NO20090835L - Nye HIV-reverstranskriptaseinhibitorer - Google Patents

Nye HIV-reverstranskriptaseinhibitorer

Info

Publication number
NO20090835L
NO20090835L NO20090835A NO20090835A NO20090835L NO 20090835 L NO20090835 L NO 20090835L NO 20090835 A NO20090835 A NO 20090835A NO 20090835 A NO20090835 A NO 20090835A NO 20090835 L NO20090835 L NO 20090835L
Authority
NO
Norway
Prior art keywords
reverse transcriptase
transcriptase inhibitors
hiv reverse
new hiv
compounds
Prior art date
Application number
NO20090835A
Other languages
English (en)
Norwegian (no)
Inventor
Choung U Kim
Thorsten A Kirschberg
Lianhong Xu
Hongyan Guo
Ill Young Lee
Michael L Mitchell
Jong Chan Son
Original Assignee
Korea Res Inst Chem Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Res Inst Chem Tech filed Critical Korea Res Inst Chem Tech
Publication of NO20090835L publication Critical patent/NO20090835L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20090835A 2006-07-24 2009-02-23 Nye HIV-reverstranskriptaseinhibitorer NO20090835L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83280606P 2006-07-24 2006-07-24
PCT/US2007/016703 WO2008016522A2 (en) 2006-07-24 2007-07-24 Hiv reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
NO20090835L true NO20090835L (no) 2009-04-23

Family

ID=38997642

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20090835A NO20090835L (no) 2006-07-24 2009-02-23 Nye HIV-reverstranskriptaseinhibitorer

Country Status (18)

Country Link
US (2) US8106064B2 (pt)
EP (1) EP2044037A2 (pt)
JP (1) JP2009544710A (pt)
KR (2) KR20110089463A (pt)
CN (1) CN101495461A (pt)
AP (1) AP2514A (pt)
AU (1) AU2007281604A1 (pt)
BR (1) BRPI0714880A2 (pt)
CA (1) CA2658479A1 (pt)
EA (1) EA200900213A1 (pt)
HR (1) HRP20090114A2 (pt)
IL (1) IL196675A0 (pt)
MX (1) MX2009000871A (pt)
NO (1) NO20090835L (pt)
NZ (1) NZ573793A (pt)
SG (1) SG174016A1 (pt)
UA (1) UA95955C2 (pt)
WO (1) WO2008016522A2 (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008016522A2 (en) 2006-07-24 2008-02-07 Gilead Sciences, Inc. Hiv reverse transcriptase inhibitors
US8354421B2 (en) * 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
CN101784532B (zh) * 2007-06-29 2014-10-22 韩国化学研究院 Hiv逆转录酶抑制剂
US8119800B2 (en) 2007-12-21 2012-02-21 Korea Research Institute Of Chemical Technology Processes for preparing HIV reverse transcriptase inhibitors
CN102056905B (zh) 2008-06-03 2014-03-26 大鹏药品工业株式会社 具有人脱氧尿苷三磷酸酶抑制活性的尿嘧啶化合物或其盐
WO2010068899A1 (en) * 2008-12-12 2010-06-17 Creighton University Nanoparticles comprising combinations of antiretroviral agents and use thereof
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
SG173647A1 (en) 2009-02-13 2011-10-28 Shionogi & Co Novel triazine derivative and pharmaceutical composition containing same
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
ES2527103T3 (es) * 2009-06-22 2015-01-20 Emcure Pharmaceuticals Limited Procedimiento para la síntesis de etravirina
GB0913636D0 (en) * 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
US20110293585A1 (en) 2010-04-21 2011-12-01 Helix Therapeutics, Inc. Compositions and methods for treatment of lysosomal storage disorders
US20110262406A1 (en) 2010-04-21 2011-10-27 Yale University Compositions and methods for targeted inactivation of hiv cell surface receptors
US9718790B2 (en) 2010-08-10 2017-08-01 Shionogi & Co., Ltd. Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same
WO2012020742A1 (ja) 2010-08-10 2012-02-16 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
KR20140003438A (ko) 2010-11-15 2014-01-09 카톨리에케 유니버시테이트 루벤 항바이러스성 축합 헤테로사이클릭 화합물
ES2661705T3 (es) 2011-10-07 2018-04-03 Gilead Sciences, Inc. Métodos para la preparación de análogos de nucleótidos antivirales
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
US9415020B2 (en) 2012-01-19 2016-08-16 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
JP6124351B2 (ja) 2012-02-09 2017-05-10 塩野義製薬株式会社 複素環および炭素環誘導体
WO2014107622A1 (en) 2013-01-07 2014-07-10 University Of Southern California Deoxyuridine triphosphatase inhibitors
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015103489A1 (en) 2014-01-03 2015-07-09 University Of Southern California Heteroatom containing deoxyuridine triphosphatase inhibitors
WO2015127389A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic enema formulations and methods of use
WO2016106050A1 (en) 2014-12-26 2016-06-30 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
JP6846351B2 (ja) 2015-01-27 2021-03-24 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘膜表面における活性薬剤の増強された輸送のための低張ヒドロゲル製剤
US10544105B2 (en) 2015-07-08 2020-01-28 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
DK3319939T3 (da) 2015-07-08 2025-02-24 Cv6 Therapeutics Ni Ltd Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer
WO2017006271A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
US10577321B2 (en) 2015-07-08 2020-03-03 University Of Southern California Deoxyuridine triphosphatase inhibitors
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
US11174271B2 (en) 2016-11-23 2021-11-16 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
WO2018098209A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
US11014924B2 (en) 2016-11-23 2021-05-25 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US10858344B2 (en) 2016-11-23 2020-12-08 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US11247984B2 (en) 2017-01-05 2022-02-15 Cv6 Therapeutics (Ni) Limited Uracil containing compounds
RU2762833C2 (ru) * 2017-03-17 2021-12-23 Мейдзи Сейка Фарма Ко., Лтд. Средство для борьбы с болезнями растений
RU2020116571A (ru) 2017-12-07 2021-11-22 Эмори Юниверсити N4-гидроксицитидин и производные и связанные с этим противовирусные применения
WO2020210805A1 (en) 2019-04-11 2020-10-15 The Johns Hopkins University Nanoparticles for drug delivery to brain
AU2023249953A1 (en) 2022-04-08 2024-10-24 Shionogi & Co., Ltd. Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same
CN115536596A (zh) * 2022-11-08 2022-12-30 巨鑫生物制药股份有限公司 一种acc007中间体的制备方法
CN117209435B (zh) * 2023-08-04 2026-05-12 浙江海昇药业股份有限公司 一种微通道制备2,6-二甲氧基-4-氨基嘧啶的方法
CN117304118A (zh) * 2023-09-15 2023-12-29 江苏艾迪药业股份有限公司 抗艾滋病药物艾诺韦林的合成方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656209A (en) 1982-05-26 1987-04-07 Ciba-Geigy Corporation Chlorinated thermoplastics stabilized with aminouracils
KR0155168B1 (ko) 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
DE69129998T2 (de) 1990-02-15 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Pyrimidindionderivate, deren Herstellung und Verwendung
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
EP0748316B1 (en) 1994-02-28 2002-05-08 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
JPH083143A (ja) 1994-06-21 1996-01-09 Mitsubishi Chem Corp 6−アラルキル置換ピリミジン誘導体の製造方法
US6174998B1 (en) 1996-03-12 2001-01-16 Roche Diagnostics Gmbh C-nucleoside derivatives and their use in the detection of nucleic acids
RU2138487C1 (ru) 1996-02-22 1999-09-27 Самдзин Фармасьютикал Ко., Лтд. Новые противовирусные гомокарбоциклические нуклеозидные производные замещенных пиримидиндионов, способ их получения и композиция, содержащая их в качестве активных ингредиентов
KR100219922B1 (ko) 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
JPH10130245A (ja) 1996-09-06 1998-05-19 Mitsubishi Chem Corp アシクロヌクレオシドの製造方法
JPH10130244A (ja) 1996-09-06 1998-05-19 Mitsubishi Chem Corp アシクロヌクレオシドの製造方法
DE69724630T2 (de) 1996-10-02 2004-07-29 Bristol-Myers Squibb Pharma Co. 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv-reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung
JPH10168068A (ja) 1996-12-05 1998-06-23 Mitsubishi Chem Corp アシクロヌクレオシドの製造方法
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
EP1068189A1 (en) * 1998-03-27 2001-01-17 Bristol-Myers Squibb Pharma Company 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinthione derivatives, their preparation and their use as hiv reverse transcriptase inhibitors
FR2779721A1 (fr) 1998-06-15 1999-12-17 Expansia Sa Substitution d'une 1,5-dialkyl uracile en position 6
FR2779722A1 (fr) 1998-06-15 1999-12-17 Expansia Sa Hydrogenation de 6-alpha-alkylcarboxy methylaryl-1,5-dialkyl uracile
US6713486B1 (en) * 1999-03-04 2004-03-30 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
AU7450300A (en) 1999-09-29 2001-04-30 Sankyo Company Limited Sulfonamide derivatives
JP2001114767A (ja) 1999-10-15 2001-04-24 Sumika Fine Chemicals Co Ltd ピリミジン化合物の製造方法、およびその中間体の製造方法
CZ20032366A3 (en) * 2001-03-02 2004-04-14 Smithkline Beecham Corporation Benzophenones as inhibitors of reverse transcriptase
JP2002284686A (ja) 2001-03-28 2002-10-03 Sankyo Co Ltd スルホンアミド化合物を含有する医薬組成物
WO2003029226A1 (en) 2001-09-26 2003-04-10 Basf Aktiengesellschaft Heterocyclyl substituted phenoxyalkyl-, phenylthioalkyl-, phenylaminoalkyl- and phenylalkyl-sulfamoylcarboxamides
WO2003057677A1 (en) 2002-01-11 2003-07-17 Syddansk Universitet Anti-retroviral 5,6-disubstituted acyclopyrimidine nucleoside derivatives
DE60309665T2 (de) 2002-01-31 2007-09-20 Ciba Speciality Chemicals Holding Inc. Stabilisierung von polyolefinen, die in permanentem kontakt mit chloriertem wasser stehen
EA009478B1 (ru) * 2002-08-23 2008-02-28 Ардеа Байосайенсиз, Инк. Ненуклеозидные ингибиторы обратной транскриптазы
WO2006070292A2 (en) 2004-10-12 2006-07-06 Queen's University At Kingston Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
US7250421B2 (en) 2005-01-31 2007-07-31 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
US20060223834A1 (en) 2005-04-04 2006-10-05 Vasu Nair Diketo acids on nucleobase scaffolds as inhibitors of Flaviviridae
CA2635845A1 (en) * 2005-12-29 2007-07-12 Janssen Pharmaceutica N.V. Prokineticin 2 receptor antagonists
EP2385042B1 (en) * 2005-12-29 2015-11-25 Janssen Pharmaceutica N.V. Prokineticin 1 receptor antagonists
WO2007106450A2 (en) 2006-03-10 2007-09-20 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase in combination therapy
WO2008016522A2 (en) * 2006-07-24 2008-02-07 Gilead Sciences, Inc. Hiv reverse transcriptase inhibitors
CN101784532B (zh) * 2007-06-29 2014-10-22 韩国化学研究院 Hiv逆转录酶抑制剂

Also Published As

Publication number Publication date
WO2008016522A2 (en) 2008-02-07
MX2009000871A (es) 2009-05-08
US20100034827A1 (en) 2010-02-11
JP2009544710A (ja) 2009-12-17
BRPI0714880A2 (pt) 2013-05-21
US8106064B2 (en) 2012-01-31
KR20110089463A (ko) 2011-08-08
WO2008016522A3 (en) 2008-12-11
AP2009004759A0 (en) 2009-02-28
SG174016A1 (en) 2011-09-29
AU2007281604A1 (en) 2008-02-07
HRP20090114A2 (hr) 2010-03-31
NZ573793A (en) 2012-01-12
UA95955C2 (ru) 2011-09-26
EA200900213A1 (ru) 2009-06-30
CA2658479A1 (en) 2008-02-07
CN101495461A (zh) 2009-07-29
IL196675A0 (en) 2009-11-18
EP2044037A2 (en) 2009-04-08
AP2514A (en) 2012-11-23
KR20090040449A (ko) 2009-04-24
US20080070920A1 (en) 2008-03-20

Similar Documents

Publication Publication Date Title
EA200971115A1 (ru) Новые ингибиторы обратной транскриптазы вич
UA95955C2 (ru) Ингибиторы обратной транскриптазы вич
NO20080865L (no) Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer
NO20072978L (no) Nye betuinderivater, preparat derav og anvendelse derav
SE0400284D0 (sv) Novel compounds
EA200970156A1 (ru) Пиридизиноновые производные
WO2008086226A8 (en) Factor xa inhibitors
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
EA200802288A1 (ru) Замещенные имидазолы, композиция на их основе, способ профилактики или лечения нежелательного тромбообразования с их помощью и способ ингибирования коагуляции образцов крови
NO20091553L (no) Fenylderivater og deres anvendelse som immunmodulatorer
NO20084418L (no) Azolopyridin-3-on derivater som inhibitorer av endoteliallipase
NO20082090L (no) Pyridopyrimidinoninhibitorer av P13K alfa
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20072371L (no) Kinuklidinderivater og deres anvendelse som muskarine M3-reseptorantagonister
EA200900135A1 (ru) Производные пиразола в качестве ингибиторов цитохрома р450
NO20092723L (no) Indazolylester og amidderivater for behandling av gluccocorticoid reseptormedierte sykdommer
NO20092286L (no) Nitrogenhaldige heterosykliske forbindelser og anvendelse derav
NO20071617L (no) Indozolonderivater som 11B-HSD1-inhibitorer
WO2009155121A3 (en) Inhibitors of pi3 kinase
PH12014501283A1 (en) 4`-azido, 3``-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication
NO20073791L (no) Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer
NO20063449L (no) Substituerte heterocykler og deres anvendelse
NO20085212L (no) Nye pyridinanaloger
EA201291217A1 (ru) ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 1-(β-D-ГЛЮКОПИРАНОЗИЛ)-2-ТИЕНИЛМЕТИЛБЕНЗОЛА КАК ИНГИБИТОРЫ НЗПГ
NO20055568L (no) Substituerte 1,4-diazepiner og anvendelser derav

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application