)	2013-08-09	2026-03-03	Ardelyx, Inc.	Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
EP3165224A1 (en)	2015-11-09	2017-05-10	Albert-Ludwigs-Universität Freiburg	Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
AR115689A1 (es)	2018-07-05	2021-02-17	Sumitomo Chemical Co	Compuestos de uracilo y su utilización
JP2022533251A (ja)	2019-05-21	2022-07-21	アルデリックス，インコーポレイテッド	患者において血清リン酸塩を低下させるための組み合わせ

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1245969B (de) *		1967-08-03	VEB Arzneimittelwerk Dresden, Radebeul	Verfahren zur Herstellung von Xanthinderivaten
CH629788A5 (de) *	1977-07-20	1982-05-14	Lonza Ag	Verfahren zur herstellung von 5,6-diaminouracil.
SE416810C (sv) *	1977-10-14	1982-07-19	Draco Ab	Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
GB8826595D0 (en) *	1988-11-14	1988-12-21	Beecham Wuelfing Gmbh & Co Kg	Active compounds

1989
- 1989-12-27 GB GB898929208A patent/GB8929208D0/en active Pending
1990
- 1990-12-18 SK SK6341-90A patent/SK278365B6/sk unknown
- 1990-12-18 NZ NZ236517A patent/NZ236517A/xx unknown
- 1990-12-18 IL IL9670890A patent/IL96708A/he not_active IP Right Cessation
- 1990-12-18 CZ CS906341A patent/CZ278328B6/cs not_active IP Right Cessation
- 1990-12-19 DE DE90500126T patent/DE69003087T2/de not_active Expired - Fee Related
- 1990-12-19 ZA ZA9010240A patent/ZA9010240B/xx unknown
- 1990-12-19 ES ES90500126T patent/ES2058864T3/es not_active Expired - Lifetime
- 1990-12-19 EP EP90500126A patent/EP0435811B1/en not_active Expired - Lifetime
- 1990-12-19 AT AT90500126T patent/ATE93860T1/de not_active IP Right Cessation
- 1990-12-19 DK DK90500126.9T patent/DK0435811T3/da active
- 1990-12-20 EG EG75090A patent/EG19436A/xx active
- 1990-12-20 IE IE463490A patent/IE64065B1/en not_active IP Right Cessation
- 1990-12-21 PT PT96332A patent/PT96332B/pt not_active IP Right Cessation
- 1990-12-21 MX MX2388490A patent/MX23884A/es unknown
- 1990-12-21 MY MYPI90002243A patent/MY105303A/en unknown
- 1990-12-21 CN CN90110056A patent/CN1029967C/zh not_active Expired - Fee Related
- 1990-12-27 WO PCT/GB1990/002027 patent/WO1991009859A1/en not_active Ceased
- 1990-12-27 CA CA002045478A patent/CA2045478C/en not_active Expired - Fee Related
- 1990-12-27 PL PL90292006A patent/PL166152B1/pl not_active IP Right Cessation
- 1990-12-27 BR BR909007258A patent/BR9007258A/pt not_active Application Discontinuation
- 1990-12-27 RU SU905001584A patent/RU2073679C1/ru not_active IP Right Cessation
- 1990-12-27 US US07/743,388 patent/US5223504A/en not_active Expired - Lifetime
- 1990-12-27 HU HU912782A patent/HU208825B/hu not_active IP Right Cessation
- 1990-12-27 JP JP3501868A patent/JPH089617B2/ja not_active Expired - Fee Related
- 1990-12-27 UA UA5001584A patent/UA32512C2/uk unknown
- 1990-12-27 KR KR1019910700878A patent/KR970001528B1/ko not_active Expired - Fee Related
- 1990-12-27 AU AU69768/91A patent/AU635104B2/en not_active Ceased
1991
- 1991-08-19 NO NO913236A patent/NO178111C/no unknown
- 1991-08-26 FI FI914014A patent/FI96207C/fi active
1995
- 1995-06-30 HU HU95P/P00698P patent/HU211573A9/hu unknown

Also Published As

Publication number	Publication date
NO178111B (no)	1995-10-16
CN1029967C (zh)	1995-10-11
WO1991009859A1 (en)	1991-07-11
FI96207B (fi)	1996-02-15
IE64065B1 (en)	1995-07-12
HUT57766A (en)	1991-12-30
AU6976891A (en)	1991-07-24
CA2045478A1 (en)	1991-06-28
DE69003087D1 (de)	1993-10-07
EG19436A (en)	1995-02-28
UA32512C2 (uk)	2001-02-15
IL96708A0 (en)	1991-09-16
HU208825B (en)	1994-01-28
NO913236D0 (no)	1991-08-19
JPH089617B2 (ja)	1996-01-31
DK0435811T3 (da)	1993-11-01
KR970001528B1 (ko)	1997-02-11
ATE93860T1 (de)	1993-09-15
IL96708A (he)	1994-06-24
ZA9010240B (en)	1991-10-30
PL166152B1 (en)	1995-04-28
MY105303A (en)	1994-09-30
BR9007258A (pt)	1992-02-25
CN1052858A (zh)	1991-07-10
IE904634A1 (en)	1991-07-17
SK278365B6 (en)	1997-01-08
AU635104B2 (en)	1993-03-11
GB8929208D0 (en)	1990-02-28
EP0435811B1 (en)	1993-09-01
PT96332A (pt)	1991-09-30
PT96332B (pt)	1998-06-30
US5223504A (en)	1993-06-29
HU211573A9 (en)	1995-12-28
EP0435811A1 (en)	1991-07-03
JPH05500226A (ja)	1993-01-21
NZ236517A (en)	1992-09-25
RU2073679C1 (ru)	1997-02-20
CZ278328B6 (en)	1993-11-17
FI914014A0 (fi)	1991-08-26
ES2058864T3 (es)	1994-11-01
FI96207C (fi)	1996-05-27
MX23884A (es)	1993-09-01
DE69003087T2 (de)	1993-12-16
KR920701207A (ko)	1992-08-11
NO913236L (no)	1991-08-19
CA2045478C (en)	1998-12-29

Publication	Publication Date	Title
EG19436A (en)	1995-02-28	Process for preparing of new xamthine derivatives.
DE3773660D1 (de)	1991-11-14	Morpholinoethylester von mycophenolsaeure und ihre derivate, ihre herstellung und verwendung in pharmazeutische zusammensetzungen.
ZA911441B (en)	1991-11-27	Aryl-and heteroarylethenylene derivatives and process for their preparation
Russo et al.	1994	Synthesis of new thienopyrimidobenzothiazoles and thienopyrimidobenzoxazoles with analgesic and antiinflammatory properties
IE41838L (en)	1976-01-25	4-(n-heterocyclic)-quinazolines; cardiac stimulants
HUT53099A (en)	1990-09-28	Process for producing new tetrahydrobenzimidazole derivatives and pharmaceutical compositions comprising such compounds
EP0156559B1 (en)	1989-08-02	8-substituted guanine derivatives
JPS623153B2 (he)	1987-01-23
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