CA2150462C - Syrup containing n-acetyl-cysteine - Google Patents

Syrup containing n-acetyl-cysteine Download PDF

Info

Publication number: CA2150462C
Authority: CA; Canada
Prior art keywords: nac; solution; sodium; syrup; agent
Prior art date: 1992-12-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002150462A

Other languages

English (en)

French (fr)

Other versions

CA2150462A1 (en

Inventor

Federico Stroppolo

Daniele Bonadeo

Alessandro Saudino

Annibale Gazzaniga

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Zambon SpA

Original Assignee

Zambon Group SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-02

Filing date

1993-11-23

Publication date

2005-04-19

1993-11-23 Application filed by Zambon Group SpA filed Critical Zambon Group SpA

1994-06-09 Publication of CA2150462A1 publication Critical patent/CA2150462A1/en

2005-04-19 Application granted granted Critical

2005-04-19 Publication of CA2150462C publication Critical patent/CA2150462C/en

2013-11-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000006188 syrup Substances 0.000 title claims abstract description 22
235000020357 syrup Nutrition 0.000 title claims abstract description 22
229960004308 acetylcysteine Drugs 0.000 title claims abstract description 7
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title abstract description 25
239000000796 flavoring agent Substances 0.000 claims abstract description 10
239000003755 preservative agent Substances 0.000 claims abstract description 10
239000003765 sweetening agent Substances 0.000 claims abstract description 9
235000003599 food sweetener Nutrition 0.000 claims abstract description 8
230000002335 preservative effect Effects 0.000 claims abstract description 8
239000002562 thickening agent Substances 0.000 claims abstract description 6
235000013355 food flavoring agent Nutrition 0.000 claims abstract description 5
239000000203 mixture Substances 0.000 claims description 25
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 7
229940037001 sodium edetate Drugs 0.000 claims description 5
229940081974 saccharin Drugs 0.000 claims description 4
235000019204 saccharin Nutrition 0.000 claims description 4
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 4
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
235000010234 sodium benzoate Nutrition 0.000 claims description 4
239000004299 sodium benzoate Substances 0.000 claims description 4
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 claims description 2
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
229960003415 propylparaben Drugs 0.000 claims description 2
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
239000000243 solution Substances 0.000 abstract description 21
239000007864 aqueous solution Substances 0.000 abstract description 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
235000019634 flavors Nutrition 0.000 description 5
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 5
239000000126 substance Substances 0.000 description 5
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 5
235000019629 palatability Nutrition 0.000 description 4
230000035943 smell Effects 0.000 description 4
239000008232 de-aerated water Substances 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
239000012299 nitrogen atmosphere Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
244000018633 Prunus armeniaca Species 0.000 description 2
235000009827 Prunus armeniaca Nutrition 0.000 description 2
235000011034 Rubus glaucus Nutrition 0.000 description 2
244000235659 Rubus idaeus Species 0.000 description 2
235000009122 Rubus idaeus Nutrition 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
238000009835 boiling Methods 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
239000008213 purified water Substances 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
240000008790 Musa x paradisiaca Species 0.000 description 1
235000018290 Musa x paradisiaca Nutrition 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
238000004500 asepsis Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004040 coloring Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000007423 decrease Effects 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
230000000510 mucolytic effect Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
235000021309 simple sugar Nutrition 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
235000019605 sweet taste sensations Nutrition 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Jellies, Jams, And Syrups (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

CA002150462A 1992-12-02 1993-11-23 Syrup containing n-acetyl-cysteine Expired - Lifetime CA2150462C (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI92A002758		1992-12-02
ITMI922758A IT1256616B (it)	1992-12-02	1992-12-02	Sciroppo contenente n-acetil-cisteina
PCT/EP1993/003280 WO1994012168A1 (en)	1992-12-02	1993-11-23	Syrup containing n-acetyl-cysteine

Publications (2)

Publication Number	Publication Date
CA2150462A1 CA2150462A1 (en)	1994-06-09
CA2150462C true CA2150462C (en)	2005-04-19

Family

ID=11364395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002150462A Expired - Lifetime CA2150462C (en)	1992-12-02	1993-11-23	Syrup containing n-acetyl-cysteine

Country Status (23)

Country	Link
JP (1)	JPH08503703A (de)
AT (1)	AT407113B (de)
AU (1)	AU667611B2 (de)
BE (1)	BE1006799A3 (de)
CA (1)	CA2150462C (de)
CH (1)	CH685371A5 (de)
CZ (1)	CZ282550B6 (de)
DE (2)	DE4396086B3 (de)
DK (1)	DK176247B1 (de)
ES (1)	ES2070806B1 (de)
FR (1)	FR2698545B1 (de)
GB (1)	GB2288977B (de)
HU (2)	HU221484B (de)
IT (1)	IT1256616B (de)
LU (1)	LU88618A1 (de)
MD (1)	MD1714G2 (de)
NL (1)	NL194957C (de)
NO (1)	NO314018B1 (de)
NZ (1)	NZ258544A (de)
RU (1)	RU2108777C1 (de)
SE (1)	SE520834C2 (de)
UA (1)	UA27142C2 (de)
WO (1)	WO1994012168A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2193087C (en) *	1994-06-23	2002-01-08	Greg George Hillebrand	Topical compositions comprising n-acetyl-l-cysteine
JP4501024B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
JP4501023B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
US8148356B2 (en) *	2005-08-24	2012-04-03	Cumberland Pharmaceuticals, Inc.	Acetylcysteine composition and uses therefor
CN102233139B (zh) *	2010-04-21	2012-09-05	重庆健能医药开发有限公司	一种乙酰半胱氨酸泡腾片及其制备方法和应用
RU2611411C1 (ru) *	2016-01-11	2017-02-21	Общество с ограниченной ответственностью "Трейдсервис"	Диспергируемая в воде таблетка ацетилцистеина и способ ее изготовления

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB905197A (en) *	1960-01-01	1962-09-05	Lab Francais Chimiotherapie	Anti-viral compositions comprising 1-phenyl-2-amino-propane-1,3-diol derivatives
CA1239349A (en) *	1983-10-10	1988-07-19	Eberhard F. Gottwald	Pharmaceutical composition containing cimetidine
BE901885A (fr) *	1985-03-06	1985-07-01	Bruschettini Srl	Composition pharmaceutique sous forme de lotion ophtalmique et son procede de preparation.
CH667590A5 (it) *	1986-07-24	1988-10-31	Inpharzam Int Sa	Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. .
CH666814A5 (it) *	1986-07-24	1988-08-31	Inpharzam Int Sa	Composizione farmaceutica idrosolubile contenente n-acetil-cisteina.
US4861797A (en) *	1987-10-15	1989-08-29	Oratech Pharmaceutical Development Corporation	Liquid ibuprofen compositions and methods of making them
CH674940A5 (de) *	1988-05-05	1990-08-15	Ibsa Inst Biochimique Sa
IT1234194B (it) *	1988-05-31	1992-05-06	Magis Farmaceutici	Composizioni farmaceutiche in forma di sciroppo contenenti pentitoli quali agenti di veicolazione
EP0373103B1 (de) *	1988-11-10	1993-03-31	Ciba-Geigy Ag	Flüssige orale Formulierung
IT1231012B (it) *	1989-07-27	1991-11-08	Zambon Spa	Composizione farmaceutica per uso orale contenente nac.
IT1248998B (it) *	1990-06-26	1995-02-11	Iscofar Sas	Composizione di gomma da masticare per la prevenzione e il trattamento della placca dentaria
DE59106133D1 (de) *	1990-10-19	1995-09-07	Spirig Ag	Feste, schnell-lösliche Arzneimittelzubereitung enthaltend S-(Carboxymethyl)-L-Cystein und/oder N-Acetylcystein.

1992
- 1992-12-02 IT ITMI922758A patent/IT1256616B/it active IP Right Grant
1993
- 1993-11-23 NL NL9320052A patent/NL194957C/nl not_active IP Right Cessation
- 1993-11-23 DE DE4396086A patent/DE4396086B3/de not_active Expired - Lifetime
- 1993-11-23 AT AT0906093A patent/AT407113B/de not_active IP Right Cessation
- 1993-11-23 CZ CZ951367A patent/CZ282550B6/cs not_active IP Right Cessation
- 1993-11-23 AU AU56266/94A patent/AU667611B2/en not_active Expired
- 1993-11-23 CA CA002150462A patent/CA2150462C/en not_active Expired - Lifetime
- 1993-11-23 UA UA95062994A patent/UA27142C2/uk unknown
- 1993-11-23 ES ES09450021A patent/ES2070806B1/es not_active Expired - Fee Related
- 1993-11-23 MD MD96-0265A patent/MD1714G2/ro unknown
- 1993-11-23 DE DE4396086T patent/DE4396086T1/de active Pending
- 1993-11-23 CH CH2423/94A patent/CH685371A5/it not_active IP Right Cessation
- 1993-11-23 HU HU9501586A patent/HU221484B/hu unknown
- 1993-11-23 NZ NZ258544A patent/NZ258544A/en not_active IP Right Cessation
- 1993-11-23 GB GB9509822A patent/GB2288977B/en not_active Expired - Lifetime
- 1993-11-23 WO PCT/EP1993/003280 patent/WO1994012168A1/en not_active Ceased
- 1993-11-23 JP JP6512747A patent/JPH08503703A/ja active Pending
- 1993-11-23 RU RU95114406A patent/RU2108777C1/ru active
- 1993-12-01 BE BE9301326A patent/BE1006799A3/fr not_active IP Right Cessation
- 1993-12-02 FR FR9314443A patent/FR2698545B1/fr not_active Expired - Lifetime
1994
- 1994-05-24 LU LU88618A patent/LU88618A1/de unknown
1995
- 1995-05-31 DK DK199500614A patent/DK176247B1/da not_active IP Right Cessation
- 1995-06-01 NO NO19952183A patent/NO314018B1/no not_active IP Right Cessation
- 1995-06-01 SE SE9502001A patent/SE520834C2/sv not_active IP Right Cessation
- 1995-06-29 HU HU95P/P00579P patent/HU211912A9/hu unknown

Also Published As

Publication number	Publication date
HU211912A9 (en)	1996-01-29
NO952183L (no)	1995-06-01
ITMI922758A1 (it)	1994-06-02
NL194957C (nl)	2003-09-02
CZ282550B6 (cs)	1997-08-13
DE4396086B3 (de)	2013-02-28
AU667611B2 (en)	1996-03-28
NL194957B (nl)	2003-05-01
AU5626694A (en)	1994-06-22
ITMI922758A0 (it)	1992-12-02
IT1256616B (it)	1995-12-12
JPH08503703A (ja)	1996-04-23
ES2070806B1 (es)	1996-01-01
GB2288977A (en)	1995-11-08
CH685371A5 (it)	1995-06-30
CZ136795A3 (en)	1995-11-15
HUT72668A (en)	1996-05-28
NO952183D0 (no)	1995-06-01
MD1714F2 (en)	2001-08-31
DE4396086T1 (de)	1995-12-07
HU9501586D0 (en)	1995-08-28
LU88618A1 (de)	1995-12-01
GB2288977B (en)	1996-09-04
UA27142C2 (uk)	2000-02-28
DK176247B1 (da)	2007-04-16
ATA906093A (de)	2000-05-15
AT407113B (de)	2000-12-27
WO1994012168A1 (en)	1994-06-09
GB9509822D0 (en)	1995-07-19
FR2698545B1 (fr)	1995-08-04
SE520834C2 (sv)	2003-09-02
HU221484B (en)	2002-10-28
MD1714G2 (ro)	2002-03-31
DK61495A (da)	1995-05-31
NO314018B1 (no)	2003-01-20
ES2070806A1 (es)	1995-06-01
SE9502001D0 (sv)	1995-06-01
CA2150462A1 (en)	1994-06-09
FR2698545A1 (fr)	1994-06-03
RU2108777C1 (ru)	1998-04-20
BE1006799A3 (fr)	1994-12-13
NL9320052A (nl)	1995-08-01
NZ258544A (en)	1996-11-26
SE9502001L (sv)	1995-07-21

Legal Events

Date	Code	Title	Description
2000-09-20	EEER	Examination request
2014-01-27	MKEX	Expiry	Effective date: 20131125

Publication	Publication Date	Title
US5082864A (en)	1992-01-21	Stabilized solutions of psychotropic agents
ES2201316T3 (es)	2004-03-16	Nuevas formulaciones liquidas estables a base de paracetamol y su modo de preparacion.
CA2121435C (en)	2002-01-22	Aqueous pharmaceutical suspension and process for preparation thereof
CZ114093A3 (en)	1994-02-16	Sulfate of 3-£2-(dimethylamino)ethyl-n-methyl-1h-indole-5-methane sulfonamide, and pharmaceutical preparations containing thereof
US5024997A (en)	1991-06-18	Palatable ibuprofen solutions
US5807894A (en)	1998-09-15	Syrup containing N-acetyl-cysteine
ES2210121T3 (es)	2004-07-01	Preparacion farmaceutica estable, que puede ser utilizada por via nasal, oral o sublingual que contiene desmopresina.
AU2009301296A1 (en)	2010-04-15	Liquid pharmaceutical formulation containing paracetamol
RS57668B2 (sr)	2022-03-31	Pedijatrijski rastvori koji sadrže beta-blokator
CA2549599A1 (en)	2005-07-14	Pregabalin composition
AU667611B2 (en)	1996-03-28	Syrup containing N-acetyl-cysteine
CA2311112A1 (en)	2000-12-04	Trovafloxacin oral suspensions
US4880835A (en)	1989-11-14	Oral liquid pharmaceutical compositions of sulindac
US5208261A (en)	1993-05-04	Stabilized solutions of psychotropic agents
JPH03173822A (ja)	1991-07-29	セファロスポリン系薬物を含有する注射用組成物
US4772589A (en)	1988-09-20	Etoposide solution in NMP
JPS5914447B2 (ja)	1984-04-04	ｐＨおよび色安定化非経口投与用水性抗性物質組成物
JPH0665071A (ja)	1994-03-08	水性溶液製剤
KR20050034619A (ko)	2005-04-14	신규한 무수 및 수성 에피나스틴 시럽 제형
JP3949184B2 (ja)	2007-07-25	塩酸アンブロキソール水性液剤
CA2120751C (en)	2004-01-20	Trimethoprim oral liquid
US20030104017A1 (en)	2003-06-05	Epinastine formulation for oral administration
CZ243898A3 (cs)	1998-11-11	Vodná formulace bambuterolu a její použití
GB2285923A (en)	1995-08-02	Pharmaceutical powder containing N-acetyl-cysteine
JP2001055334A (ja)	2001-02-27	センノシド含有水性液剤