JP6050264B2 - グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 - Google Patents

グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 Download PDF

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JP6050264B2
JP6050264B2 JP2013558454A JP2013558454A JP6050264B2 JP 6050264 B2 JP6050264 B2 JP 6050264B2 JP 2013558454 A JP2013558454 A JP 2013558454A JP 2013558454 A JP2013558454 A JP 2013558454A JP 6050264 B2 JP6050264 B2 JP 6050264B2
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phenyl
substituted
cycloalkyl
alkyl
heterocyclyl
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JP2014508184A5 (2
JP2014508184A (ja
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ヘイセル ウルリクフ
ヘイセル ウルリクフ
ラムスベクク ダニエル
ラムスベクク ダニエル
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プロビオドルグ エージー
プロビオドルグ エージー
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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JP2013558454A 2011-03-16 2012-03-16 グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 Active JP6050264B2 (ja)

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US201161453333P 2011-03-16 2011-03-16
US61/453,333 2011-03-16
PCT/EP2012/054631 WO2012123563A1 (en) 2011-03-16 2012-03-16 Benz imidazole derivatives as inhibitors of glutaminyl cyclase

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JP2014508184A JP2014508184A (ja) 2014-04-03
JP2014508184A5 JP2014508184A5 (2) 2015-05-07
JP6050264B2 true JP6050264B2 (ja) 2016-12-21

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US (1) US8530670B2 (2)
EP (1) EP2686313B1 (2)
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DK (1) DK2686313T3 (2)
ES (1) ES2570167T3 (2)
WO (1) WO2012123563A1 (2)

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JP6626822B2 (ja) * 2013-07-19 2019-12-25 シンジェンタ パーティシペーションズ アーゲー スピロ複素環式ピロリジンジオンの新規調製方法
JP2018501482A (ja) 2014-12-19 2018-01-18 プロビオドルグ エージー ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法
DE102015011780A1 (de) * 2015-09-16 2017-03-16 Hochschule Anhalt Neue Glutaminylcyclase-lnhibitoren
AU2018208458B2 (en) * 2017-01-10 2020-07-16 ETH Zürich Cell-protective compounds and their use
US10702495B2 (en) 2017-02-20 2020-07-07 Nexien Biopharma, Inc. Method and compositions for treating dystrophies and myotonia
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
EP3543231A1 (en) * 2018-03-19 2019-09-25 ETH Zurich Compounds for treating cns- and neurodegenerative diseases
CN108611370A (zh) * 2018-05-10 2018-10-02 江苏天瑞精准医疗科技有限公司 一种pimt表达质粒、扩增引物、构建方法及应用
EP3750528A1 (en) 2019-06-11 2020-12-16 Nexien Biopharma, Inc. Compositions for treating dystrophies and myotonia
KR20240024948A (ko) * 2021-06-24 2024-02-26 인실리코 메디신 아이피 리미티드 질환의 치료를 위한 베타-락탐 유도체

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