DK1268424T3 - Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte - Google Patents

Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte

Info

Publication number: DK1268424T3
Authority: DK; Denmark
Prior art keywords: perindopril; synthesis; pharmaceutically acceptable; acceptable salts; salts
Prior art date: 2000-04-06

Application number

DK01921486T

Other languages

Danish (da)

English (en)

Inventor

Pascal Langlois

Hugues Turbe

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-06

Filing date

2001-04-05

Publication date

2007-12-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8848925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1268424(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-04-05 Application filed by Servier Lab filed Critical Servier Lab

2007-12-17 Application granted granted Critical

2007-12-17 Publication of DK1268424T3 publication Critical patent/DK1268424T3/da

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
229960002582 perindopril Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK01921486T 2000-04-06 2001-04-05 Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte DK1268424T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0004379A FR2807431B1 (fr)	2000-04-06	2000-04-06	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2001/001026 WO2001058868A1 (fr)	2000-04-06	2001-04-05	Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number	Publication Date
DK1268424T3 true DK1268424T3 (da)	2007-12-17

Family

ID=8848925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01921486T DK1268424T3 (da)	2000-04-06	2001-04-05	Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte

Country Status (34)

Country	Link
US (1)	US6835843B2 (pt)
EP (1)	EP1268424B1 (pt)
JP (1)	JP3939553B2 (pt)
KR (1)	KR100507616B1 (pt)
CN (1)	CN1296355C (pt)
AP (1)	AP1385A (pt)
AT (1)	ATE369338T1 (pt)
AU (2)	AU4847001A (pt)
BG (1)	BG65984B1 (pt)
BR (1)	BRPI0109836B1 (pt)
CA (1)	CA2405486C (pt)
CY (1)	CY1108522T1 (pt)
CZ (1)	CZ302575B6 (pt)
DE (1)	DE60129800T2 (pt)
DK (1)	DK1268424T3 (pt)
EA (1)	EA005079B1 (pt)
EE (1)	EE05032B1 (pt)
ES (1)	ES2291307T3 (pt)
FR (1)	FR2807431B1 (pt)
GE (1)	GEP20063797B (pt)
HR (1)	HRP20020876B1 (pt)
HU (1)	HU227674B1 (pt)
ME (1)	ME00441B (pt)
MX (1)	MXPA02009706A (pt)
NO (1)	NO324174B1 (pt)
NZ (1)	NZ521454A (pt)
OA (1)	OA12242A (pt)
PL (1)	PL204471B1 (pt)
PT (1)	PT1268424E (pt)
RS (1)	RS50808B (pt)
SK (1)	SK286921B6 (pt)
UA (1)	UA75070C2 (pt)
WO (1)	WO2001058868A1 (pt)
ZA (1)	ZA200207419B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827860B1 (fr)	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
SI1333026T1 (sl) *	2002-01-30	2007-10-31	Servier Lab	Postopek priprave perindoprila visoke äśistoäśe in intermediatov uporabnih v sintezi
JP2005256847A (ja) *	2002-02-28	2005-09-22	Nsk Ltd	車輪用軸受ユニット
GB2395195A (en)	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
WO2004075889A1 (en)	2003-02-28	2004-09-10	Lupin Limited	Process for preparation of perindopril and salts thereof
DK1338591T3 (da) *	2003-02-28	2006-01-23	Servier Lab	Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
DE60301774T2 (de) *	2003-02-28	2006-07-20	Les Laboratoires Servier	Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
DE60301930T2 (de) *	2003-02-28	2006-07-27	Les Laboratoires Servier	Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
EP1321471B1 (fr) *	2003-03-12	2005-05-04	Les Laboratoires Servier	Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
SI1323729T1 (en) *	2003-03-12	2005-02-28	Les Laboratoires Servier	Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
ES2231760T3 (es) *	2003-03-12	2005-05-16	Les Laboratoires Servier	Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
WO2004099138A2 (en) *	2003-05-12	2004-11-18	Cipla Limited	Process for the preparation of perindopril
WO2004113293A1 (de)	2003-06-24	2004-12-29	Les Laboratoires Servier	Neue kristalline formen von perindopril erbumine
ES2271498T3 (es) *	2003-07-31	2007-04-16	Les Laboratoires Servier	Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
SI1367062T1 (sl) *	2003-07-31	2006-12-31	Servier Lab	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
BR0318561A (pt) *	2003-10-21	2006-10-10	Lupin Ltd	processo seletivo para a preparação de erbumino perindopril cristalino
DK1420029T3 (da) *	2003-12-10	2008-06-16	Servier Lab	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
LT1729739T (lt) *	2004-03-29	2016-11-10	Les Laboratoires Servier	Kietos farmacinės kompozicijos gamybos būdas
GB2413128A (en) *	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
ES2255872B1 (es) *	2004-12-31	2007-08-16	Quimica Sintetica, S.A.	Procedimiento para la preparacion de perindopril erbumina.
DE602005009918D1 (de)	2005-01-06	2008-11-06	Ipca Lab Ltd	Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
US7291745B2 (en) *	2005-03-21	2007-11-06	Glenmark Pharmaceuticals Limited	Process for the preparation of perindopril
JP2006290825A (ja) *	2005-04-13	2006-10-26	Shiono Chemical Co Ltd	アルファ型ペリンドプリルエルブミンの製造法
DE102005058166A1 (de) *	2005-12-05	2007-06-06	Hexal Ag	Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren
WO2007085933A2 (en) *	2006-01-25	2007-08-02	Glenmark Pharmaceuticals Limited	Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
WO2008114270A1 (en) *	2007-03-22	2008-09-25	Aarti Healthcare Limited	Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
FR2961105B1 (fr) *	2010-06-15	2013-02-08	Servier Lab	Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
ES2670854T3 (es) *	2012-10-10	2018-06-01	Piramal Enterprises Limited	Un proceso mejorado para la preparación de perindoprilo intermedio
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN107098949B (zh) *	2017-04-20	2021-03-16	上药东英（江苏）药业有限公司	一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3302125A1 (de) *	1983-01-22	1984-07-26	Boehringer Ingelheim KG, 6507 Ingelheim	Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

2000
- 2000-04-06 FR FR0004379A patent/FR2807431B1/fr not_active Expired - Fee Related
2001
- 2001-03-20 PL PL346555A patent/PL204471B1/pl unknown
- 2001-03-30 HU HU0101336A patent/HU227674B1/hu not_active IP Right Cessation
- 2001-04-05 CA CA002405486A patent/CA2405486C/fr not_active Expired - Fee Related
- 2001-04-05 GE GEAP20016679A patent/GEP20063797B/en unknown
- 2001-04-05 EE EEP200200575A patent/EE05032B1/xx not_active IP Right Cessation
- 2001-04-05 RS YUP-738/02A patent/RS50808B/sr unknown
- 2001-04-05 HR HR20020876A patent/HRP20020876B1/xx not_active IP Right Cessation
- 2001-04-05 CN CNB018073727A patent/CN1296355C/zh not_active Expired - Fee Related
- 2001-04-05 US US10/239,129 patent/US6835843B2/en not_active Expired - Lifetime
- 2001-04-05 SK SK1418-2002A patent/SK286921B6/sk not_active IP Right Cessation
- 2001-04-05 EA EA200201057A patent/EA005079B1/ru not_active IP Right Cessation
- 2001-04-05 OA OA1200200306A patent/OA12242A/en unknown
- 2001-04-05 AT AT01921486T patent/ATE369338T1/de active
- 2001-04-05 DK DK01921486T patent/DK1268424T3/da active
- 2001-04-05 AP APAP/P/2002/002630A patent/AP1385A/en active
- 2001-04-05 DE DE60129800T patent/DE60129800T2/de not_active Expired - Lifetime
- 2001-04-05 JP JP2001558419A patent/JP3939553B2/ja not_active Expired - Fee Related
- 2001-04-05 ES ES01921486T patent/ES2291307T3/es not_active Expired - Lifetime
- 2001-04-05 PT PT01921486T patent/PT1268424E/pt unknown
- 2001-04-05 EP EP01921486A patent/EP1268424B1/fr not_active Expired - Lifetime
- 2001-04-05 KR KR10-2002-7013376A patent/KR100507616B1/ko not_active Expired - Fee Related
- 2001-04-05 BR BRPI0109836-5A patent/BRPI0109836B1/pt not_active IP Right Cessation
- 2001-04-05 WO PCT/FR2001/001026 patent/WO2001058868A1/fr not_active Ceased
- 2001-04-05 CZ CZ20023291A patent/CZ302575B6/cs not_active IP Right Cessation
- 2001-04-05 NZ NZ52145401A patent/NZ521454A/en not_active IP Right Cessation
- 2001-04-05 ME MEP-2008-670A patent/ME00441B/me unknown
- 2001-04-05 AU AU4847001A patent/AU4847001A/xx active Pending
- 2001-04-05 MX MXPA02009706A patent/MXPA02009706A/es active IP Right Grant
- 2001-04-05 AU AU2001248470A patent/AU2001248470B2/en not_active Ceased
- 2001-05-04 UA UA2002118786A patent/UA75070C2/uk unknown
2002
- 2002-09-16 ZA ZA200207419A patent/ZA200207419B/en unknown
- 2002-10-04 NO NO20024808A patent/NO324174B1/no not_active IP Right Cessation
- 2002-11-04 BG BG107249A patent/BG65984B1/bg unknown
2007
- 2007-10-16 CY CY20071101338T patent/CY1108522T1/el unknown

Also Published As

Publication number	Publication date
CA2405486C (fr)	2008-07-29
OA12242A (en)	2003-12-08
BG107249A (bg)	2003-07-31
KR20030013381A (ko)	2003-02-14
EP1268424B1 (fr)	2007-08-08
HU227674B1 (hu)	2011-11-28
HUP0101336A3 (en)	2003-03-28
NO20024808L (no)	2002-10-04
BG65984B1 (bg)	2010-08-31
NO20024808D0 (no)	2002-10-04
CZ302575B6 (cs)	2011-07-20
PL204471B1 (pl)	2010-01-29
US6835843B2 (en)	2004-12-28
EE05032B1 (et)	2008-06-16
ME00441B (me)	2011-10-10
EP1268424A1 (fr)	2003-01-02
AU2001248470B2 (en)	2005-01-20
PT1268424E (pt)	2007-10-16
FR2807431A1 (fr)	2001-10-12
DE60129800D1 (de)	2007-09-20
AP1385A (en)	2005-04-08
PL346555A1 (en)	2001-09-10
NO324174B1 (no)	2007-09-03
SK14182002A3 (sk)	2003-02-04
MXPA02009706A (es)	2004-09-06
ZA200207419B (en)	2003-09-16
AU4847001A (en)	2001-08-20
GEP20063797B (en)	2006-04-25
CN1420867A (zh)	2003-05-28
EA200201057A1 (ru)	2003-06-26
HRP20020876A2 (en)	2004-02-29
US20030069431A1 (en)	2003-04-10
HUP0101336A2 (hu)	2002-02-28
HRP20020876B1 (en)	2010-10-31
JP2003531825A (ja)	2003-10-28
CN1296355C (zh)	2007-01-24
EA005079B1 (ru)	2004-10-28
ATE369338T1 (de)	2007-08-15
AP2002002630A0 (en)	2002-09-30
BRPI0109836B1 (pt)	2015-08-04
WO2001058868A1 (fr)	2001-08-16
YU73802A (sh)	2006-01-16
FR2807431B1 (fr)	2002-07-19
EE200200575A (et)	2004-04-15
NZ521454A (en)	2004-03-26
CA2405486A1 (fr)	2001-08-16
RS50808B (sr)	2010-08-31
KR100507616B1 (ko)	2005-08-10
SK286921B6 (sk)	2009-07-06
HK1053309A1 (en)	2003-10-17
UA75070C2 (uk)	2006-03-15
CZ20023291A3 (cs)	2003-02-12
HU0101336D0 (en)	2001-06-28
BR0109836A (pt)	2003-06-24
DE60129800T2 (de)	2008-06-05
ES2291307T3 (es)	2008-03-01
JP3939553B2 (ja)	2007-07-04
CY1108522T1 (el)	2014-04-09

Publication	Publication Date	Title
DK1268424T3 (da)	2007-12-17	Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte
DK1144395T3 (da)	2005-08-15	2-amino-benzoxazinon-derivater til behandling af fedme
IS5720A (is)	2000-11-21	Latar gegn peptídýli af VLA-4 skilyrtri frumutengingu gagnlegir til meðhöndlunar á bólguvaldandi-, sjálfónæmis, og öndunarsjúkdómum
DK1165510T3 (da)	2006-02-06	1-arensulfonyl-2-aryl-pyrrolidin- og -piperidinderivater til behandling af CNS-lidelser
NO20040278L (no)	2004-01-21	Fremgangsmate for fremstilling av perindopril
DK1367061T3 (da)	2006-05-15	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1420028T3 (da)	2007-06-18	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ZA200510324B (en)	2007-03-28	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
DK1371659T3 (da)	2005-11-21	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ITMI20000026A0 (it)	2000-01-13	Procedimento per la produzione di gas di sintesi
DK1468996T3 (da)	2008-01-07	Indolderivater til behandling af CNS-sygdomme
DK1321471T3 (da)	2005-08-29	Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
DK1420029T3 (da)	2008-06-16	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1380591T3 (da)	2006-01-23	Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
DK1380590T3 (da)	2007-01-08	Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1403275T3 (da)	2005-12-05	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1265856T3 (da)	2004-07-05	Hidtil ukendt fremgangsmåde til fremstillingen af alpha-(2,4-disulfophenyl)-N-tert-butylnitron og farmaceutisk acceptable salte deraf
NO20030127D0 (no)	2003-01-10	Indolderivater nyttige for behandling av CNS-forstyrrelser
DK1367063T3 (da)	2006-12-27	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
NO20014077L (no)	2001-10-24	Fremgangsmåte for krystallisering av N-(4-trifluormetylfenyl)- 5-metyl-isoksazol-4-karboksamid
NO20026029L (no)	2002-12-16	Indolderivater nyttige for behandlingen av CNS-forstyrrelser
DK1422236T3 (da)	2007-06-11	Syntesefremgangsmåde for perindopril og farmaceutisk acceptable salte heraf
DK1353906T3 (da)	2004-10-11	Fremgangsmåde til fremstilling af (3-cyano-1H-indol-7-yl)(4-(4-fluorphenetyl)piperazin-1-yl)-methanon og salte deraf
PL379625A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
DK1451177T3 (da)	2007-07-02	Substituerede 2-pyrrolidin-2-yl-1H-indol-derivater til behandling af migræne