HU203564B - Process for producing new orthorombos cyclosporin without solvatation - Google Patents

Process for producing new orthorombos cyclosporin without solvatation Download PDF

Info

Publication number: HU203564B
Authority: HU; Hungary
Prior art keywords: cyclosporin; orthorhombic; treatment; polyethylene glycol; particle size
Prior art date: 1987-12-21

Application number

HU886374A

Other languages

English (en)

Hungarian (hu)

Other versions

HUT49893A (en

Inventor

Danielle Giron

Martin List

Friedrich Richter

Yasuyuki Uike

Hans Peter Weber

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-09

Publication date

1991-08-28

1988-12-09 Application filed by Sandoz Ag filed Critical Sandoz Ag

1989-11-28 Publication of HUT49893A publication Critical patent/HUT49893A/hu

1991-08-28 Publication of HU203564B publication Critical patent/HU203564B/hu

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 140
108010036949 Cyclosporine Proteins 0.000 title claims abstract description 139
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

HU886374A 1987-12-21 1988-12-09 Process for producing new orthorombos cyclosporin without solvatation HU203564B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (2)

Publication Number	Publication Date
HUT49893A HUT49893A (en)	1989-11-28
HU203564B true HU203564B (en)	1991-08-28

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU886374A HU203564B (en)	1987-12-21	1988-12-09	Process for producing new orthorombos cyclosporin without solvatation

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (da)
KR (1)	KR100188305B1 (da)
AT (1)	AT403163B (da)
AU (1)	AU626274B2 (da)
BE (1)	BE1002665A4 (da)
CA (1)	CA1341396C (da)
CH (1)	CH677926A5 (da)
CY (1)	CY1799A (da)
DE (1)	DE3843054C2 (da)
DK (1)	DK175220B1 (da)
ES (1)	ES2012580A6 (da)
FI (1)	FI89065C (da)
FR (1)	FR2624863B1 (da)
GB (1)	GB2211848B (da)
GR (1)	GR1002486B (da)
HK (1)	HK102894A (da)
HU (1)	HU203564B (da)
IE (1)	IE62006B1 (da)
IL (1)	IL88719A0 (da)
IT (1)	IT1235356B (da)
LU (1)	LU87409A1 (da)
MY (1)	MY103943A (da)
NL (1)	NL195096C (da)
NO (1)	NO177228C (da)
NZ (1)	NZ227384A (da)
SE (1)	SE503174C2 (da)
SG (1)	SG99494G (da)

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US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) *	1992-05-13	1998-01-16	Sandoz Ltd	Ophthalmic compositions
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
ATE218359T1 (de)	1994-11-03	2002-06-15	Novartis Erfind Verwalt Gmbh	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en) *	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
PT988046E (pt)	1997-01-30	2004-12-31	Novartis Ag	Composicoes farmaceuticas sem oleo contendo ciclosporina a
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en)	2004-01-20	2008-12-24	Allergan, Inc.	Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
UA113627C2 (xx)	2011-05-27	2017-02-27		Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
JP6363506B2 (ja)	2011-11-15	2018-07-25	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンａ２型の懸濁剤
CN108714137B (zh) *	2011-11-15	2022-02-01	阿勒根公司	环孢菌素a形式2的可热压性悬浮液
CN104039813B (zh)	2011-11-15	2017-08-29	阿勒根公司	环孢菌素a形式2及其制备方法
KR102029513B1 (ko) *	2011-11-15	2019-10-07	알러간, 인코포레이티드	사이클로스포린 제2형의 지속 작용 제형
US20260132169A1 (en) *	2022-10-20	2026-05-14	Chugai Seiyaku Kabushiki Kaisha	Method for producing cyclic peptide crystals

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CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Also Published As

Publication number	Publication date
SE503174C2 (sv)	1996-04-15
AU2705588A (en)	1989-06-22
NZ227384A (en)	1991-09-25
NL195096C (nl)	2004-02-09
FI885869A0 (fi)	1988-12-19
NL8803125A (nl)	1989-07-17
CA1341396C (en)	2002-11-05
IE883779L (en)	1989-06-21
SE8804570D0 (sv)	1988-12-19
NO177228B (no)	1995-05-02
ATA309588A (de)	1997-04-15
LU87409A1 (fr)	1989-07-07
FI885869L (fi)	1989-06-22
FI89065B (fi)	1993-04-30
AT403163B (de)	1997-11-25
HUT49893A (en)	1989-11-28
SG99494G (en)	1994-10-28
KR100188305B1 (ko)	1999-06-01
GR1002486B (el)	1996-12-09
NO885625D0 (no)	1988-12-19
GB2211848A (en)	1989-07-12
IT8848690A0 (it)	1988-12-20
GB2211848B (en)	1991-11-06
IL88719A0 (en)	1989-07-31
SE8804570L (sv)	1989-06-22
GR880100850A (el)	1994-03-31
DE3843054C2 (de)	2003-08-21
BE1002665A4 (fr)	1991-04-30
JPH0791316B2 (ja)	1995-10-04
DK175220B1 (da)	2004-07-12
KR890009975A (ko)	1989-08-05
NO885625L (no)	1989-06-22
FI89065C (fi)	1993-09-30
MY103943A (en)	1993-10-30
JPH01211598A (ja)	1989-08-24
CH677926A5 (da)	1991-07-15
AU626274B2 (en)	1992-07-30
NO177228C (no)	1995-08-09
CY1799A (en)	1995-02-17
DK705488A (da)	1989-06-22
FR2624863A1 (fr)	1989-06-23
HK102894A (en)	1994-09-30
FR2624863B1 (fr)	1991-04-26
DK705488D0 (da)	1988-12-19
ES2012580A6 (es)	1990-04-01
DE3843054A1 (de)	1989-07-27
IT1235356B (it)	1992-06-30
GB8829556D0 (en)	1989-02-08
IE62006B1 (en)	1994-12-14

Legal Events

Date	Code	Title	Description
1997-11-28	HPC4	Succession in title of patentee	Owner name: NOVARTIS AG, CH

Publication	Publication Date	Title
KR100188305B1 (ko)	1999-06-01	신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도
AT404552B (de)	1998-12-28	Neue cyclosporin enthaltende galenische formulierungen
US5756450A (en)	1998-05-26	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
EP3104844B1 (en)	2020-02-12	Complexes of sirolimus and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
JPH0725690B2 (ja)	1995-03-22	シクロスポリン含有医薬組成物
HUT73664A (en)	1996-09-30	Pharmaceutically acceptable improved compositions containing an alcohol and a hydrophobic drug
NL195094C (nl)	2003-12-17	Farmaceutische preparaat dat opgelost cyclosporine bevat en werkwijze voor de bereiding daarvan.
JPH0768130B2 (ja)	1995-07-26	微粒子化薬剤
JP2003510267A (ja)	2003-03-18	医薬担体処方
CN102309438A (zh)	2012-01-11	一种咪达唑仑药物组合物、其制备方法及用途
SK278320B6 (en)	1996-10-02	Process for producing of cyclosporine a
WO2001051089A1 (de)	2001-07-19	Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler
HU212727B (en)	1996-10-28	Process for producing pharmaceutical compositions in form of microemulsion-prae-concentrate or microemulsion containing cyclosporin(s) as active component
WO2001051052A1 (de)	2001-07-19	Pharmazeutische zubereitung mit spezifischen pde v-hemmer