DK480381A - Fremgangsmaade til fremstilling af carbostyrilforbindelser - Google Patents

Fremgangsmaade til fremstilling af carbostyrilforbindelser

Info

Publication number
DK480381A
DK480381A DK480381A DK480381A DK480381A DK 480381 A DK480381 A DK 480381A DK 480381 A DK480381 A DK 480381A DK 480381 A DK480381 A DK 480381A DK 480381 A DK480381 A DK 480381A
Authority
DK
Denmark
Prior art keywords
carbostyric
compounds
procedure
manufacturing
manufacturing carbostyric
Prior art date
Application number
DK480381A
Other languages
English (en)
Other versions
DK155665C (da
DK155665B (da
Inventor
M Tominaga
Y H Yang
H Ogawa
K Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK480381A publication Critical patent/DK480381A/da
Priority to DK561984A priority Critical patent/DK159436C/da
Publication of DK155665B publication Critical patent/DK155665B/da
Application granted granted Critical
Publication of DK155665C publication Critical patent/DK155665C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK480381A 1980-10-31 1981-10-30 Analogifremgangsmaade til fremstilling af carbostyrilforbindelser DK155665C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK561984A DK159436C (da) 1980-10-31 1984-11-27 Substituerede piperazino-substituerede phenylcarboxylsyreforbindelser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15407180 1980-10-31
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (3)

Publication Number Publication Date
DK480381A true DK480381A (da) 1982-05-01
DK155665B DK155665B (da) 1989-05-01
DK155665C DK155665C (da) 1989-09-04

Family

ID=15576252

Family Applications (1)

Application Number Title Priority Date Filing Date
DK480381A DK155665C (da) 1980-10-31 1981-10-30 Analogifremgangsmaade til fremstilling af carbostyrilforbindelser

Country Status (24)

Country Link
US (1) US4415572A (da)
JP (1) JPS5777676A (da)
KR (1) KR860001944B1 (da)
AR (2) AR242563A1 (da)
AT (1) AT381701B (da)
AU (1) AU524419B2 (da)
BE (1) BE890942A (da)
CA (1) CA1209575A (da)
CH (2) CH650782A5 (da)
DE (2) DE3153260C2 (da)
DK (1) DK155665C (da)
ES (3) ES507198A0 (da)
FI (1) FI77450C (da)
FR (2) FR2493320B1 (da)
GB (1) GB2086896B (da)
IT (2) IT1210585B (da)
MX (1) MX8481A (da)
NL (2) NL194205C (da)
NO (1) NO158099C (da)
PH (1) PH17962A (da)
PT (1) PT73910B (da)
SE (2) SE448877B (da)
SU (1) SU1426452A3 (da)
ZA (1) ZA817515B (da)

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CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
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US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
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DE3524067A1 (de) * 1985-07-05 1987-01-08 Boehringer Mannheim Gmbh Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
JPH0625123B2 (ja) * 1985-12-12 1994-04-06 大塚製薬株式会社 カルボスチリル誘導体−シクロデキストリン包接化合物
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
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GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
DE69230131T2 (de) * 1991-07-03 2000-03-02 Otsuka Pharmaceutical Co., Ltd. Apoptoseregulator
US5750529A (en) * 1991-07-03 1998-05-12 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating compostion
WO1993011769A1 (fr) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Agent anticancereux
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
CA2121148A1 (en) * 1992-08-19 1994-03-03 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
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US5521185A (en) * 1993-03-02 1996-05-28 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting graft rejection and IL-1 production
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
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Also Published As

Publication number Publication date
IT1210585B (it) 1989-09-14
PH17962A (en) 1985-02-20
SE8106430L (sv) 1982-05-01
DE3142982A1 (de) 1982-06-24
SE8406209L (sv) 1984-12-06
SE466655B (sv) 1992-03-16
DE3142982C2 (de) 1985-12-19
FI77450B (fi) 1988-11-30
FR2493320B1 (fr) 1985-08-23
IT8149588A0 (it) 1981-10-29
SE448877B (sv) 1987-03-23
KR860001944B1 (ko) 1986-11-01
MX8481A (es) 1994-02-28
NO158099C (no) 1988-07-13
US4415572A (en) 1983-11-15
ATA460281A (de) 1986-04-15
SU1426452A3 (ru) 1988-09-23
KR830007607A (ko) 1983-11-04
DE3153260A1 (da) 1985-05-15
SE8406209D0 (sv) 1984-12-06
JPS5777676A (en) 1982-05-15
ES520638A0 (es) 1984-04-16
ES8403885A1 (es) 1984-04-16
IT8547867A0 (it) 1985-03-26
CH656616A5 (de) 1986-07-15
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
CH650782A5 (de) 1985-08-15
AR242375A1 (es) 1993-03-31
ES520637A0 (es) 1984-04-16
FR2552760A1 (fr) 1985-04-05
DE3153260C2 (da) 1989-05-24
AR242563A1 (es) 1993-04-30
ZA817515B (en) 1982-10-27
NL194205C (nl) 2001-09-04
AT381701B (de) 1986-11-25
FR2552760B1 (fr) 1988-08-05
GB2086896A (en) 1982-05-19
FI813408L (fi) 1982-05-01
ES8306743A1 (es) 1983-06-16
AU7699681A (en) 1982-05-06
NO158099B (no) 1988-04-05
NL8403096A (nl) 1985-02-01
JPH0143747B2 (da) 1989-09-22
PT73910B (en) 1983-04-18
DK155665C (da) 1989-09-04
NL194205B (nl) 2001-05-01
FI77450C (fi) 1989-03-10
ES8403886A1 (es) 1984-04-16
PT73910A (en) 1981-11-01
CA1209575A (en) 1986-08-12
DK155665B (da) 1989-05-01
IT1226479B (it) 1991-01-16
FR2493320A1 (fr) 1982-05-07
NO813678L (no) 1982-05-03
ES507198A0 (es) 1983-06-16
NL8104923A (nl) 1982-05-17
GB2086896B (en) 1984-10-10

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