SE447823B - Aminderivat av di-o-(hogre n-alkyl- och n-alkenyl-)glyceroler med antiviral aktivitet samt farmaceutisk komposition innehallande sadana derivat - Google Patents

Aminderivat av di-o-(hogre n-alkyl- och n-alkenyl-)glyceroler med antiviral aktivitet samt farmaceutisk komposition innehallande sadana derivat

Info

Publication number
SE447823B
SE447823B SE7808701A SE7808701A SE447823B SE 447823 B SE447823 B SE 447823B SE 7808701 A SE7808701 A SE 7808701A SE 7808701 A SE7808701 A SE 7808701A SE 447823 B SE447823 B SE 447823B
Authority
SE
Sweden
Prior art keywords
hexadecyl
glycerol
alkyl
carbon atoms
compound
Prior art date
Application number
SE7808701A
Other languages
English (en)
Swedish (sv)
Other versions
SE7808701L (sv
Inventor
Allen Richard Kraska
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7808701L publication Critical patent/SE7808701L/xx
Publication of SE447823B publication Critical patent/SE447823B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/15—Unsaturated ethers containing only non-aromatic carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/198—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE7808701A 1977-08-18 1978-08-16 Aminderivat av di-o-(hogre n-alkyl- och n-alkenyl-)glyceroler med antiviral aktivitet samt farmaceutisk komposition innehallande sadana derivat SE447823B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/825,535 US4166132A (en) 1977-08-18 1977-08-18 Antiviral amine derivatives of glycerol and propanediols

Publications (2)

Publication Number Publication Date
SE7808701L SE7808701L (sv) 1979-02-19
SE447823B true SE447823B (sv) 1986-12-15

Family

ID=25244254

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7808701A SE447823B (sv) 1977-08-18 1978-08-16 Aminderivat av di-o-(hogre n-alkyl- och n-alkenyl-)glyceroler med antiviral aktivitet samt farmaceutisk komposition innehallande sadana derivat
SE8401849A SE463456B (sv) 1977-08-18 1984-04-03 Aminderivat av glycerol med antiviral verkan
SE8401850A SE8401850D0 (sv) 1977-08-18 1984-04-03 Aminderivat av glycerol med antiviral verkan

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE8401849A SE463456B (sv) 1977-08-18 1984-04-03 Aminderivat av glycerol med antiviral verkan
SE8401850A SE8401850D0 (sv) 1977-08-18 1984-04-03 Aminderivat av glycerol med antiviral verkan

Country Status (35)

Country Link
US (1) US4166132A (fr)
JP (3) JPS5829939B2 (fr)
AR (2) AR219543A1 (fr)
AT (1) AT363922B (fr)
AU (1) AU503079B1 (fr)
BE (1) BE869793A (fr)
CA (1) CA1102354A (fr)
CH (1) CH634544A5 (fr)
CS (1) CS208155B2 (fr)
DD (2) DD148951A5 (fr)
DE (3) DE2857416C2 (fr)
DK (1) DK149022C (fr)
EG (1) EG13438A (fr)
ES (3) ES472659A1 (fr)
FI (1) FI67687C (fr)
FR (2) FR2421871A1 (fr)
GB (1) GB2005248B (fr)
GR (1) GR73154B (fr)
HU (2) HU177884B (fr)
IE (1) IE47151B1 (fr)
IL (1) IL55370A (fr)
IN (1) IN148386B (fr)
IT (1) IT1098280B (fr)
LU (1) LU80114A1 (fr)
MX (1) MX6091E (fr)
NL (1) NL176670C (fr)
NO (3) NO147300C (fr)
NZ (1) NZ188174A (fr)
PH (4) PH16469A (fr)
PL (3) PL116119B1 (fr)
PT (1) PT68426A (fr)
SE (3) SE447823B (fr)
SU (3) SU893128A3 (fr)
YU (3) YU41115B (fr)
ZA (1) ZA783855B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173641A (en) * 1978-05-15 1979-11-06 Pfizer Inc. Di-O-n-alkyl glycerol derivatives as immune stimulants
US4255426A (en) * 1979-07-09 1981-03-10 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
YU41932B (en) * 1979-07-09 1988-02-29 Pfizer Process for obtaining substituted piperazines and piperidi
US4312877A (en) * 1979-07-09 1982-01-26 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted piperidines, pharmaceutical compositions, thereof and use thereof
EP0094586A3 (fr) * 1982-05-13 1984-06-06 Ono Pharmaceutical Co., Ltd. Dérivés de glycérol, procédé pour leur préparation et compositions pharmaceutiques les contenant
JPS5988447A (ja) * 1982-11-11 1984-05-22 Ono Pharmaceut Co Ltd グリセリン誘導体、その製造方法及びその誘導体を含有する薬剤
JPS60100544A (ja) * 1983-11-08 1985-06-04 Ono Pharmaceut Co Ltd 新規なグリセリン誘導体，その製造方法及びその誘導体を含有する薬剤
JPS60104066A (ja) * 1983-11-10 1985-06-08 Ono Pharmaceut Co Ltd グリセリン誘導体
JPS60105650A (ja) * 1983-11-14 1985-06-11 Ono Pharmaceut Co Ltd グリセリン誘導体、その製造方法及びその誘導体を含有する薬剤
JPS6164353A (ja) * 1984-09-04 1986-04-02 川崎重工業株式会社 湿式ミルの運転方法
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5545412A (en) * 1985-01-07 1996-08-13 Syntex (U.S.A.) Inc. N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor
CA1291036C (fr) * 1986-04-23 1991-10-22 Edwin I. Stoltz Administration de medicaments par voie nasale
US4751245A (en) * 1986-06-25 1988-06-14 E. R. Squibb & Sons, Inc. Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine and method of using same
JPS63166237U (fr) * 1987-04-16 1988-10-28
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
AU614636B2 (en) * 1988-07-21 1991-09-05 Ciba Specialty Chemicals Holding Inc. Corrosion inhibition
US5176850A (en) * 1988-07-21 1993-01-05 Ciba-Geigy Corporation Substituted glycerol compounds
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
JP2604268B2 (ja) * 1990-04-09 1997-04-30 富士写真フイルム株式会社 ペプチド誘導体両親媒性化合物、その中間体、ペプチド誘導体両親媒性化合物を用いたリポソームおよび薄膜
JPH0439597A (ja) * 1990-06-01 1992-02-10 Corona:Kk 給湯装置の熱交換器
DE19521412A1 (de) * 1995-06-14 1996-12-19 Boehringer Mannheim Gmbh Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung
DE19755268A1 (de) * 1997-12-12 1999-06-17 Merck Patent Gmbh Benzamidinderivate
GB0106041D0 (en) * 2001-03-12 2001-05-02 Cancer Res Ventures Ltd Lipids and liposomes
US7622541B2 (en) * 2003-01-17 2009-11-24 The United States Of America As Represented By The Secretary Of The Navy Polyurethane coating
US7615604B2 (en) * 2003-01-17 2009-11-10 The United States Of America As Represented By The Secretary Of The Navy Diols formed by ring-opening of epoxies
WO2009129387A2 (fr) * 2008-04-16 2009-10-22 Abbott Laboratories Lipides cationiques et utilisations associees
WO2009129395A1 (fr) * 2008-04-16 2009-10-22 Abbott Laboratories Lipides cationiques et utilisations de ceux-ci
WO2009129385A1 (fr) * 2008-04-16 2009-10-22 Abbott Laboratories Lipides cationiques et utilisations de ceux-ci
US8999960B2 (en) 2008-10-08 2015-04-07 Vascular Biogenics Ltd. Oxidized thiophospholipid compounds and uses thereof
JP5752599B2 (ja) 2008-11-06 2015-07-22 ヴァスキュラー バイオジェニックス リミテッド 酸化脂質化合物およびその使用
AU2010334911A1 (en) 2009-12-23 2012-07-12 Novartis Ag Lipids, lipid compositions, and methods of using them
EP3169309B1 (fr) 2014-07-16 2023-05-10 Novartis AG Procédé d'encapsulation d'un acide nucléique dans une nanoparticule lipidique hôte
ES2855299T3 (es) 2014-11-26 2021-09-23 Vascular Biogenics Ltd Lípidos oxidados y tratamiento o prevención de la fibrosis
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738351A (en) * 1952-08-02 1956-03-13 Bristol Lab Inc Substituted glycerol ethers
GB1013603A (en) * 1961-06-08 1965-12-15 Sandoz Ltd Level-dyeing process
GB1369249A (en) * 1970-08-07 1974-10-02 Pfizer Amines the preparation thereof and their use in pharmaceutical compositions
US3960958A (en) * 1974-08-26 1976-06-01 Pfizer Inc. 3,4- AND 3,5-Dialkoxybenzylamines
US4025555A (en) * 1976-07-23 1977-05-24 Pfizer Inc. Aromatic amidines as antiviral agents in animals

Also Published As

Publication number Publication date
CH634544A5 (fr) 1983-02-15
ES479615A1 (es) 1979-08-01
NO147300B (no) 1982-12-06
AT363922B (de) 1981-09-10
AR218733A1 (es) 1980-06-30
IT7826813A0 (it) 1978-08-17
NO147300C (no) 1983-03-16
SE8401850L (sv) 1984-04-03
YU262982A (en) 1983-04-30
SU893128A3 (ru) 1981-12-23
YU41115B (en) 1986-12-31
GR73154B (fr) 1984-02-13
SE8401850D0 (sv) 1984-04-03
NL7808565A (nl) 1979-02-20
PT68426A (en) 1978-09-01
FI782518A7 (fi) 1979-02-19
YU197478A (en) 1983-02-28
NO782791L (no) 1979-02-20
PH18111A (en) 1985-03-22
PH16469A (en) 1983-10-21
GB2005248B (en) 1982-03-24
ES472659A1 (es) 1979-10-16
DE2857416C2 (de) 1984-05-24
US4166132A (en) 1979-08-28
FR2421871B1 (fr) 1982-07-02
FI67687B (fi) 1985-01-31
DD148951A5 (de) 1981-06-17
AR219543A1 (es) 1980-08-29
IN148386B (fr) 1981-02-07
JPS5929582B2 (ja) 1984-07-21
SU850005A3 (ru) 1981-07-23
SE7808701L (sv) 1979-02-19
YU263082A (en) 1983-04-30
HU181238B (en) 1983-06-28
NO154344B (no) 1986-05-26
PL209092A1 (pl) 1979-06-04
DE2835369A1 (de) 1979-02-22
NO147670B (no) 1983-02-14
SE8401849L (sv) 1984-04-03
NO154344C (no) 1986-09-03
NO147670C (no) 1983-05-25
NO813324L (no) 1979-02-20
PL115777B1 (en) 1981-04-30
YU41276B (en) 1986-12-31
SE8401849D0 (sv) 1984-04-03
JPS57167913A (en) 1982-10-16
DE2835369C2 (de) 1982-12-02
CS208155B2 (en) 1981-08-31
IL55370A0 (en) 1978-10-31
IL55370A (en) 1981-11-30
NO813325L (no) 1979-02-20
DK149022C (da) 1986-10-13
ZA783855B (en) 1979-07-25
BE869793A (fr) 1979-02-19
JPS5924144B2 (ja) 1984-06-07
MX6091E (es) 1984-11-12
DE2857415C2 (de) 1985-02-07
FR2414038A1 (fr) 1979-08-03
PL116119B1 (en) 1981-05-30
GB2005248A (en) 1979-04-19
IE47151B1 (en) 1983-12-28
FR2421871A1 (fr) 1979-11-02
IT1098280B (it) 1985-09-07
JPS5829939B2 (ja) 1983-06-25
CA1102354A (fr) 1981-06-02
AU503079B1 (en) 1979-08-23
ATA600278A (de) 1981-02-15
LU80114A1 (fr) 1980-04-21
PH17789A (en) 1984-12-13
DD143902A5 (de) 1980-09-17
PH18067A (en) 1985-03-18
IE781658L (en) 1979-02-18
NL176670B (nl) 1984-12-17
ES479616A1 (es) 1979-08-01
DK149022B (da) 1985-12-23
EG13438A (en) 1981-12-31
YU41277B (en) 1986-12-31
SU906363A3 (ru) 1982-02-15
PL116434B1 (en) 1981-06-30
FI67687C (fi) 1985-05-10
JPS57167966A (en) 1982-10-16
NL176670C (nl) 1985-05-17
SE463456B (sv) 1990-11-26
DK321478A (da) 1979-02-19
HU177884B (en) 1982-01-28
NZ188174A (en) 1984-07-31
JPS5441807A (en) 1979-04-03
FR2414038B1 (fr) 1982-07-02

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