LU87423A1 - Derives d'isoquinoleine,leur preparation et leur utilisation - Google Patents

Derives d'isoquinoleine,leur preparation et leur utilisation Download PDF

Info

Publication number: LU87423A1
Authority: LU; Luxembourg
Prior art keywords: dimethoxy; formula; dimethoxyphenyl; compound; hydrogen
Prior art date: 1988-01-08

Application number

LU87423A

Other languages

English (en)

French (fr)

Inventor

Klaus Hasspacher

Reto Naef

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-08

Filing date

1989-01-06

Publication date

1989-08-30

1989-01-06 Application filed by Sandoz Sa filed Critical Sandoz Sa

1989-08-30 Publication of LU87423A1 publication Critical patent/LU87423A1/fr

Links

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229910052739 hydrogen Inorganic materials 0.000 claims description 26
239000001257 hydrogen Substances 0.000 claims description 26
125000003545 alkoxy group Chemical group 0.000 claims description 18
-1 3,5-dimethoxyethoxyphenyl Chemical group 0.000 claims description 15
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150000002431 hydrogen Chemical group 0.000 claims description 6
125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 5
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 5
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 5
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230000000306 recurrent effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
230000007017 scission Effects 0.000 description 1
208000029138 selective IgA deficiency disease Diseases 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
208000004003 siderosis Diseases 0.000 description 1
201000009890 sinusitis Diseases 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000003506 spasmogen Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000002992 thymic effect Effects 0.000 description 1
210000005062 tracheal ring Anatomy 0.000 description 1
210000001635 urinary tract Anatomy 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

LU87423A 1988-01-08 1989-01-06 Derives d'isoquinoleine,leur preparation et leur utilisation LU87423A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8800397		1988-01-08
GB888800397A GB8800397D0 (en)	1988-01-08	1988-01-08	Improvements in/relating to organic compounds

Publications (1)

Publication Number	Publication Date
LU87423A1 true LU87423A1 (fr)	1989-08-30

Family

ID=10629678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU87423A LU87423A1 (fr)	1988-01-08	1989-01-06	Derives d'isoquinoleine,leur preparation et leur utilisation

Country Status (28)

Country	Link
US (1)	US4980359A (da)
JP (1)	JPH0649686B2 (da)
KR (1)	KR0142686B1 (da)
AT (1)	AT394365B (da)
AU (1)	AU622429B2 (da)
BE (1)	BE1002730A3 (da)
CA (1)	CA1332944C (da)
CH (1)	CH678727A5 (da)
DE (1)	DE3900233C2 (da)
DK (1)	DK5789A (da)
ES (1)	ES2010071A6 (da)
FI (1)	FI90865C (da)
FR (1)	FR2625743B1 (da)
GB (2)	GB8800397D0 (da)
GR (1)	GR1002750B (da)
HU (1)	HU205083B (da)
IE (1)	IE61914B1 (da)
IL (1)	IL88899A (da)
IT (1)	IT1229523B (da)
LU (1)	LU87423A1 (da)
MY (1)	MY103963A (da)
NL (1)	NL8900029A (da)
NZ (1)	NZ227561A (da)
PH (1)	PH25640A (da)
PL (1)	PL156099B1 (da)
PT (1)	PT89405B (da)
SE (1)	SE501548C2 (da)
ZA (1)	ZA89133B (da)

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US2723674A (en) *	1951-11-28	1955-11-15	Charles E Harris	Telephone cableman's tent
US3007541A (en) *	1959-02-24	1961-11-07	Jr John B Mast	Temporary covering and support structure therefor
GB8807922D0 (en) *	1988-04-05	1988-05-05	Fujisawa Pharmaceutical Co	Isoquinoline compound & process for preparation thereof
US4956371A (en) *	1989-09-19	1990-09-11	Euroceltique, S.A.	Substituted isoquinolines and methods of using same
GB8921304D0 (en) *	1989-09-20	1989-11-08	Wyeth John & Brother Ltd	New method of treatment and heterocyclic compounds used therein
GB9027055D0 (en) *	1990-12-13	1991-02-06	Sandoz Ltd	Organic compounds
KR930703259A (ko) *	1990-12-17	1993-11-29	알베르투스 빌헬무스 요아네스 쩨스트라텐	살균성 이소퀴놀린 유도체
CA2093577C (en) *	1992-05-07	2006-01-03	Michael Klaus	Alkyl or alkoxy substituted s-heterocyclic retinoids
US5350423A (en) *	1992-09-23	1994-09-27	Burlington Industries Inc.	Fabric finishing procedure
GB9322828D0 (en) *	1993-11-05	1993-12-22	Sandoz Ltd	Organic compounds
US5783184A (en) *	1994-12-23	1998-07-21	Smithkline Beecham Corporation	Method for treatment and diagnosis of IL-5 mediated disorders
JP2001523083A (ja) *	1994-12-23	2001-11-20	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−５により媒介される疾病の治療に有用な組み換えｉｌ−５アンタゴニスト
US7399837B2 (en) *	1995-12-22	2008-07-15	Smithkline Beecham Corporation	Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5683892A (en) *	1994-12-23	1997-11-04	Smithkline Beecham Corporation	DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
GB9622386D0 (en) *	1996-10-28	1997-01-08	Sandoz Ltd	Organic compounds
RU2174123C2 (ru) *	1996-10-28	2001-09-27	Новартис Аг	Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
IT1296985B1 (it) *	1997-12-19	1999-08-03	Zambon Spa	Derivati benzazinici inibitori della fosfodiesterasi 4
ATE356810T1 (de) *	1999-01-15	2007-04-15	Altana Pharma Ag	Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
PL200923B1 (pl)	1999-08-21	2009-02-27	Nycomed Gmbh	Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
RU2213735C2 (ru) *	2001-09-24	2003-10-10	ГУ Институт технической химии Уральского отделения РАН	Способ получения 1-замещенных 3,3-диметил-3,4-дигидроизохинолинов
AR037517A1 (es) *	2001-11-05	2004-11-17	Novartis Ag	Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
JP2006522151A (ja)	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
WO2008134724A2 (en) *	2007-04-30	2008-11-06	Smithkline Beecham Corporation	Methods for administering anti-il-5 antibodies
KR20100134702A (ko)	2008-03-28	2010-12-23	글락소스미스클라인 엘엘씨	치료 방법
AU2009303389B2 (en)	2008-10-17	2014-10-16	Wisconsin Alumni Research Foundation	Method of making biologically active alpha-beta peptides
CN110913887A (zh)	2017-06-06	2020-03-24	葛兰素史克有限责任公司	用于儿科患者的生物药物组合物和方法

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Publication number	Priority date	Publication date	Assignee	Title
GB645139A (en) *	1946-10-22	1950-10-25	Servita Gyogyszeryar Es Vegyip	Improved process for the production of isoquinoline derivatives
DE1184344B (de) *	1962-06-16	1964-12-31	Orgamol Sa	Verfahren zur Herstellung von Isochinolinderivaten
US3878215A (en) *	1971-12-01	1975-04-15	Sandoz Ag	2-Alkyl-3-substituted-4-aryl isoquinolines
DE2401453A1 (de) *	1973-01-16	1974-07-18	John James Voorhees	Pharmazeutische zusammensetzung zur behandlung von hautproliferationserkrankungen
US4018927A (en) *	1973-12-17	1977-04-19	The Regents Of The University Of Michigan	Treatment of proliferating skin diseases with papaverine alkaloids
FI750205A7 (da) *	1974-02-05	1975-08-06	Sandoz Ag
DE2811361A1 (de) *	1978-03-16	1979-09-27	Hoechst Ag	Neue isochinolinaldehyde und verfahren zu ihrer herstellung
DE3244594A1 (de) *	1982-12-02	1984-06-07	Hoechst Ag, 6230 Frankfurt	1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
HU196758B (en) *	1986-05-21	1989-01-30	Gyogyszerkutato Intezet	Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
CA1330560C (en) *	1986-05-21	1994-07-05	Maurits E. A. Vandewalle	Di- and tetrahydroisoquinoline derivatives

1988
- 1988-01-08 GB GB888800397A patent/GB8800397D0/en active Pending
1989
- 1989-01-03 HU HU8911A patent/HU205083B/hu not_active IP Right Cessation
- 1989-01-04 IT IT8947504A patent/IT1229523B/it active
- 1989-01-04 GB GB8900102A patent/GB2213482B/en not_active Expired - Lifetime
- 1989-01-05 CA CA000587599A patent/CA1332944C/en not_active Expired - Fee Related
- 1989-01-05 SE SE8900039A patent/SE501548C2/sv unknown
- 1989-01-05 ES ES8900053A patent/ES2010071A6/es not_active Expired
- 1989-01-05 DE DE3900233A patent/DE3900233C2/de not_active Expired - Fee Related
- 1989-01-06 BE BE8900018A patent/BE1002730A3/fr not_active IP Right Cessation
- 1989-01-06 MY MYPI89000013A patent/MY103963A/en unknown
- 1989-01-06 FI FI890072A patent/FI90865C/fi not_active IP Right Cessation
- 1989-01-06 LU LU87423A patent/LU87423A1/fr unknown
- 1989-01-06 JP JP1001898A patent/JPH0649686B2/ja not_active Expired - Lifetime
- 1989-01-06 ZA ZA89133A patent/ZA89133B/xx unknown
- 1989-01-06 NZ NZ227561A patent/NZ227561A/xx unknown
- 1989-01-06 PH PH38011A patent/PH25640A/en unknown
- 1989-01-06 FR FR898900128A patent/FR2625743B1/fr not_active Expired - Lifetime
- 1989-01-06 PL PL1989277092A patent/PL156099B1/pl unknown
- 1989-01-06 NL NL8900029A patent/NL8900029A/nl not_active Application Discontinuation
- 1989-01-06 IL IL8889989A patent/IL88899A/en not_active IP Right Cessation
- 1989-01-06 AU AU27795/89A patent/AU622429B2/en not_active Ceased
- 1989-01-06 PT PT89405A patent/PT89405B/pt not_active IP Right Cessation
- 1989-01-06 DK DK005789A patent/DK5789A/da not_active Application Discontinuation
- 1989-01-06 IE IE3789A patent/IE61914B1/en not_active IP Right Cessation
- 1989-01-07 KR KR1019890000151A patent/KR0142686B1/ko not_active Expired - Fee Related
- 1989-01-09 AT AT0003589A patent/AT394365B/de not_active IP Right Cessation
- 1989-01-09 CH CH59/89A patent/CH678727A5/de not_active IP Right Cessation
- 1989-01-09 GR GR890100008A patent/GR1002750B/el unknown
1990
- 1990-04-10 US US07/507,702 patent/US4980359A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL88899A (en)	1994-07-31
MY103963A (en)	1993-10-30
SE8900039L (sv)	1989-07-09
DE3900233A1 (de)	1989-07-20
FR2625743A1 (fr)	1989-07-13
DK5789A (da)	1989-07-09
PH25640A (en)	1991-08-21
NL8900029A (nl)	1989-08-01
FI90865C (fi)	1994-04-11
FR2625743B1 (fr)	1990-11-09
GB8900102D0 (en)	1989-03-01
SE8900039D0 (sv)	1989-01-05
JPH01213267A (ja)	1989-08-28
AU622429B2 (en)	1992-04-09
GB2213482B (en)	1991-09-11
FI890072A0 (fi)	1989-01-06
HU205083B (en)	1992-03-30
FI890072A7 (fi)	1989-07-09
IL88899A0 (en)	1989-08-15
PL156099B1 (pl)	1992-02-28
FI90865B (fi)	1993-12-31
US4980359A (en)	1990-12-25
GB2213482A (en)	1989-08-16
DK5789D0 (da)	1989-01-06
IT8947504A0 (it)	1989-01-04
GR1002750B (el)	1997-08-26
AU2779589A (en)	1989-07-20
DE3900233C2 (de)	2000-04-27
AT394365B (de)	1992-03-25
NZ227561A (en)	1991-11-26
CH678727A5 (da)	1991-10-31
ZA89133B (en)	1990-09-26
IE890037L (en)	1989-07-08
SE501548C2 (sv)	1995-03-13
ES2010071A6 (es)	1989-10-16
KR0142686B1 (ko)	1998-07-15
PL277092A1 (en)	1989-09-04
JPH0649686B2 (ja)	1994-06-29
PT89405B (pt)	1993-09-30
ATA3589A (de)	1991-09-15
IT1229523B (it)	1991-09-04
CA1332944C (en)	1994-11-08
GR890100008A (el)	1994-03-31
IE61914B1 (en)	1994-11-30
PT89405A (pt)	1990-02-08
BE1002730A3 (fr)	1991-05-21
KR890011851A (ko)	1989-08-22
GB8800397D0 (en)	1988-02-10
HUT52061A (en)	1990-06-28

Publication	Publication Date	Title
FR2625743A1 (fr)	1989-07-13	Derives d'isoquinoleine, leur preparation et leur utilisation
RU2060992C1 (ru)	1996-05-27	Производные дигидроизохинолинов и способ их получения
JP3839043B2 (ja)	2006-11-01	置換２−アミノテトラリン
JPS60208965A (ja)	1985-10-21	新規カルボスチリル誘導体及びその製法
ITRM940706A1 (it)	1996-05-03	"isochinoline"
CA1213280A (fr)	1986-10-28	PROCEDE DE PREPARATION DE NOUVEAUX DERIVES DE 4-(1H- INDOL-3-YL) .alpha.-METHYL PIPERIDINE-1-ETHANOL ET DE LEURS SELS
WO1995019960A1 (fr)	1995-07-27	Inhibiteurs de la monoamine oxydase b, leurs procedes de preparation et leurs applications
LU85847A1 (fr)	1985-12-16	Amides et esters dihydropyridinyldicarboxyliques pharmaceutiquement utiles
JPS6033424B2 (ja)	1985-08-02	フェニルエチルアミンの誘導体、その製造方法およびフェニルエチルアミンの誘導体を有効成分とする高血圧および心臓血管病の治療薬
JP2005533762A (ja)	2005-11-10	新規なテトラヒドロイソキノリン系鏡像異性体化合物及びその薬学的に許容される塩、その製造方法及びそれを含む製薬組成物
US11590089B2 (en)	2023-02-28	Beta-2 selective adrenergic receptor agonists
US5137910A (en)	1992-08-11	Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
AU599981B2 (en)	1990-08-02	Novel pharmaceutical compositions comprising and use of cis- 6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,-10b- hexanhydro-benzo{c}{1,6}naphthyridine
JP4216337B2 (ja)	2009-01-28	ベンゾ［ｇ］キノリン誘導体
JPS62195392A (ja)	1987-08-28	ジヒドロピリジン−５−ホスホンアミド酸類
US4034100A (en)	1977-07-05	Antihypertensive agents
EP0112252A1 (fr)	1984-06-27	Enantiomères lévogyres des dérivés de la tétrahydro-5,6,13,13a 8H-dibenzo(a, g)quinolizine, procédés d'obtention, compositions pharmaceutiques les contenant et application
AU2007321460B2 (en)	2012-05-03	Novel amides acting on the adenosine receptors
KR20050044699A (ko)	2005-05-12	선택적 ｐｄｅ4 억제제 및 아드레날린성 베타-2 수용체작용물질의 조합물
KR100512184B1 (ko)	2005-09-05	신규 테트라하이드로이소퀴놀린계 거울상 이성질체 화합물및 그의 약학적으로 허용되는 염, 그 제조방법 및 이를포함하는 약학적 조성물
EP0220104A2 (fr)	1987-04-29	Dérivés d'amino-5 pentanenitrile, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
JPH02135A (ja)	1990-01-05	多還式化合物とこれを含有する医薬組成物
EP2229361A1 (en)	2010-09-22	Tetrahydroindoles having sphingosine-1-phosphate receptor activity
JPS59148719A (ja)	1984-08-25	抗炎症組成物
BE844928A (fr)	1977-02-07	Nouveaux derives de l'indole, leur preparation et leur application comme medicaments