JP6527643B2 - Ｉｌ−８関連疾患の治療用又は予防用組成物 - Google Patents

Ｉｌ−８関連疾患の治療用又は予防用組成物 Download PDF

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JP6527643B2
JP6527643B2 JP2018531994A JP2018531994A JP6527643B2 JP 6527643 B2 JP6527643 B2 JP 6527643B2 JP 2018531994 A JP2018531994 A JP 2018531994A JP 2018531994 A JP2018531994 A JP 2018531994A JP 6527643 B2 JP6527643 B2 JP 6527643B2
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antibody
amino acid
seq
human
acid sequence
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JPWO2018025982A1 (ja
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綾子 垣内
綾子 垣内
淳彦 加藤
淳彦 加藤
修次 林
修次 林
和泉 ▲柳▼澤
和泉 ▲柳▼澤
良 今野
良 今野
幸穂 根津
幸穂 根津
直 山海
直 山海
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Chugai Pharmaceutical Co Ltd
Jichi Medical University
National Institutes of Biomedical Innovation Health and Nutrition
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Chugai Pharmaceutical Co Ltd
Jichi Medical University
National Institutes of Biomedical Innovation Health and Nutrition
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018531994A 2016-08-05 2017-08-04 Ｉｌ−８関連疾患の治療用又は予防用組成物 Active JP6527643B2 (ja)

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JP2016154174 2016-08-05
JP2016154174 2016-08-05
PCT/JP2017/028346 WO2018025982A1 (ja) 2016-08-05 2017-08-04 Ｉｌ－８関連疾患の治療用又は予防用組成物

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JP2018531994A Active JP6527643B2 (ja) 2016-08-05 2017-08-04 Ｉｌ−８関連疾患の治療用又は予防用組成物
JP2019089724A Active JP7193803B2 (ja) 2016-08-05 2019-05-10 Ｉｌ－８関連疾患の治療用又は予防用組成物
JP2022192775A Pending JP2023022238A (ja) 2016-08-05 2022-12-01 Ｉｌ－８関連疾患の治療用又は予防用組成物
JP2024115311A Pending JP2024150597A (ja) 2016-08-05 2024-07-19 Ｉｌ－８関連疾患の治療用又は予防用組成物

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JP2019089724A Active JP7193803B2 (ja) 2016-08-05 2019-05-10 Ｉｌ－８関連疾患の治療用又は予防用組成物
JP2022192775A Pending JP2023022238A (ja) 2016-08-05 2022-12-01 Ｉｌ－８関連疾患の治療用又は予防用組成物
JP2024115311A Pending JP2024150597A (ja) 2016-08-05 2024-07-19 Ｉｌ－８関連疾患の治療用又は予防用組成物

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US (4) US11053308B2 (2)
EP (1) EP3494991A4 (2)
JP (4) JP6527643B2 (2)
KR (4) KR102102734B1 (2)
CN (3) CN116271014A (2)
AU (1) AU2017305073B2 (2)
BR (1) BR112019001902A2 (2)
IL (1) IL264626B (2)
MX (2) MX2019001448A (2)
RU (1) RU2766112C2 (2)
SG (1) SG11201801024XA (2)
TW (3) TWI693940B (2)
WO (1) WO2018025982A1 (2)

Cited By (1)

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JP2019142968A (ja) * 2016-08-05 2019-08-29 中外製薬株式会社 Ｉｌ−８関連疾患の治療用又は予防用組成物

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KR102057826B1 (ko) 2008-04-11 2019-12-20 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
TWI812066B (zh) 2010-11-30 2023-08-11 日商中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
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AU2014250434B2 (en) 2013-04-02 2019-08-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
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CN114773470A (zh) 2015-02-05 2022-07-22 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CA3093729A1 (en) 2018-03-15 2019-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
EP3956365A4 (en) 2019-04-19 2023-07-05 Chugai Seiyaku Kabushiki Kaisha ANTIBODIES AND COMPOSITIONS FOR USE IN DETECTING OR CAPTURE OF A POLYPEPTIDE IN A SAMPLE AND METHODS OF DETECTING OR CAPTURE OF A POLYPEPTIDE IN A SAMPLE
CN115996949A (zh) * 2020-04-17 2023-04-21 硕腾服务有限责任公司 犬抗体变异体
KR20230004726A (ko) * 2020-04-22 2023-01-06 아케소 바이오파마, 인크. 항-cd73/항-pd-1 이중특이항체 및 이의 용도
TW202227081A (zh) * 2020-09-15 2022-07-16 美商雅力思提雅治療公司 用於治療掌蹠膿疱症之組合物及方法
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