BE1006799A3 - Sirop contenant de la n-acetyl-cysteine. - Google Patents

Sirop contenant de la n-acetyl-cysteine. Download PDF

Info

Publication number: BE1006799A3
Authority: BE; Belgium
Prior art keywords: sep; sodium; nac; solution; syrup
Prior art date: 1992-12-02

Application number

BE9301326A

Other languages

English (en)

French (fr)

Inventor

Federico Stroppolo

Daniele Vonadeo

Alessandro Saudino

Annibale Gazzaniga

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-02

Filing date

1993-12-01

Publication date

1994-12-13

1993-12-01 Application filed by Zambon Spa filed Critical Zambon Spa

1994-12-13 Application granted granted Critical

1994-12-13 Publication of BE1006799A3 publication Critical patent/BE1006799A3/fr

Links

PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title claims abstract description 27
239000006188 syrup Substances 0.000 title claims abstract description 22
235000020357 syrup Nutrition 0.000 title claims abstract description 22
229960004308 acetylcysteine Drugs 0.000 title claims abstract description 6
239000003765 sweetening agent Substances 0.000 claims abstract description 9
235000003599 food sweetener Nutrition 0.000 claims abstract description 8
239000003755 preservative agent Substances 0.000 claims abstract description 7
239000002562 thickening agent Substances 0.000 claims abstract description 6
230000002335 preservative effect Effects 0.000 claims abstract description 5
239000000796 flavoring agent Substances 0.000 claims abstract description 4
235000013355 food flavoring agent Nutrition 0.000 claims abstract description 4
239000000203 mixture Substances 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 13
239000011734 sodium Substances 0.000 claims description 13
229910052708 sodium Inorganic materials 0.000 claims description 13
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 10
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
229940081974 saccharin Drugs 0.000 claims description 7
235000019204 saccharin Nutrition 0.000 claims description 7
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 7
239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims description 2
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 2
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
229960003415 propylparaben Drugs 0.000 claims description 2
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
235000010234 sodium benzoate Nutrition 0.000 claims description 2
239000004299 sodium benzoate Substances 0.000 claims description 2
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
229940037001 sodium edetate Drugs 0.000 claims 1
239000000243 solution Substances 0.000 abstract description 21
239000007864 aqueous solution Substances 0.000 abstract description 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
239000000126 substance Substances 0.000 description 6
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 5
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
229940009662 edetate Drugs 0.000 description 4
235000019629 palatability Nutrition 0.000 description 4
239000012299 nitrogen atmosphere Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 2
244000018633 Prunus armeniaca Species 0.000 description 2
235000009827 Prunus armeniaca Nutrition 0.000 description 2
235000011034 Rubus glaucus Nutrition 0.000 description 2
244000235659 Rubus idaeus Species 0.000 description 2
235000009122 Rubus idaeus Nutrition 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
238000009835 boiling Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
235000019645 odor Nutrition 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
206010013911 Dysgeusia Diseases 0.000 description 1
240000008790 Musa x paradisiaca Species 0.000 description 1
235000018290 Musa x paradisiaca Nutrition 0.000 description 1
VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
238000004500 asepsis Methods 0.000 description 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000004040 coloring Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000007423 decrease Effects 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
230000000510 mucolytic effect Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
235000021309 simple sugar Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
235000019605 sweet taste sensations Nutrition 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Jellies, Jams, And Syrups (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

BE9301326A 1992-12-02 1993-12-01 Sirop contenant de la n-acetyl-cysteine. BE1006799A3 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI922758A IT1256616B (it)	1992-12-02	1992-12-02	Sciroppo contenente n-acetil-cisteina

Publications (1)

Publication Number	Publication Date
BE1006799A3 true BE1006799A3 (fr)	1994-12-13

Family

ID=11364395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE9301326A BE1006799A3 (fr)	1992-12-02	1993-12-01	Sirop contenant de la n-acetyl-cysteine.

Country Status (23)

Country	Link
JP (1)	JPH08503703A (de)
AT (1)	AT407113B (de)
AU (1)	AU667611B2 (de)
BE (1)	BE1006799A3 (de)
CA (1)	CA2150462C (de)
CH (1)	CH685371A5 (de)
CZ (1)	CZ282550B6 (de)
DE (2)	DE4396086B3 (de)
DK (1)	DK176247B1 (de)
ES (1)	ES2070806B1 (de)
FR (1)	FR2698545B1 (de)
GB (1)	GB2288977B (de)
HU (2)	HU221484B (de)
IT (1)	IT1256616B (de)
LU (1)	LU88618A1 (de)
MD (1)	MD1714G2 (de)
NL (1)	NL194957C (de)
NO (1)	NO314018B1 (de)
NZ (1)	NZ258544A (de)
RU (1)	RU2108777C1 (de)
SE (1)	SE520834C2 (de)
UA (1)	UA27142C2 (de)
WO (1)	WO1994012168A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE210975T1 (de) *	1994-06-23	2002-01-15	Procter & Gamble	Topisch anzuwendende zubereitungen enthaltend n- acetyl-l-cystein
JP4501024B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
JP4501023B2 (ja) *	2002-11-14	2010-07-14	小林製薬株式会社	システイン類の苦味及び臭気が軽減された組成物
US8148356B2 (en) *	2005-08-24	2012-04-03	Cumberland Pharmaceuticals, Inc.	Acetylcysteine composition and uses therefor
CN102233139B (zh) *	2010-04-21	2012-09-05	重庆健能医药开发有限公司	一种乙酰半胱氨酸泡腾片及其制备方法和应用
RU2611411C1 (ru) *	2016-01-11	2017-02-21	Общество с ограниченной ответственностью "Трейдсервис"	Диспергируемая в воде таблетка ацетилцистеина и способ ее изготовления

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2192790A (en) *	1986-07-24	1988-01-27	Inpharzam Int Sa	Acetylcysteine compositions
GB2192789A (en) *	1986-07-24	1988-01-27	Inpharzam Int Sa	Acetylcysteine compositions
FR2631831A1 (fr) *	1988-05-31	1989-12-01	Calco Anstalt	Sirops a base de xylitol, de ribitol ou d'arabitol
GB2234171A (en) *	1989-07-27	1991-01-30	Zambon Spa	Composition containing N-acetyl-cysteine of enhanced bioavailability

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB905197A (en) *	1960-01-01	1962-09-05	Lab Francais Chimiotherapie	Anti-viral compositions comprising 1-phenyl-2-amino-propane-1,3-diol derivatives
CA1239349A (en) *	1983-10-10	1988-07-19	Eberhard F. Gottwald	Pharmaceutical composition containing cimetidine
BE901885A (fr) *	1985-03-06	1985-07-01	Bruschettini Srl	Composition pharmaceutique sous forme de lotion ophtalmique et son procede de preparation.
US4861797A (en) *	1987-10-15	1989-08-29	Oratech Pharmaceutical Development Corporation	Liquid ibuprofen compositions and methods of making them
CH674940A5 (de) *	1988-05-05	1990-08-15	Ibsa Inst Biochimique Sa
ATE87476T1 (de) *	1988-11-10	1993-04-15	Ciba Geigy Ag	Fluessige orale formulierung.
IT1248998B (it) *	1990-06-26	1995-02-11	Iscofar Sas	Composizione di gomma da masticare per la prevenzione e il trattamento della placca dentaria
DK0481294T4 (da) *	1990-10-19	2001-06-18	Spirig Ag	Fast, hurtigt-opløseligt lægemiddelpræparat indeholdende N-acetylcystein

1992
- 1992-12-02 IT ITMI922758A patent/IT1256616B/it active IP Right Grant
1993
- 1993-11-23 CZ CZ951367A patent/CZ282550B6/cs not_active IP Right Cessation
- 1993-11-23 CA CA002150462A patent/CA2150462C/en not_active Expired - Lifetime
- 1993-11-23 AT AT0906093A patent/AT407113B/de not_active IP Right Cessation
- 1993-11-23 WO PCT/EP1993/003280 patent/WO1994012168A1/en not_active Ceased
- 1993-11-23 RU RU95114406A patent/RU2108777C1/ru active
- 1993-11-23 CH CH2423/94A patent/CH685371A5/it not_active IP Right Cessation
- 1993-11-23 GB GB9509822A patent/GB2288977B/en not_active Expired - Lifetime
- 1993-11-23 AU AU56266/94A patent/AU667611B2/en not_active Expired
- 1993-11-23 DE DE4396086A patent/DE4396086B3/de not_active Expired - Lifetime
- 1993-11-23 HU HU9501586A patent/HU221484B/hu unknown
- 1993-11-23 MD MD96-0265A patent/MD1714G2/ro unknown
- 1993-11-23 ES ES09450021A patent/ES2070806B1/es not_active Expired - Fee Related
- 1993-11-23 UA UA95062994A patent/UA27142C2/uk unknown
- 1993-11-23 JP JP6512747A patent/JPH08503703A/ja active Pending
- 1993-11-23 NZ NZ258544A patent/NZ258544A/en not_active IP Right Cessation
- 1993-11-23 NL NL9320052A patent/NL194957C/nl not_active IP Right Cessation
- 1993-11-23 DE DE4396086T patent/DE4396086T1/de active Pending
- 1993-12-01 BE BE9301326A patent/BE1006799A3/fr not_active IP Right Cessation
- 1993-12-02 FR FR9314443A patent/FR2698545B1/fr not_active Expired - Lifetime
1994
- 1994-05-24 LU LU88618A patent/LU88618A1/de unknown
1995
- 1995-05-31 DK DK199500614A patent/DK176247B1/da not_active IP Right Cessation
- 1995-06-01 SE SE9502001A patent/SE520834C2/sv not_active IP Right Cessation
- 1995-06-01 NO NO19952183A patent/NO314018B1/no not_active IP Right Cessation
- 1995-06-29 HU HU95P/P00579P patent/HU211912A9/hu unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2192790A (en) *	1986-07-24	1988-01-27	Inpharzam Int Sa	Acetylcysteine compositions
GB2192789A (en) *	1986-07-24	1988-01-27	Inpharzam Int Sa	Acetylcysteine compositions
FR2631831A1 (fr) *	1988-05-31	1989-12-01	Calco Anstalt	Sirops a base de xylitol, de ribitol ou d'arabitol
GB2234171A (en) *	1989-07-27	1991-01-30	Zambon Spa	Composition containing N-acetyl-cysteine of enhanced bioavailability

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 102, no. 26, 1 July 1985, Columbus, Ohio, US; abstract no. 225949r *
I.THIELENS: "STABILITY OF N-ACETYL-L-CYSTEINE IN PHARMACEUTICAL SYRUPS", FARM.TIJDSCHR.BELG., vol. 61, no. 4, 1984, pages 445 - 448 *

Also Published As

Publication number	Publication date
UA27142C2 (uk)	2000-02-28
GB9509822D0 (en)	1995-07-19
DE4396086B3 (de)	2013-02-28
IT1256616B (it)	1995-12-12
HU221484B (en)	2002-10-28
NL194957C (nl)	2003-09-02
DK61495A (da)	1995-05-31
SE9502001L (sv)	1995-07-21
ES2070806A1 (es)	1995-06-01
HU211912A9 (en)	1996-01-29
DE4396086T1 (de)	1995-12-07
CZ136795A3 (en)	1995-11-15
CZ282550B6 (cs)	1997-08-13
FR2698545B1 (fr)	1995-08-04
CA2150462A1 (en)	1994-06-09
NZ258544A (en)	1996-11-26
MD1714F2 (en)	2001-08-31
NO952183D0 (no)	1995-06-01
ATA906093A (de)	2000-05-15
JPH08503703A (ja)	1996-04-23
GB2288977A (en)	1995-11-08
AT407113B (de)	2000-12-27
NL9320052A (nl)	1995-08-01
AU667611B2 (en)	1996-03-28
SE9502001D0 (sv)	1995-06-01
ITMI922758A0 (it)	1992-12-02
NO314018B1 (no)	2003-01-20
SE520834C2 (sv)	2003-09-02
GB2288977B (en)	1996-09-04
HUT72668A (en)	1996-05-28
ITMI922758A1 (it)	1994-06-02
NL194957B (nl)	2003-05-01
HU9501586D0 (en)	1995-08-28
AU5626694A (en)	1994-06-22
WO1994012168A1 (en)	1994-06-09
LU88618A1 (de)	1995-12-01
NO952183L (no)	1995-06-01
MD1714G2 (ro)	2002-03-31
CA2150462C (en)	2005-04-19
CH685371A5 (it)	1995-06-30
FR2698545A1 (fr)	1994-06-03
ES2070806B1 (es)	1996-01-01
RU2108777C1 (ru)	1998-04-20
DK176247B1 (da)	2007-04-16

Legal Events

Date

Code

Title

Description

2013-12-31

RE20

Patent expired

Owner name: *ZAMBON GROUP S.P.A.

Effective date: 20131201

Publication	Publication Date	Title
US6103274A (en)	2000-08-15	Pharmaceutical, orally applicable composition
AU635283B2 (en)	1993-03-18	Aqeous pharmaceutical suspension for substantially water insoluble pharmaceutical actives
KR100439090B1 (ko)	2004-09-08	맛은폐성액체
EP0351301B1 (de)	1993-11-24	Arzneimittel zur Verhütung von sexuell übertragbaren Krankheiten
JPS6351325A (ja)	1988-03-04	安定化液状鎮痛組成物
FR2948029A1 (fr)	2011-01-21	Ameliorations de compositions et relatives a des compositions de nettoyage du colon
BE1000168A3 (fr)	1988-07-05	Composition pharmaceutique hydrosoluble contenant de la n-acetyl-cysteine et du sorbitol.
EP1543831A1 (de)	2005-06-22	Zusammensetzung enthaltend Pregabalin
MX2010011701A (es)	2010-12-06	Formulacion liquida para deferiprona con gusto agradable al paladar.
BE1006799A3 (fr)	1994-12-13	Sirop contenant de la n-acetyl-cysteine.
WO2008087323A2 (fr)	2008-07-24	Forme galenique pour l'administration par voie trans-muqueuse de paracetamol
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