NO329134B1 - Aminoalkoholderivater eller fosfonsyrederivater og farmasoytiske preparater som inneholder disse og som kan anvendes ved profylakse eller behandling av autoimmunsykdommer - Google Patents

Aminoalkoholderivater eller fosfonsyrederivater og farmasoytiske preparater som inneholder disse og som kan anvendes ved profylakse eller behandling av autoimmunsykdommer Download PDF

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Publication number
NO329134B1
NO329134B1 NO20043319A NO20043319A NO329134B1 NO 329134 B1 NO329134 B1 NO 329134B1 NO 20043319 A NO20043319 A NO 20043319A NO 20043319 A NO20043319 A NO 20043319A NO 329134 B1 NO329134 B1 NO 329134B1
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Prior art keywords
methyl
amino
formula
group
pyrrol
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NO20043319A
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English (en)
Norwegian (no)
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NO20043319L (no
Inventor
Takahide Nishi
Takaichi Shimozato
Shoujiro Miyazaki
Futoshi Nara
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Sankyo Co
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Publication of NO20043319L publication Critical patent/NO20043319L/no
Publication of NO329134B1 publication Critical patent/NO329134B1/no

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    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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NO20043319A 2002-01-11 2004-08-10 Aminoalkoholderivater eller fosfonsyrederivater og farmasoytiske preparater som inneholder disse og som kan anvendes ved profylakse eller behandling av autoimmunsykdommer NO329134B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002004456 2002-01-11
JP2002004484 2002-01-11
PCT/JP2003/000136 WO2003059880A1 (en) 2002-01-11 2003-01-09 Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these

Publications (2)

Publication Number Publication Date
NO20043319L NO20043319L (no) 2004-10-05
NO329134B1 true NO329134B1 (no) 2010-08-30

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NO20043319A NO329134B1 (no) 2002-01-11 2004-08-10 Aminoalkoholderivater eller fosfonsyrederivater og farmasoytiske preparater som inneholder disse og som kan anvendes ved profylakse eller behandling av autoimmunsykdommer

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US (5) US7199150B2 (de)
EP (1) EP1471054B1 (de)
JP (1) JP4270541B2 (de)
KR (2) KR20080035702A (de)
CN (1) CN100406437C (de)
AT (1) ATE435202T1 (de)
AU (1) AU2003202495B2 (de)
BR (1) BR0306811A (de)
CA (1) CA2473461C (de)
CO (1) CO5640126A2 (de)
CY (1) CY1109457T1 (de)
DE (1) DE60328161D1 (de)
DK (1) DK1471054T3 (de)
ES (1) ES2327825T3 (de)
IL (1) IL162874A0 (de)
MX (1) MXPA04006709A (de)
NO (1) NO329134B1 (de)
NZ (1) NZ533994A (de)
PL (1) PL211954B1 (de)
PT (1) PT1471054E (de)
RU (1) RU2330839C2 (de)
SI (1) SI1471054T1 (de)
TW (1) TWI283574B (de)
WO (1) WO2003059880A1 (de)
ZA (1) ZA200406333B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4771511B2 (ja) * 2003-07-08 2011-09-14 第一三共株式会社 アミノアルコ−ル誘導体又はホスホン酸誘導体を含有する医薬組成物
RU2330839C2 (ru) * 2002-01-11 2008-08-10 Санкио Компани, Лимитед Производные аминоспиртов или производные фосфорных кислот и фармацевтические композиции, содержащие указанные производные
US7241790B2 (en) * 2002-07-30 2007-07-10 University Of Virginia Patent Foundation Compounds active in spinigosine 1-phosphate signaling
GB0302094D0 (en) * 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
TW200510300A (en) * 2003-07-11 2005-03-16 Sankyo Co Amino alcohol compounds
JP2007515501A (ja) * 2003-09-19 2007-06-14 ダウ グローバル テクノロジーズ インコーポレイティド 多官能性モノマー及びそれからのポリアリーレン組成物
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2005041899A2 (en) 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
ES2232306B1 (es) * 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
TWI355934B (en) * 2004-02-24 2012-01-11 Sankyo Co Pharmaceutical composition for treatment or prophy
ATE502630T1 (de) 2004-07-16 2011-04-15 Kyorin Seiyaku Kk Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen
TW200611687A (en) * 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
JP4919374B2 (ja) * 2004-07-29 2012-04-18 第一三共株式会社 免疫抑制剤としての医薬組成物
AU2005292984B2 (en) * 2004-10-12 2011-01-20 Kyorin Pharmaceutical Co., Ltd. Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same
JP5024851B2 (ja) * 2004-10-28 2012-09-12 第一三共株式会社 光学活性4,4−二置換オキサゾリジン誘導体とその製造方法
WO2006046595A1 (ja) * 2004-10-28 2006-05-04 Sankyo Company, Limited 光学活性4,4-二置換オキサゾリジン誘導体とその製造方法
MX2007009848A (es) 2005-02-14 2008-03-10 Univ Virginia Agonistas de esfingosina 1-fosfato comprendiendo cicloalcanos y heterociclos de 5 miembros substituidos por grupos amino y fenilo.
TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ppar調節劑之醫藥組成物的用途
RU2421214C2 (ru) * 2005-10-07 2011-06-20 Киорин Фармасьютикал Ко., Лтд. Терапевтическое средство для лечения гепатита и способ лечения гепатита
MX2008009579A (es) 2006-01-27 2008-09-25 Univ Virginia Metodo para el tratamiento de dolor neuropatico.
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
AU2007212193A1 (en) 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
TW200815600A (en) 2006-08-04 2008-04-01 Daiichi Sankyo Co Ltd An enzyme for phosphorizing a medicine
JP5140593B2 (ja) * 2006-08-08 2013-02-06 杏林製薬株式会社 アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤
US8232319B2 (en) * 2006-08-08 2012-07-31 Kyorin Pharmaceutical Co., Ltd. Amino phosphate derivative and S1P receptor modulator having same as an active ingredient
AU2007323618A1 (en) 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Tetralin analogs having sphingosine 1-phosphate agonist activity
EP2099741A2 (de) 2006-11-21 2009-09-16 University Of Virginia Patent Foundation Hydrindan-analoga mit sphingosin-1-phosphatrezeptoragonistenaktivität
WO2008064337A2 (en) 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
TW200906389A (en) 2007-05-25 2009-02-16 Daiichi Sankyo Co Ltd Pharmaceutical composition comprising of therapeutic or prophylactic agents for hepatitis
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires
US20130190278A1 (en) * 2010-07-29 2013-07-25 Laboratoires Fournier Sa Compounds for the Treatment/Prevention of Ocular Inflammatory Diseases
KR20130133198A (ko) 2010-12-02 2013-12-06 다이이찌 산쿄 가부시키가이샤 피롤 유도체 및 그 제조 방법
HK1210969A1 (en) 2012-01-20 2016-05-13 奥克塞拉有限公司 Substituted heterocyclic compounds for disease treatment
KR20180093177A (ko) 2017-02-10 2018-08-21 (주)홍익바이오텍 죽염과 다공성 광물을 이용한 개껌 제조방법
EP3886854A4 (de) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1134687A (en) 1966-04-28 1968-11-27 Beecham Group Ltd Acetylenic compounds
IL36730A0 (en) 1970-05-28 1971-06-23 Chemagro Corp Phosphonamidothioates,their preparation and their use as herbicides and/or plant growth regulators
DK150068C (da) 1978-06-02 1987-06-29 Pfizer Analogifremgangsmaade til fremstilling af aminothiazoler
FR2460919A1 (fr) 1979-07-11 1981-01-30 Prod Synthese Ste Indle Amino-ethers oxydes, leur procede de preparation et leur application en therapeutique
US4363918A (en) 1979-09-11 1982-12-14 Janssen Pharmaceutica N.V. Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids
SE8107537L (sv) 1980-12-22 1982-06-23 Delalande Sa Nya derivat av heterocykliska aminoalcoyler, deras framstellningssett och deras terapeutiska anvendning
JPS58105946A (ja) 1981-12-18 1983-06-24 Tanabe Seiyaku Co Ltd アミノブタノ−ルエステル誘導体の製法
US4716155A (en) 1981-12-24 1987-12-29 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and hypotensive use thereof
IT1190793B (it) 1982-04-27 1988-02-24 Magis Farmaceutici Composti attivi nel trattamento dell'ulcera e sintomi allergici della pelle
JPS5944345A (ja) 1982-09-06 1984-03-12 Toyo Jozo Co Ltd 光学活性β―アミノ酸の製造法
US4536601A (en) 1982-09-28 1985-08-20 Dainippon Pharmaceutical Co., Ltd. Optically active N-substituted phenylalaninols and use thereof
JPS5988467A (ja) 1982-11-09 1984-05-22 Yoshitomi Pharmaceut Ind Ltd フエノキシアミノプロパノ−ル誘導体
DK302185A (da) 1984-07-05 1986-01-06 Rolland Sa A 2-amino-oxazoliner samt fremgangsmaade til deres fremstilling
JPS62123126A (ja) 1985-08-20 1987-06-04 Yoshitomi Pharmaceut Ind Ltd 細胞dna合成抑制因子
US4634689A (en) * 1985-10-31 1987-01-06 Schering Corporation Phosphinylalkanoyl imino acids
US4667038A (en) 1985-12-02 1987-05-19 Syntex (U.S.A.) Inc. Tetrahydroisoquinoline derivatives
US4792568A (en) 1986-04-14 1988-12-20 Rorer Pharmaceutical Corporation Aryl pyrroles as useful antiallergy compounds
JPS63126897A (ja) 1986-05-02 1988-05-30 Yoshitomi Pharmaceut Ind Ltd 免疫抑制因子
JPH0778052B2 (ja) 1986-11-28 1995-08-23 富士薬品工業株式会社 Dl−パントラクトンの光学分割法
JPH01104087A (ja) 1987-03-17 1989-04-21 Yoshitomi Pharmaceut Ind Ltd 免疫抑制物質の製造法
US5135947A (en) 1987-04-09 1992-08-04 Eli Lilly And Company 1-phenyl-3-naphthalenyloxypropanamines and their use as selective serotonin reuptake inhibitors
GB8712694D0 (en) 1987-05-29 1987-07-01 Scras Tetrahydrofurans etc
IL86740A (en) 1987-06-30 1992-11-15 Tanabe Seiyaku Co Thiphene derivatives,their preparation and pharmaceutical compositions containing them
EP0300688A1 (de) 1987-07-21 1989-01-25 FISONS plc Pyrrol-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammenstellungen, die sie enthalten
CA1334975C (en) 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
US5039706A (en) * 1987-11-30 1991-08-13 Du Pont Merck Pharmaceutical Company Antiinflammatory PLA2 inhibitors
NZ227365A (en) 1987-12-18 1990-10-26 Glaxo Group Ltd Aromatic amino ethers and pharmaceutical compositions
US4977171A (en) 1988-06-09 1990-12-11 Yashima Chemical Industrial Co., Ltd. Oxa- or thia-zoline derivative
WO1990002727A1 (fr) 1988-09-14 1990-03-22 Yoshitomi Pharmaceutical Industries, Ltd. Immunodepresseur
JPH02256612A (ja) 1988-12-22 1990-10-17 Tanabe Seiyaku Co Ltd 消化管機能調整剤
US5266599A (en) 1989-02-20 1993-11-30 Jouveinal S.A. Use of (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine to increase gastric discharge in a subject
US5068247A (en) 1989-07-07 1991-11-26 Yoshitomi Pharmaceutical Industries, Ltd. 2-aminopentanoic acid compounds and their use as immunosuppressants
HU212415B (en) 1989-08-25 1996-06-28 Egyt Gyogyszervegyeszeti Gyar Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components
US5234934A (en) 1989-08-25 1993-08-10 Egis Gyogyszergyar Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
FR2655043B1 (fr) 1989-11-24 1992-02-07 Adir Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5037853A (en) 1989-12-28 1991-08-06 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9000644D0 (en) 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
JPH0714905B2 (ja) 1990-02-20 1995-02-22 吉富製薬株式会社 2―アミノペンタン酸化合物の新規な製造法
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5723218A (en) 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5648270A (en) 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5501980A (en) 1994-05-20 1996-03-26 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators
JP2747849B2 (ja) 1990-08-24 1998-05-06 大鵬薬品工業株式会社 2’―デオキシヌクレオシド類の選択的アシル化方法
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
GB9027055D0 (en) 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
DK0492497T3 (da) 1990-12-24 1997-01-06 Hoechst Ag Fremgangsmåde til acylering af alkoholer med en immobiliseret pseudomonas-lipase
CA2071621C (en) 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
JP2805006B2 (ja) 1991-08-29 1998-09-30 財団法人 工業技術研究院 チオフェン系化合物及びその薬理的に許容できる塩類よりなる医薬
NL9101623A (nl) 1991-09-26 1993-04-16 Dsm Nv Werkwijze voor de bereiding van een alcohol.
ES2143993T3 (es) 1991-12-11 2000-06-01 Yoshitomi Pharmaceutical Farmaco para tratar una enfermedad autoinmune.
JP3155099B2 (ja) 1991-12-24 2001-04-09 ウェルファイド株式会社 2−アミノブタン酸化合物
JPH0667229A (ja) 1992-08-14 1994-03-11 Fuji Photo Film Co Ltd 非線形光学材料
ATE154800T1 (de) 1992-08-25 1997-07-15 Searle & Co N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren
EP0627406B1 (de) * 1992-10-21 1998-10-28 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1, 3- propandiolverbindung und immunosuppressium
US5288751A (en) 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
GB9304589D0 (en) 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9306473D0 (en) 1993-03-29 1993-05-19 Bioglan Lab Ltd Pharmaceutically useful compounds
US5641783A (en) 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5837703A (en) 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
JPH06345728A (ja) 1993-06-11 1994-12-20 Nissan Chem Ind Ltd N−置換アゾール誘導体の製造方法
US5717605A (en) * 1993-10-14 1998-02-10 Olympus Optical Co., Ltd. Color classification apparatus
JP3352184B2 (ja) 1993-11-12 2002-12-03 株式会社アズウェル ピペラジン不飽和脂肪酸誘導体
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5534980A (en) * 1994-05-31 1996-07-09 Mita Industrial Co., Ltd. Electrophotographic image forming apparatus having a charge removing means
US5948820A (en) 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
JP3870419B2 (ja) 1994-08-22 2007-01-17 三菱ウェルファーマ株式会社 ベンゼン化合物およびその医薬としての用途
JPH09124564A (ja) 1995-11-06 1997-05-13 Nikko Rika Kk 光学活性体混合物ならびにその製造方法
ATE279185T1 (de) 1995-12-28 2004-10-15 Mitsubishi Pharma Corp 2-amino-2-(2-(4-octylphenyl)ethyl)propan-1,3-di l enthaltendes arzneimittel zur topischen anwendung zur behandlung von erkrankungen die durch eine störung des immunsystems hervorgerufen werden
US6686353B1 (en) 1996-05-20 2004-02-03 Teijin Intellectual Property Center Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
JPH11209277A (ja) 1998-01-19 1999-08-03 Yoshitomi Pharmaceut Ind Ltd 医薬組成物
US6476004B1 (en) 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
DE69734215T2 (de) 1996-07-22 2006-06-29 Novo Nordisk A/S Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
EP0946180A4 (de) 1996-10-07 2003-07-23 Smithkline Beecham Corp Methoden zur stimulierung der knochenbildung
US5891892A (en) 1996-10-29 1999-04-06 Warner-Lambert Company Small molecule biaryl compounds as inhibitors of endothelin converting enzyme
GB9624038D0 (en) 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
US5732218A (en) * 1997-01-02 1998-03-24 Lucent Technologies Inc. Management-data-gathering system for gathering on clients and servers data regarding interactions between the servers, the clients, and users of the clients during real use of a network of clients and servers
DE69840169D1 (de) 1997-02-27 2008-12-11 Novartis Ag Arzneimittel zubereitung enthaltend 2-amino-2-ä2-(4-octylphenyl)ethylüpropane-1,3-diol, ein lecithin und ein saccharid
CA2286315C (en) * 1997-04-04 2007-03-06 Yoshitomi Pharmaceutical Industries Ltd. 2-aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor
WO1999001420A1 (en) 1997-07-03 1999-01-14 Taito Co., Ltd. Process for the preparation of 2-aminomalonic acid derivatives and intermediates used in the process
JPH1081623A (ja) 1997-07-11 1998-03-31 Yoshitomi Pharmaceut Ind Ltd 自己免疫疾患治療剤
NZ502872A (en) 1997-08-28 2002-10-25 Novartis Ag Mevinolin and compaction as LFA-1 antagonists for treating autoimmune diseases
JPH1180026A (ja) 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
ES2237850T3 (es) 1997-10-14 2005-08-01 Mitsubishi Pharma Corporation Compuestos de piperazina y su uso medicinal.
DE19745904A1 (de) * 1997-10-17 1999-04-22 Hoechst Ag Polymerstabilisierte Metallkolloid-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Katalysatoren für Brennstoffzellen
JPH11343300A (ja) 1998-03-13 1999-12-14 Tetsuro Fujita 新規ハプテン、それを認識する抗体およびそれらを用いた免疫学的測定法
DE19817459A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
JP4079505B2 (ja) 1998-04-28 2008-04-23 田辺三菱製薬株式会社 2−アミノ−2−[2−(4−オクチルフェニル)エチル]プロパン−1,3−ジオールの新規な製造法
CN1332726A (zh) 1998-11-02 2002-01-23 卫福有限公司 吡咯烷化合物及其药物用途
ATE288414T1 (de) 1998-11-11 2005-02-15 Novartis Pharma Gmbh Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolen
AU2164300A (en) 1998-12-04 2000-06-26 N.V. Organon Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
ATE302005T1 (de) 1998-12-18 2005-09-15 Bristol Myers Squibb Pharma Co N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
US6178821B1 (en) * 1999-01-25 2001-01-30 General Electric Company Vibration sensing device
KR100659007B1 (ko) 1999-02-10 2007-02-28 미츠비시 웰파마 가부시키가이샤 아미드 화합물 및 그 의약으로서의 용도
CN1144779C (zh) 1999-03-11 2004-04-07 杭州中美华东制药有限公司 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物
JP4627356B2 (ja) 1999-06-30 2011-02-09 昭 松森 ウイルス性心筋炎の予防または治療薬剤
MXPA02001095A (es) 1999-07-30 2002-08-20 Vertex Pharma Derivados de amina ciclicos y aciclicos.
US6451823B1 (en) 1999-09-23 2002-09-17 G.D. Searle & Co. Use of substituted N-phenoxy-N-phenyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
DE19963174A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Substituierte Pyrrol-Mannichbasen
EP1244657B1 (de) 1999-12-31 2004-12-29 Encysive Pharmaceuticals Inc. Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren
US6803375B1 (en) 2000-01-06 2004-10-12 The Regents Of The University Of California Non-peptide inhibition of T-lymphocyte activation and therapies related thereto
SK13652002A3 (sk) 2000-03-31 2004-01-08 Pfizer Products Inc. Deriváty piperazínu
US6964676B1 (en) * 2000-04-14 2005-11-15 Scimed Life Systems, Inc. Stent securement system
KR20030017502A (ko) 2000-04-28 2003-03-03 에프. 호프만-라 로슈 아게 파라(설포닐)아릴 및 헤테로아릴
JP2004516237A (ja) 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのピペリジンアミド類
NZ533997A (en) * 2000-07-13 2005-11-25 Sankyo Co Amino alcohol derivatives
JP2002053575A (ja) 2000-08-09 2002-02-19 Sankyo Co Ltd アミノアルコ−ル類
AU8533101A (en) * 2000-08-31 2002-03-13 Merck & Co Inc Phosphate derivatives as immunoregulatory agents
DE10049483A1 (de) 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10048714A1 (de) 2000-09-30 2002-04-11 Gruenenthal Gmbh 5-Amino-1-penlen-3-ol-Derivate
CA2435739A1 (en) 2001-02-22 2002-09-06 Novartis Ag Use of accelerated lymphocyte homing agents for the manufacture of a medicament for the treatment of delayed graft function
US7326801B2 (en) * 2001-03-26 2008-02-05 Novartis Ag 2-amino-propanol derivatives
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
CN1236831C (zh) 2001-05-21 2006-01-18 茵捷特数码浮质有限公司 用于经肺部途径递送蛋白质的组合物
GB0117921D0 (en) 2001-07-23 2001-09-12 Novartis Ag Organic compounds
GB0119172D0 (en) 2001-08-06 2001-09-26 Melacure Therapeutics Ab Phenyl pyrrole derivatives
AU2002332289B2 (en) 2001-09-27 2007-05-10 Kyorin Pharmaceutical Co., Ltd. Diaryl sulfide derivative, addition salt thereof, and immunosuppressant
ATE463478T1 (de) 2001-09-27 2010-04-15 Kyorin Seiyaku Kk Diaryletherderivat, dessen additionssalz und immunosuppressivum
GB0125443D0 (en) 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
US7361671B2 (en) 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
MXPA04005428A (es) * 2001-12-06 2004-12-06 Elan Pharm Inc Hidroxietilaminas substituidas.
RU2330839C2 (ru) * 2002-01-11 2008-08-10 Санкио Компани, Лимитед Производные аминоспиртов или производные фосфорных кислот и фармацевтические композиции, содержащие указанные производные
JP4771511B2 (ja) 2003-07-08 2011-09-14 第一三共株式会社 アミノアルコ−ル誘導体又はホスホン酸誘導体を含有する医薬組成物
JP2003267974A (ja) 2002-01-11 2003-09-25 Sankyo Co Ltd アミノアルコ−ル誘導体を含有する医薬組成物
US20040058894A1 (en) 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
CA2483594C (en) 2002-05-16 2011-02-15 Novartis Ag Use of edg receptor binding agents in cancer
AU2003273865A1 (en) 2002-09-13 2004-04-30 Novartis Ag Amino-propanol derivatives
MXPA05003254A (es) 2002-09-24 2005-06-08 Novartis Ag Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion.
TWI355934B (en) * 2004-02-24 2012-01-11 Sankyo Co Pharmaceutical composition for treatment or prophy
TW200611687A (en) * 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
TWI418350B (zh) 2005-06-24 2013-12-11 Sankyo Co 含有ppar調節劑之醫藥組成物的用途

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SI1471054T1 (sl) 2009-12-31
CY1109457T1 (el) 2014-08-13
EP1471054A4 (de) 2005-06-08
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US20050043386A1 (en) 2005-02-24

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