NO321137B1 - Kimaert antistoff mot humant B-lymfocyttbegrenset differensierende antigen, hybridom, sammensetning for behandling av B-celle-lymfom, samt fremgangsmater for a fremstille antistoff og farmasoytisk sammensetning. - Google Patents
Kimaert antistoff mot humant B-lymfocyttbegrenset differensierende antigen, hybridom, sammensetning for behandling av B-celle-lymfom, samt fremgangsmater for a fremstille antistoff og farmasoytisk sammensetning. Download PDFInfo
- Publication number
- NO321137B1 NO321137B1 NO19951903A NO951903A NO321137B1 NO 321137 B1 NO321137 B1 NO 321137B1 NO 19951903 A NO19951903 A NO 19951903A NO 951903 A NO951903 A NO 951903A NO 321137 B1 NO321137 B1 NO 321137B1
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- antibody
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Lubrication Of Internal Combustion Engines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97889192A | 1992-11-13 | 1992-11-13 | |
| US08/149,099 US5736137A (en) | 1992-11-13 | 1993-11-03 | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| PCT/US1993/010953 WO1994011026A2 (fr) | 1992-11-13 | 1993-11-12 | Application therapeutique d'anticorps chimeriques et radio-marques contre l'antigene a differentiation restreinte des lymphocytes b humains pour le traitement du lymphome des cellules b |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951903D0 NO951903D0 (no) | 1995-05-12 |
| NO951903L NO951903L (no) | 1995-07-13 |
| NO321137B1 true NO321137B1 (no) | 2006-03-27 |
Family
ID=26846468
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19951903A NO321137B1 (no) | 1992-11-13 | 1995-05-12 | Kimaert antistoff mot humant B-lymfocyttbegrenset differensierende antigen, hybridom, sammensetning for behandling av B-celle-lymfom, samt fremgangsmater for a fremstille antistoff og farmasoytisk sammensetning. |
| NO20061094A NO326271B1 (no) | 1992-11-13 | 2006-03-07 | Monoklonal antistoff utskillt fra ATCC deponert hybridom HB11388, anvendelse derav til fremstilling av medikamenter til behandling av B-celle-lymfom samt sammensettninger omfattende slike antistoffer. |
| NO20061095A NO329146B1 (no) | 1992-11-13 | 2006-03-07 | Vertscelle som fremstiller chimerisk anti-CD20-antistoff samt anvendelse derav ved fremstilling av medikamenter til behandling av lidelser som involverer B-celler |
| NO2006011C NO2006011I2 (no) | 1992-11-13 | 2006-09-18 | Ibritumomabtiuksetan |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20061094A NO326271B1 (no) | 1992-11-13 | 2006-03-07 | Monoklonal antistoff utskillt fra ATCC deponert hybridom HB11388, anvendelse derav til fremstilling av medikamenter til behandling av B-celle-lymfom samt sammensettninger omfattende slike antistoffer. |
| NO20061095A NO329146B1 (no) | 1992-11-13 | 2006-03-07 | Vertscelle som fremstiller chimerisk anti-CD20-antistoff samt anvendelse derav ved fremstilling av medikamenter til behandling av lidelser som involverer B-celler |
| NO2006011C NO2006011I2 (no) | 1992-11-13 | 2006-09-18 | Ibritumomabtiuksetan |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US6399061B1 (fr) |
| EP (3) | EP0752248B1 (fr) |
| JP (3) | JP3095175B2 (fr) |
| AT (2) | ATE139900T1 (fr) |
| AU (1) | AU688743B2 (fr) |
| BG (1) | BG62386B1 (fr) |
| CA (1) | CA2149329C (fr) |
| DE (3) | DE69303494T2 (fr) |
| DK (2) | DK0752248T3 (fr) |
| ES (2) | ES2152483T3 (fr) |
| FI (1) | FI112033B (fr) |
| GR (2) | GR3020731T3 (fr) |
| LU (1) | LU91089I2 (fr) |
| LV (1) | LV11732B (fr) |
| MD (1) | MD1367C2 (fr) |
| NL (1) | NL300156I2 (fr) |
| NO (4) | NO321137B1 (fr) |
| NZ (1) | NZ258392A (fr) |
| PL (2) | PL174721B1 (fr) |
| PT (1) | PT752248E (fr) |
| RO (1) | RO118524B1 (fr) |
| RU (1) | RU2139731C1 (fr) |
| WO (1) | WO1994011026A2 (fr) |
Families Citing this family (1508)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190640B1 (en) * | 1985-04-19 | 2001-02-20 | Ludwig Institute For Cancer Research | Method for treating neoplasia using humanized antibodies which bind to antigen A33 |
| US7744877B2 (en) | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| FR2724182B1 (fr) * | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
| US20030180290A1 (en) * | 1995-06-07 | 2003-09-25 | Idec Pharmaceuticals Corporation | Anti-CD80 antibody having ADCC activity for ADCC mediated killing of B cell lymphoma cells alone or in combination with other therapies |
| ATE307887T1 (de) | 1996-01-08 | 2005-11-15 | Genentech Inc | Ob-rezeptor und liganden |
| US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6183744B1 (en) * | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| EP2338915A3 (fr) | 1997-04-07 | 2011-10-12 | Genentech, Inc. | Anticorps anti-VEGF |
| JP3957765B2 (ja) | 1997-04-07 | 2007-08-15 | ジェネンテク・インコーポレイテッド | 抗ｖｅｇｆ抗体 |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US6991790B1 (en) | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
| US6610293B1 (en) | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
| US7192589B2 (en) | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
| ES2288649T3 (es) | 1997-11-21 | 2008-01-16 | Genentech, Inc. | Antigenos tipo a-33 y sus utilizaciones farmacologicas. |
| EP1947119A3 (fr) | 1997-12-12 | 2012-12-19 | Genentech, Inc. | Traitement du cancer avec un anticorps Anti-ERBB2 combiné à une chimiothérapie |
| DE69939374D1 (de) | 1998-03-17 | 2008-10-02 | Genentech Inc | Zu vegf und bmp1 homologe polypeptide |
| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| EP1865061A3 (fr) | 1998-05-15 | 2007-12-19 | Genentech, Inc. | Polypeptides allogéniques IL-17 et utilisations thérapeutiques |
| EP3112468A1 (fr) | 1998-05-15 | 2017-01-04 | Genentech, Inc. | Polypeptides allogéniques il-17 et utilisations thérapeutiques |
| NZ508878A (en) | 1998-05-15 | 2003-08-29 | Genentech Inc | IL-17B and IL-17Cactive variants of IL-17 which stimulates epithelial, endothelial and fibroblastic cells |
| EP2058334B1 (fr) | 1998-06-12 | 2012-10-31 | Genentech, Inc. | Anticorps monoclonaux, anticorps à réaction croisée et procédé de production |
| US7250494B2 (en) | 1998-06-15 | 2007-07-31 | Biosynexus Incorporated | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria |
| US20020172678A1 (en) | 2000-06-23 | 2002-11-21 | Napoleone Ferrara | EG-VEGF nucleic acids and polypeptides and methods of use |
| CA2340091C (fr) | 1998-08-11 | 2013-02-05 | Idec Pharmaceuticals Corporation | Therapies d'association contre les lymphomes malins a cellules b par l'administration d'anticorps anti-cd20 |
| US6224866B1 (en) * | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
| US20010033839A1 (en) * | 1999-10-04 | 2001-10-25 | Emilio Barbera-Guillem | Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation |
| WO2000023573A2 (fr) * | 1998-10-20 | 2000-04-27 | City Of Hope | Cellules modifiees specifiques a la molecule cd20 et utilisation de ces dernieres pour l'immunotherapie cellulaires des malignites cd20?+¿ |
| EP1131093A4 (fr) | 1998-11-09 | 2002-05-02 | Idec Pharma Corp | Traitement d'affections malignes hematologiques associees a des cellules tumorales en circulation au moyen d'un anticorps chimere anti-cd 20 |
| KR20010099788A (ko) * | 1998-11-09 | 2001-11-09 | 케네쓰 제이. 울코트 | Ｂｍｔ 또는 ｐｂｓｃ 이식을 받은 환자의 키메라항-ｃｄ２０ 항체 치료법 |
| EP1950300A3 (fr) | 1998-11-18 | 2011-03-23 | Genentech, Inc. | Variantes d'anticorps avec une affinité de liaison plus élevée en comparaison aux anticorps parents |
| EP2075335A3 (fr) | 1998-12-22 | 2009-09-30 | Genentech, Inc. | Procédés et compositions d'inhibition de la croissance de cellules néoplasiques |
| HU230769B1 (hu) | 1999-01-15 | 2018-03-28 | Genentech Inc. | Módosított effektor-funkciójú polipeptid-változatok |
| US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
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| US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
| US8383081B2 (en) * | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
| US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| CA2375912C (fr) * | 1999-06-09 | 2014-03-11 | Immunomedics, Inc. | Immunotherapie de troubles auto-immuns a l'aide d'anticorps ciblant les cellules b |
| EP1978029A3 (fr) | 1999-06-15 | 2008-10-15 | Genentech, Inc. | Polypeptides sécrétés et transmembranaires, et acides nucléiques les codant |
| CA2376596C (fr) | 1999-06-25 | 2009-10-06 | Genentech, Inc. | Anticorps anti-erbb2 humanises et traitement a l'aide de ces anticorps |
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| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
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| CA2340091C (fr) | 1998-08-11 | 2013-02-05 | Idec Pharmaceuticals Corporation | Therapies d'association contre les lymphomes malins a cellules b par l'administration d'anticorps anti-cd20 |
| KR20010099788A (ko) | 1998-11-09 | 2001-11-09 | 케네쓰 제이. 울코트 | Ｂｍｔ 또는 ｐｂｓｃ 이식을 받은 환자의 키메라항-ｃｄ２０ 항체 치료법 |
| EP1131093A4 (fr) | 1998-11-09 | 2002-05-02 | Idec Pharma Corp | Traitement d'affections malignes hematologiques associees a des cellules tumorales en circulation au moyen d'un anticorps chimere anti-cd 20 |
| US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
| AU5914201A (en) | 2000-04-25 | 2001-11-07 | Idec Pharma Corp | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
| CN101928344B (zh) | 2002-10-17 | 2014-08-13 | 根马布股份公司 | 抗cd20的人单克隆抗体 |
| EP3263596A1 (fr) | 2002-12-16 | 2018-01-03 | Genentech, Inc. | Variantes de l'immunoglobuline et leurs utilisations |
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1993
- 1993-11-12 MD MD95-0311A patent/MD1367C2/ro unknown
- 1993-11-12 RU RU95112506A patent/RU2139731C1/ru active
- 1993-11-12 WO PCT/US1993/010953 patent/WO1994011026A2/fr not_active Ceased
- 1993-11-12 EP EP96200772A patent/EP0752248B1/fr not_active Expired - Lifetime
- 1993-11-12 JP JP06512376A patent/JP3095175B2/ja not_active Expired - Lifetime
- 1993-11-12 ES ES96200772T patent/ES2152483T3/es not_active Expired - Lifetime
- 1993-11-12 PL PL93320658A patent/PL174721B1/pl unknown
- 1993-11-12 ES ES94901444T patent/ES2091684T3/es not_active Expired - Lifetime
- 1993-11-12 AU AU56032/94A patent/AU688743B2/en not_active Expired
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- 1993-11-12 AT AT94901444T patent/ATE139900T1/de active
- 1993-11-12 NZ NZ258392A patent/NZ258392A/en not_active IP Right Cessation
- 1993-11-12 RO RO95-00888A patent/RO118524B1/ro unknown
- 1993-11-12 PL PL93309002A patent/PL174494B1/pl unknown
- 1993-11-12 PT PT96200772T patent/PT752248E/pt unknown
- 1993-11-12 CA CA002149329A patent/CA2149329C/fr not_active Expired - Lifetime
- 1993-11-12 EP EP94901444A patent/EP0669836B1/fr not_active Expired - Lifetime
- 1993-11-12 DE DE200412000036 patent/DE122004000036I1/de active Pending
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- 1993-11-12 DE DE69329503T patent/DE69329503T2/de not_active Expired - Lifetime
- 1993-11-12 EP EP99123967A patent/EP1005870B1/fr not_active Expired - Lifetime
- 1993-11-12 DK DK96200772T patent/DK0752248T3/da active
- 1993-11-12 DK DK94901444.3T patent/DK0669836T3/da active
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1995
- 1995-05-12 FI FI952327A patent/FI112033B/fi not_active IP Right Cessation
- 1995-05-12 NO NO19951903A patent/NO321137B1/no not_active IP Right Cessation
- 1995-06-05 BG BG99701A patent/BG62386B1/bg unknown
- 1995-06-07 US US08/475,815 patent/US6399061B1/en not_active Expired - Lifetime
- 1995-06-07 US US08/478,967 patent/US5843439A/en not_active Expired - Lifetime
- 1995-06-07 US US08/475,813 patent/US6682734B1/en not_active Expired - Lifetime
- 1995-06-07 US US08/476,275 patent/US5776456A/en not_active Expired - Lifetime
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1996
- 1996-08-07 GR GR960402096T patent/GR3020731T3/el unknown
- 1996-09-17 LV LVP-96-373A patent/LV11732B/en unknown
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2000
- 2000-04-21 JP JP2000126317A patent/JP4091235B2/ja not_active Expired - Lifetime
- 2000-12-19 GR GR20000402807T patent/GR3035119T3/el unknown
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2001
- 2001-07-17 US US09/905,928 patent/US20030021781A1/en not_active Abandoned
- 2001-07-25 US US09/911,703 patent/US7422739B2/en not_active Expired - Fee Related
- 2001-07-25 US US09/911,692 patent/US7381560B2/en not_active Expired - Fee Related
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2004
- 2004-07-16 NL NL300156C patent/NL300156I2/nl unknown
- 2004-07-16 LU LU91089C patent/LU91089I2/fr unknown
- 2004-10-04 US US10/956,039 patent/US20050186205A1/en not_active Abandoned
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2006
- 2006-03-07 NO NO20061094A patent/NO326271B1/no not_active IP Right Cessation
- 2006-03-07 NO NO20061095A patent/NO329146B1/no not_active IP Right Cessation
- 2006-05-15 JP JP2006135870A patent/JP4203080B2/ja not_active Expired - Lifetime
- 2006-09-18 NO NO2006011C patent/NO2006011I2/no unknown
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