BE468982A - - Google Patents
Info
- Publication number
- BE468982A BE468982A BE468982DA BE468982A BE 468982 A BE468982 A BE 468982A BE 468982D A BE468982D A BE 468982DA BE 468982 A BE468982 A BE 468982A
- Authority
- BE
- Belgium
- Prior art keywords
- acid
- ester
- benzotetronic
- glyoxylic acid
- alcoholate
- Prior art date
Links
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims description 9
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- PYRZPBDTPRQYKG-UHFFFAOYSA-N cyclopentene-1-carboxylic acid Chemical compound OC(=O)C1=CCCC1 PYRZPBDTPRQYKG-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- -1 glyoxylic acid ester Chemical class 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
- C07D311/48—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring with two such benzopyran radicals linked together by a carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<Desc/Clms Page number 1> EMI1.1 " ?roc.3d,F pour la prcpuration d'un dàrivà de l'acide benzot4tronique." EMI1.2 Dans lu dej.de de brevet belge d=pose le 5* ne-, bre sous le l." 364.ù$Ùon a proposé un procédé pou- ia préparation de co,-.,,osues servant à diminuer l'in- dice de prothrombine du sang, dans lequel on condense de l'acide benzotétronique avec un ester de l'acide glyoxy- lique. On a constaté que cette condensation était accom- pagnée de réactions secondaires non souhaitables, telles que la polymérisation, ce qui a une influence défavorable sur le rendent de la réaction en produit final voulu. <Desc/Clms Page number 2> On a, à présent, constaté que la réaction @ voulue s'effectue beaucoup plus faoilement et que le rendement est amélioré, lorsqu'on utilise pour la con- densation, non pas un ester de l'acide glyoxylique, mais son alcoolate. L'alcoolate se forme par simple addition d'une molécule d'alcool et d'une molécule d'ester de l'acide glyoxylique. Divers alcools peuvent être employés pour former par addition un alooolate approprié, mais en pra- tique, on donne la préférence à l'éthylalooolate de l'ester d'aoide glyoxylique. La réaction se produit oomne suit : EMI2.1
Claims (1)
- REVENDICATION Prooédé pour la préparation d'un dérivé de l'acide benzotétronique, caractérisé en ce qu'on condense de l'a- cide benzotétronique avec un alcôolate d'ester de l'aoide glyox lique, de préférence l'éthylalooolate d'ester de l'acide glyoxylique.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE468982A true BE468982A (fr) |
Family
ID=119579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE468982D BE468982A (fr) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE468982A (fr) |
-
0
- BE BE468982D patent/BE468982A/fr unknown
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