BR112012000968B8 - composto, composição e método para inibir uma fosfatidil inositol-3 cinase. - Google Patents

composto, composição e método para inibir uma fosfatidil inositol-3 cinase.

Info

Publication number
BR112012000968B8
BR112012000968B8 BR112012000968A BR112012000968A BR112012000968B8 BR 112012000968 B8 BR112012000968 B8 BR 112012000968B8 BR 112012000968 A BR112012000968 A BR 112012000968A BR 112012000968 A BR112012000968 A BR 112012000968A BR 112012000968 B8 BR112012000968 B8 BR 112012000968B8
Authority
BR
Brazil
Prior art keywords
kinase
inhibiting
compound
composition
phosphatidyl inositol
Prior art date
Application number
BR112012000968A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112012000968A2 (pt
BR112012000968B1 (pt
BR112012000968A8 (pt
Inventor
Rommel Christian
Chan Katrina
Li Liansheng
Ren Pingda
Edward Wilson Troy
Liu Yi
Original Assignee
Intellikine Inc
Intellikine Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellikine Inc, Intellikine Llc filed Critical Intellikine Inc
Publication of BR112012000968A2 publication Critical patent/BR112012000968A2/pt
Publication of BR112012000968A8 publication Critical patent/BR112012000968A8/pt
Publication of BR112012000968B1 publication Critical patent/BR112012000968B1/pt
Publication of BR112012000968B8 publication Critical patent/BR112012000968B8/pt

Links

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
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    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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BR112012000968A 2009-07-15 2010-07-15 composto, composição e método para inibir uma fosfatidil inositol-3 cinase. BR112012000968B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/503,776 US8193182B2 (en) 2008-01-04 2009-07-15 Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US12/503,776 2009-07-15
PCT/US2010/002020 WO2011008302A1 (en) 2009-07-15 2010-07-15 Certain chemical entities, compositions and methods

Publications (4)

Publication Number Publication Date
BR112012000968A2 BR112012000968A2 (pt) 2017-12-05
BR112012000968A8 BR112012000968A8 (pt) 2017-12-26
BR112012000968B1 BR112012000968B1 (pt) 2021-05-04
BR112012000968B8 true BR112012000968B8 (pt) 2021-05-25

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BR112012000968A BR112012000968B8 (pt) 2009-07-15 2010-07-15 composto, composição e método para inibir uma fosfatidil inositol-3 cinase.

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US (13) US8193182B2 (2)
EP (4) EP3150609B1 (2)
JP (2) JP5944313B2 (2)
KR (1) KR101680406B1 (2)
CN (3) CN109912599B (2)
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CA (1) CA2768307C (2)
CY (2) CY1116424T1 (2)
DK (1) DK2456444T3 (2)
ES (1) ES2538853T3 (2)
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