DK0714911T3 - Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger - Google Patents

Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger

Info

Publication number: DK0714911T3
Authority: DK; Denmark
Prior art keywords: well; chelating groups; containing chelating; somatostatin analogues; analogues containing
Prior art date: 1994-09-06

Application number

DK95810545T

Other languages

Danish (da)

English (en)

Inventor

Rainer Albert

Christian Bruns

Peter Smith-Jones

Barbara Stolz

Gisbert Weckbecker

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-06

Filing date

1995-09-04

Publication date

2001-07-09

1995-09-04 Application filed by Novartis Ag filed Critical Novartis Ag

2001-07-09 Application granted granted Critical

2001-07-09 Publication of DK0714911T3 publication Critical patent/DK0714911T3/da

Links

239000000203 mixture Substances 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229940075620 somatostatin analogue Drugs 0.000 title 1
150000001768 cations Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940121896 radiopharmaceutical Drugs 0.000 abstract 1
239000012217 radiopharmaceutical Substances 0.000 abstract 1
230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK95810545T 1994-09-06 1995-09-04 Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger DK0714911T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9417873A GB9417873D0 (en)	1994-09-06	1994-09-06	Organic compounds

Publications (1)

Publication Number	Publication Date
DK0714911T3 true DK0714911T3 (da)	2001-07-09

Family

ID=10760870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95810545T DK0714911T3 (da)	1994-09-06	1995-09-04	Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger

Country Status (31)

Country	Link
US (2)	US6183721B1 (fr)
EP (1)	EP0714911B1 (fr)
JP (1)	JP3054346B2 (fr)
KR (1)	KR100364111B1 (fr)
CN (1)	CN1185252C (fr)
AT (1)	ATE199561T1 (fr)
AU (1)	AU703057B2 (fr)
BR (1)	BR9503936A (fr)
CA (1)	CA2157530C (fr)
CO (1)	CO4410344A1 (fr)
CZ (1)	CZ287012B6 (fr)
DE (1)	DE69520256T2 (fr)
DK (1)	DK0714911T3 (fr)
ES (1)	ES2157309T3 (fr)
FI (1)	FI117424B (fr)
GB (1)	GB9417873D0 (fr)
GR (1)	GR3035997T3 (fr)
HU (1)	HU218284B (fr)
IL (1)	IL115154A (fr)
NO (1)	NO316569B1 (fr)
NZ (1)	NZ272919A (fr)
PE (1)	PE41496A1 (fr)
PL (1)	PL182434B1 (fr)
PT (1)	PT714911E (fr)
RU (1)	RU2156774C2 (fr)
SG (1)	SG50356A1 (fr)
SI (1)	SI0714911T1 (fr)
SK (1)	SK283774B6 (fr)
TR (1)	TR199501094A2 (fr)
TW (1)	TW387898B (fr)
ZA (1)	ZA957475B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds
AT405906B (de) *	1997-03-14	1999-12-27	Irene Dr Virgolini	Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6358491B1 (en)	1999-08-27	2002-03-19	Berlex Laboratories, Inc.	Somatostatin analogs
LT2762140T (lt)	2001-02-19	2017-06-26	Novartis Ag	Solidinių smegenų navikų gydymas rapamicino dariniu
CZ20032597A3 (cs) *	2001-02-26	2004-12-15	Bristol-Myers Squibb Pharma Company	Analogy kyseliny askorbové pro metaloradiofarmaceutika
NZ530007A (en) *	2001-06-08	2006-02-24	Sod Conseils Rech Applic	Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
ITMI20011708A1 (it) *	2001-08-03	2003-02-03	Bracco Imaging Spa	Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
MXPA05000778A (es)	2002-07-18	2005-08-29	Helix Biopharma Corp	Uso de ureasa para inhibir el crecimiento de celulas cancerosas.
JP2006522100A (ja) *	2003-03-10	2006-09-28	バイオジェンアイデックインク	標的化ペプチドに対するチオール媒介性薬物結合
CN102532321B (zh)	2004-06-18	2018-10-12	Ambrx公司	新颖抗原结合多肽和其用途
JP2008520616A (ja) *	2004-11-24	2008-06-19	アプラーゲンゲゼルシャフトミットベシュレンクテルハフツング	固相ペプチド合成および精製方法
EP2192922A4 (fr)	2007-09-17	2010-09-29	Univ California	Anticorps monoclonaux humains internalisants ciblant des cellules du cancer de la prostate<i>in situ</i>
CN105388287A (zh)	2011-03-11	2016-03-09	内布拉斯加大学董事委员会	冠状动脉疾病的生物标志物
EP2922578B1 (fr)	2012-11-21	2018-12-12	Serene, Llc	Composés de liaison de récepteur somatostatine comprenant l'isotope de l'etain 117m
CN103275189B (zh) *	2013-06-06	2014-08-06	深圳翰宇药业股份有限公司	一种用于肽树脂的裂解液及其在固相裂解合成生长抑素中的应用
EP3456700A1 (fr) *	2013-10-18	2019-03-20	Deutsches Krebsforschungszentrum	Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate
ES2975747T3 (es)	2015-11-30	2024-07-12	Univ California	Administración de carga útil específica de tumor y activación inmunitaria utilizando un anticuerpo humano que se dirige a un antígeno de superficie celular de tumor altamente específico
WO2018044812A2 (fr)	2016-08-29	2018-03-08	Fred Hutchinson Cancer Research Center	Plate-forme de chélation pour l'administration de radionucléides
WO2018089829A1 (fr)	2016-11-10	2018-05-17	Fortis Therapeutics, Inc.	Cellules effectrices spécifiques de cd46 et leurs utilisations
SI3568205T1 (sl)	2017-01-12	2023-12-29	Radiomedix Inc.	Zdravljenje rakastih celic, ki prekomerno izražajo receptorje za somatostatin, z uporabo derivatov okreotida, kelatiranih v radioizotope
TW202015744A (zh)	2018-06-21	2020-05-01	法商艾普森藥品公司	用於放射性醫藥之含有體抑素類似物之組成物
TW202547563A (zh) *	2018-06-21	2025-12-16	德商愛利穆治療有限公司	用於放射性醫藥之含有體抑素類似物之組成物
US10596276B2 (en)	2018-07-25	2020-03-24	Advanced Accelerator Applications (Italy) S.R.L.	Stable, concentrated radionuclide complex solutions
US20200030466A1 (en)	2018-07-25	2020-01-30	Advanced Accelerator Applications (Italy) Srl	Stable, concentrated radionuclide complex solutions
JP7604397B2 (ja)	2019-05-20	2024-12-23	エンドサイト・インコーポレイテッド	Ｐｓｍａコンジュゲートの調製方法
AU2021320333A1 (en)	2020-08-07	2023-03-30	Fortis Therapeutics, Inc.	Immunoconjugates targeting CD46 and methods of use thereof
WO2025058000A1 (fr)	2023-09-13	2025-03-20	東レ株式会社	Composition pharmaceutique pour le traitement, la prévention et/ou le diagnostic du cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
US5006643A (en)	1987-06-24	1991-04-09	The Dow Chemical Company	Process for preparing isothiocyanato functionalized metal complexes
DE3728600A1 (de)	1987-08-27	1989-03-09	Hoechst Ag	Verfahren zur markierung von substanzen mit technetium oder rhenium
WO1989011475A1 (fr) *	1988-05-25	1989-11-30	The United States Of America, As Represented By Th	Chelates macrocycliques et leurs modes d'utilisation
GB9111199D0 (en) *	1991-05-23	1991-07-17	Sandoz Ltd	Improvements in or relating to organic compounds
MY106120A (en) *	1988-12-05	1995-03-31	Novartis Ag	Peptide derivatives.
DE69026387T2 (de)	1989-09-29	1996-11-28	Neorx Corp., Seattle, Wash.	Reduktion der nichtzielspezifischen retention von immunokonjugaten und ihren metaboliten
CA2131315A1 (fr) *	1992-03-25	1993-09-30	Geert J. Ensing	Methode peroperatoire de detection et de localisation des tissus tumoraux
US5650134A (en) *	1993-01-12	1997-07-22	Novartis Ag (Formerly Sandoz Ltd.)	Peptides
EP0607103A3 (fr) *	1993-01-12	1997-07-09	Sandoz Ltd	Analogues de somatostatine contenants des agents de chélation et leur compositions radio-marquées.
CA2179990A1 (fr) *	1994-01-12	1995-07-20	Gary Robert Bower	Agents biologiques de ciblage
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds

1994
- 1994-09-06 GB GB9417873A patent/GB9417873D0/en active Pending
1995
- 1995-09-04 PT PT95810545T patent/PT714911E/pt unknown
- 1995-09-04 SG SG1995001282A patent/SG50356A1/en unknown
- 1995-09-04 FI FI954147A patent/FI117424B/fi not_active IP Right Cessation
- 1995-09-04 PL PL95310274A patent/PL182434B1/pl unknown
- 1995-09-04 DE DE69520256T patent/DE69520256T2/de not_active Expired - Lifetime
- 1995-09-04 HU HU9502577A patent/HU218284B/hu unknown
- 1995-09-04 PE PE1995277844A patent/PE41496A1/es not_active IP Right Cessation
- 1995-09-04 IL IL11515495A patent/IL115154A/xx not_active IP Right Cessation
- 1995-09-04 DK DK95810545T patent/DK0714911T3/da active
- 1995-09-04 NZ NZ272919A patent/NZ272919A/en not_active IP Right Cessation
- 1995-09-04 RU RU95114740/04A patent/RU2156774C2/ru active
- 1995-09-04 AT AT95810545T patent/ATE199561T1/de active
- 1995-09-04 NO NO953457A patent/NO316569B1/no not_active IP Right Cessation
- 1995-09-04 ES ES95810545T patent/ES2157309T3/es not_active Expired - Lifetime
- 1995-09-04 SI SI9530491T patent/SI0714911T1/xx unknown
- 1995-09-04 SK SK1088-95A patent/SK283774B6/sk not_active IP Right Cessation
- 1995-09-04 CZ CZ19952263A patent/CZ287012B6/cs not_active IP Right Cessation
- 1995-09-04 AU AU30414/95A patent/AU703057B2/en not_active Expired
- 1995-09-04 EP EP95810545A patent/EP0714911B1/fr not_active Expired - Lifetime
- 1995-09-05 JP JP7227906A patent/JP3054346B2/ja not_active Expired - Lifetime
- 1995-09-05 KR KR1019950028905A patent/KR100364111B1/ko not_active Expired - Lifetime
- 1995-09-05 CA CA002157530A patent/CA2157530C/fr not_active Expired - Lifetime
- 1995-09-05 CN CNB951156101A patent/CN1185252C/zh not_active Expired - Lifetime
- 1995-09-05 BR BR9503936-8A patent/BR9503936A/pt not_active IP Right Cessation
- 1995-09-05 CO CO95040393A patent/CO4410344A1/es unknown
- 1995-09-06 TR TR95/01094A patent/TR199501094A2/xx unknown
- 1995-09-06 ZA ZA957475A patent/ZA957475B/xx unknown
- 1995-09-08 TW TW084109395A patent/TW387898B/zh not_active IP Right Cessation
1997
- 1997-04-23 US US08/842,125 patent/US6183721B1/en not_active Expired - Lifetime
2000
- 2000-07-05 US US09/609,844 patent/US6277356B1/en not_active Expired - Lifetime
2001
- 2001-06-06 GR GR20010400850T patent/GR3035997T3/el unknown

Also Published As

Publication number	Publication date
ZA957475B (en)	1997-03-06
SK283774B6 (sk)	2004-01-08
NO953457L (no)	1996-03-07
FI954147A0 (fi)	1995-09-04
PE41496A1 (es)	1996-10-14
HU9502577D0 (en)	1995-11-28
EP0714911A2 (fr)	1996-06-05
PT714911E (pt)	2001-08-30
NO953457D0 (no)	1995-09-04
AU3041495A (en)	1996-03-21
CA2157530C (fr)	2007-04-03
CN1185252C (zh)	2005-01-19
PL310274A1 (en)	1996-03-18
IL115154A (en)	2000-08-13
RU2156774C2 (ru)	2000-09-27
SK108895A3 (en)	1996-06-05
GR3035997T3 (en)	2001-09-28
AU703057B2 (en)	1999-03-11
GB9417873D0 (en)	1994-10-26
PL182434B1 (pl)	2002-01-31
IL115154A0 (en)	1995-12-31
NZ272919A (en)	1996-12-20
CZ226395A3 (en)	1996-03-13
US6183721B1 (en)	2001-02-06
TW387898B (en)	2000-04-21
CO4410344A1 (es)	1997-01-09
ATE199561T1 (de)	2001-03-15
SI0714911T1 (en)	2001-08-31
CZ287012B6 (en)	2000-08-16
FI954147L (fi)	1996-03-07
BR9503936A (pt)	1996-09-24
KR100364111B1 (ko)	2003-02-05
TR199501094A2 (tr)	1996-06-21
JPH0881498A (ja)	1996-03-26
SG50356A1 (en)	2000-11-21
EP0714911B1 (fr)	2001-03-07
CA2157530A1 (fr)	1996-03-07
JP3054346B2 (ja)	2000-06-19
DE69520256D1 (de)	2001-04-12
DE69520256T2 (de)	2001-08-09
NO316569B1 (no)	2004-02-23
HU218284B (en)	2000-07-28
EP0714911A3 (fr)	1996-08-21
HUT72895A (en)	1996-06-28
ES2157309T3 (es)	2001-08-16
FI117424B (fi)	2006-10-13
CN1127259A (zh)	1996-07-24
KR960010683A (ko)	1996-04-20
US6277356B1 (en)	2001-08-21

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SE8502573D0 (sv)	1985-05-23	Fluorescent lanthanide chelates useful as labels of physiologically active materials
NZ216632A (en)	1990-03-27	Multi-component, aqueous polymer compositions containing c 16 + aliphatic surface active compound as evaporation retarding agent
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FI882508A7 (fi)	1988-11-30	Ammoniumsuoloja tai muita klooria eliminoivia aineita sisältäviä hiukkasia detergenttikoostumuksia varten.
HK19393A (en)	1993-03-19	Built detergent compositions containing stabilizing agents
DE3583334D1 (de)	1991-08-01	Borverbindungen enthaltende polycarbonatzusammensetzungen.
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IT1157349B (it)	1987-02-11	Composizioni induribili contenenti epossidi
ES2173661T3 (es)	2002-10-16	Agente de lavado liquidos de baja concentracion alatamente viscosos.
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IT1163888B (it)	1987-04-08	Una composizione di rivestimento induribile sopra i 50 gradi c contenente una resina epossidica idrolizzata
AR242594A1 (es)	1993-04-30	Una composicion de goma no curada, procedimiento para su obtencion; vulcanizados y neumaticos preparados a partir de dicha composicion.
IT1148192B (it)	1986-11-26	Composizioni flemmatizzate contenenti composti suscettibili di esplosione
IT1181652B (it)	1987-09-30	Composizione di resina termoindurente a base di resolo