DK176247B1 - Sirup indeholdende N-acetylcystein - Google Patents

Sirup indeholdende N-acetylcystein Download PDF

Info

Publication number: DK176247B1
Authority: DK; Denmark
Prior art keywords: sodium; nac; solution; syrup; water
Prior art date: 1992-12-02

Application number

DK199500614A

Other languages

Danish (da)

English (en)

Other versions

DK61495A (da

Inventor

Federico Stroppolo

Daniele Bonadeo

Alessandro Saudino

Annibale Gazzaniga

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-02

Filing date

1995-05-31

Publication date

2007-04-16

1995-05-31 Application filed by Zambon Spa filed Critical Zambon Spa

1995-05-31 Publication of DK61495A publication Critical patent/DK61495A/da

2007-04-16 Application granted granted Critical

2007-04-16 Publication of DK176247B1 publication Critical patent/DK176247B1/da

Links

239000006188 syrup Substances 0.000 title claims description 19
235000020357 syrup Nutrition 0.000 title claims description 19
229960004308 acetylcysteine Drugs 0.000 title claims description 5
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title description 23
239000000203 mixture Substances 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 9
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 9
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 9
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 9
239000003755 preservative agent Substances 0.000 claims description 8
239000003765 sweetening agent Substances 0.000 claims description 8
235000003599 food sweetener Nutrition 0.000 claims description 7
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 6
239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
239000000796 flavoring agent Substances 0.000 claims description 6
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
230000002335 preservative effect Effects 0.000 claims description 6
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 6
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 6
239000002562 thickening agent Substances 0.000 claims description 5
229940081974 saccharin Drugs 0.000 claims description 4
235000019204 saccharin Nutrition 0.000 claims description 4
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 4
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
235000010234 sodium benzoate Nutrition 0.000 claims description 4
239000004299 sodium benzoate Substances 0.000 claims description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical group [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 claims description 2
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
229960003415 propylparaben Drugs 0.000 claims description 2
235000013355 food flavoring agent Nutrition 0.000 claims 1
239000000243 solution Substances 0.000 description 20
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000000126 substance Substances 0.000 description 6
235000019634 flavors Nutrition 0.000 description 5
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 5
235000019645 odor Nutrition 0.000 description 4
239000012299 nitrogen atmosphere Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
244000018633 Prunus armeniaca Species 0.000 description 2
235000009827 Prunus armeniaca Nutrition 0.000 description 2
235000011034 Rubus glaucus Nutrition 0.000 description 2
244000235659 Rubus idaeus Species 0.000 description 2
235000009122 Rubus idaeus Nutrition 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
238000009835 boiling Methods 0.000 description 2
239000003814 drug Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
240000008790 Musa x paradisiaca Species 0.000 description 1
235000018290 Musa x paradisiaca Nutrition 0.000 description 1
VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000000470 constituent Substances 0.000 description 1
229940109275 cyclamate Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000008187 granular material Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
230000000510 mucolytic effect Effects 0.000 description 1
238000012856 packing Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
235000021309 simple sugar Nutrition 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229940037001 sodium edetate Drugs 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
235000019605 sweet taste sensations Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Jellies, Jams, And Syrups (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

DK199500614A 1992-12-02 1995-05-31 Sirup indeholdende N-acetylcystein DK176247B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
ITMI922758		1992-12-02
ITMI922758A IT1256616B (it)	1992-12-02	1992-12-02	Sciroppo contenente n-acetil-cisteina
PCT/EP1993/003280 WO1994012168A1 (en)	1992-12-02	1993-11-23	Syrup containing n-acetyl-cysteine
EP9303280		1993-11-23

Publications (2)

Publication Number	Publication Date
DK61495A DK61495A (da)	1995-05-31
DK176247B1 true DK176247B1 (da)	2007-04-16

Family

ID=11364395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK199500614A DK176247B1 (da)	1992-12-02	1995-05-31	Sirup indeholdende N-acetylcystein

Country Status (23)

Country	Link
JP (1)	JPH08503703A (de)
AT (1)	AT407113B (de)
AU (1)	AU667611B2 (de)
BE (1)	BE1006799A3 (de)
CA (1)	CA2150462C (de)
CH (1)	CH685371A5 (de)
CZ (1)	CZ282550B6 (de)
DE (2)	DE4396086T1 (de)
DK (1)	DK176247B1 (de)
ES (1)	ES2070806B1 (de)
FR (1)	FR2698545B1 (de)
GB (1)	GB2288977B (de)
HU (2)	HU221484B (de)
IT (1)	IT1256616B (de)
LU (1)	LU88618A1 (de)
MD (1)	MD1714G2 (de)
NL (1)	NL194957C (de)
NO (1)	NO314018B1 (de)
NZ (1)	NZ258544A (de)
RU (1)	RU2108777C1 (de)
SE (1)	SE520834C2 (de)
UA (1)	UA27142C2 (de)
WO (1)	WO1994012168A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0766557T3 (da) *	1994-06-23	2002-04-15	Procter & Gamble	Topiske præparater omfattende N-acetyl-L-cystein
JP4501024B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
JP4501023B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
US8148356B2 (en) *	2005-08-24	2012-04-03	Cumberland Pharmaceuticals, Inc.	Acetylcysteine composition and uses therefor
CN102233139B (zh) *	2010-04-21	2012-09-05	重庆健能医药开发有限公司	一种乙酰半胱氨酸泡腾片及其制备方法和应用
RU2611411C1 (ru) *	2016-01-11	2017-02-21	Общество с ограниченной ответственностью "Трейдсервис"	Диспергируемая в воде таблетка ацетилцистеина и способ ее изготовления

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB905197A (en) *	1960-01-01	1962-09-05	Lab Francais Chimiotherapie	Anti-viral compositions comprising 1-phenyl-2-amino-propane-1,3-diol derivatives
CA1239349A (en) *	1983-10-10	1988-07-19	Eberhard F. Gottwald	Pharmaceutical composition containing cimetidine
BE901885A (fr) *	1985-03-06	1985-07-01	Bruschettini Srl	Composition pharmaceutique sous forme de lotion ophtalmique et son procede de preparation.
CH666814A5 (it) *	1986-07-24	1988-08-31	Inpharzam Int Sa	Composizione farmaceutica idrosolubile contenente n-acetil-cisteina.
CH667590A5 (it) *	1986-07-24	1988-10-31	Inpharzam Int Sa	Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. .
US4861797A (en) *	1987-10-15	1989-08-29	Oratech Pharmaceutical Development Corporation	Liquid ibuprofen compositions and methods of making them
CH674940A5 (de) *	1988-05-05	1990-08-15	Ibsa Inst Biochimique Sa
IT1234194B (it) *	1988-05-31	1992-05-06	Magis Farmaceutici	Composizioni farmaceutiche in forma di sciroppo contenenti pentitoli quali agenti di veicolazione
ES2054089T3 (es) *	1988-11-10	1994-08-01	Ciba Geigy Ag	Formulaciones orales liquidas.
IT1231012B (it) *	1989-07-27	1991-11-08	Zambon Spa	Composizione farmaceutica per uso orale contenente nac.
IT1248998B (it) *	1990-06-26	1995-02-11	Iscofar Sas	Composizione di gomma da masticare per la prevenzione e il trattamento della placca dentaria
ATE125702T1 (de) *	1990-10-19	1995-08-15	Spirig Ag	Feste, schnell-lösliche arzneimittelzubereitung enthaltend s-(carboxymethyl)-l-cystein und/oder n-acetylcystein.

1992
- 1992-12-02 IT ITMI922758A patent/IT1256616B/it active IP Right Grant
1993
- 1993-11-23 AU AU56266/94A patent/AU667611B2/en not_active Expired
- 1993-11-23 MD MD96-0265A patent/MD1714G2/ro unknown
- 1993-11-23 WO PCT/EP1993/003280 patent/WO1994012168A1/en not_active Ceased
- 1993-11-23 ES ES09450021A patent/ES2070806B1/es not_active Expired - Fee Related
- 1993-11-23 DE DE4396086T patent/DE4396086T1/de active Pending
- 1993-11-23 UA UA95062994A patent/UA27142C2/uk unknown
- 1993-11-23 CA CA002150462A patent/CA2150462C/en not_active Expired - Lifetime
- 1993-11-23 CZ CZ951367A patent/CZ282550B6/cs not_active IP Right Cessation
- 1993-11-23 NL NL9320052A patent/NL194957C/nl not_active IP Right Cessation
- 1993-11-23 DE DE4396086A patent/DE4396086B3/de not_active Expired - Lifetime
- 1993-11-23 GB GB9509822A patent/GB2288977B/en not_active Expired - Lifetime
- 1993-11-23 NZ NZ258544A patent/NZ258544A/en not_active IP Right Cessation
- 1993-11-23 RU RU95114406A patent/RU2108777C1/ru active
- 1993-11-23 JP JP6512747A patent/JPH08503703A/ja active Pending
- 1993-11-23 HU HU9501586A patent/HU221484B/hu unknown
- 1993-11-23 CH CH2423/94A patent/CH685371A5/it not_active IP Right Cessation
- 1993-11-23 AT AT0906093A patent/AT407113B/de not_active IP Right Cessation
- 1993-12-01 BE BE9301326A patent/BE1006799A3/fr not_active IP Right Cessation
- 1993-12-02 FR FR9314443A patent/FR2698545B1/fr not_active Expired - Lifetime
1994
- 1994-05-24 LU LU88618A patent/LU88618A1/de unknown
1995
- 1995-05-31 DK DK199500614A patent/DK176247B1/da not_active IP Right Cessation
- 1995-06-01 SE SE9502001A patent/SE520834C2/sv not_active IP Right Cessation
- 1995-06-01 NO NO19952183A patent/NO314018B1/no not_active IP Right Cessation
- 1995-06-29 HU HU95P/P00579P patent/HU211912A9/hu unknown

Also Published As

Publication number	Publication date
SE520834C2 (sv)	2003-09-02
SE9502001L (sv)	1995-07-21
GB9509822D0 (en)	1995-07-19
HUT72668A (en)	1996-05-28
NO314018B1 (no)	2003-01-20
ATA906093A (de)	2000-05-15
GB2288977B (en)	1996-09-04
AT407113B (de)	2000-12-27
MD1714G2 (ro)	2002-03-31
SE9502001D0 (sv)	1995-06-01
IT1256616B (it)	1995-12-12
DE4396086T1 (de)	1995-12-07
BE1006799A3 (fr)	1994-12-13
ITMI922758A1 (it)	1994-06-02
HU211912A9 (en)	1996-01-29
FR2698545A1 (fr)	1994-06-03
NL194957B (nl)	2003-05-01
UA27142C2 (uk)	2000-02-28
RU2108777C1 (ru)	1998-04-20
HU9501586D0 (en)	1995-08-28
DK61495A (da)	1995-05-31
CH685371A5 (it)	1995-06-30
AU667611B2 (en)	1996-03-28
AU5626694A (en)	1994-06-22
NO952183L (no)	1995-06-01
DE4396086B3 (de)	2013-02-28
LU88618A1 (de)	1995-12-01
NO952183D0 (no)	1995-06-01
CZ282550B6 (cs)	1997-08-13
ES2070806B1 (es)	1996-01-01
ITMI922758A0 (it)	1992-12-02
GB2288977A (en)	1995-11-08
CZ136795A3 (en)	1995-11-15
NZ258544A (en)	1996-11-26
NL9320052A (nl)	1995-08-01
HU221484B (en)	2002-10-28
JPH08503703A (ja)	1996-04-23
CA2150462A1 (en)	1994-06-09
CA2150462C (en)	2005-04-19
ES2070806A1 (es)	1995-06-01
WO1994012168A1 (en)	1994-06-09
MD1714F2 (en)	2001-08-31
NL194957C (nl)	2003-09-02
FR2698545B1 (fr)	1995-08-04

Legal Events

Date	Code	Title	Description
2013-11-25	PUP	Patent expired	Expiry date: 20150531

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US5807894A (en)	1998-09-15	Syrup containing N-acetyl-cysteine
RU2108777C1 (ru)	1998-04-20	Лечебная композиция в виде сиропа
JPH0296526A (ja)	1990-04-09	粉粒状医薬製剤
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ZA200510098B (en)	2007-04-25	Pharmaceutical formulations comprising amoxicillin and clavulanate
USRE29359E (en)	1977-08-16	Bronchodilator expectorant composition containing theophylline and a guaiacol
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