BE1002665A4 - Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. - Google Patents

Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. Download PDF

Info

Publication number: BE1002665A4
Authority: BE; Belgium
Prior art keywords: ciclosporin; crystalline form; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1987-12-21

Application number

BE8801421A

Other languages

English (en)

French (fr)

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1991-04-30

1988-12-20 Application filed by Sandoz Sa filed Critical Sandoz Sa

1991-04-30 Application granted granted Critical

1991-04-30 Publication of BE1002665A4 publication Critical patent/BE1002665A4/fr

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
108010036949 Cyclosporine Proteins 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
230000000699 topical effect Effects 0.000 abstract 2
239000013543 active substance Substances 0.000 abstract 1
230000002500 effect on skin Effects 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
230000003902 lesion Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

BE8801421A 1987-12-21 1988-12-20 Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. BE1002665A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (1)

Publication Number	Publication Date
BE1002665A4 true BE1002665A4 (fr)	1991-04-30

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE8801421A BE1002665A4 (fr)	1987-12-21	1988-12-20	Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant.

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (da)
KR (1)	KR100188305B1 (da)
AT (1)	AT403163B (da)
AU (1)	AU626274B2 (da)
BE (1)	BE1002665A4 (da)
CA (1)	CA1341396C (da)
CH (1)	CH677926A5 (da)
CY (1)	CY1799A (da)
DE (1)	DE3843054C2 (da)
DK (1)	DK175220B1 (da)
ES (1)	ES2012580A6 (da)
FI (1)	FI89065C (da)
FR (1)	FR2624863B1 (da)
GB (1)	GB2211848B (da)
GR (1)	GR1002486B (da)
HK (1)	HK102894A (da)
HU (1)	HU203564B (da)
IE (1)	IE62006B1 (da)
IL (1)	IL88719A0 (da)
IT (1)	IT1235356B (da)
LU (1)	LU87409A1 (da)
MY (1)	MY103943A (da)
NL (1)	NL195096C (da)
NO (1)	NO177228C (da)
NZ (1)	NZ227384A (da)
SE (1)	SE503174C2 (da)
SG (1)	SG99494G (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en) *	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko)	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
HK1004520A1 (en) *	1992-05-13	1998-11-27	Novartis Ag	Ophthalmic compositions containing a cyclosporin
PT589843E (pt)	1992-09-25	2002-04-29	Novartis Ag	Composicoes farmaceuticas contendo ciclosporinas
SK164796A3 (en)	1994-11-03	1997-06-04	Dresden Arzneimittel	Novel cyclosporine preparation forms for oral administration of and process for producing them
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en) *	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
SK285019B6 (sk)	1997-01-30	2006-04-06	Novartis Ag	Tvrdá želatínová tobolka
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
DE602005011928D1 (de)	2004-01-20	2009-02-05	Allergan Inc	Zusammensetzungen für die lokalisierte therapie des auges, vorzugsweise enthaltend triamcinolon-acetonid und hyaluronsäure
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
MY180581A (en) *	2011-05-27	2020-12-02	Allergan Inc	A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof
BR112014011768A2 (pt) *	2011-11-15	2017-05-09	Allergan Inc	forma 2 de ciclosporina a e método de produção da mesma
WO2013074610A1 (en)	2011-11-15	2013-05-23	Allergan, Inc.	Sustained action formulation of cyclosporin form 2
EP3701939A1 (en) *	2011-11-15	2020-09-02	Allergan, Inc.	Suspensions of cyclosporin a form 2
US20130123194A1 (en) *	2011-11-15	2013-05-16	Allergan, Inc.	Autoclavable suspensions of cyclosporin a form 2
TW202430537A (zh) *	2022-10-20	2024-08-01	日商中外製藥股份有限公司	環狀胜肽的結晶的製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (da) *	1975-11-04	1979-12-28	Sandoz Ag
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE MERCK INDEX, édition 10, 1983, page 396, résumé no.2748, Merck & Co., Inc., Rahway, N.J., US; "Cyclosporins" *

Also Published As

Publication number	Publication date
DE3843054C2 (de)	2003-08-21
GR880100850A (el)	1994-03-31
FR2624863B1 (fr)	1991-04-26
DK705488D0 (da)	1988-12-19
JPH01211598A (ja)	1989-08-24
ATA309588A (de)	1997-04-15
NL195096C (nl)	2004-02-09
NO885625L (no)	1989-06-22
NL8803125A (nl)	1989-07-17
CY1799A (en)	1995-02-17
GB2211848A (en)	1989-07-12
HUT49893A (en)	1989-11-28
DE3843054A1 (de)	1989-07-27
IT1235356B (it)	1992-06-30
HK102894A (en)	1994-09-30
AT403163B (de)	1997-11-25
CH677926A5 (da)	1991-07-15
SE503174C2 (sv)	1996-04-15
AU626274B2 (en)	1992-07-30
SE8804570D0 (sv)	1988-12-19
FI89065C (fi)	1993-09-30
IE883779L (en)	1989-06-21
NO177228B (no)	1995-05-02
SG99494G (en)	1994-10-28
ES2012580A6 (es)	1990-04-01
DK175220B1 (da)	2004-07-12
GR1002486B (el)	1996-12-09
HU203564B (en)	1991-08-28
DK705488A (da)	1989-06-22
IE62006B1 (en)	1994-12-14
FI885869L (fi)	1989-06-22
FI89065B (fi)	1993-04-30
SE8804570L (sv)	1989-06-22
MY103943A (en)	1993-10-30
IL88719A0 (en)	1989-07-31
KR100188305B1 (ko)	1999-06-01
FR2624863A1 (fr)	1989-06-23
FI885869A0 (fi)	1988-12-19
KR890009975A (ko)	1989-08-05
GB8829556D0 (en)	1989-02-08
JPH0791316B2 (ja)	1995-10-04
IT8848690A0 (it)	1988-12-20
NO885625D0 (no)	1988-12-19
NO177228C (no)	1995-08-09
GB2211848B (en)	1991-11-06
LU87409A1 (fr)	1989-07-07
CA1341396C (en)	2002-11-05
NZ227384A (en)	1991-09-25
AU2705588A (en)	1989-06-22

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Legal Events

Date

Code

Title

Description

2008-12-31

RE20

Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20081220