NO323378B1 - Pyrrolo(2,3-d)pyrimidinforbindelser, anvendelse derav samt farmasoytisk preparat. - Google Patents

Pyrrolo(2,3-d)pyrimidinforbindelser, anvendelse derav samt farmasoytisk preparat. Download PDF

Info

Publication number: NO323378B1
Authority: NO; Norway
Prior art keywords: methyl; compound according; amino; pharmaceutically acceptable; carbonyl
Prior art date: 1999-12-10

Application number

NO20022738A

Other languages

English (en)

Norwegian (no)

Other versions

NO20022738L (no

NO20022738D0 (no

Inventor

Todd Andrew Blumenkopf

Mark Edward Flanagan

Michael John Munchhof

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-10

Filing date

2002-06-07

Publication date

2007-04-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22618882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO323378(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-06-07 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2002-06-07 Publication of NO20022738L publication Critical patent/NO20022738L/no

2002-06-07 Publication of NO20022738D0 publication Critical patent/NO20022738D0/no

2007-04-16 Publication of NO323378B1 publication Critical patent/NO323378B1/no

Links

239000000825 pharmaceutical preparation Substances 0.000 title claims description 14
150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 128
150000003839 salts Chemical class 0.000 claims description 44
-1 cyano, amino Chemical group 0.000 claims description 36
108010019421 Janus Kinase 3 Proteins 0.000 claims description 32
102000006500 Janus Kinase 3 Human genes 0.000 claims description 32
238000002360 preparation method Methods 0.000 claims description 24
241000124008 Mammalia Species 0.000 claims description 23
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 22
239000003795 chemical substances by application Substances 0.000 claims description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
208000035475 disorder Diseases 0.000 claims description 14
230000002265 prevention Effects 0.000 claims description 14
206010039073 rheumatoid arthritis Diseases 0.000 claims description 14
206010052779 Transplant rejections Diseases 0.000 claims description 13
210000000056 organ Anatomy 0.000 claims description 13
125000002252 acyl group Chemical group 0.000 claims description 12
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239000002260 anti-inflammatory agent Substances 0.000 claims description 12
210000000987 immune system Anatomy 0.000 claims description 12
239000001257 hydrogen Substances 0.000 claims description 11
229910052739 hydrogen Inorganic materials 0.000 claims description 11
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 10
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206010012601 diabetes mellitus Diseases 0.000 claims description 10
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206010025135 lupus erythematosus Diseases 0.000 claims description 9
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 9
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
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GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 5
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KLCACFBGIDQWHE-UHFFFAOYSA-N 1-[3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methylpiperidin-1-yl]propan-1-one Chemical compound C1N(C(=O)CC)CCC(C)C1NCC1=NC=NC2=C1C(Cl)=CN2 KLCACFBGIDQWHE-UHFFFAOYSA-N 0.000 claims description 2
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125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 2
125000004093 cyano group Chemical group *C#N 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
URCTYVNPUZEJJF-UHFFFAOYSA-N n-methyl-n-(4-methyl-1-propylsulfonylpiperidin-3-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound C1N(S(=O)(=O)CCC)CCC(C)C1N(C)C1=NC=NC2=C1C=CN2 URCTYVNPUZEJJF-UHFFFAOYSA-N 0.000 claims description 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
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Classifications

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NO20022738A 1999-12-10 2002-06-07 Pyrrolo(2,3-d)pyrimidinforbindelser, anvendelse derav samt farmasoytisk preparat. NO323378B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17017999P	1999-12-10	1999-12-10
PCT/IB2000/001742 WO2001042246A2 (en)	1999-12-10	2000-11-23	PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS

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Publication Number	Publication Date
NO20022738L NO20022738L (no)	2002-06-07
NO20022738D0 NO20022738D0 (no)	2002-06-07
NO323378B1 true NO323378B1 (no)	2007-04-16

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US (7)	US6627754B2 (sr)
EP (2)	EP1382339B1 (sr)
JP (1)	JP4078074B2 (sr)
KR (1)	KR100477818B1 (sr)
CN (1)	CN1195755C (sr)
AP (1)	AP1905A (sr)
AR (1)	AR026534A1 (sr)
AT (2)	ATE380031T1 (sr)
AU (1)	AU777911B2 (sr)
BG (1)	BG65821B1 (sr)
BR (1)	BRPI0016263B8 (sr)
CA (1)	CA2393640C (sr)
CO (1)	CO5271665A1 (sr)
CR (1)	CR6655A (sr)
CU (1)	CU23220A3 (sr)
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CZ (1)	CZ303875B6 (sr)
DE (2)	DE60037345T2 (sr)
DK (2)	DK1382339T3 (sr)
DZ (1)	DZ3248A1 (sr)
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- 2000-11-23 SK SK756-2002A patent/SK287188B6/sk not_active IP Right Cessation
- 2000-11-23 IL IL14961600A patent/IL149616A0/xx unknown
- 2000-11-23 ES ES03024332T patent/ES2295495T3/es not_active Expired - Lifetime
- 2000-11-23 EE EEP200200304A patent/EE05351B1/xx unknown
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- 2000-11-23 CZ CZ20021846A patent/CZ303875B6/cs not_active IP Right Cessation
- 2000-11-23 UA UA2002064708A patent/UA72290C2/uk unknown
- 2000-11-23 AU AU12950/01A patent/AU777911B2/en not_active Expired
- 2000-11-23 CN CNB008169411A patent/CN1195755C/zh not_active Ceased
- 2000-11-23 ES ES00974738T patent/ES2208433T3/es not_active Expired - Lifetime
- 2000-11-23 RS YU41302A patent/RS51574B/sr unknown
- 2000-11-23 DK DK00974738T patent/DK1235830T3/da active
- 2000-11-23 AP APAP/P/2002/002543A patent/AP1905A/en active
- 2000-11-23 MX MXPA02005675A patent/MXPA02005675A/es active IP Right Grant
- 2000-11-23 NZ NZ528905A patent/NZ528905A/en not_active IP Right Cessation
- 2000-11-23 EA EA200200506A patent/EA006227B1/ru not_active IP Right Cessation
- 2000-11-23 PL PL355907A patent/PL218519B1/pl unknown
- 2000-11-23 KR KR10-2002-7007385A patent/KR100477818B1/ko not_active Expired - Lifetime
- 2000-11-23 CA CA002393640A patent/CA2393640C/en not_active Expired - Lifetime
- 2000-11-23 TR TR2002/01498T patent/TR200201498T2/xx unknown
- 2000-11-23 OA OA1200200178A patent/OA12118A/en unknown
- 2000-11-23 WO PCT/IB2000/001742 patent/WO2001042246A2/en not_active Ceased
- 2000-11-23 PT PT03024332T patent/PT1382339E/pt unknown
- 2000-11-23 GE GE4828A patent/GEP20053479B/en unknown
- 2000-11-24 PA PA20008507301A patent/PA8507301A1/es unknown
- 2000-11-27 HN HN2000000265A patent/HN2000000265A/es unknown
- 2000-12-05 TW TW089125918A patent/TWI248935B/zh not_active IP Right Cessation
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- 2000-12-06 PE PE2000001307A patent/PE20011096A1/es not_active IP Right Cessation
- 2000-12-06 EG EG20001516A patent/EG24399A/xx active
- 2000-12-07 AR ARP000106506A patent/AR026534A1/es active IP Right Grant
- 2000-12-07 CO CO00093680A patent/CO5271665A1/es not_active Application Discontinuation
- 2000-12-08 SV SV2000000236A patent/SV2002000236A/es unknown
- 2000-12-08 TN TNTNSN00239A patent/TNSN00239A1/fr unknown
- 2000-12-08 MY MYPI20005795A patent/MY130760A/en unknown
- 2000-12-08 EC EC2000003819A patent/ECSP003819A/es unknown
- 2000-12-08 US US09/732,669 patent/US6627754B2/en not_active Ceased
- 2000-12-08 UY UY26477A patent/UY26477A1/es not_active IP Right Cessation
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2002
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- 2002-06-20 BG BG106855A patent/BG65821B1/bg unknown
2003
- 2003-08-13 US US10/640,227 patent/US6956041B2/en not_active Expired - Lifetime
2005
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2006
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2007
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2008
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Also Published As

Publication number	Publication date
DE60007552D1 (de)	2004-02-05
US20050288313A1 (en)	2005-12-29
EG24399A (en)	2009-04-29
CZ20021846A3 (cs)	2003-06-18
BR0016263A (pt)	2002-08-13
BRPI0016263B1 (pt)	2016-07-26
TNSN00239A1 (fr)	2005-11-10
EP1235830B1 (en)	2004-01-02
MA26851A1 (fr)	2004-12-20
NO20022738L (no)	2002-06-07
HK1051195A1 (en)	2003-07-25
AU1295001A (en)	2001-06-18
IS2173B (is)	2006-11-15
BRPI0016263B8 (pt)	2021-05-25
DK1382339T3 (da)	2008-01-28
ES2295495T3 (es)	2008-04-16
WO2001042246A2 (en)	2001-06-14
US20060241131A1 (en)	2006-10-26
UY26477A1 (es)	2001-06-29
CR6655A (es)	2003-11-07
SK7562002A3 (en)	2003-08-05
US20040053947A1 (en)	2004-03-18
SK287188B6 (sk)	2010-02-08
KR20020061637A (ko)	2002-07-24
IL149616A (en)	2010-02-17
HRP20020509A2 (en)	2004-08-31
TWI248935B (en)	2006-02-11
CN1195755C (zh)	2005-04-06
US20070292430A1 (en)	2007-12-20
TW200427453A (en)	2004-12-16
HUP0203503A2 (hu)	2003-02-28
MXPA02005675A (es)	2002-09-02
WO2001042246A3 (en)	2001-11-22
NZ518884A (en)	2004-02-27
BG65821B1 (bg)	2010-01-29
AP2002002543A0 (en)	2002-06-30
OA12118A (en)	2006-05-04
TR200201498T2 (tr)	2003-01-21
RS51574B (sr)	2011-08-31
MY130760A (en)	2007-07-31
HUP0203503A3 (en)	2004-12-28
UA72290C2 (uk)	2005-02-15
US7601727B2 (en)	2009-10-13
YU41302A (sh)	2005-03-15
CU23220A3 (es)	2007-07-20
GT200000208A (es)	2002-06-01
DE60037345D1 (de)	2008-01-17
ES2208433T3 (es)	2004-06-16
EA200200506A1 (ru)	2002-12-26
NZ528905A (en)	2005-03-24
DE60007552T2 (de)	2004-09-23
BG106855A (bg)	2002-12-29
SI1235830T1 (en)	2004-06-30
ZA200204535B (en)	2003-09-29
NO20022738D0 (no)	2002-06-07
CA2393640A1 (en)	2001-06-14
CY1108850T1 (el)	2014-07-02
CN1409712A (zh)	2003-04-09
EP1235830A2 (en)	2002-09-04
CA2393640C (en)	2006-09-05
CO5271665A1 (es)	2003-04-30
US7842699B2 (en)	2010-11-30
PA8507301A1 (es)	2002-02-21
PT1382339E (pt)	2008-02-06
GEP20053479B (en)	2005-03-25
EP1382339B1 (en)	2007-12-05
ATE257157T1 (de)	2004-01-15
DE60037345T2 (de)	2008-11-13
IL149616A0 (en)	2002-11-10
HN2000000265A (es)	2001-04-11
AP1905A (en)	2008-10-20
USRE41783E1 (en)	2010-09-28
AU777911B2 (en)	2004-11-04
ECSP003819A (es)	2001-06-11
AR026534A1 (es)	2003-02-12
EE200200304A (et)	2003-06-16
TWI264305B (en)	2006-10-21
EE05351B1 (et)	2010-10-15
US6956041B2 (en)	2005-10-18
JP4078074B2 (ja)	2008-04-23
DZ3248A1 (fr)	2001-06-14
EP1382339A1 (en)	2004-01-21
TR200400105T4 (tr)	2004-02-23
DK1235830T3 (da)	2004-03-29
HRP20020509B1 (en)	2005-06-30
ATE380031T1 (de)	2007-12-15
SV2002000236A (es)	2002-06-07
PT1235830E (pt)	2004-04-30
PL218519B1 (pl)	2014-12-31
US6627754B2 (en)	2003-09-30
CZ303875B6 (cs)	2013-06-05
US20010053782A1 (en)	2001-12-20
IS6383A (is)	2002-05-14
PE20011096A1 (es)	2001-10-25
US20100035903A1 (en)	2010-02-11
PL355907A1 (en)	2004-05-31
HU229671B1 (en)	2014-04-28
KR100477818B1 (ko)	2005-03-22
JP2003516405A (ja)	2003-05-13
US7265221B2 (en)	2007-09-04
US7091208B2 (en)	2006-08-15
EA006227B1 (ru)	2005-10-27

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2020-12-07	MK1K	Patent expired

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