FR2552760B1 - Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese - Google Patents

Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Info

Publication number: FR2552760B1
Authority: FR; France
Prior art keywords: obtaining; synthesis intermediates; carbostyrile; derivatives; carbostyrile derivatives
Prior art date: 1980-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR848416085A

Other languages

English (en)

Other versions

FR2552760A1 (fr

Inventor

Michiaki Tominaga

Yung-Hsiung Yang

Hidenori Ogawa

Kazuyuki Nakagawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Otsuka Pharmaceutical Co Ltd

Original Assignee

Otsuka Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-31

Filing date

1984-10-19

Publication date

1988-08-05

1984-10-19 Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd

1985-04-05 Publication of FR2552760A1 publication Critical patent/FR2552760A1/fr

1988-08-05 Application granted granted Critical

1988-08-05 Publication of FR2552760B1 publication Critical patent/FR2552760B1/fr

Status Expired legal-status Critical Current

Links

230000015572 biosynthetic process Effects 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

FR848416085A 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese Expired FR2552760B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP55154071A JPS5777676A (en)	1980-10-31	1980-10-31	Carbostyril derivative

Publications (2)

Publication Number	Publication Date
FR2552760A1 FR2552760A1 (fr)	1985-04-05
FR2552760B1 true FR2552760B1 (fr)	1988-08-05

Family

ID=15576252

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FR8120470A Expired FR2493320B1 (fr)	1980-10-31	1981-10-30	Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant
FR848416085A Expired FR2552760B1 (fr)	1980-10-31	1984-10-19	Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FR8120470A Expired FR2493320B1 (fr)	1980-10-31	1981-10-30	Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant

Country Status (24)

Country	Link
US (1)	US4415572A (fr)
JP (1)	JPS5777676A (fr)
KR (1)	KR860001944B1 (fr)
AR (2)	AR242563A1 (fr)
AT (1)	AT381701B (fr)
AU (1)	AU524419B2 (fr)
BE (1)	BE890942A (fr)
CA (1)	CA1209575A (fr)
CH (2)	CH650782A5 (fr)
DE (2)	DE3142982C2 (fr)
DK (1)	DK155665C (fr)
ES (3)	ES8306743A1 (fr)
FI (1)	FI77450C (fr)
FR (2)	FR2493320B1 (fr)
GB (1)	GB2086896B (fr)
IT (2)	IT1210585B (fr)
MX (1)	MX8481A (fr)
NL (2)	NL194205C (fr)
NO (1)	NO158099C (fr)
PH (1)	PH17962A (fr)
PT (1)	PT73910B (fr)
SE (2)	SE448877B (fr)
SU (1)	SU1426452A3 (fr)
ZA (1)	ZA817515B (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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JPS5883677A (ja) *	1981-11-11	1983-05-19	Otsuka Pharmaceut Co Ltd	カルボスチリル誘導体
JPS5929667A (ja) *	1982-08-13	1984-02-16	Otsuka Pharmaceut Co Ltd	カルボスチリル誘導体および強心剤
CH655110A5 (de) *	1982-09-03	1986-03-27	Otsuka Pharma Co Ltd	Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4730000A (en) *	1984-04-09	1988-03-08	Abbott Laboratories	Quinoline antibacterial compounds
NZ209876A (en) *	1983-10-17	1988-03-30	Duphar Int Res	Piperazines and pharmaceutical compositions
JPS60126270A (ja) *	1983-12-14	1985-07-05	Otsuka Pharmaceut Co Ltd	カルボスチリル誘導体
PT79699B (en) *	1983-12-22	1986-12-10	Pfizer	Process for preparing quinolone inotropic agents
US4774246A (en) *	1984-01-26	1988-09-27	Abbott Laboratories	Quinoline antibacterial compounds
NZ212209A (en) *	1984-05-29	1988-08-30	Pfizer	Quinolone derivatives and pharmaceutical compositions
JPS60256133A (ja) *	1984-06-01	1985-12-17	Fuji Photo Film Co Ltd	放射線画像情報記録読取装置
DE3582371D1 (de) *	1984-07-06	1991-05-08	Otsuka Pharma Co Ltd	Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben.
US4760064A (en) *	1984-12-18	1988-07-26	Otsuka Pharmaceutical Co., Ltd.	Carbostyril compounds, compositions containing same and processes for preparing same
JPH07100696B2 (ja) *	1984-12-18	1995-11-01	大塚製薬株式会社	カルボスチリル誘導体
JPS61145162A (ja) *	1984-12-19	1986-07-02	Otsuka Pharmaceut Co Ltd	カルボスチリル誘導体
DE3586794T2 (de) *	1984-12-21	1993-05-27	Duphar Int Res	Arzneimittel mit psychotroper wirkung.
EP0190472B1 (fr) *	1984-12-21	1989-07-12	Duphar International Research B.V	Médicaments à activité antipsychotique
US4845100A (en) *	1985-04-12	1989-07-04	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
DE3524067A1 (de) *	1985-07-05	1987-01-08	Boehringer Mannheim Gmbh	Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
US4666913A (en) *	1985-11-22	1987-05-19	William H. Rorer, Inc.	Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) *	1985-11-28	1986-01-02	Pfizer Ltd	Quinolone cardiac stimulants
JPH0625123B2 (ja) *	1985-12-12	1994-04-06	大塚製薬株式会社	カルボスチリル誘導体−シクロデキストリン包接化合物
US4687770A (en) *	1985-12-23	1987-08-18	Abbott Laboratories	Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) *	1985-12-23	1987-08-25	Abbott Laboratories	Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US5358949A (en) *	1986-03-05	1994-10-25	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
DK111387A (da) *	1986-03-05	1987-09-06	Otsuka Pharma Co Ltd	Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
US5166160A (en) *	1986-12-23	1992-11-24	Burroughs Wellcome Co.	Quinoline compound
GB8630702D0 (en) *	1986-12-23	1987-02-04	Wellcome Found	Quinoline compound
JPS63225357A (ja) *	1987-03-12	1988-09-20	Otsuka Pharmaceut Co Ltd	カルボスチリル誘導体
GB8827189D0 (en) *	1988-11-21	1988-12-29	Fujisawa Pharmaceutical Co	2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
ES2138971T3 (es)	1991-07-03	2000-02-01	Otsuka Pharma Co Ltd	Regulador de la apoptosis.
US5543412A (en) *	1991-07-03	1996-08-06	Otsuka Pharmaceutical Co., Ltd.	Hepatitis treatment with carbostyril compounds
WO1993011769A1 (fr) *	1991-12-10	1993-06-24	Otsuka Pharmaceutical Co., Ltd	Agent anticancereux
JP2686887B2 (ja) *	1992-08-11	1997-12-08	キッセイ薬品工業株式会社	ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
US5464833A (en) *	1992-08-19	1995-11-07	Otsuka Pharmaceutical Co., Ltd.	Apoptosis regulating composition
JP2826790B2 (ja) *	1992-12-26	1998-11-18	キッセイ薬品工業株式会社	３，４−ジヒドロカルボスチリル誘導体
CA2134880A1 (fr) *	1993-03-02	1994-09-03	Otsuka Pharmaceutical Co., Ltd.	Inhibiteur du rejet de greffons et inhibiteur de la production d'il-1
JPH0733664A (ja) *	1993-07-26	1995-02-03	Otsuka Pharmaceut Co Ltd	平滑筋細胞増殖抑制剤
GB9326373D0 (en) *	1993-12-23	1994-02-23	Zeneca Ltd	Chemical compounds
GB9326232D0 (en) *	1993-12-23	1994-02-23	Zeneca Ltd	Chemical compounds
US5504093A (en) *	1994-08-01	1996-04-02	Otsuka Pharmaceutical Co., Ltd.	Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
AU708053B2 (en)	1996-03-29	1999-07-29	Duphar International Research B.V.	Piperazine and piperidine compounds
GB2312843A (en) *	1996-05-07	1997-11-12	Merck & Co Inc	Method of treating rheumatoid arthritis
US5684007A (en) *	1996-09-05	1997-11-04	Otsuka Pharmaceutical Co., Ltd.	Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
US6566372B1 (en) *	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
US6667313B1 (en)	1999-08-27	2003-12-23	Ligand Pharmaceuticals Inc.	8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
PL353792A1 (en)	1999-08-27	2003-12-01	Ligand Pharmaceuticals Incorporatedligand Pharmaceuticals Incorporated	Androgen receptor modulator compounds and methods
WO2001019770A2 (fr)	1999-09-14	2001-03-22	Ligand Pharmaceuticals Incorporated	Modulateurs rxr a profil pharmacologique ameliore
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
JP4709759B2 (ja) *	2003-08-22	2011-06-22	リガンド・ファーマシューティカルズ・インコーポレイテッド	アンドロゲン受容体モジュレーター化合物としての６−シクロアミノ−２−キノリノン誘導体
WO2006097459A1 (fr) *	2005-03-14	2006-09-21	Nycomed Gmbh	Procede de prevention des maladies cardiovasculaires
WO2007037187A1 (fr)	2005-09-27	2007-04-05	Shionogi & Co., Ltd.	Dérivé sulfonamide ayant une activité antagoniste de récepteur pgd2
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
EP2810951B1 (fr)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
CA2730603C (fr)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonistes de la guanylate cyclase utiles dans le traitement des affections gastro-intestinales, de l'inflammation gastro-intestinale, du cancer gastro-intestinal et d'autres affections
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (fr)	2011-03-01	2024-03-05	Synergy Pharmaceuticals Inc.	Procede de preparation d'agonistes du guanylate cyclase c
EP3718557A3 (fr)	2013-02-25	2020-10-21	Bausch Health Ireland Limited	Agoniste du récepteur de la guanylate cyclase sp-333 à utiliser lors du nettoyage du côlon
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
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KR20160042039A (ko)	2013-08-09	2016-04-18	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (fr)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combinaison pour baisser le phosphate sérique chez un patient

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1278385B (de) *	1965-03-30	1968-09-26	Bayer Ag	Aufhellungsmittel
GB1299172A (en) *	1968-10-15	1972-12-06	Lilly Industries Ltd	Heterocyclic anti-inflammatory agents
DE2719562C2 (de) *	1976-05-08	1986-05-07	Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo	3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
JPS54130589A (en) *	1978-03-31	1979-10-09	Yoshitomi Pharmaceut Ind Ltd	Pyridazine derivative and its preparation
JPS54135785A (en) *	1978-04-12	1979-10-22	Yoshitomi Pharmaceut Ind Ltd	Pyridazinone derivative and its preparation
JPS54138585A (en) *	1978-04-18	1979-10-27	Yoshitomi Pharmaceut Ind Ltd	Pyridazine derivative and its preparation
JPS54141785A (en) *	1978-04-26	1979-11-05	Yoshitomi Pharmaceut Ind Ltd	Preparation of carboxylic acid derivative
JPS6017072B2 (ja) *	1978-09-05	1985-04-30	三菱電機株式会社	赤熱金属検出器
JPS5549319A (en) *	1978-10-06	1980-04-09	Yoshitomi Pharmaceut Ind Ltd	Remedy for suppression of blood platelet-agglutination
JPS5553283A (en) *	1978-10-12	1980-04-18	Yoshitomi Pharmaceut Ind Ltd	Pyridazinone derivative
JPS5576872A (en) *	1978-12-06	1980-06-10	Yoshitomi Pharmaceut Ind Ltd	Imidazolidinone derivative
JPS5583781A (en) *	1978-12-19	1980-06-24	Yoshitomi Pharmaceut Ind Ltd	Pyridazinone derivative

1980
- 1980-10-31 JP JP55154071A patent/JPS5777676A/ja active Granted
1981
- 1981-10-29 ZA ZA817515A patent/ZA817515B/xx unknown
- 1981-10-29 DE DE3142982A patent/DE3142982C2/de not_active Expired
- 1981-10-29 ES ES507198A patent/ES8306743A1/es not_active Expired
- 1981-10-29 CA CA000389068A patent/CA1209575A/fr not_active Expired
- 1981-10-29 DE DE3153260A patent/DE3153260C2/de not_active Expired
- 1981-10-29 SU SU813349303A patent/SU1426452A3/ru active
- 1981-10-29 AT AT0460281A patent/AT381701B/de not_active IP Right Cessation
- 1981-10-29 IT IT8149588A patent/IT1210585B/it active
- 1981-10-30 CH CH6942/81A patent/CH650782A5/de not_active IP Right Cessation
- 1981-10-30 US US06/316,572 patent/US4415572A/en not_active Expired - Lifetime
- 1981-10-30 DK DK480381A patent/DK155665C/da not_active IP Right Cessation
- 1981-10-30 AU AU76996/81A patent/AU524419B2/en not_active Expired
- 1981-10-30 PH PH26427A patent/PH17962A/en unknown
- 1981-10-30 NL NL8104923A patent/NL194205C/nl not_active IP Right Cessation
- 1981-10-30 BE BE0/206407A patent/BE890942A/fr not_active IP Right Cessation
- 1981-10-30 SE SE8106430A patent/SE448877B/sv not_active IP Right Cessation
- 1981-10-30 CH CH199/85A patent/CH656616A5/de not_active IP Right Cessation
- 1981-10-30 NO NO813678A patent/NO158099C/no not_active IP Right Cessation
- 1981-10-30 FI FI813408A patent/FI77450C/fi not_active IP Right Cessation
- 1981-10-30 GB GB8132743A patent/GB2086896B/en not_active Expired
- 1981-10-30 FR FR8120470A patent/FR2493320B1/fr not_active Expired
- 1981-10-30 PT PT73910A patent/PT73910B/pt unknown
- 1981-10-31 KR KR1019810004240A patent/KR860001944B1/ko not_active Expired
1983
- 1983-03-15 ES ES520638A patent/ES8403886A1/es not_active Expired
- 1983-03-15 ES ES520637A patent/ES520637A0/es active Granted
- 1983-05-06 AR AR83292954A patent/AR242563A1/es active
1984
- 1984-03-21 AR AR84296053A patent/AR242375A1/es active
- 1984-10-11 NL NL8403096A patent/NL8403096A/nl not_active Application Discontinuation
- 1984-10-19 FR FR848416085A patent/FR2552760B1/fr not_active Expired
- 1984-12-06 SE SE8406209A patent/SE466655B/sv not_active IP Right Cessation
1985
- 1985-03-26 IT IT8547867A patent/IT1226479B/it active
- 1985-08-09 MX MX848185A patent/MX8481A/es unknown

Also Published As

Publication number	Publication date
NL194205C (nl)	2001-09-04
AU7699681A (en)	1982-05-06
DE3142982C2 (de)	1985-12-19
SE8106430L (sv)	1982-05-01
ES520638A0 (es)	1984-04-16
FI813408L (fi)	1982-05-01
DE3153260A1 (fr)	1985-05-15
GB2086896A (en)	1982-05-19
NO158099C (no)	1988-07-13
PT73910A (en)	1981-11-01
FR2552760A1 (fr)	1985-04-05
AR242563A1 (es)	1993-04-30
CA1209575A (fr)	1986-08-12
ES8403886A1 (es)	1984-04-16
MX8481A (es)	1994-02-28
SE448877B (sv)	1987-03-23
DK155665C (da)	1989-09-04
SE8406209L (sv)	1984-12-06
ZA817515B (en)	1982-10-27
KR830007607A (ko)	1983-11-04
DE3142982A1 (de)	1982-06-24
KR860001944B1 (ko)	1986-11-01
NL8104923A (nl)	1982-05-17
CH650782A5 (de)	1985-08-15
DK480381A (da)	1982-05-01
CH656616A5 (de)	1986-07-15
ES507198A0 (es)	1983-06-16
JPS5777676A (en)	1982-05-15
FR2493320A1 (fr)	1982-05-07
NL8403096A (nl)	1985-02-01
SE8406209D0 (sv)	1984-12-06
PT73910B (en)	1983-04-18
DK155665B (da)	1989-05-01
AR242375A1 (es)	1993-03-31
NL194205B (nl)	2001-05-01
IT1210585B (it)	1989-09-14
JPH0143747B2 (fr)	1989-09-22
ES8306743A1 (es)	1983-06-16
US4415572A (en)	1983-11-15
GB2086896B (en)	1984-10-10
AU524419B2 (en)	1982-09-16
BE890942A (fr)	1982-02-15
NO158099B (no)	1988-04-05
SU1426452A3 (ru)	1988-09-23
FI77450B (fi)	1988-11-30
IT8149588A0 (it)	1981-10-29
ATA460281A (de)	1986-04-15
IT8547867A0 (it)	1985-03-26
FI77450C (fi)	1989-03-10
ES8403885A1 (es)	1984-04-16
IT1226479B (it)	1991-01-16
FR2493320B1 (fr)	1985-08-23
SE466655B (sv)	1992-03-16
AT381701B (de)	1986-11-25
DE3153260C2 (fr)	1989-05-24
ES520637A0 (es)	1984-04-16
PH17962A (en)	1985-02-20
NO813678L (no)	1982-05-03

Publication	Publication Date	Title
RO93871A (fr)	1988-02-29	Procede d'obtention des derives de propargyloxyacetonitryle substitus
RO93218A (fr)	1987-12-31	Procede pour la preparation des derives de 2-oxyndole
RO82526A (fr)	1984-10-31	Procede d'obtention des derives de flavane
PT73010B (fr)	1982-07-01	Procede de synthese de chloroformiates alpha-chlores et nouveaux chloformiates alpha-chlores
PT79003A (fr)	1984-08-01	Procede pour l'obtention de derives de la benzanidrine a activite antiminobienne
RO84236A (fr)	1984-05-23	Procede d'obtention des derives de composes acyle-ureiques
FR2550538B1 (fr)	1988-03-04	Procede pour la synthese de l'aspartam
PT70408A (fr)	1979-12-01	Procede d'obtention de noveaux aryltrifluoroethanols
FR2422671B1 (fr)	1985-06-28	Procede pour l'obtention d'ethylsilanes
BE880009A (fr)	1980-05-13	Procede pour l'epuration du tryptophane et de derives du tryptophane et produits obtenus
BE889492A (fr)	1981-11-03	Procede de synthese de derives du 3-cetocyclopentene-5-oxy
BE875699A (fr)	1979-08-16	Procede ameliore pour la synthese de l'haloperidol
FR2462423B1 (fr)	1986-09-26	Procede d'obtention de chlorothiolformiates
RO79323A2 (fr)	1983-07-07	Procede d'obtention de p-toluensulfonamide
BE865224A (fr)	1978-07-17	Derives d'imidazole et procede pour leur synthese
RO81362A2 (fr)	1983-02-15	Procede d'obtention du chlorhydrate de vibramycine
RO77722A2 (fr)	1981-12-25	Procede continu et installation pour l'obtention des chlorothiolformiates
RO90402A2 (fr)	1986-09-30	Procede pour l'obtention de l'hydrazodicarboxamide
RO82673A2 (fr)	1983-10-15	Procede pour la synthese de 5-bromisatine
RO81615A (fr)	1983-09-26	Procede d'obtention des derives de nitrobenzonitryle
RO79162A2 (fr)	1982-06-25	Derive de diethyle5-amino5-2-amino-pentane et procede d'obtention
RO88701A2 (fr)	1986-02-28	Procede d'obtention de alpha-l-aspartyl-lphenylalaninate de methyle
RO80020A2 (fr)	1982-12-06	Procede pour l'obtention de la biomasse proteique
RO79325A (fr)	1982-08-17	Procede continu d'obtention des dichlorhydrinones de glycerine
RO81761A2 (fr)	1983-06-01	Procede pour l'obtention du trichloracetonutryle