JPH08503703A - Ｎ−アセチルシステインを含むシロップ - Google Patents
Ｎ−アセチルシステインを含むシロップInfo
- Publication number
- JPH08503703A JPH08503703A JP6512747A JP51274794A JPH08503703A JP H08503703 A JPH08503703 A JP H08503703A JP 6512747 A JP6512747 A JP 6512747A JP 51274794 A JP51274794 A JP 51274794A JP H08503703 A JPH08503703 A JP H08503703A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- syrup
- nac
- solution
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006188 syrup Substances 0.000 title claims abstract description 21
- 235000020357 syrup Nutrition 0.000 title claims abstract description 21
- 229960004308 acetylcysteine Drugs 0.000 title claims abstract description 7
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title abstract description 26
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 239000003765 sweetening agent Substances 0.000 claims abstract description 9
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical class OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 229940037001 sodium edetate Drugs 0.000 claims description 5
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 229940081974 saccharin Drugs 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019204 saccharin Nutrition 0.000 claims description 4
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- -1 hydroxypropyl Chemical group 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 229940109275 cyclamate Drugs 0.000 claims 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 21
- 235000011194 food seasoning agent Nutrition 0.000 abstract description 6
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 239000004278 EU approved seasoning Substances 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 5
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 5
- 230000002335 preservative effect Effects 0.000 description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 244000018633 Prunus armeniaca Species 0.000 description 2
- 235000009827 Prunus armeniaca Nutrition 0.000 description 2
- 235000011034 Rubus glaucus Nutrition 0.000 description 2
- 244000235659 Rubus idaeus Species 0.000 description 2
- 235000009122 Rubus idaeus Nutrition 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000000510 mucolytic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Jellies, Jams, And Syrups (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922758A IT1256616B (it) | 1992-12-02 | 1992-12-02 | Sciroppo contenente n-acetil-cisteina |
| IT92A002758 | 1992-12-02 | ||
| PCT/EP1993/003280 WO1994012168A1 (en) | 1992-12-02 | 1993-11-23 | Syrup containing n-acetyl-cysteine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08503703A true JPH08503703A (ja) | 1996-04-23 |
Family
ID=11364395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6512747A Pending JPH08503703A (ja) | 1992-12-02 | 1993-11-23 | Ｎ−アセチルシステインを含むシロップ |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPH08503703A (de) |
| AT (1) | AT407113B (de) |
| AU (1) | AU667611B2 (de) |
| BE (1) | BE1006799A3 (de) |
| CA (1) | CA2150462C (de) |
| CH (1) | CH685371A5 (de) |
| CZ (1) | CZ282550B6 (de) |
| DE (2) | DE4396086T1 (de) |
| DK (1) | DK176247B1 (de) |
| ES (1) | ES2070806B1 (de) |
| FR (1) | FR2698545B1 (de) |
| GB (1) | GB2288977B (de) |
| HU (2) | HU221484B (de) |
| IT (1) | IT1256616B (de) |
| LU (1) | LU88618A1 (de) |
| MD (1) | MD1714G2 (de) |
| NL (1) | NL194957C (de) |
| NO (1) | NO314018B1 (de) |
| NZ (1) | NZ258544A (de) |
| RU (1) | RU2108777C1 (de) |
| SE (1) | SE520834C2 (de) |
| UA (1) | UA27142C2 (de) |
| WO (1) | WO1994012168A1 (de) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004161701A (ja) * | 2002-11-14 | 2004-06-10 | Kobayashi Pharmaceut Co Ltd | システイン類の苦味及び臭気が軽減された組成物 |
| JP2004161700A (ja) * | 2002-11-14 | 2004-06-10 | Kobayashi Pharmaceut Co Ltd | システイン類の苦味及び臭気が軽減された組成物 |
| JP2009506030A (ja) * | 2005-08-24 | 2009-02-12 | カンバーランド ファーマシューティカルズ，インコーポレーテッド | アセチルシステイン組成物及びその使用 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE210975T1 (de) * | 1994-06-23 | 2002-01-15 | Procter & Gamble | Topisch anzuwendende zubereitungen enthaltend n- acetyl-l-cystein |
| CN102233139B (zh) * | 2010-04-21 | 2012-09-05 | 重庆健能医药开发有限公司 | 一种乙酰半胱氨酸泡腾片及其制备方法和应用 |
| RU2611411C1 (ru) * | 2016-01-11 | 2017-02-21 | Общество с ограниченной ответственностью "Трейдсервис" | Диспергируемая в воде таблетка ацетилцистеина и способ ее изготовления |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB905197A (en) * | 1960-01-01 | 1962-09-05 | Lab Francais Chimiotherapie | Anti-viral compositions comprising 1-phenyl-2-amino-propane-1,3-diol derivatives |
| CA1239349A (en) * | 1983-10-10 | 1988-07-19 | Eberhard F. Gottwald | Pharmaceutical composition containing cimetidine |
| BE901885A (fr) * | 1985-03-06 | 1985-07-01 | Bruschettini Srl | Composition pharmaceutique sous forme de lotion ophtalmique et son procede de preparation. |
| CH667590A5 (it) * | 1986-07-24 | 1988-10-31 | Inpharzam Int Sa | Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. . |
| CH666814A5 (it) * | 1986-07-24 | 1988-08-31 | Inpharzam Int Sa | Composizione farmaceutica idrosolubile contenente n-acetil-cisteina. |
| US4861797A (en) * | 1987-10-15 | 1989-08-29 | Oratech Pharmaceutical Development Corporation | Liquid ibuprofen compositions and methods of making them |
| CH674940A5 (de) * | 1988-05-05 | 1990-08-15 | Ibsa Inst Biochimique Sa | |
| IT1234194B (it) * | 1988-05-31 | 1992-05-06 | Magis Farmaceutici | Composizioni farmaceutiche in forma di sciroppo contenenti pentitoli quali agenti di veicolazione |
| ES2054089T3 (es) * | 1988-11-10 | 1994-08-01 | Ciba Geigy Ag | Formulaciones orales liquidas. |
| IT1231012B (it) * | 1989-07-27 | 1991-11-08 | Zambon Spa | Composizione farmaceutica per uso orale contenente nac. |
| IT1248998B (it) * | 1990-06-26 | 1995-02-11 | Iscofar Sas | Composizione di gomma da masticare per la prevenzione e il trattamento della placca dentaria |
| DK0481294T4 (da) * | 1990-10-19 | 2001-06-18 | Spirig Ag | Fast, hurtigt-opløseligt lægemiddelpræparat indeholdende N-acetylcystein |
-
1992
- 1992-12-02 IT ITMI922758A patent/IT1256616B/it active IP Right Grant
-
1993
- 1993-11-23 CZ CZ951367A patent/CZ282550B6/cs not_active IP Right Cessation
- 1993-11-23 AU AU56266/94A patent/AU667611B2/en not_active Expired
- 1993-11-23 DE DE4396086T patent/DE4396086T1/de active Pending
- 1993-11-23 NL NL9320052A patent/NL194957C/nl not_active IP Right Cessation
- 1993-11-23 MD MD96-0265A patent/MD1714G2/ro unknown
- 1993-11-23 JP JP6512747A patent/JPH08503703A/ja active Pending
- 1993-11-23 UA UA95062994A patent/UA27142C2/uk unknown
- 1993-11-23 HU HU9501586A patent/HU221484B/hu unknown
- 1993-11-23 WO PCT/EP1993/003280 patent/WO1994012168A1/en not_active Ceased
- 1993-11-23 NZ NZ258544A patent/NZ258544A/en not_active IP Right Cessation
- 1993-11-23 ES ES09450021A patent/ES2070806B1/es not_active Expired - Fee Related
- 1993-11-23 DE DE4396086A patent/DE4396086B3/de not_active Expired - Lifetime
- 1993-11-23 AT AT0906093A patent/AT407113B/de not_active IP Right Cessation
- 1993-11-23 CH CH2423/94A patent/CH685371A5/it not_active IP Right Cessation
- 1993-11-23 RU RU95114406A patent/RU2108777C1/ru active
- 1993-11-23 CA CA002150462A patent/CA2150462C/en not_active Expired - Lifetime
- 1993-11-23 GB GB9509822A patent/GB2288977B/en not_active Expired - Lifetime
- 1993-12-01 BE BE9301326A patent/BE1006799A3/fr not_active IP Right Cessation
- 1993-12-02 FR FR9314443A patent/FR2698545B1/fr not_active Expired - Lifetime
-
1994
- 1994-05-24 LU LU88618A patent/LU88618A1/de unknown
-
1995
- 1995-05-31 DK DK199500614A patent/DK176247B1/da not_active IP Right Cessation
- 1995-06-01 NO NO19952183A patent/NO314018B1/no not_active IP Right Cessation
- 1995-06-01 SE SE9502001A patent/SE520834C2/sv not_active IP Right Cessation
- 1995-06-29 HU HU95P/P00579P patent/HU211912A9/hu unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004161701A (ja) * | 2002-11-14 | 2004-06-10 | Kobayashi Pharmaceut Co Ltd | システイン類の苦味及び臭気が軽減された組成物 |
| JP2004161700A (ja) * | 2002-11-14 | 2004-06-10 | Kobayashi Pharmaceut Co Ltd | システイン類の苦味及び臭気が軽減された組成物 |
| JP2009506030A (ja) * | 2005-08-24 | 2009-02-12 | カンバーランド ファーマシューティカルズ，インコーポレーテッド | アセチルシステイン組成物及びその使用 |
| KR101408336B1 (ko) * | 2005-08-24 | 2014-06-20 | 큠버랜드 파마슈티컬즈 인코포레이티드 | 아세틸시스테인 조성물 및 그의 용도 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040413 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050531 |