SG3493G - Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them - Google Patents

Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them

Info

Publication number: SG3493G
Authority: SG; Singapore
Prior art keywords: trimethoxybenzyl; dimethoxymethyl; bis; preparation; pharmaceutical compositions
Prior art date: 1984-07-18

Application number

SG34/93A

Other languages

English (en)

Original Assignee

Wellcome Found

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-18

Filing date

1993-01-08

Publication date

1993-03-12

1993-01-08 Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found

1993-03-12 Publication of SG3493G publication Critical patent/SG3493G/en

Links

BYTJTAASKAVKPX-UHFFFAOYSA-N 1-[dimethoxy-(2-methoxyphenyl)methyl]-2,3-bis(dimethoxymethyl)isoquinolin-2-ium Chemical class COC(OC)C=1[N+](=C(C2=CC=CC=C2C=1)C(C1=C(C=CC=C1)OC)(OC)OC)C(OC)OC BYTJTAASKAVKPX-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001450 anions Chemical group 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
239000000842 neuromuscular blocking agent Substances 0.000 abstract 1
229940125706 skeletal muscle relaxant agent Drugs 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Jib Cranes (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Cephalosporin Compounds (AREA)
Cosmetics (AREA)
Fats And Perfumes (AREA)
Meat, Egg Or Seafood Products (AREA)

SG34/93A 1984-07-18 1993-01-08 Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them SG3493G (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848418303A GB8418303D0 (en)	1984-07-18	1984-07-18	Compounds

Publications (1)

Publication Number	Publication Date
SG3493G true SG3493G (en)	1993-03-12

Family

ID=10564058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG34/93A SG3493G (en)	1984-07-18	1993-01-08	Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them

Country Status (30)

Country	Link
US (1)	US4761418A (de)
EP (1)	EP0181055B1 (de)
JP (1)	JPH0662568B2 (de)
AT (1)	ATE60759T1 (de)
AU (1)	AU574481B2 (de)
BG (1)	BG60411B2 (de)
CA (1)	CA1273341A (de)
CY (1)	CY1687A (de)
DD (1)	DD235638A5 (de)
DE (2)	DE19675039I2 (de)
DK (1)	DK168093B1 (de)
ES (1)	ES8609260A1 (de)
FI (1)	FI85019C (de)
GB (1)	GB8418303D0 (de)
GE (1)	GEP19960468B (de)
HK (1)	HK47593A (de)
HU (1)	HU193996B (de)
IE (1)	IE58138B1 (de)
IL (1)	IL75833A (de)
LT (1)	LT2078B (de)
LU (1)	LU88801I2 (de)
LV (1)	LV5483A3 (de)
MC (1)	MC1690A1 (de)
MX (1)	MX9203667A (de)
NL (1)	NL940023I2 (de)
NZ (1)	NZ212766A (de)
PL (1)	PL146066B1 (de)
SG (1)	SG3493G (de)
SU (1)	SU1468414A3 (de)
ZA (1)	ZA855407B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) *	1994-09-06	1996-04-23	Bencherif; Merouane	Depolarizing skeletal muscle relaxants
DE69830157T2 (de) *	1997-03-25	2006-05-11	Avera Pharmaceuticals, Inc., San Diego	Substituierte isochinoline als ultrakurz wirkende neuromuskuläre blocker
GB0204087D0 (en) *	2002-02-21	2002-04-10	Legislator 1563 Ltd	Di-ester derivatives as short acting neuromuscular blockers
EP1684753A2 (de) *	2003-10-28	2006-08-02	Cornell Research Foundation, Inc.	Neuromuskuläre blockiermittel und ihre antagonisten
US7872137B2 (en) *	2006-06-20	2011-01-18	Farmabios S.P.A.	Process for the preparation of mivacurium chloride
JP5213137B2 (ja) *	2006-12-06	2013-06-19	コーネルリサーチファウンデーション，インコーポレイテッド	中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト
AU2008222298A1 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
WO2008117271A1 (en) *	2007-03-26	2008-10-02	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
AU2008273724B2 (en) *	2007-05-01	2013-05-23	Chemagis Ltd.	Process for Producing Cisatracurium and Associated Intermediates
WO2009007946A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
WO2008132748A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
AU2008264802A1 (en) *	2007-06-18	2008-12-24	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
WO2009057086A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel r,r'-atracurium salts
ITMI20080319A1 (it) *	2008-02-28	2009-08-29	Recordati Chem Pharm	Processo per la risoluzione di derivati isochinolinici
BRPI0907656A2 (pt) *	2008-05-01	2019-08-27	Chemagis Ltd	composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio
WO2010107488A1 (en)	2009-03-17	2010-09-23	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh)	2009-08-19	2017-03-15	康奈尔大学	供生理注射用的半胱氨酸
WO2013021398A2 (en) *	2011-08-05	2013-02-14	Sequent Scientific Limited	A process for preparation of mivacurium chloride
JP6236077B2 (ja) *	2012-06-29	2017-11-22	コーネル・ユニバーシティーＣｏｒｎｅｌｌＵｎｉｖｅｒｓｉｔｙ	持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
CN107778237A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN107782821B (zh) *	2016-08-26	2021-11-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂的分析方法
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) *	2017-09-30	2018-09-07	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) *	2019-07-29	2022-04-29	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) *	2019-11-11	2021-03-09	武汉大安制药有限公司	一种5’-甲氧基劳丹素的拆分方法
CN116410078B (zh) *	2021-12-29	2026-04-03	苏州特瑞药业股份有限公司	一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (zh) *	2023-12-25	2025-07-03	上海森辉医药有限公司	一种四氢异喹啉及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB863717A (en) *	1958-07-03	1961-03-22	Allen & Hanburys Ltd	Tetrahydropapaverine derivatives and their preparation
US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
JPS5455577A (en) *	1977-08-01	1979-05-02	Masachiyuusetsutsu Gen Hosupit	Blocking agent of neuromuscle
US4192877A (en) *	1977-08-01	1980-03-11	Massachusetts General Hospital	Neuromuscular blocking agents
US4235906A (en) *	1978-07-21	1980-11-25	Massachusetts General Hospital	Bis-isoquinolinium compounds, compositions and methods of use
CA1125287A (en) *	1978-07-21	1982-06-08	John J. Savarese	Bis isoquinolinium compositions and methods of use
US4491665A (en) *	1979-10-19	1985-01-01	Burroughs Wellcome Co.	Method of preparing isomers of bis isoquinolinium compounds
CA1153380A (en) *	1979-10-19	1983-09-06	Hassan A. El-Sayad	Neuromuscular blocking tetrahydroisoquinolinium salts
DE3165714D1 (en) *	1980-12-17	1984-09-27	Wellcome Found	Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体

1984
- 1984-07-18 GB GB848418303A patent/GB8418303D0/en active Pending
1985
- 1985-07-11 PL PL1985254571A patent/PL146066B1/pl unknown
- 1985-07-17 MC MC851781A patent/MC1690A1/fr unknown
- 1985-07-17 HU HU852745A patent/HU193996B/hu unknown
- 1985-07-17 SU SU853926201A patent/SU1468414A3/ru active
- 1985-07-17 DE DE1996175039 patent/DE19675039I2/de active Active
- 1985-07-17 DE DE8585305097T patent/DE3581699D1/de not_active Expired - Lifetime
- 1985-07-17 IL IL75833A patent/IL75833A/xx not_active IP Right Cessation
- 1985-07-17 ZA ZA855407A patent/ZA855407B/xx unknown
- 1985-07-17 AU AU45108/85A patent/AU574481B2/en not_active Expired
- 1985-07-17 NZ NZ212766A patent/NZ212766A/en unknown
- 1985-07-17 FI FI852807A patent/FI85019C/fi not_active IP Right Cessation
- 1985-07-17 CA CA000486916A patent/CA1273341A/en not_active Expired - Lifetime
- 1985-07-17 ES ES545319A patent/ES8609260A1/es not_active Expired
- 1985-07-17 AT AT85305097T patent/ATE60759T1/de active
- 1985-07-17 LU LU88801C patent/LU88801I2/fr unknown
- 1985-07-17 EP EP85305097A patent/EP0181055B1/de not_active Expired - Lifetime
- 1985-07-17 JP JP60157963A patent/JPH0662568B2/ja not_active Expired - Lifetime
- 1985-07-17 US US06/756,025 patent/US4761418A/en not_active Expired - Lifetime
- 1985-07-17 DK DK324985A patent/DK168093B1/da not_active IP Right Cessation
- 1985-07-17 IE IE179185A patent/IE58138B1/en not_active IP Right Cessation
- 1985-07-17 DD DD85278691A patent/DD235638A5/de unknown
1992
- 1992-06-26 MX MX9203667A patent/MX9203667A/es unknown
1993
- 1993-01-08 SG SG34/93A patent/SG3493G/en unknown
- 1993-03-10 LV LV930178A patent/LV5483A3/xx unknown
- 1993-04-07 LT LTRP478A patent/LT2078B/xx not_active IP Right Cessation
- 1993-05-13 HK HK475/93A patent/HK47593A/en not_active IP Right Cessation
- 1993-09-14 BG BG098109A patent/BG60411B2/bg unknown
- 1993-10-10 CY CY1687A patent/CY1687A/xx unknown
- 1993-12-06 GE GEAP19931677A patent/GEP19960468B/en unknown
1994
- 1994-11-18 NL NL940023C patent/NL940023I2/nl unknown

Also Published As

Publication number	Publication date
LV5483A3 (lv)	1994-03-10
PL146066B1 (en)	1988-12-31
NL940023I1 (nl)	1995-01-02
FI85019B (fi)	1991-11-15
ZA855407B (en)	1986-04-30
US4761418A (en)	1988-08-02
FI852807A0 (fi)	1985-07-17
LT2078B (lt)	1993-06-15
FI852807L (fi)	1986-01-19
AU4510885A (en)	1986-01-23
MX9203667A (es)	1992-07-31
IL75833A0 (en)	1985-11-29
IE851791L (en)	1986-01-18
HU193996B (en)	1987-12-28
GB8418303D0 (en)	1984-08-22
DE19675039I2 (de)	2003-01-09
MC1690A1 (fr)	1986-07-18
ATE60759T1 (de)	1991-02-15
LU88801I2 (fr)	1996-11-05
FI85019C (fi)	1992-02-25
CA1273341A (en)	1990-08-28
AU574481B2 (en)	1988-07-07
ES545319A0 (es)	1986-09-01
IL75833A (en)	1988-11-30
DK168093B1 (da)	1994-02-07
DK324985D0 (da)	1985-07-17
IE58138B1 (en)	1993-07-14
DD235638A5 (de)	1986-05-14
PL254571A1 (en)	1986-07-15
HK47593A (en)	1993-05-21
GEP19960468B (en)	1996-08-29
JPH0662568B2 (ja)	1994-08-17
DK324985A (da)	1986-01-19
ES8609260A1 (es)	1986-09-01
DE3581699D1 (de)	1991-03-14
NL940023I2 (nl)	1998-06-02
JPS6187666A (ja)	1986-05-06
HUT40626A (en)	1987-01-28
EP0181055A1 (de)	1986-05-14
SU1468414A3 (ru)	1989-03-23
EP0181055B1 (de)	1991-02-06
BG60411B2 (bg)	1995-02-28
NZ212766A (en)	1988-03-30
CY1687A (en)	1993-10-10

Publication	Publication Date	Title
SG3493G (en)	1993-03-12	Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them
NZ208831A (en)	1988-09-29	Imidazolium derivatives and pharmaceutical compositions
DE3562238D1 (en)	1988-05-26	Substituted sulfonamidobenzamides, antiarrythmic agents and compositions thereof
IL66009A0 (en)	1982-09-30	2-aryl-3,4-diazabicyclo(4.n.0)alk-2-en-5-ones,their preparation and pharmaceutical compositions containing them
IL78691A (en)	1989-09-28	Quinolylglycinamide derivatives,their preparation and pharmaceutical compositions containing them
ES8305684A1 (es)	1983-05-01	Procedimiento para la obtencion de derivados aminopropanolicos de 2-hidroxi b-fenil-propiofenonas.
ZA879280B (en)	1989-08-30	Basically substituted phenylacetonitriles,their preparation and drugs containing these compounds
DE3369983D1 (en)	1987-04-09	Isoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use
IL94693A0 (en)	1991-04-15	Dibenzo(1,5)dioxocin-5-one derivatives,their preparation and pharmaceutical compositions containing them
DE3468875D1 (en)	1988-02-25	Substituted isoquinoline derivatives, method for their preparation, and pharmaceutical compositions containing these compounds
IL69848A0 (en)	1983-12-30	15-cycloaliphatic derivatives of 11,14-didehydrocarboprostacyclins,their preparation and pharmaceutical compositions containing them
IL69274A (en)	1986-08-31	(substituted amino)derivatives of 3-benzylidene-pyrrolo(2,1-b)quinazolin-9-ones and 6-benzylidene-pyrido(2,1-b)quinazolin-11-ones,their preparation and pharmaceutical compositions containing them
ES2027507A6 (es)	1992-06-01	Procedimiento de preparacion de derivados selenofenicos.
ZA8683B (en)	1986-08-27	Antihypertensive agents,pharmaceutical compositions containing them and process for the preparation of the agents and compositions
GR850484B (de)	1985-06-26