LT3483164T - Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai - Google Patents

Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai

Info

Publication number
LT3483164T
LT3483164T LTEP18209919.2T LT18209919T LT3483164T LT 3483164 T LT3483164 T LT 3483164T LT 18209919 T LT18209919 T LT 18209919T LT 3483164 T LT3483164 T LT 3483164T
Authority
LT
Lithuania
Prior art keywords
pkr
activators
pyruvate kinase
pyrrolopyrrole
compositions
Prior art date
Application number
LTEP18209919.2T
Other languages
English (en)
Lithuanian (lt)
Inventor
Anna Ericsson
Neal Green
Gary Gustafson
Bingsong Han
David LANCIA JR.
Lorna MITCHELL
David Richard
Tatiana Shelekhin
Chase C. Smith
Zhongguo Wang
Xiaozhang Zheng
Original Assignee
Forma Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics, Inc. filed Critical Forma Therapeutics, Inc.
Publication of LT3483164T publication Critical patent/LT3483164T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTEP18209919.2T 2017-03-20 2018-03-20 Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai LT3483164T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762473751P 2017-03-20 2017-03-20

Publications (1)

Publication Number Publication Date
LT3483164T true LT3483164T (lt) 2020-05-11

Family

ID=61911726

Family Applications (2)

Application Number Title Priority Date Filing Date
LT18716455T LT3448859T (lt) 2017-03-20 2018-03-20 Pirolpirolo kompozicijos, kaip piruvato kinazės (pkr) aktyvatoriai
LTEP18209919.2T LT3483164T (lt) 2017-03-20 2018-03-20 Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LT18716455T LT3448859T (lt) 2017-03-20 2018-03-20 Pirolpirolo kompozicijos, kaip piruvato kinazės (pkr) aktyvatoriai

Country Status (32)

Country Link
US (8) US10208052B1 (it)
EP (3) EP3680241A1 (it)
JP (2) JP6594570B2 (it)
KR (2) KR102296703B1 (it)
CN (2) CN109311897B (it)
AR (2) AR111295A1 (it)
AU (4) AU2018240172C1 (it)
CA (1) CA3024181C (it)
CY (2) CY1122393T1 (it)
DK (2) DK3483164T3 (it)
EA (1) EA201992215A1 (it)
ES (2) ES2788856T3 (it)
HR (2) HRP20191665T1 (it)
HU (2) HUE049979T2 (it)
IL (2) IL269447B (it)
LT (2) LT3448859T (it)
MA (3) MA50589A (it)
MD (2) MD3483164T2 (it)
MX (2) MX378512B (it)
NZ (2) NZ763766A (it)
PL (2) PL3448859T3 (it)
PT (2) PT3483164T (it)
RS (2) RS59306B1 (it)
RU (3) RU2707751C1 (it)
SA (1) SA519410164B1 (it)
SG (1) SG11201908670SA (it)
SI (2) SI3448859T1 (it)
SM (2) SMT201900517T1 (it)
TN (2) TN2020000045A1 (it)
TW (2) TWI772389B (it)
WO (1) WO2018175474A1 (it)
ZA (1) ZA201906278B (it)

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TWI633087B (zh) 2012-06-13 2018-08-21 赫孚孟拉羅股份公司 新穎二氮雜螺環烷及氮雜螺環烷
EP3590940B1 (en) 2012-09-25 2021-06-09 F. Hoffmann-La Roche AG Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
NO3074400T3 (it) 2013-11-26 2018-04-14
MA39792B1 (fr) 2014-03-26 2019-12-31 Hoffmann La Roche Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
EP3122751B1 (en) 2014-03-26 2019-10-30 F.Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MX387736B (es) 2015-09-04 2025-03-18 Hoffmann La Roche Derivados de fenoximetilo.
PE20180451A1 (es) 2015-09-24 2018-03-05 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
CN107635995B (zh) 2015-09-24 2022-08-19 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
KR20180054634A (ko) * 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
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WO2020061252A1 (en) * 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
US10675274B2 (en) 2018-09-19 2020-06-09 Forma Therapeutics, Inc. Activating pyruvate kinase R
WO2020061255A1 (en) * 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
EP3852790A4 (en) * 2018-09-19 2022-08-10 Forma Therapeutics, Inc. INHIBITION OF UBIQUITIN-SPECIFIC PEPTIDASE 9X
WO2020191022A1 (en) * 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
WO2021055863A1 (en) * 2019-09-19 2021-03-25 Forma Therapeutics, Inc. Pyruvate kinase r (pkr) activating compositions
HUE072832T2 (hu) * 2019-09-19 2025-12-28 Novo Nordisk Healthcare Ag Piruvát kináz R-t (PKR) aktiváló készítmények
WO2021058002A1 (zh) * 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂的晶型及其应用
WO2021202796A1 (en) * 2020-04-01 2021-10-07 Global Blood Therapeutics, Inc. Pyrrolidine-pyrazoles as pyruvate kinase activators
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
EP4455136A4 (en) * 2021-12-21 2025-11-05 Scinnohub Pharmaceutical Co Ltd COMPOUND CONTAINING A BIS(AZANYLYLIDENE)SULFONYL STRUCTURE AND ITS USE IN MEDICINE
JP2025536754A (ja) 2022-11-21 2025-11-07 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ピロロ［３，４－ｃ］ピロールの合成
CN115957219B (zh) * 2022-12-27 2024-04-19 北京大学 M2亚型丙酮酸激酶凝聚体的解聚剂在制备抗衰老药物中的应用
CN121511081A (zh) * 2023-05-05 2026-02-10 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构的化合物作为pkm2激动剂的新用途
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TW202606703A (zh) * 2024-07-05 2026-02-16 大陸商廣東東陽光藥業股份有限公司 雜環並環類化合物、其藥物組合物及其用途

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US20200069643A1 (en) 2020-03-05

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