NZ227384A - Ciclosporin in non-solvate orthorhombic crystal form; pharmaceutical compositions - Google Patents

Ciclosporin in non-solvate orthorhombic crystal form; pharmaceutical compositions

Info

Publication number: NZ227384A
Authority: NZ; New Zealand
Prior art keywords: ciclosporin; pharmaceutical compositions; crystal form; orthorhombic crystal; solvate
Prior art date: 1987-12-21

Application number

NZ227384A

Other languages

English (en)

Inventor

Danielle Giron

Martin List

Friedrich Richter

Uike Yasuyuki

Hans Peter Weber

Original Assignee

Sandoz Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-19

Publication date

1991-09-25

1988-12-19 Application filed by Sandoz Ltd filed Critical Sandoz Ltd

1991-09-25 Publication of NZ227384A publication Critical patent/NZ227384A/xx

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
239000013078 crystal Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000012453 solvate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NZ227384A 1987-12-21 1988-12-19 Ciclosporin in non-solvate orthorhombic crystal form; pharmaceutical compositions NZ227384A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (1)

Publication Number	Publication Date
NZ227384A true NZ227384A (en)	1991-09-25

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ227384A NZ227384A (en)	1987-12-21	1988-12-19	Ciclosporin in non-solvate orthorhombic crystal form; pharmaceutical compositions

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (da)
KR (1)	KR100188305B1 (da)
AT (1)	AT403163B (da)
AU (1)	AU626274B2 (da)
BE (1)	BE1002665A4 (da)
CA (1)	CA1341396C (da)
CH (1)	CH677926A5 (da)
CY (1)	CY1799A (da)
DE (1)	DE3843054C2 (da)
DK (1)	DK175220B1 (da)
ES (1)	ES2012580A6 (da)
FI (1)	FI89065C (da)
FR (1)	FR2624863B1 (da)
GB (1)	GB2211848B (da)
GR (1)	GR1002486B (da)
HK (1)	HK102894A (da)
HU (1)	HU203564B (da)
IE (1)	IE62006B1 (da)
IL (1)	IL88719A0 (da)
IT (1)	IT1235356B (da)
LU (1)	LU87409A1 (da)
MY (1)	MY103943A (da)
NL (1)	NL195096C (da)
NO (1)	NO177228C (da)
NZ (1)	NZ227384A (da)
SE (1)	SE503174C2 (da)
SG (1)	SG99494G (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) *	1992-05-13	1998-01-16	Sandoz Ltd	Ophthalmic compositions
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
ATE218359T1 (de)	1994-11-03	2002-06-15	Novartis Erfind Verwalt Gmbh	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en) *	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
PT988046E (pt)	1997-01-30	2004-12-31	Novartis Ag	Composicoes farmaceuticas sem oleo contendo ciclosporina a
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en)	2004-01-20	2008-12-24	Allergan, Inc.	Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
UA113627C2 (xx)	2011-05-27	2017-02-27		Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
JP6363506B2 (ja)	2011-11-15	2018-07-25	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンａ２型の懸濁剤
CN108714137B (zh) *	2011-11-15	2022-02-01	阿勒根公司	环孢菌素a形式2的可热压性悬浮液
CN104039813B (zh)	2011-11-15	2017-08-29	阿勒根公司	环孢菌素a形式2及其制备方法
KR102029513B1 (ko) *	2011-11-15	2019-10-07	알러간, 인코포레이티드	사이클로스포린 제2형의 지속 작용 제형
US20260132169A1 (en) *	2022-10-20	2026-05-14	Chugai Seiyaku Kabushiki Kaisha	Method for producing cyclic peptide crystals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (da) *	1975-11-04	1979-12-28	Sandoz Ag
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Also Published As

Publication number	Publication date
SE503174C2 (sv)	1996-04-15
AU2705588A (en)	1989-06-22
NL195096C (nl)	2004-02-09
FI885869A0 (fi)	1988-12-19
NL8803125A (nl)	1989-07-17
CA1341396C (en)	2002-11-05
IE883779L (en)	1989-06-21
SE8804570D0 (sv)	1988-12-19
NO177228B (no)	1995-05-02
ATA309588A (de)	1997-04-15
LU87409A1 (fr)	1989-07-07
FI885869L (fi)	1989-06-22
FI89065B (fi)	1993-04-30
AT403163B (de)	1997-11-25
HUT49893A (en)	1989-11-28
SG99494G (en)	1994-10-28
KR100188305B1 (ko)	1999-06-01
GR1002486B (el)	1996-12-09
NO885625D0 (no)	1988-12-19
GB2211848A (en)	1989-07-12
IT8848690A0 (it)	1988-12-20
GB2211848B (en)	1991-11-06
IL88719A0 (en)	1989-07-31
SE8804570L (sv)	1989-06-22
GR880100850A (el)	1994-03-31
DE3843054C2 (de)	2003-08-21
BE1002665A4 (fr)	1991-04-30
JPH0791316B2 (ja)	1995-10-04
DK175220B1 (da)	2004-07-12
KR890009975A (ko)	1989-08-05
NO885625L (no)	1989-06-22
FI89065C (fi)	1993-09-30
MY103943A (en)	1993-10-30
JPH01211598A (ja)	1989-08-24
CH677926A5 (da)	1991-07-15
AU626274B2 (en)	1992-07-30
NO177228C (no)	1995-08-09
CY1799A (en)	1995-02-17
HU203564B (en)	1991-08-28
DK705488A (da)	1989-06-22
FR2624863A1 (fr)	1989-06-23
HK102894A (en)	1994-09-30
FR2624863B1 (fr)	1991-04-26
DK705488D0 (da)	1988-12-19
ES2012580A6 (es)	1990-04-01
DE3843054A1 (de)	1989-07-27
IT1235356B (it)	1992-06-30
GB8829556D0 (en)	1989-02-08
IE62006B1 (en)	1994-12-14

Legal Events

Date

Code

Title

Description

2001-11-30

RENW

Renewal (renewal fees accepted)

2014-04-30

ERR

Error or correction

Free format text: THE OWNER HAS BEEN CORRECTED TO 890887, NOVARTIS AG, LICHTSTRASSE 35, CH-4056 BASEL, CH

Effective date: 20140409

Publication	Publication Date	Title
GB2222770B (en)	1992-07-29	Pharmaceutical compositions containing cyclosporins
GB2196964B (en)	1990-07-18	Pharmaceutical compositions
NZ222980A (en)	1989-11-28	3-aryloxy-3-substituted propanamines and pharmaceutical compositions
NZ223096A (en)	1990-09-26	Peptidylaminodiols and pharmaceutical compositions
GB8716301D0 (en)	1987-08-19	Pharmaceutical compositions
GB8723121D0 (en)	1987-11-04	Pharmaceutical compositions
GB8717582D0 (en)	1987-09-03	Pharmaceutical compositions
GB8714625D0 (en)	1987-07-29	Pharmaceutical compositions
NZ223314A (en)	1989-09-27	N-heterocyclic-n-(4-piperidyl)amides and pharmaceutical compositions
GB8829556D0 (en)	1989-02-08	New cyclosporin crystal form processes for its production pharmaceutical compositions containing it and its use
NZ226450A (en)	1990-05-28	Crystalline-1-carbacephalosporin and pharmaceutical compositions
GB8708587D0 (en)	1987-05-13	Pharmaceutical compositions
GB8717581D0 (en)	1987-09-03	Pharmaceutical compositions
GB2191696B (en)	1991-01-16	Pharmaceutical compositions
GB8618259D0 (en)	1986-09-03	Pharmaceutical compositions
GB2190838B (en)	1990-12-12	Pharmaceutical compositions
GB8629781D0 (en)	1987-01-21	Pharmaceutical compositions
GB8723120D0 (en)	1987-11-04	Pharmaceutical compositions
GB8723118D0 (en)	1987-11-04	Pharmaceutical compositions
GB8706947D0 (en)	1987-04-29	Pharmaceutical compositions
NZ219748A (en)	1989-05-29	Indenopyrimidines and pharmaceutical compositions
GB8621756D0 (en)	1986-10-15	Pharmaceutical compositions
GR871999B (en)	1988-04-26	Pharmaceutical compositions
GB8620073D0 (en)	1986-10-01	Pharmaceutical compositions
GB8615041D0 (en)	1986-07-23	Pharmaceutical compositions