JP4015193B2 - 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法 - Google Patents

反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法 Download PDF

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JP4015193B2
JP4015193B2 JP52074497A JP52074497A JP4015193B2 JP 4015193 B2 JP4015193 B2 JP 4015193B2 JP 52074497 A JP52074497 A JP 52074497A JP 52074497 A JP52074497 A JP 52074497A JP 4015193 B2 JP4015193 B2 JP 4015193B2
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sequence
polynucleotide
recombination
sequences
dna
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JP2000500981A (ja
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ウィレム ピー． シー． ステマー，
アンドレアス クラメリ，
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マキシジェン， インコーポレイテッド
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Priority claimed from US08/564,955 external-priority patent/US5811238A/en
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    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
    • C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
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    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02006—Beta-lactamase (3.5.2.6)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP52074497A 1995-11-30 1996-12-02 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法 Expired - Fee Related JP4015193B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/564,955 1995-11-30
US08/564,955 US5811238A (en) 1994-02-17 1995-11-30 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US08/621,859 1996-03-25
US08/621,859 US6117679A (en) 1994-02-17 1996-03-25 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
PCT/US1996/019256 WO1997020078A1 (en) 1995-11-30 1996-12-02 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP11267847A Division JP2000308490A (ja) 1995-11-30 1999-09-21 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法
JP2004101193A Division JP2004187694A (ja) 1995-11-30 2004-03-30 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法

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JP2000500981A JP2000500981A (ja) 2000-02-02
JP4015193B2 true JP4015193B2 (ja) 2007-11-28

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JP52074497A Expired - Fee Related JP4015193B2 (ja) 1995-11-30 1996-12-02 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法
JP11267847A Pending JP2000308490A (ja) 1995-11-30 1999-09-21 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法
JP2004101193A Withdrawn JP2004187694A (ja) 1995-11-30 2004-03-30 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法

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JP11267847A Pending JP2000308490A (ja) 1995-11-30 1999-09-21 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法
JP2004101193A Withdrawn JP2004187694A (ja) 1995-11-30 2004-03-30 反復的選択および組換えにより所望の特徴を有するポリヌクレオチドを作製する方法

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US (8) US6117679A (2)
EP (4) EP0876509B2 (2)
JP (3) JP4015193B2 (2)
AT (2) ATE205878T1 (2)
AU (1) AU713952B2 (2)
CA (1) CA2239099C (2)
DE (4) DE911396T1 (2)
DK (2) DK0911396T3 (2)
ES (2) ES2164929T5 (2)
IL (1) IL124675A0 (2)
WO (1) WO1997020078A1 (2)

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US6180406B1 (en) 2001-01-30
US6291242B1 (en) 2001-09-18
ES2164929T5 (es) 2010-04-12
EP0876509B1 (en) 2001-09-19
US6413774B1 (en) 2002-07-02
EP0911396B1 (en) 2001-09-19
DE911396T1 (de) 2001-04-05
IL124675A0 (en) 1998-12-06
ES2164929T3 (es) 2002-03-01
AU1087397A (en) 1997-06-19
WO1997020078A1 (en) 1997-06-05
EP0911396A2 (en) 1999-04-28
ES2165124T3 (es) 2002-03-01
EP0911396A3 (en) 1999-05-06
ATE205878T1 (de) 2001-10-15
DE876509T1 (de) 2001-04-05
US6344356B1 (en) 2002-02-05
US6573098B1 (en) 2003-06-03
JP2004187694A (ja) 2004-07-08
EP0876509A4 (en) 1999-04-28
DE69615411D1 (de) 2001-10-25
EP1138763A3 (en) 2002-02-27
JP2000500981A (ja) 2000-02-02
EP1138763A2 (en) 2001-10-04
EP0876509A1 (en) 1998-11-11
DE69615406T2 (de) 2002-06-20
JP2000308490A (ja) 2000-11-07
DK0911396T3 (da) 2002-02-18
US6323030B1 (en) 2001-11-27
DE69615406D1 (de) 2001-10-25
EP0876509B2 (en) 2009-11-11
DK0876509T4 (da) 2010-04-19
CA2239099C (en) 2004-11-30
US6117679A (en) 2000-09-12
CA2239099A1 (en) 1997-06-05
DK0876509T3 (da) 2002-02-18
EP1103606A3 (en) 2001-08-22
EP1103606A2 (en) 2001-05-30
DE69615411T2 (de) 2002-06-20

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