ZA894639B - Propeptides - Google Patents

Propeptides

Info

Publication number: ZA894639B
Authority: ZA; South Africa
Prior art keywords: amino acid; insulin; acid residues; precursors; chain
Prior art date: 1988-06-20

Application number

ZA894639A

Other languages

English (en)

Inventor

Ib Jonassen

Jonassen Ib

Ib Groth Clausen

Groth Clausen Ib

Ejner Bech Jensen

Bech Jensen Ejner

Allan Svendsen

Svendsen Allan

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-20

Filing date

1989-06-19

Publication date

1991-12-24

1989-06-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1991-12-24 Publication of ZA894639B publication Critical patent/ZA894639B/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 9
125000000539 amino acid group Chemical group 0.000 abstract 5
102000004877 Insulin Human genes 0.000 abstract 4
108090001061 Insulin Proteins 0.000 abstract 4
229940125396 insulin Drugs 0.000 abstract 4
239000002243 precursor Substances 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

ZA894639A 1988-06-20 1989-06-19 Propeptides ZA894639B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK336188A DK336188D0 (da)	1988-06-20	1988-06-20	Propeptider

Publications (1)

Publication Number	Publication Date
ZA894639B true ZA894639B (en)	1991-12-24

Family

ID=8122004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA894639A ZA894639B (en)	1988-06-20	1989-06-19	Propeptides

Country Status (17)

Country	Link
US (2)	US5202415A (fr)
EP (1)	EP0347845B1 (fr)
JP (1)	JP2766999B2 (fr)
KR (1)	KR0140238B1 (fr)
AT (1)	ATE93239T1 (fr)
AU (1)	AU618612B2 (fr)
CA (1)	CA1337976C (fr)
DE (1)	DE68908491T2 (fr)
DK (1)	DK336188D0 (fr)
ES (1)	ES2059627T3 (fr)
FI (1)	FI102294B (fr)
IE (1)	IE64303B1 (fr)
NO (1)	NO177499C (fr)
NZ (1)	NZ229615A (fr)
PT (1)	PT90897B (fr)
WO (1)	WO1989012647A1 (fr)
ZA (1)	ZA894639B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
DK72793D0 (da) *	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
KR100253916B1 (ko) *	1997-12-29	2000-05-01	김충환	사람 인슐린 전구체의 제조방법
US7169889B1 (en)	1999-06-19	2007-01-30	Biocon Limited	Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6777207B2 (en)	1999-12-29	2004-08-17	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
CA2392844A1 (fr)	1999-12-29	2001-07-12	Novo Nordisk A/S	Procede de fabrication de precurseurs d'insuline et analogues des precurseurs d'insuline presentant un meilleur rendement de fermentation dans la levure
US7378390B2 (en)	1999-12-29	2008-05-27	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US6521738B2 (en)	1999-12-29	2003-02-18	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
KR100449454B1 (ko) *	2000-10-02	2004-09-21	이현철	단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
CN1406131A (zh) *	2000-12-25	2003-03-26	株式会社资生堂	活化交感神经的香料组合物
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
US6867183B2 (en) *	2001-02-15	2005-03-15	Nobex Corporation	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
ATE443082T1 (de) *	2001-04-02	2009-10-15	Novo Nordisk As	Insulinvorstufen und verfahren zu deren herstellung
WO2002079251A2 (fr) *	2001-04-02	2002-10-10	Novo Nordisk A/S	Methode de fabrication de precurseurs d'insuline humaine
US7105314B2 (en)	2001-04-02	2006-09-12	Novo Nordisk A/S	Method for making human insulin precursors
US6858580B2 (en) *	2001-06-04	2005-02-22	Nobex Corporation	Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) *	2001-06-04	2010-05-11	Biocon Limited	Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) *	2001-06-04	2004-03-30	Nobex Corporation	Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en)	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) *	2001-06-04	2004-12-28	Nobex Corporation	Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US20030040601A1 (en) *	2001-06-08	2003-02-27	Ivan Diers	Method for making insulin precursors and insulin analog precursors
WO2002100887A2 (fr) *	2001-06-08	2002-12-19	Novo Nordisk A/S	Methode de production de precurseurs de l'insuline et d'analogues des precurseurs de l'insuline
US7196059B2 (en) *	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) *	2001-09-07	2007-01-23	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
AU2003236521A1 (en) *	2002-06-13	2003-12-31	Nobex Corporation	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
WO2004085472A1 (fr) *	2003-03-27	2004-10-07	Novo Nordisk A/S	Procede de fabrication de precurseurs de l'insuline humaine et insuline humaine
ATE405660T1 (de)	2003-06-17	2008-09-15	Sembiosys Genetics Inc	Verfahren zur insulinproduktion in pflanzen
CN103223160B (zh) *	2004-07-19	2015-02-18	比奥孔有限公司	胰岛素-低聚物共轭物,制剂及其用途
HUE029512T2 (en)	2006-09-22	2017-03-28	Novo Nordisk As	Protease Resistant Insulin Analogs
US9241908B2 (en) *	2007-10-16	2016-01-26	Biocon Limited	Orally administrable solid pharmaceutical composition and a process thereof
PT2612677E (pt)	2009-06-26	2015-09-10	Novo Nordisk As	Preparação compreendendo insulina, nicotinamida e arginina
US20130331320A1 (en)	2010-12-14	2013-12-12	Novo Nordisk A/S	Fast-acting insulin in combination with long-acting insulin
CA2821613A1 (fr)	2010-12-14	2012-06-21	Novo Nordisk A/S	Preparation comportant de l'insuline, du nicotinamide et un acide amine
WO2013186138A1 (fr)	2012-06-14	2013-12-19	Novo Nordisk A/S	Préparation comprenant de l'insuline, du nicotinamide et de l'arginine
AU2020418207A1 (en)	2019-12-30	2022-08-25	Gan & Lee Pharmaceuticals Co., Ltd.	Long-acting GLP-1 compound
CN118420744A (zh)	2019-12-30	2024-08-02	甘李药业股份有限公司	胰岛素衍生物
US20250340610A1 (en)	2022-01-28	2025-11-06	Gan & Lee Pharmaceuticals Co., Ltd.	Acylated insulin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ196609A (en) *	1980-03-27	1984-02-03	Lilly Co Eli	Preparation of proinsulin-like insulin precursors
US4430266A (en) *	1980-11-28	1984-02-07	Eli Lilly And Company	Process for producing an insulin precursor
US5015575A (en) *	1983-04-07	1991-05-14	Chiron Corporation	Hybrid DNA synthesis of insulin
DE3327928A1 (de) *	1983-08-03	1985-02-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
DK347086D0 (da) *	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
KR900701842A (ko) *	1988-07-20	1990-12-04	헨리 브뢰늄	인간 인슐린 동족체와 그를 포함하는 제제
AU641631B2 (en) *	1988-12-23	1993-09-30	Novo Nordisk A/S	Human insulin analogues

1988
- 1988-06-20 DK DK336188A patent/DK336188D0/da not_active Application Discontinuation
1989
- 1989-06-19 WO PCT/DK1989/000152 patent/WO1989012647A1/fr not_active Ceased
- 1989-06-19 CA CA000603208A patent/CA1337976C/fr not_active Expired - Fee Related
- 1989-06-19 ZA ZA894639A patent/ZA894639B/xx unknown
- 1989-06-19 PT PT90897A patent/PT90897B/pt not_active IP Right Cessation
- 1989-06-19 US US07/623,739 patent/US5202415A/en not_active Expired - Lifetime
- 1989-06-19 AU AU38600/89A patent/AU618612B2/en not_active Ceased
- 1989-06-19 JP JP1507202A patent/JP2766999B2/ja not_active Expired - Fee Related
- 1989-06-19 IE IE197689A patent/IE64303B1/en not_active IP Right Cessation
- 1989-06-20 EP EP89111221A patent/EP0347845B1/fr not_active Expired - Lifetime
- 1989-06-20 DE DE89111221T patent/DE68908491T2/de not_active Expired - Lifetime
- 1989-06-20 ES ES89111221T patent/ES2059627T3/es not_active Expired - Lifetime
- 1989-06-20 NZ NZ229615A patent/NZ229615A/en unknown
- 1989-06-20 AT AT89111221T patent/ATE93239T1/de not_active IP Right Cessation
1990
- 1990-02-20 KR KR90700348A patent/KR0140238B1/ko not_active Expired - Fee Related
- 1990-12-19 FI FI906285A patent/FI102294B/fi not_active IP Right Cessation
- 1990-12-19 NO NO905470A patent/NO177499C/no unknown
1992
- 1992-09-23 US US07/952,696 patent/US5324641A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU618612B2 (en)	1992-01-02
CA1337976C (fr)	1996-01-23
FI102294B1 (fi)	1998-11-13
FI102294B (fi)	1998-11-13
US5324641A (en)	1994-06-28
EP0347845A2 (fr)	1989-12-27
FI906285A0 (fi)	1990-12-19
NO905470D0 (no)	1990-12-19
NO177499B (no)	1995-06-19
AU3860089A (en)	1990-01-12
US5202415A (en)	1993-04-13
DK336188D0 (da)	1988-06-20
IE891976L (en)	1989-12-20
NO905470L (no)	1991-02-18
WO1989012647A1 (fr)	1989-12-28
DE68908491D1 (de)	1993-09-23
ES2059627T3 (es)	1994-11-16
PT90897A (pt)	1989-12-29
KR900701841A (ko)	1990-12-04
PT90897B (pt)	1995-03-31
IE64303B1 (en)	1995-07-26
JP2766999B2 (ja)	1998-06-18
EP0347845A3 (fr)	1991-07-03
NZ229615A (en)	1991-03-26
ATE93239T1 (de)	1993-09-15
NO177499C (no)	1995-09-27
DE68908491T2 (de)	1994-01-20
JPH03505206A (ja)	1991-11-14
KR0140238B1 (en)	1998-07-01
EP0347845B1 (fr)	1993-08-18

Publication	Publication Date	Title
IE891976L (en)	1989-12-20	Propeptides
DK323687A (da)	1987-06-25	Insulinprecursorer og fremgangsmaade til fremstilling deraf
SG49097A1 (en)	1998-05-18	Nucleotide sequences coding for a protein with urease activity
AU3255497A (en)	1998-02-02	Method for the production of polypeptides
AU7565991A (en)	1991-11-27	Variant cd44 surface proteins, dna sequences coding them, antibodies against these proteins and their use in diagnosis and therapy
AU4683489A (en)	1990-06-21	Tgf-beta 1/beta 2: a novel chimeric transforming growth factor-beta
DE60233722D1 (de)	2009-10-29	Insulinvorstufen und verfahren zu deren herstellung
DK301090A (da)	1990-12-19	Insulinprecursorer
NZ232178A (en)	1991-10-25	Preparation of insulin precursor
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf
IL89896A0 (en)	1989-12-15	Protein antibiotic kedarcidin,its production and pharmaceutical compositions containing it