JPH0791316B2 - 新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途 - Google Patents

新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途

Info

Publication number
JPH0791316B2
JPH0791316B2 JP63321857A JP32185788A JPH0791316B2 JP H0791316 B2 JPH0791316 B2 JP H0791316B2 JP 63321857 A JP63321857 A JP 63321857A JP 32185788 A JP32185788 A JP 32185788A JP H0791316 B2 JPH0791316 B2 JP H0791316B2
Authority
JP
Japan
Prior art keywords
cyclosporine
iii
treatment
orthorhombic
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63321857A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01211598A (ja
Inventor
ダニエル・ジロン
マーチン・リスト
フリードリッヒ・リヒテル
ヤスユキ・ウイケ
ハンス・ペーター・ウェーバー
Original Assignee
サンド・アクチエンゲゼルシャスト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by サンド・アクチエンゲゼルシャスト filed Critical サンド・アクチエンゲゼルシャスト
Publication of JPH01211598A publication Critical patent/JPH01211598A/ja
Publication of JPH0791316B2 publication Critical patent/JPH0791316B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP63321857A 1987-12-21 1988-12-20 新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途 Expired - Lifetime JPH0791316B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US136230 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28
US212548 1988-06-28
US172613 1998-10-15

Publications (2)

Publication Number Publication Date
JPH01211598A JPH01211598A (ja) 1989-08-24
JPH0791316B2 true JPH0791316B2 (ja) 1995-10-04

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63321857A Expired - Lifetime JPH0791316B2 (ja) 1987-12-21 1988-12-20 新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途

Country Status (27)

Country Link
JP (1) JPH0791316B2 (da)
KR (1) KR100188305B1 (da)
AT (1) AT403163B (da)
AU (1) AU626274B2 (da)
BE (1) BE1002665A4 (da)
CA (1) CA1341396C (da)
CH (1) CH677926A5 (da)
CY (1) CY1799A (da)
DE (1) DE3843054C2 (da)
DK (1) DK175220B1 (da)
ES (1) ES2012580A6 (da)
FI (1) FI89065C (da)
FR (1) FR2624863B1 (da)
GB (1) GB2211848B (da)
GR (1) GR1002486B (da)
HK (1) HK102894A (da)
HU (1) HU203564B (da)
IE (1) IE62006B1 (da)
IL (1) IL88719A0 (da)
IT (1) IT1235356B (da)
LU (1) LU87409A1 (da)
MY (1) MY103943A (da)
NL (1) NL195096C (da)
NO (1) NO177228C (da)
NZ (1) NZ227384A (da)
SE (1) SE503174C2 (da)
SG (1) SG99494G (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) * 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
DK0589843T3 (da) 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
ATE218359T1 (de) 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
PT988046E (pt) 1997-01-30 2004-12-31 Novartis Ag Composicoes farmaceuticas sem oleo contendo ciclosporina a
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en) 2004-01-20 2008-12-24 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
UA113627C2 (xx) 2011-05-27 2017-02-27 Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
JP6363506B2 (ja) 2011-11-15 2018-07-25 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ２型の懸濁剤
CN108714137B (zh) * 2011-11-15 2022-02-01 阿勒根公司 环孢菌素a形式2的可热压性悬浮液
CN104039813B (zh) 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法
KR102029513B1 (ko) * 2011-11-15 2019-10-07 알러간, 인코포레이티드 사이클로스포린 제2형의 지속 작용 제형
US20260132169A1 (en) * 2022-10-20 2026-05-14 Chugai Seiyaku Kabushiki Kaisha Method for producing cyclic peptide crystals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (da) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Also Published As

Publication number Publication date
SE503174C2 (sv) 1996-04-15
AU2705588A (en) 1989-06-22
NZ227384A (en) 1991-09-25
NL195096C (nl) 2004-02-09
FI885869A0 (fi) 1988-12-19
NL8803125A (nl) 1989-07-17
CA1341396C (en) 2002-11-05
IE883779L (en) 1989-06-21
SE8804570D0 (sv) 1988-12-19
NO177228B (no) 1995-05-02
ATA309588A (de) 1997-04-15
LU87409A1 (fr) 1989-07-07
FI885869L (fi) 1989-06-22
FI89065B (fi) 1993-04-30
AT403163B (de) 1997-11-25
HUT49893A (en) 1989-11-28
SG99494G (en) 1994-10-28
KR100188305B1 (ko) 1999-06-01
GR1002486B (el) 1996-12-09
NO885625D0 (no) 1988-12-19
GB2211848A (en) 1989-07-12
IT8848690A0 (it) 1988-12-20
GB2211848B (en) 1991-11-06
IL88719A0 (en) 1989-07-31
SE8804570L (sv) 1989-06-22
GR880100850A (el) 1994-03-31
DE3843054C2 (de) 2003-08-21
BE1002665A4 (fr) 1991-04-30
DK175220B1 (da) 2004-07-12
KR890009975A (ko) 1989-08-05
NO885625L (no) 1989-06-22
FI89065C (fi) 1993-09-30
MY103943A (en) 1993-10-30
JPH01211598A (ja) 1989-08-24
CH677926A5 (da) 1991-07-15
AU626274B2 (en) 1992-07-30
NO177228C (no) 1995-08-09
CY1799A (en) 1995-02-17
HU203564B (en) 1991-08-28
DK705488A (da) 1989-06-22
FR2624863A1 (fr) 1989-06-23
HK102894A (en) 1994-09-30
FR2624863B1 (fr) 1991-04-26
DK705488D0 (da) 1988-12-19
ES2012580A6 (es) 1990-04-01
DE3843054A1 (de) 1989-07-27
IT1235356B (it) 1992-06-30
GB8829556D0 (en) 1989-02-08
IE62006B1 (en) 1994-12-14

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