NO314018B1 - Sirup inneholdende N-acetyl-cystein - Google Patents

Sirup inneholdende N-acetyl-cystein Download PDF

Info

Publication number: NO314018B1
Authority: NO; Norway
Prior art keywords: syrup; solution; nac; cysteine; acetyl
Prior art date: 1992-12-02

Application number

NO19952183A

Other languages

English (en)

Norwegian (no)

Other versions

NO952183L (no

NO952183D0 (no

Inventor

Federico Stroppolo

Daniele Bonadeo

Alessandro Saudino

Annibale Gazzaniga

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-02

Filing date

1995-06-01

Publication date

2003-01-20

1995-06-01 Application filed by Zambon Spa filed Critical Zambon Spa

1995-06-01 Publication of NO952183L publication Critical patent/NO952183L/no

1995-06-01 Publication of NO952183D0 publication Critical patent/NO952183D0/no

2003-01-20 Publication of NO314018B1 publication Critical patent/NO314018B1/no

Links

239000006188 syrup Substances 0.000 title claims description 21
235000020357 syrup Nutrition 0.000 title claims description 21
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title description 18
229960004308 acetylcysteine Drugs 0.000 title description 3
239000000203 mixture Substances 0.000 claims description 14
239000003755 preservative agent Substances 0.000 claims description 6
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
230000002335 preservative effect Effects 0.000 claims description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
229960003415 propylparaben Drugs 0.000 claims description 2
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
235000010234 sodium benzoate Nutrition 0.000 claims description 2
239000004299 sodium benzoate Substances 0.000 claims description 2
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
229940037001 sodium edetate Drugs 0.000 claims 1
239000000243 solution Substances 0.000 description 20
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
150000001875 compounds Chemical class 0.000 description 6
239000003765 sweetening agent Substances 0.000 description 5
235000003599 food sweetener Nutrition 0.000 description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
239000003814 drug Substances 0.000 description 3
239000012299 nitrogen atmosphere Substances 0.000 description 3
239000002562 thickening agent Substances 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
238000009835 boiling Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical group [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000004500 asepsis Methods 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
230000009965 odorless effect Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
235000019605 sweet taste sensations Nutrition 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
230000008719 thickening Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Pulmonology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Jellies, Jams, And Syrups (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

NO19952183A 1992-12-02 1995-06-01 Sirup inneholdende N-acetyl-cystein NO314018B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI922758A IT1256616B (it)	1992-12-02	1992-12-02	Sciroppo contenente n-acetil-cisteina
PCT/EP1993/003280 WO1994012168A1 (en)	1992-12-02	1993-11-23	Syrup containing n-acetyl-cysteine

Publications (3)

Publication Number	Publication Date
NO952183L NO952183L (no)	1995-06-01
NO952183D0 NO952183D0 (no)	1995-06-01
NO314018B1 true NO314018B1 (no)	2003-01-20

Family

ID=11364395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19952183A NO314018B1 (no)	1992-12-02	1995-06-01	Sirup inneholdende N-acetyl-cystein

Country Status (23)

Country	Link
JP (1)	JPH08503703A (de)
AT (1)	AT407113B (de)
AU (1)	AU667611B2 (de)
BE (1)	BE1006799A3 (de)
CA (1)	CA2150462C (de)
CH (1)	CH685371A5 (de)
CZ (1)	CZ282550B6 (de)
DE (2)	DE4396086B3 (de)
DK (1)	DK176247B1 (de)
ES (1)	ES2070806B1 (de)
FR (1)	FR2698545B1 (de)
GB (1)	GB2288977B (de)
HU (2)	HU221484B (de)
IT (1)	IT1256616B (de)
LU (1)	LU88618A1 (de)
MD (1)	MD1714G2 (de)
NL (1)	NL194957C (de)
NO (1)	NO314018B1 (de)
NZ (1)	NZ258544A (de)
RU (1)	RU2108777C1 (de)
SE (1)	SE520834C2 (de)
UA (1)	UA27142C2 (de)
WO (1)	WO1994012168A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0766557T3 (da) *	1994-06-23	2002-04-15	Procter & Gamble	Topiske præparater omfattende N-acetyl-L-cystein
JP4501023B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
JP4501024B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
US8148356B2 (en) *	2005-08-24	2012-04-03	Cumberland Pharmaceuticals, Inc.	Acetylcysteine composition and uses therefor
CN102233139B (zh) *	2010-04-21	2012-09-05	重庆健能医药开发有限公司	一种乙酰半胱氨酸泡腾片及其制备方法和应用
RU2611411C1 (ru) *	2016-01-11	2017-02-21	Общество с ограниченной ответственностью "Трейдсервис"	Диспергируемая в воде таблетка ацетилцистеина и способ ее изготовления

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB905197A (en) *	1960-01-01	1962-09-05	Lab Francais Chimiotherapie	Anti-viral compositions comprising 1-phenyl-2-amino-propane-1,3-diol derivatives
CA1239349A (en) *	1983-10-10	1988-07-19	Eberhard F. Gottwald	Pharmaceutical composition containing cimetidine
BE901885A (fr) *	1985-03-06	1985-07-01	Bruschettini Srl	Composition pharmaceutique sous forme de lotion ophtalmique et son procede de preparation.
CH667590A5 (it) *	1986-07-24	1988-10-31	Inpharzam Int Sa	Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. .
CH666814A5 (it) *	1986-07-24	1988-08-31	Inpharzam Int Sa	Composizione farmaceutica idrosolubile contenente n-acetil-cisteina.
US4861797A (en) *	1987-10-15	1989-08-29	Oratech Pharmaceutical Development Corporation	Liquid ibuprofen compositions and methods of making them
CH674940A5 (de) *	1988-05-05	1990-08-15	Ibsa Inst Biochimique Sa
IT1234194B (it) *	1988-05-31	1992-05-06	Magis Farmaceutici	Composizioni farmaceutiche in forma di sciroppo contenenti pentitoli quali agenti di veicolazione
DE58903964D1 (de) *	1988-11-10	1993-05-06	Ciba Geigy Ag	Fluessige orale formulierung.
IT1231012B (it) *	1989-07-27	1991-11-08	Zambon Spa	Composizione farmaceutica per uso orale contenente nac.
IT1248998B (it) *	1990-06-26	1995-02-11	Iscofar Sas	Composizione di gomma da masticare per la prevenzione e il trattamento della placca dentaria
DE59106133D1 (de) *	1990-10-19	1995-09-07	Spirig Ag	Feste, schnell-lösliche Arzneimittelzubereitung enthaltend S-(Carboxymethyl)-L-Cystein und/oder N-Acetylcystein.

1992
- 1992-12-02 IT ITMI922758A patent/IT1256616B/it active IP Right Grant
1993
- 1993-11-23 DE DE4396086A patent/DE4396086B3/de not_active Expired - Lifetime
- 1993-11-23 NL NL9320052A patent/NL194957C/nl not_active IP Right Cessation
- 1993-11-23 WO PCT/EP1993/003280 patent/WO1994012168A1/en not_active Ceased
- 1993-11-23 CH CH2423/94A patent/CH685371A5/it not_active IP Right Cessation
- 1993-11-23 CZ CZ951367A patent/CZ282550B6/cs not_active IP Right Cessation
- 1993-11-23 RU RU95114406A patent/RU2108777C1/ru active
- 1993-11-23 UA UA95062994A patent/UA27142C2/uk unknown
- 1993-11-23 JP JP6512747A patent/JPH08503703A/ja active Pending
- 1993-11-23 AT AT0906093A patent/AT407113B/de not_active IP Right Cessation
- 1993-11-23 CA CA002150462A patent/CA2150462C/en not_active Expired - Lifetime
- 1993-11-23 NZ NZ258544A patent/NZ258544A/en not_active IP Right Cessation
- 1993-11-23 GB GB9509822A patent/GB2288977B/en not_active Expired - Lifetime
- 1993-11-23 DE DE4396086T patent/DE4396086T1/de active Pending
- 1993-11-23 MD MD96-0265A patent/MD1714G2/ro unknown
- 1993-11-23 ES ES09450021A patent/ES2070806B1/es not_active Expired - Fee Related
- 1993-11-23 AU AU56266/94A patent/AU667611B2/en not_active Expired
- 1993-11-23 HU HU9501586A patent/HU221484B/hu unknown
- 1993-12-01 BE BE9301326A patent/BE1006799A3/fr not_active IP Right Cessation
- 1993-12-02 FR FR9314443A patent/FR2698545B1/fr not_active Expired - Lifetime
1994
- 1994-05-24 LU LU88618A patent/LU88618A1/de unknown
1995
- 1995-05-31 DK DK199500614A patent/DK176247B1/da not_active IP Right Cessation
- 1995-06-01 SE SE9502001A patent/SE520834C2/sv not_active IP Right Cessation
- 1995-06-01 NO NO19952183A patent/NO314018B1/no not_active IP Right Cessation
- 1995-06-29 HU HU95P/P00579P patent/HU211912A9/hu unknown

Also Published As

Publication number	Publication date
LU88618A1 (de)	1995-12-01
MD1714F2 (en)	2001-08-31
ITMI922758A0 (it)	1992-12-02
NZ258544A (en)	1996-11-26
WO1994012168A1 (en)	1994-06-09
AU5626694A (en)	1994-06-22
HUT72668A (en)	1996-05-28
DE4396086T1 (de)	1995-12-07
UA27142C2 (uk)	2000-02-28
HU211912A9 (en)	1996-01-29
ATA906093A (de)	2000-05-15
CZ136795A3 (en)	1995-11-15
DE4396086B3 (de)	2013-02-28
MD1714G2 (ro)	2002-03-31
NL9320052A (nl)	1995-08-01
FR2698545B1 (fr)	1995-08-04
NL194957B (nl)	2003-05-01
IT1256616B (it)	1995-12-12
SE9502001L (sv)	1995-07-21
SE520834C2 (sv)	2003-09-02
NO952183L (no)	1995-06-01
GB2288977B (en)	1996-09-04
SE9502001D0 (sv)	1995-06-01
JPH08503703A (ja)	1996-04-23
NL194957C (nl)	2003-09-02
CZ282550B6 (cs)	1997-08-13
CH685371A5 (it)	1995-06-30
HU221484B (en)	2002-10-28
AT407113B (de)	2000-12-27
BE1006799A3 (fr)	1994-12-13
DK176247B1 (da)	2007-04-16
ES2070806A1 (es)	1995-06-01
ES2070806B1 (es)	1996-01-01
AU667611B2 (en)	1996-03-28
NO952183D0 (no)	1995-06-01
FR2698545A1 (fr)	1994-06-03
HU9501586D0 (en)	1995-08-28
CA2150462C (en)	2005-04-19
GB2288977A (en)	1995-11-08
GB9509822D0 (en)	1995-07-19
ITMI922758A1 (it)	1994-06-02
RU2108777C1 (ru)	1998-04-20
DK61495A (da)	1995-05-31
CA2150462A1 (en)	1994-06-09

Legal Events

Date	Code	Title	Description
2014-01-13	MK1K	Patent expired

Publication	Publication Date	Title
KR100451269B1 (ko)	2005-08-17	경구투여용약제학적제산제조성물
AU635283B2 (en)	1993-03-18	Aqeous pharmaceutical suspension for substantially water insoluble pharmaceutical actives
US7985429B2 (en)	2011-07-26	Flavored colonic cleansing system
JPH0639378B2 (ja)	1994-05-25	医薬組成物
ES2210121T3 (es)	2004-07-01	Preparacion farmaceutica estable, que puede ser utilizada por via nasal, oral o sublingual que contiene desmopresina.
JPH05306221A (ja)	1993-11-19	腸管洗浄液用組成物及び腸管洗浄液
EP1543831A1 (de)	2005-06-22	Zusammensetzung enthaltend Pregabalin
NO314018B1 (no)	2003-01-20	Sirup inneholdende N-acetyl-cystein
JP3805646B2 (ja)	2006-08-02	医薬液剤
PT90356B (pt)	1994-07-29	Processo para a preparacao de composicoes farmaceuticas contendo solucoes aquosas de pentamidina
JPS63156719A (ja)	1988-06-29	シロツプ剤
US5807894A (en)	1998-09-15	Syrup containing N-acetyl-cysteine
CN109984996B (zh)	2022-01-18	恩替卡韦口服溶液及其制备方法
KR100254107B1 (ko)	2000-05-01	안정한 복합비타민 내복액제
US5064857A (en)	1991-11-12	Liquid bismuth containing medicinal product, process for producing it and its use
KR20060010838A (ko)	2006-02-02	아목시실린 및 클라블라네이트를 포함하는 약제학적 제형
JP2019069914A (ja)	2019-05-09	漢方医薬組成物、漢方製剤
CN113081949A (zh)	2021-07-09	一种复方葡萄糖酸钙口服凝胶制剂及其制备方法
JP2724856B2 (ja)	1998-03-09	酸味組成物
DK201200057U1 (da)	2012-04-27	Forbedringer i og vedrørende colonrensesammensætninger
JPH03201970A (ja)	1991-09-03	イチョウ葉エキス含有シロップ
GB2285923A (en)	1995-08-02	Pharmaceutical powder containing N-acetyl-cysteine
JP2003192574A (ja)	2003-07-09	弱アルカリで安定化される薬剤を含む医薬用液剤
Eriksson et al.	1983	The influence of the sweetening agent on the oral absorption of penicillin V
JPH072681A (ja)	1995-01-06	硫酸マグネシウムを主成分とするしゃ下内用液剤