BRPI0500478A - Processo para a sìntese de compostos de 1,3-diidro-2h-3-benzazepin-2-ona, e aplicação na sìntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável - Google Patents

Processo para a sìntese de compostos de 1,3-diidro-2h-3-benzazepin-2-ona, e aplicação na sìntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável

Info

Publication number
BRPI0500478A
BRPI0500478A BR0500478-0A BRPI0500478A BRPI0500478A BR PI0500478 A BRPI0500478 A BR PI0500478A BR PI0500478 A BRPI0500478 A BR PI0500478A BR PI0500478 A BRPI0500478 A BR PI0500478A
Authority
BR
Brazil
Prior art keywords
synthesis
ivabradine
pharmaceutically acceptable
compounds
application
Prior art date
Application number
BR0500478-0A
Other languages
English (en)
Inventor
Jean-Michel Lerestif
Jean-Pierre Lecouve
Daniel Brigot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0500478A publication Critical patent/BRPI0500478A/pt
Publication of BRPI0500478B1 publication Critical patent/BRPI0500478B1/pt
Publication of BRPI0500478B8 publication Critical patent/BRPI0500478B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE COMPOSTOS DE 1,3-DIIDRO-2H-3-BENZAZEPIN-2-ONA, E APLICAçãO NA SìNTESE DE IVABRADINA E SAIS DE ADIçãO DESTA COM UM áCIDO FARMACEUTICAMENTE ACEITáVEL". A presente invenção refere-se a um processo para a síntese de compostos de fórmula (1): em que R~ 1~, e R~ 2~ , que podem ser iguais ou diferentes, cada qual representa um grupo (C~ 1~-C~ 8~)alcóxi linear ou ramificado ou formam, juntos com o átomo de carbono transportando-os, um anel de 1,3-dioxano, 1,3-dioxolano ou 1,3-dioxepano. Aplicação na sintese de ivabradina, sais de adição desta com um ácido farmaceuticamente aceitável, e hidratos desta.
BRPI0500478A 2004-04-13 2005-02-17 processo para a síntese de compostos de 1,3-diidro-2h-3-benzazepin-2-ona, e aplicação na síntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável BRPI0500478B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403829 2004-04-13
FR0403829A FR2868776B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (3)

Publication Number Publication Date
BRPI0500478A true BRPI0500478A (pt) 2005-11-16
BRPI0500478B1 BRPI0500478B1 (pt) 2019-04-02
BRPI0500478B8 BRPI0500478B8 (pt) 2021-05-25

Family

ID=34941960

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0500478A BRPI0500478B8 (pt) 2004-04-13 2005-02-17 processo para a síntese de compostos de 1,3-diidro-2h-3-benzazepin-2-ona, e aplicação na síntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável

Country Status (32)

Country Link
US (1) US7074920B2 (pt)
EP (1) EP1589014B1 (pt)
JP (2) JP4511970B2 (pt)
KR (1) KR100636500B1 (pt)
CN (1) CN1332951C (pt)
AR (1) AR047686A1 (pt)
AT (1) ATE375339T1 (pt)
AU (1) AU2005200860B2 (pt)
BR (1) BRPI0500478B8 (pt)
CA (1) CA2496721C (pt)
CY (1) CY1107101T1 (pt)
DE (1) DE602005002776T2 (pt)
DK (1) DK1589014T3 (pt)
EA (1) EA007744B1 (pt)
ES (1) ES2294652T3 (pt)
FR (1) FR2868776B1 (pt)
GE (1) GEP20074137B (pt)
HR (1) HRP20070503T3 (pt)
MA (1) MA27599A1 (pt)
ME (1) ME01402B (pt)
MX (1) MXPA05003695A (pt)
MY (1) MY141223A (pt)
NO (1) NO329438B1 (pt)
NZ (1) NZ538327A (pt)
PL (1) PL1589014T3 (pt)
PT (1) PT1589014E (pt)
RS (1) RS50546B (pt)
SG (1) SG116573A1 (pt)
SI (1) SI1589014T1 (pt)
UA (1) UA81772C2 (pt)
WO (1) WO2005111026A1 (pt)
ZA (1) ZA200501467B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
PT2471780E (pt) 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos
ES2402765T3 (es) 2008-12-22 2013-05-08 Krka, D.D., Novo Mesto Procedimiento de preparación de ivabradina
EP2534135A2 (en) 2010-02-12 2012-12-19 KRKA, D.D., Novo Mesto Novel forms of ivabradine hydrochloride
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3519735A1 (de) * 1985-06-01 1986-12-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP2568416B2 (ja) * 1986-11-04 1997-01-08 大塚製薬株式会社 ヒドロフルオレン誘導体
JPH0495078A (ja) * 1990-08-08 1992-03-27 Nippon Shoji Kk ピリミドン誘導体の製造法、そのための中間体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
TW279860B (pt) * 1993-11-12 1996-07-01 Ciba Geigy Ag
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
GEP20074137B (en) 2007-06-25
JP2010043096A (ja) 2010-02-25
NO20050885D0 (no) 2005-02-18
DK1589014T3 (da) 2008-02-25
JP2005298479A (ja) 2005-10-27
HK1079776A1 (en) 2006-04-13
UA81772C2 (uk) 2008-02-11
CA2496721C (fr) 2010-09-07
EA200500237A1 (ru) 2005-10-27
HRP20070503T3 (en) 2007-12-31
WO2005111026A1 (fr) 2005-11-24
MA27599A1 (fr) 2005-11-01
FR2868776A1 (fr) 2005-10-14
PL1589014T3 (pl) 2008-01-31
EA007744B1 (ru) 2006-12-29
BRPI0500478B8 (pt) 2021-05-25
CY1107101T1 (el) 2012-10-24
EP1589014B1 (fr) 2007-10-10
RS50546B (sr) 2010-05-07
US7074920B2 (en) 2006-07-11
ME01402B (me) 2010-05-07
FR2868776B1 (fr) 2008-04-18
EP1589014A1 (fr) 2005-10-26
MXPA05003695A (es) 2006-01-24
AU2005200860B2 (en) 2010-08-05
DE602005002776D1 (de) 2007-11-22
KR100636500B1 (ko) 2006-10-18
ATE375339T1 (de) 2007-10-15
CN1332951C (zh) 2007-08-22
CA2496721A1 (fr) 2005-10-13
ZA200501467B (en) 2005-11-30
BRPI0500478B1 (pt) 2019-04-02
US20050227962A1 (en) 2005-10-13
JP4511970B2 (ja) 2010-07-28
AU2005200860A1 (en) 2005-10-27
SI1589014T1 (sl) 2008-02-29
NO329438B1 (no) 2010-10-18
AR047686A1 (es) 2006-02-01
NO20050885L (no) 2005-10-14
NZ538327A (en) 2005-11-25
PT1589014E (pt) 2007-12-13
MY141223A (en) 2010-03-31
ES2294652T3 (es) 2008-04-01
KR20060042120A (ko) 2006-05-12
DE602005002776T2 (de) 2008-08-28
SG116573A1 (en) 2005-11-28
CN1683342A (zh) 2005-10-19

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2867 DE 16-12-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.