NZ500078A - Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals - Google Patents

Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals

Info

Publication number
NZ500078A
NZ500078A NZ500078A NZ50007898A NZ500078A NZ 500078 A NZ500078 A NZ 500078A NZ 500078 A NZ500078 A NZ 500078A NZ 50007898 A NZ50007898 A NZ 50007898A NZ 500078 A NZ500078 A NZ 500078A
Authority
NZ
New Zealand
Prior art keywords
antibody
vegf
seq
variant
amino acid
Prior art date
Application number
NZ500078A
Other languages
English (en)
Inventor
James A Wells
Leonard G Presta
Henry B Lowman
Yvonne Man-Yee Chen
Manuel Baca
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27125626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ500078(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/908,469 external-priority patent/US6884879B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NZ500078A publication Critical patent/NZ500078A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Air Bags (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
NZ500078A 1997-04-07 1998-04-03 Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals NZ500078A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83350497A 1997-04-07 1997-04-07
US08/908,469 US6884879B1 (en) 1997-04-07 1997-08-06 Anti-VEGF antibodies
PCT/US1998/006604 WO1998045331A2 (en) 1997-04-07 1998-04-03 Anti-vegf antibodies

Publications (1)

Publication Number Publication Date
NZ500078A true NZ500078A (en) 2001-10-26

Family

ID=27125626

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ500078A NZ500078A (en) 1997-04-07 1998-04-03 Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals

Country Status (25)

Country Link
US (2) US7060269B1 (de)
EP (4) EP1325932B9 (de)
JP (1) JP3957765B2 (de)
KR (2) KR100816621B1 (de)
CN (1) CN100480269C (de)
AT (2) ATE293640T1 (de)
AU (1) AU743758B2 (de)
BR (1) BRPI9809387B8 (de)
CA (1) CA2286330C (de)
CY (3) CY2005008I2 (de)
DE (5) DE122007000021I1 (de)
DK (2) DK0973804T3 (de)
ES (2) ES2273415T3 (de)
FR (2) FR05C0020I2 (de)
GE (1) GEP20105118B (de)
IL (1) IL132240A0 (de)
LT (1) LTPA2005005I1 (de)
LU (2) LU91167I2 (de)
NL (2) NL300193I2 (de)
NO (3) NO324264B1 (de)
NZ (1) NZ500078A (de)
PT (1) PT1325932E (de)
SI (1) SI1325932T1 (de)
TR (1) TR199903123T2 (de)
WO (1) WO1998045331A2 (de)

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ATE349470T1 (de) 2007-01-15
BRPI9809387B1 (pt) 2016-11-22
EP1325932A3 (de) 2003-10-29
CY2007012I2 (el) 2009-11-04
LU91320I2 (fr) 2007-04-30
CA2286330A1 (en) 1998-10-15
NO994869D0 (no) 1999-10-06
JP3957765B2 (ja) 2007-08-15
ES2273415T3 (es) 2007-05-01
TR199903123T2 (xx) 2000-05-22
FR05C0020I1 (de) 2005-05-27
US7297334B2 (en) 2007-11-20
WO1998045331A3 (en) 1998-12-03
EP1325932B9 (de) 2006-07-19
NL300278I2 (nl) 2007-10-01
DE69836729T2 (de) 2007-12-13
EP1650220A3 (de) 2006-05-03
EP1787999B1 (de) 2010-08-04
DE122005000050I1 (de) 2005-12-29
DE122005000026I1 (de) 2005-08-04
KR100870353B1 (ko) 2008-11-25
NO2007014I1 (no) 2008-01-14
FR05C0020I2 (fr) 2008-05-09
NO324264B1 (no) 2007-09-17
NL300278I1 (nl) 2007-06-01
CY2005008I1 (el) 2009-11-04
EP1325932A2 (de) 2003-07-09
HK1023577A1 (en) 2000-09-15
CY1106382T1 (el) 2010-07-28
ES2236634T3 (es) 2005-07-16
NL300193I2 (nl) 2005-10-03
GEP20105118B (en) 2010-11-25
PT1325932E (pt) 2005-06-30
CN100480269C (zh) 2009-04-22
NO2007015I2 (de) 2011-11-28
NL300193I1 (nl) 2005-07-01
IL132240A0 (en) 2001-03-19
CY2007012I1 (el) 2009-11-04
CY2005008I2 (el) 2017-11-14
DE122007000021I1 (de) 2007-05-24
JP2001509817A (ja) 2001-07-24
DE69829891D1 (de) 2005-05-25
EP1650220A2 (de) 2006-04-26
NO994869L (no) 1999-12-06
NO2007015I1 (no) 2008-01-14
KR20080003453A (ko) 2008-01-07
US20050112126A1 (en) 2005-05-26
BR9809387A (pt) 2001-09-11
EP1787999A1 (de) 2007-05-23
EP1325932B1 (de) 2005-04-20
EP1650220B1 (de) 2007-09-05
DE69836729D1 (de) 2007-02-08
AU743758B2 (en) 2002-02-07
ATE293640T1 (de) 2005-05-15

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